Adiponectin and PPARγ: Cooperative and Interdependent Actions of Two Key Regulators of Metabolism

Vitamins and Hormones

Volumn 90, Issue , 2012, Pages 143-162

  Astapova, Olga ^a   Leff, Todd ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adiponectin; Adipose tissue; Diabetes; Gene transcription; Insulin resistance; Nuclear receptors; PPAR ; Transcription factors

Indexed keywords

EID: 84866599312     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-398313-8.00006-3     Document Type: Chapter

References (78)

1. Altshuler D., Hirschhorn J.N., Klannemark M., Lindgren C.M., Vohl M.C., Nemesh J., et al. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nature Genetics 2000, 26:76-80.
2. Amin R.H., Mathews S.T., Alli A., Leff T. Endogenously produced adiponectin protects cardiomyocytes from hypertrophy by a PPARgamma-dependent autocrine mechanism. American Journal of Physiology. Heart and Circulatory Physiology 2010, 299:H690-H698.
3. Amin R.H., Mathews S.T., Camp H.S., Ding L., Leff T. Selective activation of PPARgamma in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance. American Journal of Physiology. Endocrinology and Metabolism 2010, 298:E28-E37.
4. Beckers S., Peeters A.V., de Freitas F., Mertens I.L., Verhulst S.L., Haentjens D., et al. Association study and mutation analysis of adiponectin shows association of variants in APM1 with complex obesity in women. Annals of Human Genetics 2009, 73:492-501.
5. Breitfeld J., Stumvoll M., Kovacs P. Genetics of adiponectin. Biochimie 2012, Epub ahead of print. 2012 Mar 15.
6. Chen S., Hu Z., Zhang K. Effect of Troglitazone on expression of adhesion molecules and eNOS in human saphenous vein graft. Journal of Huazhong University of Science and Technology 2007, 27:657-659.
7. Chen W., Roeder R.G. Mediator-dependent nuclear receptor function. Seminars in Cell & Developmental Biology 2011, 22:749-758.
8. Chu K., Lee S.-T., Koo J.-S., Jung K.-H., Kim E.-H., Sinn D.-I., et al. Peroxisome proliferator-activated receptor-gamma-agonist, rosiglitazone, promotes angiogenesis after focal cerebral ischemia. Brain Research 2006, 1093:208-218.
9. Combs T.P., Wagner J.A., Berger J., Doebber T., Wang W.-J., Zhang B.B., et al. Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: A potential mechanism of insulin sensitization. Endocrinology 2002, 143:998-1007.
10. Deeb S.S., Fajas L., Nemoto M., Pihlajamäki J., Mykkänen L., Kuusisto J., et al. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nature Genetics 1998, 20:284-287.
11. Ding G., Qin Q., He N., Francis-David S., Hou J., Liu J., et al. Adiponectin and its receptors are expressed in adult ventricular cardiomyocytes and upregulated by activation of peroxisome proliferator-activated receptor gamma. Journal of Molecular and Cellular Cardiology 2007, 43:73-84.
12. Djaouti L., Jourdan T., Demizieux L., Chevrot M., Gresti J., Vergès B., et al. Different effects of pioglitazone and rosiglitazone on lipid metabolism in mouse cultured liver explants. Diabetes/Metabolism Research and Reviews 2010, 26:297-305.
13. Engeli S., Feldpausch M., Gorzelniak K., Hartwig F., Heintze U., Janke J., et al. Association between adiponectin and mediators of inflammation in obese women. Diabetes 2003, 52:942-947.
14. Fantuzzi G. Adiponectin and inflammation: Consensus and controversy. The Journal of Allergy and Clinical Immunology 2008, 121:326-330.
15. Foryst-Ludwig A., Clemenz M., Hohmann S., Hartge M., Sprang C., Frost N., et al. Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma. PLoS Genetics 2008, 4:e1000108.
16. Goya K., Sumitani S., Otsuki M., Xu X., Yamamoto H., Kurebayashi S., et al. The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells. Journal of Diabetes and Its Complications 2006, 20:336-342.
17. Heiker J.T., Kosel D., Beck-Sickinger A.G. Molecular mechanisms of signal transduction via adiponectin and adiponectin receptors. Biological Chemistry 2010, 391:1005-1018.
18. Heikkinen S., Argmann C., Feige J.N., Koutnikova H., Champy M.-F., Dali-Youcef N., et al. The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface. Cell Metabolism 2009, 9:88-98.
19. Hevener A.L., He W., Barak Y., Le J., Bandyopadhyay G., Olson P., et al. Muscle-specific Pparg deletion causes insulin resistance. Nature Medicine 2003, 9:1491-1497.
20. Hirose H., Kawai T., Yamamoto Y., Taniyama M., Tomita M., Matsubara K., et al. Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes. Metabolism 2002, 51:314-317.
21. Hiuge A., Tenenbaum A., Maeda N., Benderly M., Kumada M., Fisman E.Z., et al. Effects of peroxisome proliferator-activated receptor ligands, bezafibrate and fenofibrate, on adiponectin level. Arteriosclerosis, Thrombosis, and Vascular Biology 2007, 27:635-641.
22. Hiuge-Shimizu A., Maeda N., Hirata A., Nakatsuji H., Nakamura K., Okuno A., et al. Dynamic changes of adiponectin and S100A8 levels by the selective peroxisome proliferator-activated receptor-gamma agonist rivoglitazone. Arteriosclerosis, Thrombosis, and Vascular Biology 2011, 31:792-799.
23. Huang P.-H., Sata M., Nishimatsu H., Sumi M., Hirata Y., Nagai R. Pioglitazone ameliorates endothelial dysfunction and restores ischemia-induced angiogenesis in diabetic mice. Biomedicine and Pharmacotherapy 2008, 62:46-52.
24. Iwaki M., Matsuda M., Maeda N., Funahashi T., Matsuzawa Y., Makishima M., et al. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes 2003, 52:1655-1663.
25. Jeninga E., Gurnell M., Kalkhoven E. Functional implications of genetic variation in human PPARgamma. Trends in Endocrinology and Metabolism 2009, 20(8):380-387.
26. Jones J., Barrick C., Kim K., Lindner J., Blondeau B., Fujimoto Y., et al. Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:6207-6212.
27. Kim M.-J., Kim H.K. Effect of garlic on high fat induced obesity. Acta Biologica Hungarica 2011, 62:244-254.
28. Kim K.-Y., Kim J.K., Jeon J.H., Yoon S.R., Choi I., Yang Y. c-Jun N-terminal kinase is involved in the suppression of adiponectin expression by TNF-alpha in 3T3-L1 adipocytes. Biochemical and Biophysical Research Communications 2005, 327:460-467.
29. Kita A., Yamasaki H., Kuwahara H., Moriuchi A., Fukushima K., Kobayashi M., et al. Identification of the promoter region required for human adiponectin gene transcription: Association with CCAAT/enhancer binding protein-beta and tumor necrosis factor-alpha. Biochemical and Biophysical Research Communications 2005, 331:484-490.
30. Kobayashi N., Ohno T., Yoshida K., Fukushima H., Mamada Y., Nomura M., et al. Cardioprotective mechanism of telmisartan via PPAR-gamma-eNOS pathway in dahl salt-sensitive hypertensive rats. American Journal of Hypertension 2008, 21:576-581.
31. Koenen T.B., Tack C.J., Kroese J.M., Hermus A.R., Sweep F.C.G., van der Laak J., et al. Pioglitazone treatment enlarges subcutaneous adipocytes in insulin-resistant patients. The Journal of Clinical Endocrinology and Metabolism 2009, 94:4453-4457.
32. Kudoh A., Satoh H., Hirai H., Watanabe T. Pioglitazone upregulates adiponectin receptor 2 in 3T3-L1 adipocytes. Life Sciences 2011, 88:1055-1062.
33. Kume S., Uzu T., Araki S.-I., Sugimoto T., Isshiki K., Chin-Kanasaki M., et al. Role of altered renal lipid metabolism in the development of renal injury induced by a high-fat diet. Journal of the American Society of Nephrology 2007, 18:2715-2723.
34. Landrier J.-F., Gouranton E., El Yazidi C., Malezet C., Balaguer P., Borel P., et al. Adiponectin expression is induced by vitamin E via a peroxisome proliferator-activated receptor gamma-dependent mechanism. Endocrinology 2009, 150:5318-5325.
35. Larrieta E., Velasco F., Vital P., López-Aceves T., Lazo-de-la-Vega-Monroy M.L., Rojas A., et al. Pharmacological concentrations of biotin reduce serum triglycerides and the expression of lipogenic genes. European Journal of Pharmacology 2010, 644:263-268.
36. Lefterova M., Zhang Y., Steger D., Schupp M., Schug J., Cristancho A., et al. PPARgamma and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scale. Genes & Development 2008, 22:2941-2952.
37. Lengi A.J., Corl B.A. Factors influencing the differentiation of bovine preadipocytes in vitro. Journal of Animal Science 2010, 88:1999-2008.
38. Lim J.-Y., Kim W.H., Park S.I. GO6976 prevents TNF-alpha-induced suppression of adiponectin expression in 3T3-L1 adipocytes: Putative involvement of protein kinase C. FEBS Letters 2008, 582:3473-3478.
39. Liu M., Zhou L., Xu A., Lam K.S.L., Wetzel M.D., Xiang R., et al. A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:18302-18307.
40. Lonard D.M., O'malley B.W. Nuclear receptor coregulators: Judges, juries, and executioners of cellular regulation. Molecular Cell 2007, 27:691-700.
41. Long Q., Lei T., Feng B., Yin C., Jin D., Wu Y., et al. Peroxisome proliferator-activated receptor-gamma increases adiponectin secretion via transcriptional repression of endoplasmic reticulum chaperone protein ERp44. Endocrinology 2010, 151:3195-3203.
42. Maeda N., Takahashi M., Funahashi T., Kihara S., Nishizawa H., Kishida K., et al. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes 2001, 50:2094-2099.
43. Neschen S., Morino K., Rossbacher J.C., Pongratz R.L., Cline G.W., Sono S., et al. Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice. Diabetes 2006, 55:924-928.
44. Nishiumi S., Yabushita Y., Furuyashiki T., Fukuda I., Ashida H. Involvement of SREBPs in 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced disruption of lipid metabolism in male guinea pig. Toxicology and Applied Pharmacology 2008, 229:281-289.
45. Odegaard J.I., Ricardo-Gonzalez R.R., Goforth M.H., Morel C.R., Subramanian V., Mukundan L., et al. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 2007, 447:1116-1120.
46. Pajvani U.B., Hawkins M., Combs T.P., Rajala M.W., Doebber T., Berger J.P., et al. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. The Journal of Biological Chemistry 2004, 279:12152-12162.
47. Petrović V., Buzadzić B., Korać A., Vasilijević A., Janković A., Korać B. NO modulates the molecular basis of rat interscapular brown adipose tissue thermogenesis. Comparative Biochemistry and Physiology, Toxicology & Pharmacology 2010, 152:147-159.
48. Phillips S.A., Ciaraldi T.P., Kong A.P.S., Bandukwala R., Aroda V., Carter L., et al. Modulation of circulating and adipose tissue adiponectin levels by antidiabetic therapy. Diabetes 2003, 52:667-674.
49. Piguet A.-C., Stroka D., Zimmermann A., Dufour J.-F. Hypoxia aggravates non-alcoholic steatohepatitis in mice lacking hepatocellular PTEN. Clinical Science 2010, 118:401-410.
50. Pita J., Panadero A., Soriano-Guillén L., Rodríguez E., Rovira A. The insulin sensitizing effects of PPAR-γ agonist are associated to changes in adiponectin index and adiponectin receptors in Zucker fatty rats. Regulatory Peptides 2012, 174:18-25.
51. Polikandriotis J.A., Mazzella L.J., Rupnow H.L., Hart C.M. Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms. Arteriosclerosis, Thrombosis, and Vascular Biology 2005, 25:1810-1816.
52. Qiang L., Wang H., Farmer S. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Molecular and Cellular Biology 2007, 27:4698-4707.
53. Qiao L., MacLean P., Schaack J., Orlicky D., Darimont C., Pagliassotti M., et al. C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer. Diabetes 2005, 54:1744-1754.
54. Riera-Guardia N., Rothenbacher D. The effect of thiazolidinediones on adiponectin serum level: A meta-analysis. Diabetes, Obesity & Metabolism 2008, 10:367-375.
55. Rodríguez A., Gómez-Ambrosi J., Catalán V., Gil M.J., Becerril S., Sáinz N., et al. Acylated and desacyl ghrelin stimulate lipid accumulation in human visceral adipocytes. International Journal of Obesity and Related Metabolic Disorders 2009, 33:541-552.
56. Sam S., Haffner S., Davidson M.H., D'Agostino R., Perez A., Mazzone T. Pioglitazone-mediated changes in lipoprotein particle composition are predicted by changes in adiponectin level in type 2 diabetes. The Journal of Clinical Endocrinology and Metabolism 2012, 97:E110-E114.
57. Schild R.L., Sonnenberg-Hirche C.M., Schaiff W.T., Bildirici I., Nelson D.M., Sadovsky Y. The kinase p38 regulates peroxisome proliferator activated receptor-gamma in human trophoblasts. Placenta 2006, 27:191-199.
58. Seo J.B., Moon H.M., Noh M.J., Lee Y.S., Jeong H.W., Yoo E.J., et al. Adipocyte determination- and differentiation-dependent factor 1/sterol regulatory element-binding protein 1c regulates mouse adiponectin expression. The Journal of Biological Chemistry 2004, 279:22108-22117.
59. Shen W., Hao J., Feng Z., Tian C., Chen W., Packer L., et al. Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway. British Journal of Pharmacology 2011, 162:1213-1224.
60. Sugii S., Olson P., Sears D.D., Saberi M., Atkins A.R., Barish G.D., et al. PPARgamma activation in adipocytes is sufficient for systemic insulin sensitization. Proceedings of the National Academy of Sciences of the United States of America 2009, 106:22504-22509.
61. Sutinen J., Kannisto K., Korsheninnikova E., Fisher R.M., Ehrenborg E., Nyman T., et al. Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy. American Journal of Physiology. Endocrinology and Metabolism 2004, 286:E941-E949.
62. Takata N., Awata T., Inukai K., Watanabe M., Ohkubo T., Kurihara S., et al. Pro12Ala substitution in peroxisome proliferator-activated receptor gamma 2 is associated with low adiponectin concentrations in young Japanese men. Metabolism 2004, 53:1548-1551.
63. Tontonoz P., Spiegelman B. Fat and beyond: The diverse biology of PPARgamma. Annual Review of Biochemistry 2008, 77:289-312.
64. Tsai Y.-S., Tsai P.-J., Jiang M.-J., Chou T.-Y., Pendse A., Kim H.-S., et al. Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity. Molecular Endocrinology 2009, 23:1787-1798.
65. Vasilijević A., Vojcić L., Dinulović I., Buzadzić B., Korać A., Petrović V., et al. Expression pattern of thermogenesis-related factors in interscapular brown adipose tissue of alloxan-treated rats: Beneficial effect of L-arginine. Nitric Oxide 2010, 23:42-50.
66. Wang Y., Lam K.S.L., Yau M.-H., Xu A. Post-translational modifications of adiponectin: Mechanisms and functional implications. The Biochemical Journal 2008, 409:623-633.
67. Wang Z.V., Scherer P.E. DsbA-L is a versatile player in adiponectin secretion. Proceedings of the National Academy of Sciences of the United States of America 2008, 105:18077-18078.
68. Wang Z., Schraw T., Kim J., Khan T., Rajala M., Follenzi A., et al. Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Molecular and Cellular Biology 2007, 27:3716-3731.
69. Wolf G. New insights into thiol-mediated regulation of adiponectin secretion. Nutrition Reviews 2008, 66:642-645.
70. Xiao X., Su G., Brown S., Chen L., Ren J., Zhao P. Peroxisome proliferator-activated receptors gamma and alpha agonists stimulate cardiac glucose uptake via activation of AMP-activated protein kinase. The Journal of Nutritional Biochemistry 2010, 21(7):621-626.
71. Yamazaki T., Shiraishi S., Kishimoto K., Miura S., Ezaki O. An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fat. The Journal of Nutritional Biochemistry 2011, 22:543-553.
72. Yang W.-S., Hsiung C.A., Ho L.-T., Chen Y.-T., He C.-T., Curb J.D., et al. Genetic epistasis of adiponectin and PPARgamma2 genotypes in modulation of insulin sensitivity: A family-based association study. Diabetologia 2003, 46:977-983.
73. Yu J., Javorschi S., Hevener A., Kruszynska Y., Norman R., Sinha M., et al. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes 2002, 51:2968-2974.
74. Yuen C.Y., Wong W.T., Tian X.Y., Wong S.L., Lau C.W., Yu J., et al. Telmisartan inhibits vasoconstriction via PPARγ-dependent expression and activation of endothelial nitric oxide synthase. Cardiovascular Research 2011, 90:122-129.
75. Zappalà G., Rechler M.M. IGFBP-3, hypoxia and TNF-alpha inhibit adiponectin transcription. Biochemical and Biophysical Research Communications 2009, 382:785-789.
76. Zhang Y.-L., Hernandez-Ono A., Siri P., Weisberg S., Conlon D., Graham M.J., et al. Aberrant hepatic expression of PPARgamma2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis. The Journal of Biological Chemistry 2006, 281:37603-37615.
77. Zhang X., Xu A., Chung S.K., Cresser J.H.B., Sweeney G., Wong R.L.C., et al. Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice. Diabetes 2011, 60:486-495.
78. Zhao L.F., Iwasaki Y., Zhe W., Nishiyama M., Taguchi T., Tsugita M., et al. Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription. Endocrine Journal 2010, 57:317-324.