Lentiviral short hairpin RNA screen of human kinases and phosphatases to identify potential biomarkers in oral squamous cancer cells

International Journal of Oncology

Volumn 39, Issue 5, 2011, Pages 1221-1231

  Yeh, Ming Han ^a   Tsai, Tzung Chieh ^b   Kuo, Han Peng ^a   Chang, Nai Wen ^c   Lee, Miao Rong ^c   Chung, Jing Gung ^d   Tsai, Ming Hsui ^e   Liu, Jah Yao ^a,f   Kao, Ming Ching ^a,d  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b NATIONAL CHIAYI UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Biomarkers; High throughput screening assays; Kinases; Oral cancer; Phosphoprotein phosphatases; RNA interference

Indexed keywords

BRCA2 PROTEIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE IV; CD135 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; EPHRIN RECEPTOR A1; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE 9; MYO9B PROTEIN; NATRIURETIC PEPTIDE RECEPTOR B; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEIN S100B; SCYL1 PROTEIN; SCYL2 PROTEIN; SFRS2 PROTEIN; SHC1 PROTEIN; SHORT HAIRPIN RNA; SMAD4 PROTEIN; STK11IP PROTEIN; STK32A PROTEIN; TGFBR2 PROTEIN; TINF2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRIB2 PROTEIN; TRIPARTITE MOTIF CONTAINING 24 PROTEIN; TRIPARTITE MOTIF CONTAINING 28 PROTEIN; TUMOR MARKER; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS RNA;

ARTICLE; BIOINFORMATICS; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CANCER SCREENING; CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LENTIVIRINAE; MOUTH CARCINOMA; NONHUMAN; PRIORITY JOURNAL; VIRAL GENE DELIVERY SYSTEM;

CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; COMPUTATIONAL BIOLOGY; FMS-LIKE TYROSINE KINASE 3; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VECTORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; I-KAPPA B KINASE; LENTIVIRUS; MOUTH NEOPLASMS; NF-KAPPA B; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHOTRANSFERASES; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REPRODUCIBILITY OF RESULTS; RNA, SMALL INTERFERING; SHC SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION; TUMOR MARKERS, BIOLOGICAL;

EID: 80053199133     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1100     Document Type: Article

References (38)

1. Argiris A, Karamouzis MV, Raben D and Ferris RL: Head and neck cancer. Lancet 371: 1695-1709, 2008. (Pubitemid 351671886)
2. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108, 2005. (Pubitemid 40372904)
3. Pfeifer GP, Denissenko MF, Olivier M, Tretyakova N, Hecht SS and Hainaut P: Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers. Oncogene 21: 7435-7451, 2002. (Pubitemid 35305599)
4. Ogden GR: Alcohol and oral cancer. Alcohol 35: 169-173, 2005.
5. Chen YJ, Chang JT, Liao CT, et al: Head and neck cancer in the betel quid chewing area: recent advances in molecular carcinogenesis. Cancer Sci 99: 1507-1514, 2008.
6. Licitra L, Perrone F, Bossi P, et al: High-risk human papillomavirus affects prognosis in patients with surgically treated oropharyngeal squamous cell carcinoma. J Clin Oncol 24: 5630-5636, 2006. (Pubitemid 46631302)
7. Chang NW, Pei RJ, Tseng HC, et al: Co-treating with arecoline and 4-nitroquinoline 1-oxide to establish a mouse model mimicking oral tumorigenesis. Chem Biol Interact 183: 231-237, 2010.
8. Califano J, Van der Riet P, Westra W, et al: Genetic progression model for head and neck cancer: implications for field cancerization. Cancer Res 56: 2488-2492, 1996. (Pubitemid 26170679)
9. Campo-Trapero J, Cano-Sanchez J, Palacios-Sanchez B, Sanchez-Gutierrez JJ, Gonzalez-Moles MA and Bascones-Martinez A: Update on molecular pathology in oral cancer and precancer. Anticancer Res 28: 1197-1205, 2008. (Pubitemid 351578858)
10. Kujan O, Oliver RJ, Khattab A, Roberts SA, Thakker N and Sloan P: Evaluation of a new binary system of grading oral epi-thelial dysplasia for prediction of malignant transformation. Oral Oncol 42: 987-993, 2006. (Pubitemid 44573884)
11. Rosin MP, Cheng X, Poh C, et al: Use of allelic loss to predict malignant risk for low-grade oral epithelial dysplasia. Clin Cancer Res 6: 357-362, 2000. (Pubitemid 30111451)
12. Partridge M, Pateromichelakis S, Phillips E, Emilion GG, A'Hern RP and Langdon JD: A case-control study confirms that microsaellite assay can identify patients at risk of developing oral squamous cell carcinoma within a field of cancerization. Cancer Res 60: 3893-3898, 2000. (Pubitemid 32204583)
13. Hanahan D and Weinberg RA: The hallmarks of cancer. Cell 100: 57-70, 2000. (Pubitemid 30046295)
14. Blume-Jensen P and Hunter T: Oncogenic kinase signalling. Nature 411: 355-365, 2001. (Pubitemid 32467045)
15. Ostman A, Hellberg C and Bohmer FD: Protein-tyrosine phosphatases and cancer. Nat Rev Cancer 6: 307-320, 2006.
16. Sheu JJ, Hua CH, Wan L, et al: Functional genomic analysis identified epidermal growth factor receptor activation as the most common genetic event in oral squamous cell carcinoma. Cancer Res 69: 2568-2576, 2009.
17. Hamakawa H, Nakashiro K, Sumida T, et al: Basic evidence of molecular targeted therapy for oral cancer and salivary gland cancer. Head Neck 30: 800-809, 2008. (Pubitemid 351913858)
18. Duffy MJ and Crown J: A personalized approach to cancer treatment: how biomarkers can help. Clin Chem 54: 1770-1779, 2008.
19. Moffat J, Grueneberg DA, Yang X, et al: A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124: 1283-1298, 2006.
20. Ekins S, Nikolsky Y, Bugrim A, Kirillov E and Nikolskaya T: Pathway mapping tools for analysis of high content data. Methods Mol Biol 356: 319-350, 2007.
21. Ou CC, Hsu SC, Hsieh YH, et al: Downregulation of HER2 by RIG1 involves the PI3K/Akt pathway in ovarian cancer cells. Carcinogenesis 29: 299-306, 2008.
22. Rosnet O, Schiff C, Pebusque MJ, et al: Human FLT3/FLK2 gene: cDNA cloning and expression in hematopoietic cells. Blood 82: 1110-1119, 1993. (Pubitemid 23253983)
23. Chuang TC, Liu JY, Lin CT, et al: Human manganese superoxide dismutase suppresses HER2/neu-mediated breast cancer malignancy. FEBS Lett 581: 4443-4449, 2007.
24. Birmingham A, Selfors LM, Forster T, et al: Statistical methods for analysis of high-throughput RNA interference screens. Nat Methods 6: 569-575, 2009.
25. Dijkstra EW: A note on two problems in connexion with graphs. Numerische Mathematik 1: 269-271, 1959.
26. Neil JR and Schiemann WP: Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression. Cancer Res 68: 1462-1470, 2008. (Pubitemid 351346854)
27. Grosjean-Raillard J, Ades L, Boehrer S, et al: Flt3 receptor inhi-bition reduces constitutive NFkappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia. Apoptosis 13: 1148-1161, 2008.
28. Ondrey FG, Dong G, Sunwoo J, et al: Constitutive activation of transcription factors NF-(kappa)B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines. Mol Carcinog 26: 119-129, 1999. (Pubitemid 29480441)
29. Chen X, Jorgenson E and Cheung ST: New tools for functional genomic analysis. Drug Discov Today 14: 754-760, 2009.
30. Moffat J and Sabatini DM: Building mammalian signalling pathways with RNAi screens. Nat Rev Mol Cell Biol 7: 177-187, 2006.
31. Stirewalt DL and Radich JP: The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer 3: 650-665, 2003. (Pubitemid 37328820)
32. Chow LQ and Eckhardt SG: Sunitinib: from rational design to clinical efficacy. J Clin Oncol 25: 884-896, 2007. (Pubitemid 350002890)
33. Lu SL, Reh D, Li AG, et al: Overexpression of transforming growth factor beta1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation. Cancer Res 64: 4405-4410, 2004. (Pubitemid 38856909)
34. Wakefield LM and Roberts AB: TGF-beta signaling: positive and negative effects on tumorigenesis. Curr Opin Genet Dev 12: 22-29, 2002. (Pubitemid 34094985)
35. MacKeigan JP, Murphy LO and Blenis J: Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat Cell Biol 7: 591-600, 2005. (Pubitemid 40796982)
36. Zhou BP, Liao Y, Xia W, Spohn B, Lee MH and Hung MC: Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 3: 245-252, 2001. (Pubitemid 32201319)
37. Li Y, Dowbenko D and Lasky LA: AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival. J Biol Chem 277: 11352-11361, 2002. (Pubitemid 34952901)
38. Allison M: Is personalized medicine finally arriving? Nat Biotechnol 26: 509-517, 2008.