Idebenone Protects against Retinal Damage and Loss of Vision in a Mouse Model of Leber's Hereditary Optic Neuropathy

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Heitz, Fabrice D ^a   Erb, Michael ^a   Anklin, Corinne ^a   Robay, Dimitri ^a   Pernet, Vincent ^b   Gueven, Nuri ^a,c  

^a Santhera Pharmaceuticals   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF TASMANIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

IDEBENONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LINE; CELL STRAIN RGC 5; CONCENTRATION RESPONSE; DRUG EFFICACY; DRUG PENETRATION; EYE PROTECTION; GENE MUTATION; GLIOSIS; IN VITRO STUDY; IN VIVO STUDY; LEBER HEREDITARY OPTIC NEUROPATHY; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OPTIC NERVE ATROPHY; RAT; RETINA; RETINA GANGLION CELL; RETINA INJURY; SINGLE DRUG DOSE; THICKNESS; VISUAL ACUITY; VISUAL IMPAIRMENT;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; CELL LINE; CELL SURVIVAL; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; ELECTRON TRANSPORT COMPLEX I; HUMANS; INTRAVITREAL INJECTIONS; MALE; MICE; MITOCHONDRIA; MUTATION; OPTIC ATROPHY, HEREDITARY, LEBER; RETINAL GANGLION CELLS; ROTENONE; UBIQUINONE; VISUAL ACUITY;

MUS; RODENTIA;

EID: 84866511200     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045182     Document Type: Article

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