Tacrine-mefenamic acid hybrids for inhibition of acetylcholinesterase

MedChemComm

Volumn 2, Issue 5, 2011, Pages 406-412

  Bornstein, Joshua J ^a   Eckroat, Todd J ^a   Houghton, Jacob L ^a   Jones, Christopher K ^a   Green, Keith D ^a   Garneau Tsodikova, Sylvie ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; MEFENAMIC ACID; REACTIVE OXYGEN METABOLITE; TACRINE;

ALZHEIMER DISEASE; ARTICLE; BRAIN FUNCTION; CHEMICAL STRUCTURE; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; ENZYME MECHANISM; IC 50; IN VITRO STUDY; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL;

EID: 79959538767     PISSN: 20402503     EISSN: 20402511     Source Type: Journal    
DOI: 10.1039/c0md00256a     Document Type: Article

References (33)

1. K. D. Green, V. R. Porter, Y. Zhang and S. Garneau-Tsodikova, Biochemistry, 2010, 49, 6219-6227.
2. K. D. Green, M. Fridman and S. Garneau-Tsodikova, ChemBioChem, 2009, 10, 2191-2194.
3. A. R. Kim, R. J. Rylett and B. H. Shilton, Biochemistry, 2006, 45, 14621-14631.
4. R. C. Petersen, R. G. Thomas, M. Grundman, D. Bennett, R. Doody, S. Ferris, D. Galasko, S. Jin, J. Kaye, A. Levey, E. Pfeiffer, M. Sano, C. H. van Dyck and L. J. Thal, N. Engl. J. Med., 2005, 352, 2379-2388.
5. C. Courtney, D. Farrell, R. Gray, R. Hills, L. Lynch, E. Sellwood, S. Edwards, W. Hardyman, J. Raftery, P. Crome, C. Lendon, H. Shaw and P. Bentham, Lancet, 2004, 363, 2105-2115.
6. P. L. McGeer, M. Schulzer and E. G. McGeer, Neurology, 1996, 47, 425-432.
7. P. L. McGeer and E. G. McGeer, Neurobiol. Aging, 2007, 28, 639-647.
8. P. L. McGeer, J. Rogers and E. G. McGeer, J. Alzheimers Dis., 2006, 9, 271-276.
9. C. A. Szekely, T. Town and P. P. Zandi, Subcellular Biochemistry, 2007, 42, 229-248.
10. Y. Joo, H. S. Kim, R. S. Woo, C. H. Park, K. Y. Shin, J. P. Lee, K. A. Chang, S. Kim and Y. H. Suh, Mol Pharmacol, 2006, 69, 76-84.
11. P. Camps, X. Formosa, D. Munoz-Torrero, J. Petrignet, A. Badia and M. V. Clos, J. Med. Chem., 2005, 48, 1701-1704.
12. D. Alonso, I. Dorronsoro, L. Rubio, P. Munoz, E. Garcia-Palomero, M. Del Monte, A. Bidon-Chanal, M. Orozco, F. J. Luque, A. Castro, M. Medina and A. Martinez, Bioorg. Med. Chem., 2005, 13, 6588-6597.
13. S. Butini, E. Guarino, G. Campiani, M. Brindisi, S. S. Coccone, I. Fiorini, E. Novellino, T. Belinskaya, A. Saxena and S. Gemma, Bioorg. Med. Chem. Lett., 2008, 18, 5213-5216.
14. D. Shao, C. Zou, C. Luo, X. Tang and Y. Li, Bioorg. Med. Chem. Lett., 2004, 14, 4639-4642.
15. M. I. Rodriguez-Franco, M. I. Fernandez-Bachiller, C. Perez, B. Hernandez-Ledesma and B. Bartolome, J. Med. Chem., 2006, 49, 459-462.
16. S. Muraoka and T. Miura, Life Sci., 2009, 84, 272-277.
17. S. Muraoka and T. Miura, Life Sci., 2003, 72, 1897-1907.
18. T. Thomas, T. G. Nadackal and K. Thomas, NeuroReport, 2001, 12, 3263-3267.
19. N. C. Inestrosa, A. Alvarez, C. A. Perez, R. D. Moreno, M. Vicente, C. Linker, O. I. Casanueva, C. Soto and J. Garrido, Neuron, 1996, 16, 881-891.
20. M. Bartolini, C. Bertucci, V. Cavrini and V. Andrisano, Biochem. Pharmacol., 2003, 65, 407-416.
21. D. M. Du and P. R. Carlier, Curr. Pharm. Des., 2004, 10, 3141-3156.
22. M. K. Hu, L. J. Wu, G. Hsiao and M. H. Yen, J. Med. Chem., 2002, 45, 2277-2282.
23. P. R. Carlier, E. S. Chow, Y. Han, J. Liu, J. El Yazal and Y. P. Pang, J. Med. Chem., 1999, 42, 4225-4231.
24. G. L. Ellman, K. D. Courtney, V. Andres, Jr. and R. M. Feather-Stone, Biochem. Pharmacol., 1961, 7, 88-95.
25. M. I. Fernandez-Bachiller, C. Perez, N. E. Campillo, J. A. Paez, G. C. Gonzalez-Munoz, P. Usan, E. Garcia-Palomero, M. G. Lopez, M. Villarroya, A. G. Garcia, A. Martinez and M. I. Rodriguez-Franco, ChemMedChem, 2009, 4, 828-841.
26. E. H. Rydberg, B. Brumshtein, H. M. Greenblatt, D. M. Wong, D. Shaya, L. D. Williams, P. R. Carlier, Y. P. Pang, I. Silman and J. L. Sussman, J. Med. Chem., 2006, 49, 5491-5500.
27. L. Fang, B. Kraus, J. Lehmann, J. Heilmann, Y. Zhang and M. Decker, Bioorg. Med. Chem. Lett., 2008, 18, 2905-2909.
28. M. Harel, I. Schalk, L. Ehret-Sabatier, F. Bouet, M. Goeldner, C. Hirth, P. H. Axelsen, I. Silman and J. L. Sussman, Proc. Natl. Acad. Sci. U. S. A., 1993, 90, 9031-9035.
29. C. H. da Silva, V. L. Campo, I. Carvalho and C. A. Taft, J. Mol. Graphics Modell., 2006, 25, 169-175.
30. Y. P. Pang, P. Quiram, T. Jelacic, F. Hong and S. Brimijoin, J. Biol. Chem., 1996, 271, 23646-23649.
31. G. Johnson and S. W. Moore, Biochem. Biophys. Res. Commun., 1999, 258, 758-762.
32. A. Alvarez, C. Opazo, R. Alarcon, J. Garrido and N. C. Inestrosa, J. Mol. Biol., 1997, 272, 348-361.
33. A. E. Reyes, D. R. Perez, A. Alvarez, J. Garrido, M. K. Gentry, B. P. Doctor and N. C. Inestrosa, Biochem. Biophys. Res. Commun., 1997, 232, 652-655.