Inhibitors of Trypanosoma cruzi trypanothione reductase revealed by virtual screening and parallel synthesis

Journal of Medicinal Chemistry

Volumn 48, Issue 15, 2005, Pages 4793-4802

  Meiering, Svea ^a   Inhoff, Oliver ^a   Mies, Jan ^b   Vincek, Adam ^b   Garcia, Gabriel ^b   Kramer, Bernd ^b   Dormeyer, Matthias ^b   Krauth Siegel, R Luise ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b 4SC AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,7 BIS[(4 PHENYLBUT 3 YNIMIDOYL)AMINO]HEPTANE; 1,8 BIS(4 BENZYLOXY 3 METHOXYBENZIMIDOYLAMINO)OCTANE; 4,4' BIS(4 BENZYLOXY 3 METHOXYBENZIMIDOYLAMINO)DICYCLOHEXYL METHANE; 4,4' BIS(4 BENZYLOXY 3 METHOXYBENZIMIDOYLAMINO)DIPHENYL ETHER; AMIDINE; ANTIPROTOZOAL AGENT; BENZENE DERIVATIVE; CHLORHEXIDINE; ENZYME INHIBITOR; GLUTATHIONE REDUCTASE; PIPERIDINE DERIVATIVE; TRYPANOTHIONE REDUCTASE; TRYPANOTHIONE REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CHAGAS DISEASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HIGH THROUGHPUT SCREENING; NONHUMAN; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

AMIDINES; ANIMALS; CHLORHEXIDINE; HUMANS; MODELS, MOLECULAR; NADH, NADPH OXIDOREDUCTASES; PIPERIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOSOMA CRUZI;

EID: 22744459375     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050027z     Document Type: Article

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