Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives

Mechanisms of Ageing and Development

Volumn 90, Issue 3, 1996, Pages 195-207

  Nakata, Kunihiko ^a   Kawase, Michi ^a   Ogino, Shinya ^a   Kinoshita, Chieko ^a   Murata, Hideaki ^a   Sakaue, Takahiro ^b   Ogata, Kazumi ^b   Ohmori, Shinji ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b SENJU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Age; Cystathionase; Cystathionine synthase; Cysteine; Cysteine derivatives; Glutathione

Indexed keywords

ACETYLCYSTEINE; CYSTATHIONINE BETA SYNTHASE; CYSTATHIONINE GAMMA LYASE; CYSTEINE; CYSTEINE DERIVATIVE; GLUTATHIONE; LIVER ENZYME; MALEIC ACID DIETHYL ESTER; THIAZOLIDINE DERIVATIVE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ENZYME ACTIVITY; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0030607109     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/0047-6374(96)01771-X     Document Type: Article

References (31)

1. [1] G. A. Hazelton and C. A. Lang, Glutathione contents of tissues in the aging mouse. Biochem. J., 188 (1980) 25-30.
2. [2] L.A. Videla, V. Fernandez and A. Valenzuela, Age-dependent changes in rat liver lipid peroxidation and glutathione content induced by acute ethanol ingestion. Cell Biochem. Function, 5 (1987) 273-280.
3. [3] S. Laganiere and B.P. Yu, Effect of chronic food restriction in aging rats II. Liver cytosolic antioxidants and related enzymes. Mech. Ageing Dev., 48 (1989) 221-230.
4. [4] G.B. de Quiroga, R. Pérez-Campo and M.L. Torres, Anti-oxidant defences and peroxidation in liver and brain of aged rats. Biochem. J., 272 (1990) 247-250.
5. [5] S.G. Jenkinson, C.A. Duncan, C.L. Bryan and R.A. Lawrence, Effects of age on rat glutathione metabolism. Am. J. Med. Sci., 302 (1991) 347-352.
6. [6] L.E. Rikans and Y. Cai, Age-associated enhancement of diquat-induced lipid peroxidation and cytotoxicity in isolated rat hepatocytes. J. Pharmacol. Exp. Ther., 262 (1992) 271-278.
7. [7] J. Sastre, J.V. Rodriguez, F.V. Pallardó, E. Gasco, M. Asensi, J.V. Ferrer, J. Miquel and J. Viña, Effect of aging on metabolic zonation in rat liver: acinar distribution of GSH metabolism. Mech. Ageing Dev., 62 (1992) 181-190.
8. [8] L.E. Rikans and Y. Cai, Diquat-induced oxidative damage in BCNU-pretreated hepatocytes of mature and old rats. Toxicol. Appl. Pharmacol., 118 (1993) 263-270.
9. [9] A. Fischer-Nielsen, H.E. Poulsen, B.A. Hansen, N. Tygstrup and S. Keiding, Age dependence of rat liver function measurements. J. Hepat., 9 (1989) 190-197.
10. [10] S.J. Stohs, J.M. Hassing, W.A. Al-Turk and A.N. Masoud, Glutathione levels in hepatic and extrahepatic tissues of mice as a function of age. Age, 3 (1980) 11-14.
11. [11] S.J. Stohs, T. Lawson and W.A. Al-Turk, Changes in glutathione and glutathione metabolizing enzymes in erythrocytes and lymphocytes of mice as a function of age. Gen. Pharmac., 15 (1984) 267-270.
12. [12] B.L. Vogt and J.P. Richie, Fasting-induced depletion of glutathione in the aging mouse. Biochem. Pharmacol., 46 (1993) 257-263.
13. [13] S. Ohmori, M. Ikeda, H. Hattori, K. Hagiwara and C. Iwase, A simple and specific colorimetric determination of cysteine with p-dimethylaminocinnamaldehyde. J. Clin. Chem. Clin. Biochem., 21 (1983) 851-857.
14. [14] S. Ohmori, K. Nakata, K. Nishihara, S. Yamamoto, M. Kawase and S. Tsuboi, Sensitive determination of cystathionine and assays for cystathionine β- and γ-lyase, as well as cystathionine β-synthase, using high-performance liquid chromatography. J. Chromatogr., 574 (1992) 35-40.
15. [15] S. Matsumoto, M. Tesigawara, S. Tsuboi and S. Ohmori, Determination of glutathione and glutathione disulfide in biological samples using acrylonitrile as a thiol-blocking reagent. Anal. Sci., 12 (1996) 91-95.
16. [16] M.K. Gaitonde, A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids. Biochem. J., 104 (1967) 627-633.
17. [17] B. Saville, A scheme for the colorimetric determination of microgram amounts of thiols. Analyst, 83 (1958) 670-672.
18. [18] R. J. Richardson and S.D. Murphy. Effect of glutathione depletion on tissue deposition of methylmercury in rats. Toxicol. Appl. Pharmacol., 31 (1975) 505-519.
19. [19] N. Kaplowitz, T.Y. Aw and M. Ookhtens, The regulation of hepatic glutathione. Ann. Rev. Pharmacol. Toxcol., 25 (1985) 715-744.
20. [20] M. Teshigawara, S. Matsumoto, S. Tsuboi and S. Ohmori, Changes in levels of glutathione and related compounds and activities of glutathione-related enzymes during rat liver regeneration. Res. Exp. Med., 195 (1995) 55-60.
21. [21] G. Gaull, J.A. Sturman and N.C.R. Räihä, Development of mammalian sulfur metabolism: Absence of cystathionase in human fetal tissues. Pediatr. Res., 6 (1972) 538-547.
22. [22] S. Awata, K. Nakayama, H. Mikasa and H. Kodama, Activities of cystathionine-related enzymes in tissues of growing rats. Sulfur Amino Acids, 7 (1984) 407-410.
23. [23] R.D. White, D.M. Wilson, J.A. Glosson, D.C. Madsen, W.B. Rowe and D.I. Goldberg, Toxicity evaluations of L-cysteine and procysteine. a cysteine prodrug, given once intravenously to neonatal rats. Toxicol. Lett., 69 (1993) 15-24.
24. [24] N.D. Schonbeck, M. Skalski and J.A. Shafer, Reactions of pyridoxal 5-phosphate, 6-aminocaproic acid, cysteine, and penicillamine. J. Biol. Chem., 250 (1975) 5343-5351.
25. [25] A.J.L. Cooper, M.T. Haber and A. Meister, On the chemistry and biochemistry of 3-mercaptopyruvic acid, the α-keto acid analog of cysteine. J. Biol. Chem., 257(1982) 816-824.
26. [26] J.M. Estrela, G.T. Sáez, L. Such and J. Vina, The effect of cysteine and N-acetylcysteine on rat liver glutathione (GSH). Biochem. Pharmacol., 32 (1983) 3483-3485.
27. [27] G.B. Corcoran and B.K. Wong, Role of glutathione in prevention of acetaminophen-induced hepatotoxicity by N-acetyl-L-cysteine in vivo: Studies with N-acetyl-D-cysteine in mice. J. Pharmacol. Exp. Ther., 238 (1986) 54-61.
28. [28] J.M. Williamson and A. Meister, Stimulation of hepatic glutathione formation by administration of L-2-oxothiazolidine-4-carboxylate, a 5-oxo-L-prolinase substrate. Proc. Natl. Acad. Sci. USA, 78 (1981) 936-939.
29. [29] G.A. Hazelton, J.J. Hjelle and C.D. Klaassen, Effects of cysteine pro-drugs on acetaminophen-induced hepatotoxicity. J. Pharmacol. Exp. Ther., 237 (1986) 341-349.
30. [30] L. Wlodek, H. Rommelspacher, R. Susilo, J. Radomski and G. Höfle, Thiazolidine derivatives as source of free L-cysteine in rat tissue. Biochem. Pharmacol., 46 (1993) 1917-1928.
31. [31] Y. Kitamura, Y. Kamisaki and T. Itoh. Hepatoprotective effects of cystathionine against acetaminophen-induced necrosis. J. Pharmacol. Exp. Ther., 250 (1989) 667-671.