메뉴 건너뛰기




Volumn 34, Issue 4, 2012, Pages 905-915

Vitamin E prevents the age-dependent and palmitate-induced disturbances of sphingolipid turnover in liver cells

Author keywords

A Tocopherol; Ceramide; Liver cells; Old age; Palmitic acid; Sphingomyelinases; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; CARBON 14; CERAMIDE; GLUTATHIONE; LIPOSOME; PALMITIC ACID; SERINE PALMITOYLTRANSFERASE; SPHINGOLIPID; SPHINGOMYELIN;

EID: 84866520506     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-011-9288-3     Document Type: Article
Times cited : (15)

References (48)
  • 1
    • 3042586648 scopus 로고    scopus 로고
    • Inflammatory mediator and β-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E
    • DOI 10.1016/j.freeradbiomed.2004.04.007, PII S0891584904003107
    • Ayasolla K, Khan M, Singh AK, Singh I (2004) Inflammatory mediator and beta-amyloid (25-35)-induced ceramide generation and iNOS expression are inhibited by vitamin E. Free Radic Biol Med 37:325-338. doi:10.1016/j. freeradbiomed.2004.04.007 (Pubitemid 38833999)
    • (2004) Free Radical Biology and Medicine , vol.37 , Issue.3 , pp. 325-338
    • Ayasolla, K.1    Khan, M.2    Singh, A.K.3    Singh, I.4
  • 2
    • 77951093666 scopus 로고    scopus 로고
    • Effects of long-term fish oil-enriched diet on the sphingolipid metabolism in brain of old rats
    • doi:10.1016/j. exger.2010.02.010
    • Babenko NA, Semenova YA (2010) Effects of long-term fish oil-enriched diet on the sphingolipid metabolism in brain of old rats. Exp Gerontol 45:375-380. doi:10.1016/j. exger.2010.02.010
    • (2010) Exp Gerontol , vol.45 , pp. 375-380
    • Babenko, N.A.1    Semenova, Y.A.2
  • 3
    • 29744439528 scopus 로고    scopus 로고
    • Effects of Chamomilla recutita flavonoids on age-related liver sphingolipid turnover in rats
    • DOI 10.1016/j.exger.2005.08.008, PII S0531556505001968
    • Babenko N, Shakhova E (2006) Effects of Chamomilla recutita flavonoids on age-related liver sphingolipid turnover in rats. Exp Geront 41:32-39. doi:10.1016/j.exger.2005.08.008 (Pubitemid 43031365)
    • (2006) Experimental Gerontology , vol.41 , Issue.1 , pp. 32-39
    • Babenko, N.A.1    Shakhova, E.G.2
  • 4
    • 40549113673 scopus 로고    scopus 로고
    • Effects of flavonoids on sphingolipid turnover in the toxin-damaged liver and liver cells
    • DOI 10.1186/1476-511X-7-1
    • Babenko N, Shakhova E (2008) Effects of flavonoids on sphingolipid turnover in the toxin-damaged liver and liver cells. Lipids Health Dis 7:1. doi:10.1186/1476-511X-7-1 (Pubitemid 351361855)
    • (2008) Lipids in Health and Disease , vol.7 , pp. 1
    • Babenko, N.A.1    Shakhova, E.G.2
  • 6
    • 26044457028 scopus 로고    scopus 로고
    • Protective role of Vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver
    • DOI 10.1016/j.cbi.2005.08.001, PII S0009279705001857
    • Bansal AK, Bansal M, Soni G, Bhatnagar D (2005) Protective role of vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver. Chem Biol Interect 156:101-111. doi:10.1016/j.cbi.2005.08.001 (Pubitemid 41406233)
    • (2005) Chemico-Biological Interactions , vol.156 , Issue.2-3 , pp. 101-111
    • Bansal, A.K.1    Bansal, M.2    Soni, G.3    Bhatnagar, D.4
  • 7
    • 70449246528 scopus 로고
    • Phosphorus assay in column chromatography
    • Bartlett GR (1959) Phosphorus assay in column chromatography. J Biol Chem234:466-468
    • (1959) J Biol Chem , vol.234 , pp. 466-468
    • Bartlett, G.R.1
  • 8
    • 73649194769 scopus 로고
    • Improved method for the determination of blood glutathione
    • Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882-888
    • (1963) J Lab Clin Med , vol.61 , pp. 882-888
    • Beutler, E.1    Duron, O.2    Kelly, B.M.3
  • 9
    • 0033729123 scopus 로고    scopus 로고
    • De novosynthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase
    • Blázquez C, Galve-Roperh I, Guzmán M (2000) De novosynthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase. FASEB J 14:2315- 2322
    • (2000) FASEB J , vol.14 , pp. 2315-2322
    • Blázquez, C.1    Galve-Roperh, I.2    Guzmán, M.3
  • 10
    • 33845261493 scopus 로고
    • A rapidmethod of total lipid extraction and purification
    • Bligh EG, Dyer WJ (1959) A rapidmethod of total lipid extraction and purification. Can J Biochem Physiol 37:911-917
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 11
    • 21444434296 scopus 로고    scopus 로고
    • UV-C light induces raft-associated acid sphingomyelinase and JNK activation and translocation independently on a nuclear signal
    • DOI 10.1074/jbc.M412867200
    • Charruyer A, Grazide S, Bezombes C, Muller S, Laurent G, Jaffrezou JP (2005) UV-C light induces raft-associated acid sphingomyelinase and JNK activation and translocation independently on a nuclear signal. J Biol Chem 280:19196-19204. doi:10.1074/jbc.M412867200 (Pubitemid 41379626)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.19 , pp. 19196-19204
    • Charruyer, A.1    Grazide, S.2    Bezombes, C.3    Muller, S.4    Laurent, G.5    Jaffrezou, J.-P.6
  • 12
    • 26444530166 scopus 로고    scopus 로고
    • Age-related changes in neutral sphingomyelin-specific phospholipase C activity in striatum, hippocampus, and frontal cortex: Implication for sensitivity to stress and inflammation
    • DOI 10.1016/j.neuint.2005.06.011, PII S0197018605001919
    • Crivello NA, Rosenberg IH, Dallal GE, Bielinski D, Joseph JA (2005) Age-related changes in neutral sphingomyelinspecific phospholipase C activity in striatum, hippocampus, and frontal cortex: Implication for sensitivity to stress and inflammation. Neurochem Int 47:573-579. doi:10.1016/j. neuint.2005.06.011 (Pubitemid 41437902)
    • (2005) Neurochemistry International , vol.47 , Issue.8 , pp. 573-579
    • Crivello, N.A.1    Rosenberg, I.H.2    Dallal, G.E.3    Bielinski, D.4    Joseph, J.A.5
  • 13
    • 0035880016 scopus 로고    scopus 로고
    • Sphingomyelin and ceramide as regulators of development and lifespan
    • DOI 10.1016/S0047-6374(01)00246-9, PII S0047637401002469
    • Cutler RG, Mattson MP (2001) Sphingomyelin and ceramide as regulators of development and lifespan. Mech Ageing Dev 122:895-908. doi:10.1016/S0047- 6374(01)00246-9 (Pubitemid 32441613)
    • (2001) Mechanisms of Ageing and Development , vol.122 , Issue.9 , pp. 895-908
    • Cutler, R.G.1    Mattson, M.P.2
  • 14
    • 0037098871 scopus 로고    scopus 로고
    • Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: Involvement of diacylglycerol/ceramide production and oxidative stress induction
    • DOI 10.1016/S0891-5849(02)00879-1, PII S0891584902008791
    • Denis U, Lecomte M, Paget C, Ruggiero D, Wiernsperger N, Lagarde M (2002) Advanced glycation end-products induce apoptosis of bovine retinal pericytes in culture: Involvement of diacylglycerol/ceramide production and oxidative stress induction. Free Radic Biol Med 33:236-247. doi:10.1016/S0891-5849(02)00879-1 (Pubitemid 34775195)
    • (2002) Free Radical Biology and Medicine , vol.33 , Issue.2 , pp. 236-247
    • Denis, U.1    Lecomte, M.2    Paget, C.3    Ruggiero, D.4    Wiernsperger, N.5    Lagarde, M.6
  • 15
    • 33748664357 scopus 로고    scopus 로고
    • TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis
    • DOI 10.1038/sj.onc.1209568, PII 1209568
    • Dumitru CA, Gulbins E (2006) TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis. Oncogene 25:5612-5625. doi:10.1038/sj.onc.1209568 (Pubitemid 44387617)
    • (2006) Oncogene , vol.25 , Issue.41 , pp. 5612-5625
    • Dumitru, C.A.1    Gulbins, E.2
  • 16
    • 0010026348 scopus 로고
    • Preparation and properties of liposomes containing vitamin E
    • In: Packes L, Fuchs J (eds) Marsel Dekker, New York
    • Freisleben H-Y, Mentrup E (1992) Preparation and properties of liposomes containing vitamin E. In: Packes L, Fuchs J (eds) Vitamin E in Health and Disease. Marsel Dekker, New York, pp 193-206
    • (1992) Vitamin E in Health and Disease , pp. 193-206
    • Freisleben, H.-Y.1    Mentrup, E.2
  • 17
    • 0034235389 scopus 로고    scopus 로고
    • Human placenta sphingomyelinase, an exogenous acidic pH-optimum sphingomyelinase, induces oxidative stress, glutathione depletion, and apoptosis in rat hepatocytes
    • Garcia-Ruiz C, Mari M, Morales A, Colell A, Ardite E, Fernandez-Checa JC (2000) Human placenta sphingomyelinase, induces oxidative stress, glutathione depletion, and apoptosis in rat hepatocytes. Hepatology 32:56-65. doi:10.1053/jhep.2000.8267 (Pubitemid 30432366)
    • (2000) Hepatology , vol.32 , Issue.1 , pp. 56-65
    • Garcia-Ruiz, C.1    Mari, M.2    Morales, A.3    Colell, A.4    Ardite, E.5    Fernandez-Checa, J.C.6
  • 19
    • 27144445085 scopus 로고    scopus 로고
    • Ultraviolet A-induced signaling involves a ceramide-mediated autocrine loop leading to ceramide de novo synthesis
    • doi101111/j0022-202X200523782x
    • Grether-Beck S, Timmer A, Felsner I, Brenden H, Brammertz D, Krutmann J (2005) Ultraviolet A-induced signaling involves a ceramide-mediated autocrine loop leading to ceramide de novo synthesis. J Invest Dermatol 125:545-553. doi:10.1111/j.0022-202X.2005.23782.x
    • (2005) J Invest Dermatol , vol.125 , pp. 545-553
    • Grether-Beck, S.1    Timmer, A.2    Felsner, I.3    Brenden, H.4    Brammertz, D.5    Krutmann, J.6
  • 22
    • 66049092034 scopus 로고    scopus 로고
    • Neutral sphingomyelinase-induced ceramide accumulation by oxidative stress during carbon tetrachloride intoxication
    • doi:10.1016/j. tox.200904040
    • Ichi I, Kamikawa C, Nakagawa T, Kobayashi K, Kataoka R, Nagata E, Kitamura Y, Nakazaki C, Matsura T, Kojo S (2009) Neutral sphingomyelinase- induced ceramide accumulation by oxidative stress during carbon tetrachloride intoxication. Toxicology 261:33-40. doi:10.1016/j. tox.2009.04.040
    • (2009) Toxicology , vol.261 , pp. 33-40
    • Ichi, I.1    Kamikawa, C.2    Nakagawa, T.3    Kobayashi, K.4    Kataoka, R.5    Nagata, E.6    Kitamura, Y.7    Nakazaki, C.8    Matsura, T.9    Kojo, S.10
  • 23
    • 0037379665 scopus 로고    scopus 로고
    • Increase in diacylglycerol production by liver and liver cell nuclei at old age
    • DOI 10.1016/S0531-5565(02)00246-2, PII S0531556502002462
    • Kavok NS, Krasilnikova OA, Babenko NA (2003) Increase in diacylglycerol production by liver and liver nuclei at old age. Exp Gerontol 38:441-447. doi:10.1016/j.exger.2005.08.008 (Pubitemid 36379080)
    • (2003) Experimental Gerontology , vol.38 , Issue.4 , pp. 441-447
    • Kavok, N.S.1    Krasilnikova, O.A.2    Babenko, N.A.3
  • 24
    • 0002447120 scopus 로고
    • A spectrophotometric determination of sphingosine
    • Lauter CJ, Trams EG (1962) A spectrophotometric determination of sphingosine. J Lipid Res 3:135-138
    • (1962) J Lipid Res , vol.3 , pp. 135-138
    • Lauter, C.J.1    Trams, E.G.2
  • 25
    • 0034578528 scopus 로고    scopus 로고
    • Activation of sphingolipid turnover and chronic generation of ceramide and sphingosine in liver during aging
    • Lightle SA, Oakley JI, Nikolova-Karakashian MN (2000) Activation of sphingolipid turnover and chronic generation of ceramide and sphingosine in liver during aging. Mech Ageing Dev 120:111-125
    • (2000) Mech Ageing Dev , vol.120 , pp. 111-125
    • Lightle, S.A.1    Oakley, J.I.2    Nikolova-Karakashian, M.N.3
  • 27
    • 0030960327 scopus 로고    scopus 로고
    • Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione
    • DOI 10.1074/jbc.272.26.16281
    • Liu B, Hannun YA (1997) Inhibition of the neutral magnesiumdependent sphingomyelinase by glutathione. J Biol Chem 272:16281-16287. doi:10.1074/jbc.272.26.16281 (Pubitemid 27276449)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.26 , pp. 16281-16287
    • Liu, B.1    Hannun, Y.A.2
  • 29
    • 0035008208 scopus 로고    scopus 로고
    • Neutral magnesium-dependent sphingomyelinase from liver plasma membrane: Purification and inhibition by ubiquinol
    • DOI 10.1023/A:1010704715979
    • Martín SF, Navarro F, Forthoffer N, Navas P, Villalba JM (2001) Neutral magnesium-dependent sphingomyelinase from liver plasma membrane: Purification and inhibition by ubiquinol. J Bioenerg Biomembr 33:143-153 (Pubitemid 32466390)
    • (2001) Journal of Bioenergetics and Biomembranes , vol.33 , Issue.2 , pp. 143-153
    • Martin, S.F.1    Navarro, F.2    Forthoffer, N.3    Navas, P.4    Villalba, J.M.5
  • 31
    • 0034808951 scopus 로고    scopus 로고
    • UVA radiation stimulates ceramide production: Relationship to oxidative stress and potential role in ERK, JNK, and p38 activation
    • doi:10.1006/bbrc.20014348
    • Mazière C, Conte MA, Leborgne L, Levade T, Hornebeck W, Santus R, Mazière JC (2001) UVA radiation stimulates ceramide production: Relationship to oxidative stress and potential role in ERK, JNK, and p38 activation. Biochem Biophys Res Commun 281:289-294. doi:10.1006/bbrc.2001.4348
    • (2001) Biochem Biophys Res Commun , vol.281 , pp. 289-294
    • Mazière, C.1    Conte, M.A.2    Leborgne, L.3    Levade, T.4    Hornebeck, W.5    Santus, R.6    Mazière, J.C.7
  • 32
    • 0021814377 scopus 로고
    • Activities of serine palmitoyltransferase (3-ketosphinganine synthase) in microsomes from different rat tissues
    • MerrillAHJr, NixonDW,Williams RD(1985) Activities of serine palmitoyltransferase (3-ketosphinganine synthase) in microsomes from different rat tissues. J Lipid Res 26:617-622 (Pubitemid 15073734)
    • (1985) Journal of Lipid Research , vol.26 , Issue.5 , pp. 617-622
    • Merrill Jr., A.H.1    Nixon, D.W.2    Williams, R.D.3
  • 34
    • 66349088529 scopus 로고    scopus 로고
    • Hepatic triacylglycerol accumulation and insulin resistance
    • doi:10.1194/jlr.R800053-JLR200
    • Nagle CA, Klett EL, Coleman RA (2009) Hepatic triacylglycerol accumulation and insulin resistance. J Lipid Res 50: S74-S79. doi:10.1194/jlr.R800053-JLR200
    • (2009) J Lipid Res , vol.50
    • Nagle, C.A.1    Klett, E.L.2    Coleman, R.A.3
  • 36
    • 0030607109 scopus 로고    scopus 로고
    • Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives
    • DOI 10.1016/0047-6374(96)01771-X
    • Nakata K, Kawase M, Ogino S, Kinoshita C, Murata H, Sakaue T, Ogata T, Ohmori S (1996) Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives. Mech Ageing Dev 90:195-207. doi:10.1016/0047-6374(96) 01771-X (Pubitemid 26331619)
    • (1996) Mechanisms of Ageing and Development , vol.90 , Issue.3 , pp. 195-207
    • Nakata, K.1    Kawase, M.2    Ogino, S.3    Kinoshita, C.4    Murata, H.5    Sakaue, T.6    Ogata, K.7    Ohmori, S.8
  • 37
    • 0034708594 scopus 로고    scopus 로고
    • Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis
    • DOI 10.1074/jbc.275.12.9078
    • Perry DK, Carton J, Shah AK, Meredith F, Uhlinger DJ, Hannun YA (2000) Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J Biol Chem 275:9078-9084. doi:10.1074/jbc.275.12. 9078 (Pubitemid 30180269)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.12 , pp. 9078-9084
    • Perry, D.K.1    Carton, J.2    Shah, A.K.3    Meredith, F.4    Uhlinger, D.J.5    Hannun, Y.A.6
  • 38
    • 0032531429 scopus 로고    scopus 로고
    • Induction of NF-kappaB activity during haloperidol-induced oxidative toxicity in clonal hippocampal cells: Suppression of NF-kappaB and neuroprotection by antioxidants
    • Post A, Holsboer F, Behl C (1998) Induction of NF-kappaB activity during haloperidol-induced oxidative toxicity in clonal hippocampal cells: Suppression of NF-kappaB and neuroprotection by antioxidants. J Neurosci 18:8236- 8246 (Pubitemid 28465001)
    • (1998) Journal of Neuroscience , vol.18 , Issue.20 , pp. 8236-8246
    • Post, A.1    Holsboer, F.2    Behl, C.3
  • 39
    • 35848937327 scopus 로고    scopus 로고
    • Regulation of neutral sphingomyelinase-2 by GSH: A new insight to the role of oxidative stress in aging-associated inflammation
    • DOI 10.1194/jlr.M700227-JLR200
    • Rutkute K, Asmis RH, Nikolova-Karakashian MN (2007) Regulation of neutral sphingomyelinase-2 by GSH: A new insight to the role of oxidative stress in agingassociated inflammation. J Lipid Res 48:2443-2452. doi:10.1194/jlr.M700227- JLR200 (Pubitemid 350058755)
    • (2007) Journal of Lipid Research , vol.48 , Issue.11 , pp. 2443-2452
    • Rutkute, K.1    Asmis, R.H.2    Nikolova-Karakashian, M.N.3
  • 40
    • 33746874469 scopus 로고    scopus 로고
    • Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptor cells
    • DOI 10.1111/j.1471-4159.2006.03977.x
    • Sanvicens N, Cotter TG (2006) Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptors. J Neurochem 98:1432-1444. doi:10.1111/j.1471- 4159.2006.03977.x (Pubitemid 44200435)
    • (2006) Journal of Neurochemistry , vol.98 , Issue.5 , pp. 1432-1444
    • Sanvicens, N.1    Cotter, T.G.2
  • 41
    • 27744607641 scopus 로고    scopus 로고
    • Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment. Implications for endothelial apoptosis
    • Sathishkumar S, Boyanovsky B, Karakashian AA, Rozenova K, Giltiay NV, Kudrimoti M, Mohiuddin M, Ahmed MM, Nikolova-KarakashianM(2005) Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment: Implications for endothelial apoptosis. Cancer Biol Ther 4:979-986. doi:10.4161/cbt.4.9.1915 (Pubitemid 41598594)
    • (2005) Cancer Biology and Therapy , vol.4 , Issue.9 , pp. 979-986
    • Sathishkumar, S.1    Boyanovsky, B.2    Karakashian, A.A.3    Rozenova, K.4    Giltiay, N.V.5    Kudrimoti, M.6    Mohiuddin, M.7    Ahmed, M.M.8    Nikolova-Karakashian, M.9
  • 43
    • 33845399346 scopus 로고    scopus 로고
    • Hydrogen peroxide and hydroxyl radicals mediate palmitate-induced cytotoxicity to hepatoma cells: Relation to mitochondrial permeability transition
    • DOI 10.1080/10715760600943900, PII ULL23122406J8K81
    • Strivastava S, Chan C (2007) Hydrogen peroxide and hydroxyl radicals mediate palmitate-induced cytotoxicity to hepatoma cells: Relation to mitochondrial permeability transition. Free Radical Res 41:38-49. doi:10.1080/10715760600943900 (Pubitemid 44896873)
    • (2007) Free Radical Research , vol.41 , Issue.1 , pp. 38-49
    • Srivastava, S.1    Chan, C.2
  • 44
    • 0042845711 scopus 로고    scopus 로고
    • Protection against hepatic ischemia-reperfusion injury in rats by oral pretreatment with guercetin
    • Su JF, Guo CJ, Wei JY, Yang JJ, Jiang YG, Li YF (2003) Protection against hepatic ischemia-reperfusion injury in rats by oral pretreatment with guercetin. Biomed Environ Sci 16:1-8
    • (2003) Biomed Environ Sci , vol.16 , pp. 1-8
    • Su, J.F.1    Guo, C.J.2    Wei, J.Y.3    Yang, J.J.4    Jiang, Y.G.5    Li, Y.F.6
  • 45
    • 59849098608 scopus 로고    scopus 로고
    • Modulating serine palmitoyl transferase (SPT) expression and activity unveils a critical role in lipid-induced insulin resistance in rat skeletal muscle cells
    • doi:10.1042/BJ20081149
    • Watson ML, Coghlan M, Hundal HS (2009) Modulating serine palmitoyl transferase (SPT) expression and activity unveils a critical role in lipid-induced insulin resistance in rat skeletal muscle cells. Biochem J 417:791-801. doi:10.1042/BJ20081149
    • (2009) Biochem J , vol.417 , pp. 791-801
    • Watson, M.L.1    Coghlan, M.2    Hundal, H.S.3
  • 46
    • 33745828301 scopus 로고    scopus 로고
    • Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
    • DOI 10.1152/ajpendo.00644.2005
    • Wei Y, Wang D, Topczewski F, Pagliassotti MJ (2006) Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am J Physiol Endocrinol Metab 291:E275-E281. doi:10.1152/ajpendo. 00644.2005 (Pubitemid 44035286)
    • (2006) American Journal of Physiology - Endocrinology and Metabolism , vol.291 , Issue.2
    • Wei, Y.1    Wang, D.2    Topczewski, F.3    Pagliassotti, M.J.4
  • 47
    • 84866509124 scopus 로고    scopus 로고
    • Vitamin E regulates SMase activity, GSH levels, and inhibits neuronal death in stroke-prone spontaneously hypertensive rats during hypoxia and reoxygenation
    • doi:10.1016/j.neuroscience.2010.07.013
    • Yamagata K, Ichinose S, Tagawa C, Tagami M (2009) Vitamin E regulates SMase activity, GSH levels, and inhibits neuronal death in stroke-prone spontaneously hypertensive rats during hypoxia and reoxygenation. J Exp Stroke Transl Med 2:2. doi:10.1016/j.neuroscience.2010.07.013
    • (2009) J Exp Stroke Transl Med , vol.2 , pp. 2
    • Yamagata, K.1    Ichinose, S.2    Tagawa, C.3    Tagami, M.4
  • 48
    • 34249657837 scopus 로고    scopus 로고
    • Activation of acid sphingomyelinase by protein kinase Cd-mediated phosphorylation
    • DOI 10.1074/jbc.M609424200
    • Zeidan YH, Hannun YA (2007) Activation of acid sphingomyelinase by protein kinase Cd-mediated phosphorylation. J Biol Chem 282:11549-11561. doi:10.1074/jbc.M609424200 (Pubitemid 47100781)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.15 , pp. 11549-11561
    • Zeidan, Y.H.1    Hannun, Y.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.