Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy

European Journal of Human Genetics

Volumn 21, Issue 1, 2013, Pages 62-68

  Chadderton, Naomi ^a   Palfi, Arpad ^a   Millington Ward, Sophia ^a   Gobbo, Oliverio ^a   Overlack, Nora ^b   Carrigan, Matthew ^a   O'Reilly, Mary ^a   Campbell, Matthew ^a   Ehrhardt, Carsten ^a   Wolfrum, Uwe ^b   Humphries, Peter ^a   Kenna, Paul F ^a   Jane Farrar, G ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

AAV; gene therapy; LHON; mitochondria; NDI1; retina

Indexed keywords

MANGANESE; NADH QUINONE OXIDOREDUCTASE 1; PARVOVIRUS VECTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; LEBER HEREDITARY OPTIC NEUROPATHY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEOTIDE SEQUENCE; OPTOKINETIC STIMULATION; PRIORITY JOURNAL; RETINA GANGLION CELL; SEROTYPE; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; DEPENDOVIRUS; DISEASE MODELS, ANIMAL; ELECTRON TRANSPORT COMPLEX I; GENETIC VECTORS; HUMANS; INTRAVITREAL INJECTIONS; MICE; MICROTUBULE-ASSOCIATED PROTEINS; OPTIC ATROPHY; OPTIC ATROPHY, HEREDITARY, LEBER; RETINAL GANGLION CELLS; SACCHAROMYCES CEREVISIAE PROTEINS;

MURINAE;

EID: 84871188632     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2012.112     Document Type: Article

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