The trypanothione system and its implications in the therapy of trypanosomatid diseases

International Journal of Medical Microbiology

Volumn 302, Issue 4-5, 2012, Pages 216-220

  Flohé, Leopold ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Drugability; Target validation; Trypanothione reductase; Trypanothione synthetase; Tryparedoxin; Tryparedoxin peroxidases

Indexed keywords

DISULFIDE; GLUTATHIONYLSPERMIDINE SYNTHETASE; HYDROPEROXIDE; ORNITHINE; ORNITHINE DECARBOXYLASE; OXIDOREDUCTASE; PEROXIDASE; PUTRESCINE; SPERMIDINE SYNTHASE; THIOREDOXIN; THIOREDOXIN REDUCTASE; TRYPANOTHIONE; TRYPANOTHIONE REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HIGH THROUGHPUT SCREENING; KINETOPLASTIDA; MOLECULAR WEIGHT; NONHUMAN; OXIDATION REDUCTION REACTION; PARASITE DEVELOPMENT; PARASITE SURVIVAL; PROTEIN FUNCTION; TRYPANOSOMATID INFECTION;

AMIDE SYNTHASES; ANIMALS; DRUG DISCOVERY; EUGLENOZOA INFECTIONS; GLUTATHIONE; HUMANS; NADH, NADPH OXIDOREDUCTASES; OXIDATION-REDUCTION; PEROXIDASES; PEROXIREDOXINS; PROTOZOAN PROTEINS; SPERMIDINE; THIOREDOXINS; TRYPANOCIDAL AGENTS; TRYPANOSOMATINA;

EID: 84866625634     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2012.07.008     Document Type: Article

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