MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult

Journal of Neuroinflammation

Volumn 5, Issue , 2008, Pages

  Thompson, Wendy L ^a   Karpus, William J ^a,b   Van Eldik, Linda J ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; CORTICOTROPIN; ENDOTOXIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; BETA CHEMOKINE; CCL2 PROTEIN, MOUSE;

ACUTE PHASE RESPONSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CELL ACTIVATION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; CORTICOTROPIN BLOOD LEVEL; CYTOKINE RELEASE; ENCEPHALITIS; ENDOTOXEMIA; ENZYME IMMUNOASSAY; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PROTEIN FUNCTION; SYSTEMIC DISEASE; UPREGULATION; ANIMAL; BLOOD; BRAIN; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; GENETICS; HISTOLOGY; IMMUNOLOGY; INFLAMMATION; METABOLISM; MOUSE MUTANT;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; BRAIN; CHEMOKINE CCL2; CHEMOKINES, CC; CORTICOSTERONE; FEMALE; INFLAMMATION; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; TUMOR NECROSIS FACTOR-ALPHA;

EID: 51249095407     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-5-35     Document Type: Article

References (49)

1. Hart BL Biological basis of the behavior of sick animals Neuroscience and biobehavioral reviews 1988, 12(2):123-137 10.1016/ S0149-7634(88)80004-6 3050629
2. Dantzer R Cytokine-induced sickness behaviour: A neuroimmune response to activation of innate immunity European journal of pharmacology 2004, 500(1-3):399-411 10.1016/j.ejphar.2004.07.040 15464048
3. Franchimont D Overview of the actions of glucocorticoids on the immune response: A good model to characterize new pathways of immunosuppression for new treatment strategies Annals of the New York Academy of Sciences 2004, 1024:124-137 10.1196/annals.1321.009 15265777
4. Beishuizen A Thijs LG Endotoxin and the hypothalamo-pituitary-adrenal (HPA) axis Journal of endotoxin research 2003, 9(1):3-24 12691614
5. Glezer I Rivest S Glucocorticoids: Protectors of the brain during innate immune responses Neuroscientist 2004, 10(6):538-552 10.1177/ 1073858404263494 15534039
6. Correa SG Maccioni M Rivero VE Iribarren P Sotomayor CE Riera CM Cytokines and the immune-neuroendocrine network: What did we learn from infection and autoimmunity? Cytokine & growth factor reviews 2007, 18(1-2):125-134 10.1016/j.cytogfr.2007.01.011 17347025
7. Chakravarty S Herkenham M Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines J Neurosci 2005, 25(7):1788-1796 10.1523/ JNEUROSCI.4268-04.2005 15716415
8. Ransohoff RM Kivisakk P Kidd G Three or more routes for leukocyte migration into the central nervous system Nature reviews 2003, 3(7):569-581 10.1038/nri1130 12876559
9. Ralay Ranaivo H Craft JM Hu W Guo L Wing LK Van Eldik LJ Watterson DM Glia as a therapeutic target: Selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration J Neurosci 2006, 26(2):662-670 10.1523/JNEUROSCI.4652-05.2006 16407564
10. Ban E Haour F Lenstra R Brain interleukin 1 gene expression induced by peripheral lipopolysaccharide administration Cytokine 1992, 4(1):48-54 10.1016/1043-4666(92)90036-Q 1535519
11. Gatti S Bartfai T Induction of tumor necrosis factor-alpha mRNA in the brain after peripheral endotoxin treatment: Comparison with interleukin-1 family and interleukin-6 Brain research 1993, 624(1-2):291-294 10.1016/0006-8993(93)90090-A 8252403
12. Turnbull AV Rivier CL Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: Actions and mechanisms of action Physiological reviews 1999, 79(1):1-71 9922367
13. Gourmala NG Buttini M Limonta S Sauter A Boddeke HW Differential and time-dependent expression of monocyte chemoattractant protein-1 mRNA by astrocytes and macrophages in rat brain: Effects of ischemia and peripheral lipopolysaccharide administration Journal of neuroimmunology 1997, 74(1-2):35-44 10.1016/S0165-5728(96)00203-2 9119977
14. Thibeault I Laflamme N Rivest S Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP-1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines The Journal of comparative neurology 2001, 434(4):461-477 10.1002/cne.1187 11343293
15. Zisman DA Kunkel SL Strieter RM Tsai WC Bucknell K Wilkowski J Standiford TJ MCP-1 protects mice in lethal endotoxemia J Clin Invest 1997, 99(12):2832-2836 508132 9185504 10.1172/JCI119475
16. Standiford TJ Strieter RM Lukacs NW Kunkel SL Neutralization of IL-10 increases lethality in endotoxemia. Cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor J Immunol 1995, 155(4):2222-2229 7636269
17. Gourmala NG Limonta S Bochelen D Sauter A Boddeke HW Localization of macrophage inflammatory protein: Macrophage inflammatory protein-1 expression in rat brain after peripheral administration of lipopolysaccharide and focal cerebral ischemia Neuroscience 1999, 88(4):1255-1266 10.1016/S0306-4522(98)00295-4 10336134
18. Rossi D Zlotnik A The biology of chemokines and their receptors Annual review of immunology 2000, 18:217-242 10.1146/annurev.immunol.18.1.217 10837058
19. Cardona AE Li M Liu L Savarin C Ransohoff RM Chemokines in and out of the central nervous system: Much more than chemotaxis and inflammation Journal of leukocyte biology 2008, 18467654
20. Stamatovic SM Shakui P Keep RF Moore BB Kunkel SL Van Rooijen N Andjelkovic AV Monocyte chemoattractant protein-1 regulation of blood-brain barrier permeability J Cereb Blood Flow Metab 2005, 25(5):593-606 10.1038/sj.jcbfm.9600055 15689955
21. Daly C Rollins BJ Monocyte chemoattractant protein-1 (CCL2) in inflammatory disease and adaptive immunity: Therapeutic opportunities and controversies Microcirculation 2003, 10(3-4):247-257 12851642
22. Hughes PM Allegrini PR Rudin M Perry VH Mir AK Wiessner C Monocyte chemoattractant protein-1 deficiency is protective in a murine stroke model J Cereb Blood Flow Metab 2002, 22(3):308-317 10.1097/ 00004647-200203000-00008 11891436
23. Kennedy KJ Strieter RM Kunkel SL Lukacs NW Karpus WJ Acute and relapsing experimental autoimmune encephalomyelitis are regulated by differential expression of the CC chemokines macrophage inflammatory protein-1alpha and monocyte chemotactic protein-1 Journal of neuroimmunology 1998, 92(1-2):98-108 10.1016/S0165-5728(98)00187-8 9916884
24. Ramnath RD Ng SW Guglielmotti A Bhatia M Role of MCP-1 in endotoxemia and sepsis International immunopharmacology 2008, 8(6):810-818 10.1016/ j.intimp.2008.01.033 18442784
25. Speyer CL Gao H Rancilio NJ Neff TA Huffnagle GB Sarma JV Ward PA Novel chemokine responsiveness and mobilization of neutrophils during sepsis The American journal of pathology 2004, 165(6):2187-2196 1618724 15579460
26. Gomes RN Figueiredo RT Bozza FA Pacheco P Amancio RT Laranjeira AP Castro-Faria-Neto HC Bozza PT Bozza MT Increased susceptibility to septic and endotoxic shock in monocyte chemoattractant protein 1/cc chemokine ligand 2-deficient mice correlates with reduced interleukin 10 and enhanced macrophage migration inhibitory factor production Shock (Augusta, Ga 2006, 26(5):457-463 10.1097/01.shk.0000228801.56223.92 17047515
27. Depaolo RW Lathan R Rollins BJ Karpus WJ The chemokine CCL2 is required for control of murine gastric Salmonella enterica infection Infection and immunity 2005, 73(10):6514-6522 10.1128/IAI.73.10.6514-6522.2005 16177325 1230974
28. Matsukawa A Hogaboam CM Lukacs NW Lincoln PM Strieter RM Kunkel SL Endogenous monocyte chemoattractant protein-1 (MCP-1) protects mice in a model of acute septic peritonitis: Cross-talk between MCP-1 and leukotriene B4 J Immunol 1999, 163(11):6148-6154 10570305
29. Kalehua AN Nagel JE Whelchel LM Gides JJ Pyle RS Smith RJ Kusiak JW Taub DD Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration Experimental cell research 2004, 297(1):197-211 10.1016/ j.yexcr.2004.02.031 15194436
30. Gu L Tseng S Horner RM Tam C Loda M Rollins BJ Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1 Nature 2000, 404(6776):407-411 10.1038/35006097 10746730
31. Beutler B Milsark IW Cerami AC Passive immunization against cachectin/ tumor necrosis factor protects mice from lethal effect of endotoxin Science 1985, 229(4716):869-871 10.1126/science.3895437 3895437
32. Ohlsson K Bjork P Bergenfeldt M Hageman R Thompson RC Interleukin-1 receptor antagonist reduces mortality from endotoxin shock Nature 1990, 348(6301):550-552 10.1038/348550a0 2147233
33. Prigent H Maxime V Annane D Science review: Mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids Critical care (London, England) 2004, 8(4):243-252 522845 15312206
34. Qin L Wu X Block ML Liu Y Breese GR Hong JS Knapp DJ Crews FT Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration Glia 2007, 55(5):453-462 10.1002/glia.20467 17203472
35. Semmler A Frisch C Debeir T Ramanathan M Okulla T Klockgether T Heneka MT Long-term cognitive impairment, neuronal loss and reduced cortical cholinergic innervation after recovery from sepsis in a rodent model Experimental neurology 2007, 204(2):733-740 10.1016/ j.expneurol.2007.01.003 17306796
36. Ikeda T Mishima K Aoo N Egashira N Iwasaki K Fujiwara M Ikenoue T Combination treatment of neonatal rats with hypoxia-ischemia and endotoxin induces long-lasting memory and learning impairment that is associated with extended cerebral damage American journal of obstetrics and gynecology 2004, 191(6):2132-2141 10.1016/j.ajog.2004.04.039 15592303
37. Qin L He J Hanes RN Pluzarev O Hong JS Crews FT Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment Journal of neuroinflammation 2008, 5:10 2373291 18348728 10.1186/1742-2094-5-10
38. Lacroix S Rivest S Effect of acute systemic inflammatory response and cytokines on the transcription of the genes encoding cyclooxygenase enzymes (COX-1 and COX-2) in the rat brain Journal of neurochemistry 1998, 70(2):452-466 9453538
39. Nadeau S Rivest S Regulation of the gene encoding tumor necrosis factor alpha (TNF-alpha) in the rat brain and pituitary in response in different models of systemic immune challenge Journal of neuropathology and experimental neurology 1999, 58(1):61-77 10.1097/ 00005072-199901000-00008 10068315
40. Quan N Whiteside M Herkenham M Time course and localization patterns of interleukin-1beta messenger RNA expression in brain and pituitary after peripheral administration of lipopolysaccharide Neuroscience 1998, 83(1):281-293 10.1016/S0306-4522(97)00350-3 9466417
41. Brochu S Olivier M Rivest S Neuronal activity and transcription of proinflammatory cytokines, IkappaBalpha, and iNOS in the mouse brain during acute endotoxemia and chronic infection with Trypanosoma brucei brucei Journal of neuroscience research 1999, 57(6):801-816 10.1002/ (SICI)1097-4547(19990915)57:6<801::AID-JNR5>3.0.CO;2-B 10467251
42. Hayashi M Luo Y Laning J Strieter RM Dorf ME Production and function of monocyte chemoattractant protein-1 and other beta-chemokines in murine glial cells Journal of neuroimmunology 1995, 60(1-2):143-150 10.1016/ 0165-5728(95)00064-9 7642742
43. Rankine EL Hughes PM Botham MS Perry VH Felton LM Brain cytokine synthesis induced by an intraparenchymal injection of LPS is reduced in MCP-1-deficient mice prior to leucocyte recruitment The European journal of neuroscience 2006, 24(1):77-86 10.1111/j.1460-9568.2006.04891.x 16882009
44. Bell MD Taub DD Perry VH Overriding the brain's intrinsic resistance to leukocyte recruitment with intraparenchymal injections of recombinant chemokines Neuroscience 1996, 74(1):283-292 10.1016/0306-4522(96)00083-8 8843093
45. Kumai Y Ooboshi H Takada J Kamouchi M Kitazono T Egashira K Ibayashi S Iida M Anti-monocyte chemoattractant protein-1 gene therapy protects against focal brain ischemia in hypertensive rats J Cereb Blood Flow Metab 2004, 24(12):1359-1368 10.1097/00004647-200412000-00005 15625410
46. Chen Y Hallenbeck JM Ruetzler C Bol D Thomas K Berman NE Vogel SN Overexpression of monocyte chemoattractant protein 1 in the brain exacerbates ischemic brain injury and is associated with recruitment of inflammatory cells J Cereb Blood Flow Metab 2003, 23(6):748-755 10.1097/ 01.WCB.0000071885.63724.20 12796723
47. Muessel MJ Klein RM Wilson AM Berman NE Ablation of the chemokine monocyte chemoattractant protein-1 delays retrograde neuronal degeneration, attenuates microglial activation, and alters expression of cell death molecules Brain research 2002, 103(1-2):12-27 10.1016/ S0169-328X(02)00158-4 12106688
48. Babcock AA Kuziel WA Rivest S Owens T Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS J Neurosci 2003, 23(21):7922-7930 12944523
49. Song L Pachter JS Monocyte chemoattractant protein-1 alters expression of tight junction-associated proteins in brain microvascular endothelial cells Microvascular research 2004, 67(1):78-89 10.1016/j.mvr.2003.07.001 14709405