Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: A divinyl ketone as key intermediate

Journal of Medicinal Chemistry

Volumn 48, Issue 23, 2005, Pages 7400-7410

  Lee, Brittany ^a   Bauer, Holger ^a,b   Melchers, Johannes ^a   Ruppert, Thomas ^a   Rattray, Lauren ^c   Yardley, Vanessa ^c   Davioud Charvet, Elisabeth ^a,b   Luise Krauth Siegel, R ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b INSTITUT PASTEUR DE LILLE   (France)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTINE; FLAVOPROTEIN; KETONE; MANNICH BASE; TRYPANOTHIONE REDUCTASE;

ALKYLATION; ARTICLE; CARBOXY TERMINAL SEQUENCE; DEAMINATION; ENZYME ACTIVE SITE; ENZYME INACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; OXIDATION REDUCTION REACTION; REACTION ANALYSIS; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

ANIMALS; ANTIMALARIALS; ANTIPROTOZOAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIMETHYL SULFOXIDE; DRUG STORAGE; GLUTATHIONE; GLUTATHIONE REDUCTASE; HUMANS; KETONES; LEISHMANIA DONOVANI; MAGNETIC RESONANCE SPECTROSCOPY; MANNICH BASES; NADH, NADPH OXIDOREDUCTASES; PLASMODIUM FALCIPARUM; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; THIOREDOXIN REDUCTASE (NADPH); TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI RHODESIENSE; TRYPANOSOMA CRUZI;

EID: 28544450142     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0504860     Document Type: Article

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