An increase in liver PPARγ2 is an initial event to induce fatty liver in response to a diet high in butter: PPARγ2 knockdown improves fatty liver induced by high-saturated fat

Journal of Nutritional Biochemistry

Volumn 22, Issue 6, 2011, Pages 543-553

  Yamazaki, Tomomi ^a   Shiraishi, Sayaka ^a   Kishimoto, Kyoko ^a   Miura, Shinji ^a   Ezaki, Osamu ^a  

^a NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

Author keywords

PPAR ; SREBP 1c; Steatosis

Indexed keywords

1 ACYLGLYCEROPHOSPHATE ACYLTRANSFERASE; ACETYL COENZYME A CARBOXYLASE; ADIPOPHILIN; CD36 ANTIGEN; CD68 ANTIGEN; DIACYLGLYCEROL ACYLTRANSFERASE; FATTY ACID SYNTHASE; GLYCEROL 3 PHOSPHATE ACYLTRANSFERASE; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; SAFFLOWER OIL; SATURATED FATTY ACID; SHORT HAIRPIN RNA; STEAROYL COENZYME A; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; BLOOD ANALYSIS; BODY WEIGHT; BUTTER; CALORIC INTAKE; CONTROLLED STUDY; FATTY LIVER; GENE OVEREXPRESSION; LIPOGENESIS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; WESTERN BLOTTING;

ANIMALS; BUTTER; FATTY ACIDS; FATTY LIVER; GENE KNOCKDOWN TECHNIQUES; LIVER; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; PPAR GAMMA; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

CARTHAMUS TINCTORIUS; MUS;

EID: 79955868038     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2010.04.009     Document Type: Article

References (44)

1. Clark J.M., Brancati F.L., Diehl A.M. Nonalcoholic fatty liver disease. Gastroenterology 2002, 122:1649-1657.
2. Tiikkainen M., Bergholm R., Vehkavaara S., Rissanen A., Häkkinen A.M., Tamminen M., et al. Effects of identical weight loss on body composition and features of insulin resistance in obese women with high and low liver fat content. Diabetes 2003, 52:701-707.
3. Westerbacka J., Lammi K., Häkkinen A.M., Rissanen A., Salminen I., Aro A., et al. Dietary fat content modifies liver fat in overweight nondiabetic subjects. J Clin Endocrinol Metab 2005, 90:2804-2809.
4. Musso G., Gambino R., De Michieli F., Cassader M., Rizzetto M., Durazzo M., et al. Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology 2003, 37:909-916.
5. Clarke S.D. Nonalcoholic steatosis and steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription. Am J Physiol Gastrointest Liver Physiol 2001, 281:G865-869.
6. Gavrilova O., Haluzik M., Matsusue K., Cutson J.J., Johnson L., Dietz K.R., et al. Liver peroxisome proliferator-activated receptor γ contributes to hepatic steatosis, triacylglycerol clearance, and regulation of body fat mass. J Biol Chem 2003, 278:34268-34276.
7. Matsusue K., Haluzik M., Lambert G., Yim S.H., Gavrilova O., Ward J.M., et al. Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest 2003, 111:737-747.
8. Yu S., Matsusue K., Kashireddy P., Cao W.Q., Yeldandi V., Yeldandi A.V., et al. Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor γ 1 (PPARγ 1) overexpression. J Biol Chem 2003, 278:498-505.
9. Herzig S., Hedrick S., Morantte I., Koo S.H., Galimi F., Montminy M. CREB controls hepatic lipid metabolism through nuclear hormone receptor PPAR-γ Nature 2003, 426:190-193.
10. Koonen D.P., Jacobs R.L., Febbraio M., Young M.E., Soltys C.L., Ong H., et al. Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity. Diabetes 2007, 56:2863-2871.
11. Magnusson B., Asp L., Boström P., Ruiz M., Stillemark-Billton P., Lindén D., et al. Adipocyte differentiation-related protein promotes fatty acid storage in cytosolic triglycerides and inhibits secretion of very low-density lipoproteins. Arterioscler Thromb Vas Biol 2006, 26:1566-1571.
12. Zhu Y., Qi C., Korenberg J.R., Chen X.N., Noya D., Rao M.S., et al. Structural organization of mouse peroxisome proliferator-activated receptor γ (mPPAR γ) gene: alternative promoter use and different splicing yield two mPPAR γ isoforms. Proc Natl Acad Sci U S A 1995, 92:7921-7925.
13. Horton J.D., Shimomura I. Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis. Curr Opin Lipidol 1999, 10:143-150.
14. Lin J., Yang R., Tarr P.T., Wu P.H., Handschin C., Li S., et al. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1α coactivation of SREBP. Cell 2005, 120:261-273.
15. Arsov T., Larter C.Z., Nolan C.J., Petrovsky N., Goodnow C.C., Teoh N.C., et al. Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. Biochem Biophys Res Commun 2006, 342:1152-1159.
16. Inoue M., Ohtake T., Motomura W., Takahashi N., Hosoki Y., Miyoshi S., et al. Increased expression of PPARγ in high fat diet-induced liver steatosis in mice. Biochem Biophys Res Commun 2005, 336:215-222.
17. Motomura W., Inoue M., Ohtake T., Takahashi N., Nagamine M., Tanno S., et al. Up-regulation of ADRP in fatty liver in human and liver steatosis in mice fed with high fat diet. Biochem Biophys Res Commun 2006, 340:1111-1118.
18. Sampath H., Miyazaki M., Dobrzyn A., Ntambi J.M. Stearoyl-CoA desaturase-1 mediates the pro-lipogenic effects of dietary saturated fat. J Biol Chem 2007, 282:2483-2493.
19. Moon Y.A., Hammer R.E., Horton J.D. Deletion of ELOVL5 leads to fatty liver through activation of SREBP-1c in mice. J Lipid Res 2009, 50:412-423.
20. Yamazaki T., Nakamori A., Sasaki E., Wada S., Ezaki O. Fish oil prevents sucrose- induced fatty liver but exacerbates high-safflower oil-induced fatty liver in ddY mice. Hepatology 2007, 46:1779-1790.
21. Folch J., Lees M., Sloane Stanley G.H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957, 226:497-509.
22. Brown M.S., Goldstein J.L. Selective versus total insulin resistance: a pathogenic paradox. Cell Metabolism 2008, 7:95-96.
23. Chitturi S., Abeygunasekera S., Farrell G.C., Holmes-Walker J., Hui J.M., Fung C., et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002, 35:373-379.
24. Marchesini G., Brizi M., Morselli-Labate A.M., Bianchi G., Bugianesi E., McCullough A.J., et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med 1999, 107:450-455.
25. Sanyal A.J., Campbell-Sargent C., Mirshahi F., Rizzo W.B., Contos M.J., Sterling R.K., et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001, 120:1183-1192.
26. Cohen P., Friedman J.M. Leptin and the control of metabolism: role for stearoyl-CoA desaturase-1 (SCD-1). J Nutr 2004, 134:2455S-2463S.
27. Thuresson E.R. Inhibition of glycerol-3-phosphate acyltransferase as a potential treatment for insulin resistance and type 2 diabetes. Curr Opin Investig Drugs 2004, 5:411-418.
28. Agarwal A.K., Arioglu E., De Almeida S., Akkoc N., Taylor S.I., Bowcock A.M., et al. AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. Nat Genet 2002, 31:21-23.
29. Stone S.J., Levin M.C., Farese R.V. Membrane topology and identification of key functional amino acid residues of murine acyl-CoA: diacylglycerol acyltransferase-2. J Biol Chem 2006, 281:40273-40282.
30. Yamazaki T., Sasaki E., Kakinuma C., Yano T., Miura S., Ezaki O. Increased very low density lipoprotein secretion and gonadal fat mass in mice overexpressing liver DGAT1. J Biol Chem 2005, 280:21506-21514.
31. Shimano H., Yahagi N., Amemiya-Kudo M., Hasty A.H., Osuga J., Tamura Y., et al. Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes. J Biol Chem 1999, 274:35832-35839.
32. Reddy J.K., Mannaerts G.P. Peroxisomal lipid metabolism. Annu Rev Nutr 1994, 14:343-370.
33. Herz J., Gerard R.D. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc Natl Acad Sci U S A 1993, 90:2812-2816.
34. Zhang Y.L., Hernandez-Ono A., Siri P., Weisberg S., Conlon D., Graham M.J., et al. Aberrant hepatic expression of PPARγ2 stimulates hepatic lipogenesis in a mouse model of obesity, insulin resistance, dyslipidemia, and hepatic steatosis. J Biol Chem 2006, 281:37603-37615.
35. Miller C.W., Ntambi J.M. Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression. Proc Natl Acad Sci U S A 1996, 93:9443-9448.
36. Schadinger S.E., Bucher N.L., Schreiber B.M., Farmer S.R. PPARγ2 regulates lipogenesis and lipid accumulation in steatotic hepatocytes. Am. J Physiol Endocrinol Metab 2005, 288:E1195-1205.
37. Vuppalanchi R., Chalasani N. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: selected practical issues in their evaluation and management. Hepatology 2009, 49:306-317.
38. Riera-Guardia N., Rothenbacher D. The effect of thiazolidinediones on adiponectin serum level: a meta-analysis. Diabetes Obes Metab 2008, 10:367-375.
39. Xu A., Wang Y., Keshaw H., Xu L.Y., Lam K.S., Cooper G.J. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 2003, 112:91-100.
40. Awazawa M., Ueki K., Inabe K., Yamauchi T., Kaneko K., Okazaki Y., et al. Adiponectin suppresses hepatic SREBP1c expression in an AdipoR1/LKB1/AMPK dependent pathway. Biochem Biophys Res Commun 2009, 382:51-56.
41. Seo J.B., Moon H.M., Kim W.S., Lee Y.S., Jeong H.W., Yoo E.J., et al. Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor γ expression. Mol Cell Biol 2004, 24:3430-3444.
42. Zhou J., Zhai Y., Mu Y., Gong H., Uppal H., Toma D., et al. A novel pregnane X receptor-mediated and sterol regulatory element-binding protein- independent lipogenic pathway. J Biol Chem 2006, 281:15013-15020.
43. Edvardsson U., Ljungberg A., Oscarsson J. Insulin and oleic acid increase PPARγ2 expression in cultured mouse hepatocytes. Biochem Biophys Res Commun 2006, 340:111-117.
44. Rieusset J., Andreelli F., Auboeuf D., Roques M., Vallier P., Riou J.P., et al. Insulin acutely regulates the expression of the peroxisome proliferator- activated receptor-γ in human adipocytes. Diabetes 1999, 48:699-705.