Implication of RNA-binding protein La in proliferation, migration and invasion of lymph node-metastasized hypopharyngeal SCC cells

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Sommer, Gunhild ^a,b   Rossa, Carlos ^c   Chi, Angela C ^a   Neville, Brad W ^a   Heise, Tilman ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; GELATINASE A; LA ANTIGEN; SMALL INTERFERING RNA; AUTOANTIGEN; RIBONUCLEOPROTEIN; SS B ANTIGEN; SS-B ANTIGEN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER INVASION; CARCINOGENESIS; CELL CYCLE PROGRESSION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE ACTIVITY; HYPOPHARYNX CARCINOMA; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LYMPH NODE METASTASIS; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN RNA BINDING; RNA SEQUENCE; SQUAMOUS CELL CARCINOMA; TUMOR GROWTH; WESTERN BLOTTING; CELL CYCLE; CELL MOTION; DISEASE COURSE; GENE EXPRESSION REGULATION; GENETICS; HELA CELL; HUMAN; HYPOPHARYNX TUMOR; METABOLISM; PATHOLOGY;

AUTOANTIGENS; BETA CATENIN; CARCINOMA, SQUAMOUS CELL; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; DISEASE PROGRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HUMANS; HYPOPHARYNGEAL NEOPLASMS; LYMPHATIC METASTASIS; MATRIX METALLOPROTEINASE 2; NEOPLASM INVASIVENESS; RIBONUCLEOPROTEINS;

EID: 80053922396     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025402     Document Type: Article

References (56)

1. Parkin DM, Bray F, Ferlay J, Pisani P, (2001) Estimating the world cancer burden: Globocan 2000. Int J Cancer 94: 153-156.
2. Parkin DM, Bray F, Ferlay J, Pisani P, (2005) Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108.
3. Beenken SW, Urist MM, (2003) Current surgical diagnosis and treatment. In: Way LW, Doherty GM, editors. New York, McGraw-Hill pp. 282-297.
4. Jemal A, Siegel R, Ward E, Hao Y, Xu J, et al. (2009) Cancer statistics. CA Cancer J Clin 59: 225-249.
5. Sano D, Myers JN, (2007) Metastasis of squamous cell carcinoma of the oral tongue. Cancer Metastasis Rev 26: 645-662.
6. Brenet F, Socci ND, Sonenberg N, Holland EC, (2009) Akt phosphorylation of La regulates specific mRNA translation in glial progenitors. Oncogene 28: 128-139.
7. Fok V, Friend K, Steitz JA, (2006) Epstein-Barr virus noncoding RNAs are confined to the nucleus, whereas their partner, the human La protein, undergoes nucleocytoplasmic shuttling. J Cell Biol 173: 319-325.
8. Troster H, Metzger TE, Semsei I, Schwemmle M, Winterpacht A, et al. (1994) One gene, two transcripts: isolation of an alternative transcript encoding for the autoantigen La/SS-B from a cDNA library of a patient with primary Sjogrens' syndrome. J Exp Med 180: 2059-2067.
9. Chambers JC, Kenan D, Martin BJ, Keene JD, (1988) Genomic structure and amino acid sequence domains of the human La autoantigen. J Biol Chem 263: 18043-18051.
10. Park JM, Kohn MJ, Bruinsma MW, Vech C, Intine RV, et al. (2006) The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells. Mol Cell Biol 26: 1445-1451.
11. Kenan DJ, Keene JD, (2004) La gets its wings. Nat Struct Mol Biol 11: 303-305.
12. Wolin SL, Cedervall T, (2002) The La protein. Annu Rev Biochem 71: 375-403.
13. Horke S, Reumann K, Schweizer M, Will H, Heise T, (2004) Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA. J Biol Chem 279: 26563-26570.
14. Carter MS, Sarnow P, (2000) Distinct mRNAs that encode La autoantigen are differentially expressed and contain internal ribosome entry sites. J Biol Chem 275: 28301-28307.
15. Schwartz EI, Intine RV, Maraia RJ, (2004) CK2 is responsible for phosphorylation of human La protein serine-366 and can modulate rpL37 5′-terminal oligopyrimidine mRNA metabolism. Mol Cell Biol 24: 9580-9591.
16. Intine RV, Sakulich AL, Koduru SB, Huang Y, Pierstorff E, et al. (2000) Control of transfer RNA maturation by phosphorylation of the human La antigen on serine 366. Mol Cell 6: 339-348.
17. Broekhuis CH, Neubauer G, van der Heijden A, Mann M, Proud CG, et al. (2000) Detailed analysis of the phosphorylation of the human La (SS-B) autoantigen. (De)phosphorylation does not affect its subcellular distribution. Biochemistry 39: 3023-3033.
18. van Niekerk EA, Willis DE, Chang JH, Reumann K, Heise T, et al. (2007) Sumoylation in axons triggers retrograde transport of the RNA-binding protein La. Proc Natl Acad Sci U S A 104: 12913-12918.
19. Belisova A, Semrad K, Mayer O, Kocian G, Waigmann E, et al. (2005) RNA chaperone activity of protein components of human Ro RNPs. RNA 11: 1084-1094.
20. Pannone BK, Xue D, Wolin SL, (1998) A role for the yeast La protein in U6 snRNP assembly: evidence that the La protein is a molecular chaperone for RNA polymerase III transcripts. EMBO J 17: 7442-7453.
21. Sommer G, Dittmann J, Kuehnert J, Reumann K, Schwartz PE, et al. (2011) The RNA-binding protein La contributes to cell proliferation and CCND1 expression. Oncogene 30: 434-444.
22. Holcik M, Korneluk RG, (2000) Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: role of La autoantigen in XIAP translation. Mol Cell Biol 20: 4648-4657.
23. Trotta R, Vignudelli T, Candini O, Intine RV, Pecorari L, et al. (2003) BCR/ABL activates mdm2 mRNA translation via the La antigen. Cancer Cell 3: 145-160.
24. Kremerskothen J, Nettermann M, op de Bekke A, Bachmann M, Brosius J, (1998) Identification of human autoantigen La/SS-B as BC1/BC200 RNA-binding protein. DNA Cell Biol 17: 751-759.
25. Al-Ejeh F, Darby JM, Brown MP, (2007) The La autoantigen is a malignancy-associated cell death target that is induced by DNA-damaging drugs. Clin Cancer Res 13: 5509s-5518s.
26. Carey TE, Kimmel KA, Schwartz DR, Richter DE, Baker SR, et al. (1983) Antibodies to human squamous cell carcinoma. Otolaryngol Head Neck Surg 91: 482-491.
27. Elbashir SM, Harborth J, Weber K, Tuschl T, (2002) Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods 26: 199-213.
28. Rodriguez LG, Wu X, Guan JL, (2005) Wound-healing assay. Methods Mol Biol 294: 23-29.
29. Liang CC, Park AY, Guan JL, (2007) In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2: 329-333.
30. Windler-Hart SL, Chen KY, Chenn A, (2005) A cell behavior screen: identification, sorting, and enrichment of cells based on motility. BMC Cell Biol 6: 14.
31. Zhao J, Guan JL, (2009) Signal transduction by focal adhesion kinase in cancer. Cancer Metastasis Rev 28: 35-49.
32. Lai SL, Chien AJ, Moon RT, (2009) Wnt/Fz signaling and the cytoskeleton: potential roles in tumorigenesis. Cell Res 19: 532-545.
33. Bernstein BW, Bamburg JR, (2010) ADF/cofilin: a functional node in cell biology. Trends Cell Biol 20: 187-195.
34. Harris TJ, Tepass U, (2010) Adherens junctions: from molecules to morphogenesis. Nat Rev Mol Cell Biol 11: 502-514.
35. Heuberger J, Birchmeier W, (2010) Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling. Cold Spring Harb Perspect Biol 2: a002915.
36. Takemaru KI, Ohmitsu M, Li FQ, (2008) An oncogenic hub: beta-catenin as a molecular target for cancer therapeutics. Handb Exp Pharmacol pp. 261-284.
37. Yang F, Zeng Q, Yu G, Li S, Wang CY, (2006) Wnt/beta-catenin signaling inhibits death receptor-mediated apoptosis and promotes invasive growth of HNSCC. Cell Signal 18: 679-687.
38. Jones KJ, Korb E, Kundel MA, Kochanek AR, Kabraji S, et al. (2008) CPEB1 regulates beta-catenin mRNA translation and cell migration in astrocytes. Glia 56: 1401-1413.
39. Iwai S, Yonekawa A, Harada C, Hamada M, Katagiri W, et al. (2010) Involvement of the Wnt-beta-catenin pathway in invasion and migration of oral squamous carcinoma cells. Int J Oncol 37: 1095-1103.
40. Goto M, Mitra RS, Liu M, Lee J, Henson BS, et al. (2010) Rap1 stabilizes beta-catenin and enhances beta-catenin-dependent transcription and invasion in squamous cell carcinoma of the head and neck. Clin Cancer Res 16: 65-76.
41. Inge LJ, Rajasekaran SA, Wolle D, Barwe SP, Ryazantsev S, et al. (2008) alpha-Catenin overrides Src-dependent activation of beta-catenin oncogenic signaling. Mol Cancer Ther 7: 1386-1397.
42. Molinolo AA, Amornphimoltham P, Squarize CH, Castilho RM, Patel V, et al. (2009) Dysregulated molecular networks in head and neck carcinogenesis. Oral Oncol 45: 324-334.
43. Lo Muzio L, (2001) A possible role for the WNT-1 pathway in oral carcinogenesis. Crit Rev Oral Biol Med 12: 152-165.
44. Ueda G, Sunakawa H, Nakamori K, Shinya T, Tsuhako W, et al. (2006) Aberrant expression of beta- and gamma-catenin is an independent prognostic marker in oral squamous cell carcinoma. Int J Oral Maxillofac Surg 35: 356-361.
45. Yu Z, Weinberger PM, Provost E, Haffty BG, Sasaki C, et al. (2005) beta-Catenin functions mainly as an adhesion molecule in patients with squamous cell cancer of the head and neck. Clin Cancer Res 11: 2471-2477.
46. Chen P, Parks WC, (2009) Role of matrix metalloproteinases in epithelial migration. J Cell Biochem 108: 1233-1243.
47. Deryugina EI, Quigley JP, (2006) Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 25: 9-34.
48. Deryugina EI, Quigley JP, (2010) Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: contrasting, overlapping and compensatory functions. Biochim Biophys Acta 1803 103-120: 103-120.
49. Kessenbrock K, Plaks V, Werb Z, (2010) Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141: 52-67.
50. Rosenthal EL, Matrisian LM, (2006) Matrix metalloproteases in head and neck cancer. Head Neck 28: 639-648.
51. Gialeli C, Theocharis AD, Karamanos NK, (2011) Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting. FEBS J 278: 16-27.
52. Gao ZB, Duan YQ, Zhang L, Chen DW, Ding PT, (2005) Expression of matrix metalloproteinase 2 and its tissue inhibitor in oral squamous cell carcinoma. Int J Mol Med 16: 599-603.
53. Mitra RS, Goto M, Lee JS, Maldonado D, Taylor JM, et al. (2008) Rap1GAP promotes invasion via induction of matrix metalloproteinase 9 secretion, which is associated with poor survival in low N-stage squamous cell carcinoma. Cancer Res 68: 3959-3969.
54. Patel BP, Shah SV, Shukla SN, Shah PM, Patel PS, (2007) Clinical significance of MMP-2 and MMP-9 in patients with oral cancer. Head Neck 29: 564-572.
55. Ruokolainen H, Paakko P, Turpeenniemi-Hujanen T, (2006) Tissue and circulating immunoreactive protein for MMP-2 and TIMP-2 in head and neck squamous cell carcinoma-tissue immunoreactivity predicts aggressive clinical course. Mod Pathol 19: 208-217.
56. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, et al. (2001) Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411: 494-498.