IKZF1 deletions predict a poor prognosis in children with B-cell progenitor acute lymphoblastic leukemia: A multicenter analysis in Taiwan

Cancer Science

Volumn 102, Issue 10, 2011, Pages 1874-1881

  Yang, Yung Li ^a,b,c   Hung, Chia Cheng ^d   Chen, Jiann Shiuh ^e   Lin, Kai Hsin ^b   Jou, Shiann Tarng ^b   Hsiao, Chih Cheng ^f   Sheen, Jiunn Ming ^f   Cheng, Chao Neng ^e   Wu, Kang Hsi ^g   Lin, Shu Rung ^h   Yu, Sung Liang ^d   Chen, Hsuan Yu ⁱ   Lu, Meng Yao ^b   Wang, Shih Chung ^j   Chang, Hsiu Hao ^b   Lin, Shu Wha ^d   Su, Yi Ning ^c   Lin, Dong Tsamn ^a,b  

^a Department of Laboratory Medicine ^*  (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c Graduate Institute of Clinical Medicine   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^e NATIONAL CHENG KUNG UNIVERSITY HOSPITAL   (Taiwan)

^f CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^g CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^h CHUNG YUAN CHRISTIAN UNIVERSITY   (Taiwan)

ⁱ INSTITUTE OF STATISTICAL SCIENCE   (Taiwan)

^j CHANGHUA CHRISTIAN HOSPITAL   (Taiwan)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLELE; ARTICLE; CAPILLARY ELECTROPHORESIS; CHILD; CONTROLLED STUDY; CYTOGENETICS; EVENT FREE SURVIVAL; EXON; FEMALE; GENE; GENE DELETION; GENE MUTATION; GENE SEQUENCE; HIGH RESOLUTION MELTING ANALYSIS; HUMAN; IKZF1 GENE; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY (TOPIC); MULTIPLEX POLYMERASE CHAIN REACTION; OVERALL SURVIVAL; PRE B LYMPHOCYTE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; SCHOOL CHILD; TAIWAN;

ADOLESCENT; B-LYMPHOCYTES; BASE SEQUENCE; CHILD; CHILD, PRESCHOOL; DISEASE-FREE SURVIVAL; FEMALE; GENETIC MARKERS; HUMANS; IKAROS TRANSCRIPTION FACTOR; INFANT; INFANT, NEWBORN; MALE; MULTIVARIATE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROGNOSIS; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION; TAIWAN; TREATMENT FAILURE; TUMOR MARKERS, BIOLOGICAL;

EID: 80053386361     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2011.02031.x     Document Type: Article

References (32)

1. Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet 2008; 371: 1030-43.
2. Pui CH, Campana D, Pei D et al. Treating childhood acute lymphoblastic leukemia without cranial irradiation. N Engl J Med 2009; 360: 2730-41.
3. Einsiedel HG, von Stackelberg A, Hartmann R et al. Long-term outcome in children with relapsed ALL by risk-stratified salvage therapy: results of trial acute lymphoblastic leukemia-relapse study of the Berlin-Frankfurt-Munster Group 87. J Clin Oncol 2005; 23: 7942-50.
4. Ferrando AA, Neuberg DS, Staunton J et al. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 2002; 1: 75-87.
5. Yeoh EJ, Ross ME, Shurtleff SA et al. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 2002; 1: 133-43.
6. Holleman A, Cheok MH, den Boer ML et al. Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment. N Engl J Med 2004; 351: 533-42.
7. Lugthart S, Cheok MH, den Boer ML et al. Identification of genes associated with chemotherapy crossresistance and treatment response in childhood acute lymphoblastic leukemia. Cancer Cell 2005; 7: 375-86.
8. Flotho C, Coustan-Smith E, Pei D et al. A set of genes that regulate cell proliferation predicts treatment outcome in childhood acute lymphoblastic leukemia. Blood 2007; 110: 1271-7.
9. Kang H, Chen IM, Wilson CS et al. Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia. Blood 2010; 115: 1394-405.
10. Cario G, Stanulla M, Fine BM et al. Distinct gene expression profiles determine molecular treatment response in childhood acute lymphoblastic leukemia. Blood 2005; 105: 821-6.
11. Mullighan CG, Goorha S, Radtke I et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007; 446: 758-64.
12. Mullighan CG, Miller CB, Radtke I et al. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature 2008; 453: 110-4.
13. Kawamata N, Ogawa S, Zimmermann M et al. Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray. Blood 2008; 111: 776-84.
14. Kuiper RP, Schoenmakers EFPM, van Reijmersdal SV et al. High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression. Leukemia 2007; 21: 1258-66.
15. Mullighan CG, Su X, Zhang J et al. Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. N Engl J Med 2009; 360: 470-80.
16. Martinelli G, Iacobucci I, Storlazzi CT et al. IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP Report. J Clin Oncol 2009; 27: 5202-7.
17. Hung CC, Chen CP, Lin SP et al. Quantitative assay of deletion or duplication genotype by capillary electrophoresis system: application in Prader-Willi syndrome and Duchenne muscular dystrophy. Clin Chem 2006; 52: 2203-10.
18. Vossen RH, Aten E, Roos A, den Dunnen JT. High-resolution melting analysis (HRMA): more than just sequence variant screening. Hum Mutat 2009; 30: 860-6.
19. Liang DC, Hung IJ, Yang CP et al. Unexpected mortality from the use of E. coli L-asparaginase during remission induction therapy for childhood acute lymphoblastic leukemia: a report from the Taiwan Pediatric Oncology Group. Leukemia 1999; 13: 155-60.
20. Lin WY, Liu HC, Yeh TC, Wang LY, Liang DC. Triple intrathecal therapy without cranial irradiation for central nervous system preventive therapy in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer 2008; 50: 523-7.
21. Liang DC, Yang CP, Lin DT et al. Long-term results of Taiwan Pediatric Oncology Group studies 1997 and 2002 for childhood acute lymphoblastic leukemia. Leukemia 2010; 24: 397-405.
22. Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med 2006; 354: 166-78.
23. Kuiper RP, Waanders E, van der Velden VH et al. IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL. Leukemia 2010; 24: 1258-64.
24. Harvey RC, Mullighan CG, Chen IM et al. Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia. Blood 2010; 115: 5312-21.
25. Kuiper RP, Waanders E, van der Velden VH et al. IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL. Leukemia 2010; 24: 1258-64.
26. Waanders E, van der Velden VHJ, van der Schoot CE et al. Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia. Leukemia 2011; 25: 254-8.
27. Harvey RC, Mullighan CG, Wang X et al. Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome. Blood 2010; 116: 4874-84.
28. Den Boer ML, van Slegtenhorst M, De Menezes RX et al. A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncol 2009; 10: 125-34.
29. Okamoto R, Ogawa S, Nowak D et al. Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia. Haematologica 2010; 95: 1481-8.
30. Mullighan CG, Zhang J, Harvey RC et al. JAK mutations in high-risk childhood acute lymphoblastic leukemia. Proc Natl Acad Sci USA 2009; 106: 9414-8.
31. Yoda A, Yoda Y, Chiaretti S et al. Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia. Proc Natl Acad Sci USA 2010; 107: 252-7.
32. Cario G, Zimmermann M, Romey R et al. Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol. Blood 2010; 115: 5393-7.