Safrole induces cell death in human tongue squamous cancer SCC-4 cells through mitochondria-dependent caspase activation cascade apoptotic signaling pathways

Environmental Toxicology

Volumn 27, Issue 7, 2012, Pages 433-444

  Yu, Fu Shun ^a   Huang, An Cheng ^b   Yang, Jai Sing ^a   Yu, Chun Shu ^a   Lu, Chi Cheng ^c   Chiang, Jo Hua ^c   Chiu, Chang Fang ^d   Chung, Jing Gung ^a,e  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b St Mary's Medicine Nursing and Management College   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e ASIA UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Caspase cascades; Mitochondria; Safrole; Tongue cancer SCC 4 cells

Indexed keywords

APOPTOTIC SIGNALING; CASPASE ACTIVATION; CASPASE-3; CASPASES; CYTOCHROME C; CYTOTOXIC EFFECTS; DOWN-REGULATION; HUMAN TONGUE; MRNA EXPRESSION; NATURAL PRODUCTS; PHYTOTOXINS; PROTEIN EXPRESSIONS; PROTEIN LEVEL; REAL-TIME PCR; SAFROLE; SEQUENTIAL ACTIVATION; SIGNAL PATHWAYS; SQUAMOUS CARCINOMA; TIME-DEPENDENT; TONGUE CANCER; UP-REGULATION; WESTERN BLOTTING;

CYTOTOXICITY; DISEASES; FLOW CYTOMETRY; MITOCHONDRIA; POLYMERASE CHAIN REACTION;

CELL DEATH;

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; SAFROLE;

APOPTOSIS; CANCER; CARCINOGEN; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE EXPRESSION; PHENOLIC COMPOUND; POLYMERASE CHAIN REACTION; PROTEIN; PUBLIC HEALTH; SIGNALING; TOXIN;

APOPTOSIS; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, SQUAMOUS CELL; CASPASE 3; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; CELL SURVIVAL; DNA DAMAGE; HUMANS; MITOCHONDRIA; SAFROLE; SIGNAL TRANSDUCTION; TONGUE NEOPLASMS;

MYRISTICA FRAGRANS; MYRRHIS ODORATA; OCIMUM; SASSAFRAS;

EID: 84862689490     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.20658     Document Type: Article

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