Apoptosis triggered by vitexin in U937 human leukemia cells via a mitochondrial signaling pathway

Oncology Reports

Volumn 28, Issue 5, 2012, Pages 1883-1888

  Lee, Chao Ying ^a   Chien, Yung Shin ^b   Chiu, Tai Hui ^a   Huang, Wen Wen ^a   Lu, Chi Cheng ^c   Chiang, Jo Hua ^c   Yang, Jai Sing ^b  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Caspase 3; Intrinsic signaling; U937 human leukemia cells; Vitexin

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CASPASE 3; CASPASE 7; CASPASE 9; PROTEIN BCL 2; VITEXIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER PREVENTION; CELL ASSAY; CELL CYCLE ARREST; CELL STRAIN U937; CELL VIABILITY; CONTROLLED STUDY; DNA CONTENT; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; LEUKEMIA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOSIS INHIBITION; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WESTERN BLOTTING;

APIGENIN; APOPTOSIS; CASPASE 3; CASPASE 9; CELL CYCLE CHECKPOINTS; DNA, NEOPLASM; DOWN-REGULATION; HUMANS; LEUKEMIA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; U937 CELLS; UP-REGULATION;

EID: 84866439177     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2012.2000     Document Type: Article

References (28)

1. Lin JP, Yang JS, Lin JJ, et al: Rutin inhibits human leukemia tumor growth in a murine xenograft model in vivo. Environ Toxicol 27: 480-484, 2012.
2. Yang YL, Hung CC, Chen JS, et al: IKZF1 deletions predict a poor prognosis in children with B-cell progenitor acute lympho blastic leukemia: a multicenter analysis in Taiwan. Cancer Sci 102: 1874-1881, 2011.
3. Lowenberg B, Downing JR and Burnett A: Acute myeloid leukemia. N Engl J Med 341: 1051-1062, 1999. (Pubitemid 29451802)
4. Lee SJ, Kim KH, Park JS, et al: Comparative analysis of cell surface proteins in chronic and acute leukemia cell lines. Biochem Biophys Res Commun 357: 620-626, 2007. (Pubitemid 46653824)
5. Stahnke K, Eckhoff S, Mohr A, Meyer LH and Debatin KM: Apoptosis induction in peripheral leukemia cells by remission induction treatment in vivo: Selective depletion and apoptosis in a CD34+ subpopulation of leukemia cells. Leukemia 17: 2130-2139, 2003. (Pubitemid 37428378)
6. Olsson I, Bergh G, Ehinger M and Gullberg U: Cell differentiation in acute myeloid leukemia. Eur J Haematol 57: 1-16, 1996. (Pubitemid 26241803)
7. Lu CC, Yang JS, Chiang JH, et al: Novel quinazolinone MJ-29 triggers endoplasmic reticulum stress and intrinsic apoptosis in murine leukemia WEHI-3 cells and inhibits leukemic mice. PLoS One 7: e36831, 2012.
8. Tsai JC, Huang GJ, Chiu TH, et al: Antioxidant activities of phenolic components from various plants of Desmodium species. Afr J Pharm Pharmacol 5: 468-476, 2011.
9. Zhou Y, Liu YE, Cao J, et al: Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth. Clin Cancer Res 15: 5161-5169, 2009.
10. Banskota AH, Tezuka Y, Adnyana IK, et al: Hepatoprotective effect of combretum quadrangulare and its constituents. Biol Pharm Bull 23: 456-460, 2000. (Pubitemid 30241816)
11. Kelloff GJ, Crowell JA, Steele VE, et al: Progress in cancer chemoprevention: Development of diet-derived chemopreventive agents. J Nutr 130: 467S-471S, 2000. (Pubitemid 30073775)
12. Lavrik IN, Golks A and Krammer PH: Caspases: pharmaco logical manipulation of cell death. J Clin Invest 115: 2665-2672, 2005. (Pubitemid 41434390)
13. Cory S, Huang DC and Adams JM: The Bcl-2 family: roles in cell survival and oncogenesis. Oncogene 22: 8590-8607, 2003. (Pubitemid 38028528)
14. Klampfer L, Cammenga J, Wisniewski HG and Nimer SD: Sodium salicylate activates caspases and induces apoptosis of myeloid leukemia cell lines. Blood 93: 2386-2394, 1999. (Pubitemid 29153643)
15. Aggarwal BB, Van Kuiken ME, Iyer LH, Harikumar KB and Sung B: Molecular targets of nutraceuticals derived from dietary spices: Potential role in suppression of inflammation and tumorigenesis. Exp Biol Med 234: 825-849, 2009.
16. Yang JS, Hour MJ, Huang WW, Lin KL, Kuo SC and Chung JG: MJ-29 inhibits tubulin polymerization, induces mitotic arrest, and triggers apoptosis via cyclin-dependent kinase 1-mediated Bcl-2 phosphorylation in human leukemia U937 cells. J Pharmacol Exp Ther 334: 477-488, 2010.
17. Chang YH, Yang JS, Kuo SC and Chung JG: Induction of mitotic arrest and apoptosis by a novel synthetic quinolone analogue, CWC-8, via intrinsic and extrinsic apoptotic pathways in human osteogenic sarcoma U-2 OS cells. Anticancer Res 29: 3139-3148, 2009.
18. Chiang JH, Yang JS, Ma CY, et al: Danthron, an anthraquinone derivative, induces DNA damage and caspase cascades-mediated apoptosis in SNU-1 human gastric cancer cells through mito chondrial permeability transition pores and Bax-triggered pathways. Chem Res Toxicol 24: 20-29, 2011.
19. Lu CC, Yang JS, Huang AC, et al: Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells. Mol Nutr Food Res 54: 967-976, 2010.
20. Kuo CL, Wu SY, Ip SW, et al: Apoptotic death in curcumin-treated NPC-TW 076 human nasopharyngeal carcinoma cells is mediated through the ROS, mitochondrial depolarization and caspase-3-dependent signaling responses. Int J Oncol 39: 319-328, 2011.
21. Chung JG, Yang JS, Huang LJ, et al: Proteomic approach to studying the cytotoxicity of YC-1 on U937 leukemia cells and antileukemia activity in orthotopic model of leukemia mice. Proteomics 7: 3305-3317, 2007.
22. Wu PP, Liu KC, Huang WW, et al: Triptolide induces apoptosis in human adrenal cancer NCI-H295 cells through a mitochondrial-dependent pathway. Oncol Rep 25: 551-557, 2011.
23. Huang WW, Chiu YJ, Fan MJ, et al : Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells. Mol Nutr Food Res 54: 1585-1595, 2010.
24. Lee H, Park MT, Choi BH, et al : Endoplasmic reticulum stress-induced JNK activation is a critical event leading to mito chondria-mediated cell death caused by β-lapachone treatment. PLoS One 6: e21533, 2011.
25. Dong L, Fan Y, Shaox and Chen Z: Vitexin protects against myocardial ischemia/reperfusion injury in Langendorff-perfused rat hearts by attenuating inflammatory response and apoptosis. Food Chem Toxicol 49: 3211-3216, 2011.
26. Kim R, Emi M, Tanabe K and Murakami S: Role of the unfolded protein response in cell death. Apoptosis 11: 5-13, 2006. (Pubitemid 43151639)
27. Breckenridge DG, Germain M, Mathai JP, Nguyen M and Shore GC: Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene 22: 8608-8618, 2003. (Pubitemid 38019196)
28. Orrenius S: Reactive oxygen species in mitochondria-mediated cell death. Drug Metab Rev 39: 443-455, 2007.