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Volumn 20, Issue 9, 2012, Pages 3038-3048
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Inhibition of cholinesterase activity and amyloid aggregation by berberine-phenyl-benzoheterocyclic and tacrine-phenyl-benzoheterocyclic hybrids
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Author keywords
Alzheimer's disease; Amyloid; Cholinesterase; Multifunctional drug
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Indexed keywords
2 (4 METHOXYPHENYL)BENZOFURAN;
2 (HYDROXYMETHYL)PHENOL;
2 [4 (2 BROMOETHOXY)PHENYL]BENZOFURAN;
2 [4 (3 BROMOETHOXY)PHENYL] 1H INDOLE;
2 [4 (3 BROMOETHOXY)PHENYL]BENZO[D]OXAZOLE;
2 [4 (3 BROMOETHOXY)PHENYL]BENZO[D]THIAZOLE;
2 [4 (3 BROMOPROPOXY)PHENYL] 1H INDOLE;
2 [4 (3 BROMOPROPOXY)PHENYL]BENZO[D]OXAZOLE;
2 [4 (3 BROMOPROPOXY)PHENYL]BENZO[D]THIAZOLE;
2 [4 (3 BROMOPROPOXY)PHENYL]BENZOFURAN;
2 BROMO 1 (4 HYDROXYPHENYL)ETHANONE;
2 HYDROXYBENZYLTRIPHENYLPHOSPHONIUM BROMIDE;
4 (1H INDOL 2 YL)PHENOL;
4 (BENZOFURAN 2 YL)PHENOL;
4 (BENZOTHIAZOLE 2 YL)PHENOL;
4 (BENZOXAZOLE 2 YL)PHENOL;
9 O 2 [4 (2 ETHOXY)PHENYL]BENZOFURAN BERBERINE BROMIDE;
9 O 2 [4 (3 ETHOXY)PHENYL] 1H INDOLE BERBERINE BROMIDE;
9 O 2 [4 (3 ETHOXY)PHENYL]BENZO[D]THIAZOLE BERBERINE BROMIDE;
9 O 2 [4 (3 O PROPOXY)PHENYL]BENZO[D]THIAZOLE BERBERINE BROMIDE;
9 O 2 [4 (3 PROPOXY)PHENYL] 1H INDOLE BERBERINE BROMIDE;
9 O 2 [4 (3 PROPOXY)PHENYL]BENZOFURAN BERBERINE BROMIDE;
9 O N (3 BROMOPROPYL) 1H INDOLE 2 CARBOXAMIDE BERBERINE BROMIDE;
9 O N (3 PROPYL)BENZOFURAN 2 CARBOXAMIDE BERBERINE BROMIDE;
AMYLOID PROTEIN;
BERBERINE DERIVATIVE;
BERBERINE PHENYL BENZOHETEROCYCLIC DERIVATIVE;
CHOLINERGIC RECEPTOR BLOCKING AGENT;
TACRINE PHENYL BENZOHETEROCYCLIC DERIVATIVE;
UNCLASSIFIED DRUG;
UNINDEXED DRUG;
ALZHEIMER DISEASE;
ARTICLE;
CONCENTRATION RESPONSE;
CONTROLLED STUDY;
DRUG DESIGN;
DRUG MECHANISM;
DRUG POTENCY;
DRUG SCREENING;
DRUG SELECTIVITY;
DRUG STRUCTURE;
DRUG SYNTHESIS;
DRUG TARGETING;
ENZYME ACTIVITY;
ENZYME INHIBITION;
IC 50;
IN VITRO STUDY;
MOLECULAR MODEL;
PROTEIN AGGREGATION;
STRUCTURE ACTIVITY RELATION;
ACETYLCHOLINESTERASE;
ALZHEIMER DISEASE;
AMYLOID BETA-PEPTIDES;
BERBERINE;
BINDING SITES;
BUTYRYLCHOLINESTERASE;
CHOLINESTERASE INHIBITORS;
CHOLINESTERASES;
ENZYME ACTIVATION;
HETEROCYCLIC COMPOUNDS;
HUMANS;
KINETICS;
MOLECULAR DYNAMICS SIMULATION;
PROTEIN STRUCTURE, TERTIARY;
TACRINE;
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EID: 84859891133
PISSN: 09680896
EISSN: 14643391
Source Type: Journal
DOI: 10.1016/j.bmc.2012.02.059 Document Type: Article |
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Times cited : (83)
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References (23)
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