메뉴 건너뛰기




Volumn 11, Issue 5, 2012, Pages 337-350

Nonstandard drugs and feasible new interventions for autoimmune hepatitis: Part I

Author keywords

Autoimmune hepatitis; Nonstandard drugs; Rescue agents; Salvage therapy

Indexed keywords

AZATHIOPRINE; BUDESONIDE; CALCINEURIN INHIBITOR; CORTICOSTEROID; CYCLOSPORIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISOLONE; PREDNISONE; RAPAMYCIN; TACROLIMUS; TIOGUANINE;

EID: 84866397703     PISSN: 18715281     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152812803251006     Document Type: Article
Times cited : (13)

References (223)
  • 1
    • 68149089466 scopus 로고    scopus 로고
    • Current and future treatments of autoimmune hepatitis
    • Czaja, A.J. Current and future treatments of autoimmune hepatitis. Expert Rev. Gastroenterol. Hepatol., 2009, 3 (3), 269-291.
    • (2009) Expert Rev. Gastroenterol. Hepatol. , vol.3 , Issue.3 , pp. 269-291
    • Czaja, A.J.1
  • 2
    • 77952711598 scopus 로고    scopus 로고
    • Practice Guidelines of the American Association for the Study of Liver Diseases. Diagnosis and management of autoimmune hepatitis
    • Manns, M.P.; Czaja, A.J.; Gorham, J.D.; Krawitt, E.L.; Mieli-Vergani, G.; Vergani, D.; Vierling, J.M. Practice Guidelines of the American Association for the Study of Liver Diseases. Diagnosis and management of autoimmune hepatitis. Hepatology, 2010, 51 (6), 2193-2213.
    • (2010) Hepatology , vol.51 , Issue.6 , pp. 2193-2213
    • Manns, M.P.1    Czaja, A.J.2    Gorham, J.D.3    Krawitt, E.L.4    Mieli-Vergani, G.5    Vergani, D.6    Vierling, J.M.7
  • 4
    • 0015051285 scopus 로고
    • Controlled prospective trial of corticosteroid therapy in active chronic hepatitis
    • Cook, G.C.; Mulligan, R.; Sherlock, S. Controlled prospective trial of corticosteroid therapy in active chronic hepatitis. Q. J. Med., 1971, 40 (158), 159-185.
    • (1971) Q.J. Med. , vol.40 , Issue.158 , pp. 159-185
    • Cook, G.C.1    Mulligan, R.2    Sherlock, S.3
  • 5
    • 0015432456 scopus 로고
    • Clinical, biochemical, and histological remission of severe chronic active liver disease: A controlled study of treatments and early prognosis
    • Soloway, R.D.; Summerskill, W.H.; Baggenstoss, A.H.; Geall, M.G.; Gitnick, G.L.; Elveback, I.R.; Schoenfield, L.J. Clinical, biochemical, and histological remission of severe chronic active liver disease: a controlled study of treatments and early prognosis. Gastroenterology, 1972, 63 (5), 820-833.
    • (1972) Gastroenterology , vol.63 , Issue.5 , pp. 820-833
    • Soloway, R.D.1    Summerskill, W.H.2    Baggenstoss, A.H.3    Geall, M.G.4    Gitnick, G.L.5    Elveback, I.R.6    Schoenfield, L.J.7
  • 6
    • 0015916642 scopus 로고
    • Controlled trial of prednisone and azathioprine in active chronic hepatitis
    • Murray-Lyon, I.M.; Stern, R.B.; Williams, R. Controlled trial of prednisone and azathioprine in active chronic hepatitis. Lancet, 1973, 1 (7806), 735-737.
    • (1973) Lancet , vol.1 , Issue.7806 , pp. 735-737
    • Murray-Lyon, I.M.1    Stern, R.B.2    Williams, R.3
  • 7
    • 29444453466 scopus 로고    scopus 로고
    • Diverse manifestations and evolving treatments of autoimmune hepatitis
    • Czaja, A.J. Diverse manifestations and evolving treatments of autoimmune hepatitis. Minerva Gastroenterol. Dietol., 2005, 51 (4), 313-333.
    • (2005) Minerva Gastroenterol. Dietol. , vol.51 , Issue.4 , pp. 313-333
    • Czaja, A.J.1
  • 8
    • 67651241981 scopus 로고    scopus 로고
    • Non-classical phenotypes of autoimmune hepatitis and advances in diagnosis and treatment
    • Czaja, A.J.; Bayraktar, Y. Non-classical phenotypes of autoimmune hepatitis and advances in diagnosis and treatment. World J. Gastroenterol., 2009, 15 (19), 2314-2328.
    • (2009) World J. Gastroenterol. , vol.15 , Issue.19 , pp. 2314-2328
    • Czaja, A.J.1    Bayraktar, Y.2
  • 9
    • 68849087156 scopus 로고    scopus 로고
    • Special clinical challenges in autoimmune hepatitis: The elderly, males, pregnancy, mild disease, fulminant onset, and nonwhite patients
    • Czaja, A.J. Special clinical challenges in autoimmune hepatitis: the elderly, males, pregnancy, mild disease, fulminant onset, and nonwhite patients. Semin. Liver Dis., 2009, 29 (3), 315-330.
    • (2009) Semin. Liver Dis. , vol.29 , Issue.3 , pp. 315-330
    • Czaja, A.J.1
  • 10
    • 82255177207 scopus 로고    scopus 로고
    • Autoimmune hepatitis in special patient populations
    • Czaja, A.J. Autoimmune hepatitis in special patient populations. Best Pract. Res. Clin. Gastroenterol., 2011, 25 (6), 689-700.
    • (2011) Best Pract. Res. Clin. Gastroenterol. , vol.25 , Issue.6 , pp. 689-700
    • Czaja, A.J.1
  • 11
    • 0028027857 scopus 로고
    • The nature and prognostic implications of autoimmune hepatitis with an acute presentation
    • Nikias, G.A.; Batts, K.P.; Czaja, A.J. The nature and prognostic implications of autoimmune hepatitis with an acute presentation. J. Hepatol., 1994, 21 (5), 866-871.
    • (1994) J. Hepatol. , vol.21 , Issue.5 , pp. 866-871
    • Nikias, G.A.1    Batts, K.P.2    Czaja, A.J.3
  • 12
    • 77649253794 scopus 로고    scopus 로고
    • Difficult treatment decisions in autoimmune hepatitis
    • Czaja, A.J. Difficult treatment decisions in autoimmune hepatitis. World J. Gastroenterol., 2010, 16 (8), 934-947.
    • (2010) World J. Gastroenterol. , vol.16 , Issue.8 , pp. 934-947
    • Czaja, A.J.1
  • 13
    • 84859487734 scopus 로고    scopus 로고
    • Autoantibody-negative autoimmune hepatitis
    • Czaja, A.J. Autoantibody-negative autoimmune hepatitis. Dig. Dis. Sci., 2012, 57 (3), 610-624.
    • (2012) Dig. Dis. Sci. , vol.57 , Issue.3 , pp. 610-624
    • Czaja, A.J.1
  • 14
    • 0031948143 scopus 로고    scopus 로고
    • Frequency and nature of the variant syndromes of autoimmune liver disease
    • Czaja, A.J. Frequency and nature of the variant syndromes of autoimmune liver disease. Hepatology, 1998, 28 (2), 360-365.
    • (1998) Hepatology , vol.28 , Issue.2 , pp. 360-365
    • Czaja, A.J.1
  • 15
    • 0034836373 scopus 로고    scopus 로고
    • Autoimmune hepatitis and its variant syndromes
    • Ben-Ari, Z.; Czaja, A.J. Autoimmune hepatitis and its variant syndromes. Gut, 2001, 49 (4), 589-594.
    • (2001) Gut , vol.49 , Issue.4 , pp. 589-594
    • Ben-Ari, Z.1    Czaja, A.J.2
  • 16
    • 58149136329 scopus 로고    scopus 로고
    • Frequency, behavior, and prognostic implications of antimitochondrial antibodies in type 1 autoimmune hepatitis
    • Montano-Loza, A.J.; Carpenter, H.A.; Czaja, A.J. Frequency, behavior, and prognostic implications of antimitochondrial antibodies in type 1 autoimmune hepatitis. J. Clin. Gastroenterol., 2008, 42 (9), 1047-1053.
    • (2008) J. Clin. Gastroenterol. , vol.42 , Issue.9 , pp. 1047-1053
    • Montano-Loza, A.J.1    Carpenter, H.A.2    Czaja, A.J.3
  • 18
    • 80055084532 scopus 로고    scopus 로고
    • Recurrent autoimmune hepatitis after liver transplantation
    • Czaja, A.J. Recurrent autoimmune hepatitis after liver transplantation. Ann. Gastroenterol. Hepatol., 2010, 1 (1), 79-89.
    • (2010) Ann. Gastroenterol. Hepatol. , vol.1 , Issue.1 , pp. 79-89
    • Czaja, A.J.1
  • 20
    • 84866384808 scopus 로고    scopus 로고
    • Diagnosis, pathogenesis, and treatment of autoimmune hepatitis after liver transplantation
    • [Epub ahead of print]
    • Czaja, A.J. Diagnosis, pathogenesis, and treatment of autoimmune hepatitis after liver transplantation. Dig. Dis. Sci., 2012, [Epub ahead of print].
    • (2012) Dig. Dis. Sci.
    • Czaja, A.J.1
  • 21
    • 84856174358 scopus 로고    scopus 로고
    • Cryptogenic chronic hepatitis and its changing guise in adults
    • Czaja, A.J. Cryptogenic chronic hepatitis and its changing guise in adults. Dig. Dis. Sci., 2011, 56 (12), 3421-3438.
    • (2011) Dig. Dis. Sci. , vol.56 , Issue.12 , pp. 3421-3438
    • Czaja, A.J.1
  • 22
    • 84866391821 scopus 로고    scopus 로고
    • Advances in the current treatment of autoimmune hepatitis
    • 2012, [Epub ahead of print April 3; DOI:10.1007/s10620-012-2151-2]
    • Czaja, A.J. Advances in the current treatment of autoimmune hepatitis. Dig. Dis. Sci., 2012, [Epub ahead of print 2012 April 3; DOI:10.1007/s10620-012-2151-2].
    • (2012) Dig. Dis. Sci.
    • Czaja, A.J.1
  • 24
  • 25
    • 0023812878 scopus 로고
    • Features reflective of early prognosis in corticosteroid-treated severe autoimmune chronic active hepatitis
    • Czaja, A.J.; Rakela, J.; Ludwig, J. Features reflective of early prognosis in corticosteroid-treated severe autoimmune chronic active hepatitis. Gastroenterology, 1988, 95 (2), 448-453.
    • (1988) Gastroenterology , vol.95 , Issue.2 , pp. 448-453
    • Czaja, A.J.1    Rakela, J.2    Ludwig, J.3
  • 26
    • 0035002235 scopus 로고    scopus 로고
    • Longterm management and prognosis of autoimmune hepatitis (AIH): A single center experience
    • Kanzler, S.; Lohr, H.; Gerken, G.; Galle, P.R.; Lohse, A.W. Longterm management and prognosis of autoimmune hepatitis (AIH): a single center experience. Z. Gastroenterol., 2001, 39 (5), 339-341, 344-338.
    • (2001) Z. Gastroenterol. , vol.39 , Issue.5
    • Kanzler, S.1    Lohr, H.2    Gerken, G.3    Galle, P.R.4    Lohse, A.W.5
  • 27
    • 67349145925 scopus 로고    scopus 로고
    • Rapidity of treatment response and outcome in type 1 autoimmune hepatitis
    • Czaja, A.J. Rapidity of treatment response and outcome in type 1 autoimmune hepatitis. J. Hepatol., 2009, 51 (1), 161-167.
    • (2009) J. Hepatol. , vol.51 , Issue.1 , pp. 161-167
    • Czaja, A.J.1
  • 28
    • 0018843784 scopus 로고
    • Clinical features and prognosis of severe chronic active liver disease (CALD) after corticosteroid-induced remission
    • Czaja, A.J.; Ammon, H.V.; Summerskill, W.H. Clinical features and prognosis of severe chronic active liver disease (CALD) after corticosteroid-induced remission. Gastroenterology, 1980, 78 (3), 518-523.
    • (1980) Gastroenterology , vol.78 , Issue.3 , pp. 518-523
    • Czaja, A.J.1    Ammon, H.V.2    Summerskill, W.H.3
  • 29
    • 0020635770 scopus 로고
    • Relapse following treatment withdrawal in patients with autoimmune chronic active hepatitis
    • Hegarty, J.E.; Nouri Aria, K.T.; Portmann, B.; Eddleston, A.L.; Williams, R. Relapse following treatment withdrawal in patients with autoimmune chronic active hepatitis. Hepatology, 1983, 3 (5), 685-689.
    • (1983) Hepatology , vol.3 , Issue.5 , pp. 685-689
    • Hegarty, J.E.1    Nouri Aria, K.T.2    Portmann, B.3    Eddleston, A.L.4    Williams, R.5
  • 30
    • 0036211577 scopus 로고    scopus 로고
    • Sustained remission after corticosteroid therapy for type 1 autoimmune hepatitis: A retrospective analysis
    • Czaja, A.J.; Menon, K.V.; Carpenter, H.A. Sustained remission after corticosteroid therapy for type 1 autoimmune hepatitis: a retrospective analysis. Hepatology, 2002, 35 (4), 890-897.
    • (2002) Hepatology , vol.35 , Issue.4 , pp. 890-897
    • Czaja, A.J.1    Menon, K.V.2    Carpenter, H.A.3
  • 31
    • 34047223229 scopus 로고    scopus 로고
    • Consequences of treatment withdrawal in type 1 autoimmune hepatitis
    • Montano-Loza, A.J.; Carpenter, H.A.; Czaja, A.J. Consequences of treatment withdrawal in type 1 autoimmune hepatitis. Liver Int., 2007, 27 (4), 507-515.
    • (2007) Liver Int. , vol.27 , Issue.4 , pp. 507-515
    • Montano-Loza, A.J.1    Carpenter, H.A.2    Czaja, A.J.3
  • 32
    • 77954424177 scopus 로고    scopus 로고
    • Late relapse of type 1 autoimmune hepatitis after corticosteroid withdrawal
    • Czaja, A.J. Late relapse of type 1 autoimmune hepatitis after corticosteroid withdrawal. Dig. Dis. Sci., 2010, 55 (6), 1761-1769.
    • (2010) Dig. Dis. Sci. , vol.55 , Issue.6 , pp. 1761-1769
    • Czaja, A.J.1
  • 33
    • 77953889134 scopus 로고    scopus 로고
    • Advances in the diagnosis, pathogenesis and management of autoimmune hepatitis
    • Czaja, A.J.; Manns, M.P. Advances in the diagnosis, pathogenesis and management of autoimmune hepatitis. Gastroenterology, 2010, 139 (1), 58-72.
    • (2010) Gastroenterology , vol.139 , Issue.1 , pp. 58-72
    • Czaja, A.J.1    Manns, M.P.2
  • 34
    • 79958130348 scopus 로고    scopus 로고
    • Autoimmune hepatitis: The dilemma of rare diseases
    • Manns, M.P. Autoimmune hepatitis: the dilemma of rare diseases. Gastroenterology, 2011, 140 (7), 1874-1876.
    • (2011) Gastroenterology , vol.140 , Issue.7 , pp. 1874-1876
    • Manns, M.P.1
  • 35
    • 36349017310 scopus 로고    scopus 로고
    • Features associated with treatment failure in type 1 autoimmune hepatitis and predictive value of the model of end-stage liver disease
    • Montano-Loza, A.J.; Carpenter, H.A.; Czaja, A.J. Features associated with treatment failure in type 1 autoimmune hepatitis and predictive value of the model of end-stage liver disease. Hepatology, 2007, 46 (4), 1138-1145.
    • (2007) Hepatology , vol.46 , Issue.4 , pp. 1138-1145
    • Montano-Loza, A.J.1    Carpenter, H.A.2    Czaja, A.J.3
  • 36
    • 44949148177 scopus 로고    scopus 로고
    • Safety issues in the management of autoimmune hepatitis
    • Czaja, A.J. Safety issues in the management of autoimmune hepatitis. Expert Opin. Drug Saf., 2008, 7 (3), 319-333.
    • (2008) Expert Opin. Drug Saf. , vol.7 , Issue.3 , pp. 319-333
    • Czaja, A.J.1
  • 37
    • 0021217938 scopus 로고
    • Complete resolution of inflammatory activity following corticosteroid treatment of HBsAg-negative chronic active hepatitis
    • Czaja, A.J.; Davis, G.L.; Ludwig, J.; Taswell, H.F. Complete resolution of inflammatory activity following corticosteroid treatment of HBsAg-negative chronic active hepatitis. Hepatology, 1984, 4 (4), 622-627.
    • (1984) Hepatology , vol.4 , Issue.4 , pp. 622-627
    • Czaja, A.J.1    Davis, G.L.2    Ludwig, J.3    Taswell, H.F.4
  • 38
    • 0019381696 scopus 로고
    • Corticosteroidtreated chronic active hepatitis in remission: Uncertain prognosis of chronic persistent hepatitis
    • Czaja, A.J.; Ludwig, J.; Baggenstoss, A.H.; Wolf, A. Corticosteroidtreated chronic active hepatitis in remission: uncertain prognosis of chronic persistent hepatitis. N. Engl. J. Med., 1981, 304 (1), 5-9.
    • (1981) N. Engl. J. Med. , vol.304 , Issue.1 , pp. 5-9
    • Czaja, A.J.1    Ludwig, J.2    Baggenstoss, A.H.3    Wolf, A.4
  • 39
    • 84866770664 scopus 로고    scopus 로고
    • Autoimmune hepatitis: Focusing on treatments other than steroids
    • [in press]
    • Czaja, A.J. Autoimmune hepatitis: focusing on treatments other than steroids. Can. J. Gastroenterol., 2012, [in press].
    • (2012) Can. J. Gastroenterol.
    • Czaja, A.J.1
  • 40
    • 77957893679 scopus 로고    scopus 로고
    • Emerging opportunities for site-specific molecular and cellular interventions in autoimmune hepatitis
    • Czaja, A.J. Emerging opportunities for site-specific molecular and cellular interventions in autoimmune hepatitis. Dig. Dis. Sci., 2010, 55 (10), 2712-2726.
    • (2010) Dig. Dis. Sci. , vol.55 , Issue.10 , pp. 2712-2726
    • Czaja, A.J.1
  • 41
    • 80055088856 scopus 로고    scopus 로고
    • Promising pharmacological, molecular and cellular treatments of autoimmune hepatitis
    • Czaja, A.J. Promising pharmacological, molecular and cellular treatments of autoimmune hepatitis. Curr. Pharm. Des., 2011, 17 (29), 3120-3140.
    • (2011) Curr. Pharm. Des. , vol.17 , Issue.29 , pp. 3120-3140
    • Czaja, A.J.1
  • 42
    • 41149153531 scopus 로고    scopus 로고
    • Autoimmune hepatitis. Part A: Pathogenesis
    • Czaja, A.J. Autoimmune hepatitis. Part A: pathogenesis. Expert Rev. Gastroenterol. Hepatol., 2007, 1 (1), 113-128.
    • (2007) Expert Rev. Gastroenterol. Hepatol. , vol.1 , Issue.1 , pp. 113-128
    • Czaja, A.J.1
  • 43
    • 0023242606 scopus 로고
    • Sustained remission after corticosteroid therapy of severe hepatitis B surface antigen-negative chronic active hepatitis
    • Czaja, A.J.; Beaver, S.J.; Shiels, M.T. Sustained remission after corticosteroid therapy of severe hepatitis B surface antigen-negative chronic active hepatitis. Gastroenterology, 1987, 92 (1), 215-219.
    • (1987) Gastroenterology , vol.92 , Issue.1 , pp. 215-219
    • Czaja, A.J.1    Beaver, S.J.2    Shiels, M.T.3
  • 44
    • 11844269814 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids
    • Czock, D.; Keller, F.; Rasche, F.M.; Haussler, U. Pharmacokinetics and pharmacodynamics of systemically administered glucocorticoids. Clin. Pharmacokinet., 2005, 44 (1), 61-98.
    • (2005) Clin. Pharmacokinet. , vol.44 , Issue.1 , pp. 61-98
    • Czock, D.1    Keller, F.2    Rasche, F.M.3    Haussler, U.4
  • 45
    • 0019949152 scopus 로고
    • Comparative serum prednisone and prednisolone concentrations following administration to patients with chronic active liver disease
    • Uribe, M.; Summerskill, W.H.; Go, V.L. Comparative serum prednisone and prednisolone concentrations following administration to patients with chronic active liver disease. Clin. Pharmacokinet., 1982, 7 (5), 452-459.
    • (1982) Clin. Pharmacokinet. , vol.7 , Issue.5 , pp. 452-459
    • Uribe, M.1    Summerskill, W.H.2    Go, V.L.3
  • 46
    • 0028260082 scopus 로고
    • Bioavailability and reversible metabolism of prednisone and prednisolone in man
    • Garg, V.; Jusko, W.J. Bioavailability and reversible metabolism of prednisone and prednisolone in man. Biopharm. Drug Dispos., 1994, 15 (2), 163-172.
    • (1994) Biopharm. Drug Dispos. , vol.15 , Issue.2 , pp. 163-172
    • Garg, V.1    Jusko, W.J.2
  • 47
    • 0018236134 scopus 로고
    • Oral prednisone for chronic active liver disease: Dose responses and bioavailability studies
    • Uribe, M.; Schalm, S.W.; Summerskill, W.H.; Go, V.L. Oral prednisone for chronic active liver disease: dose responses and bioavailability studies. Gut, 1978, 19 (12), 1131-1135.
    • (1978) Gut , vol.19 , Issue.12 , pp. 1131-1135
    • Uribe, M.1    Schalm, S.W.2    Summerskill, W.H.3    Go, V.L.4
  • 48
    • 0018474635 scopus 로고
    • Corticosteroid pharmacokinetics in liver disease
    • Uribe, M.; Go, V.L. Corticosteroid pharmacokinetics in liver disease. Clin. Pharmacokinet., 1979, 4 (3), 233-240.
    • (1979) Clin. Pharmacokinet. , vol.4 , Issue.3 , pp. 233-240
    • Uribe, M.1    Go, V.L.2
  • 49
    • 0017647710 scopus 로고
    • Prednisone for chronic active liver disease: Pharmacokinetics, including conversion to prednisolone
    • Schalm, S.W.; Summerskill, W.H.; Go, V.L. Prednisone for chronic active liver disease: pharmacokinetics, including conversion to prednisolone. Gastroenterology, 1977, 72 (5 Pt 1), 910-913.
    • (1977) Gastroenterology , vol.72 , Issue.5 PART 1 , pp. 910-913
    • Schalm, S.W.1    Summerskill, W.H.2    Go, V.L.3
  • 50
    • 0029820720 scopus 로고    scopus 로고
    • Cytokine modulation by glucocorticoids: Mechanisms and actions in cellular studies
    • discussion 91-82
    • Brattsand, R.; Linden, M. Cytokine modulation by glucocorticoids: mechanisms and actions in cellular studies. Aliment. Pharmacol. Ther., 1996, 10 (Suppl 2), 81-90; discussion 91-82.
    • (1996) Aliment. Pharmacol. Ther. , vol.10 , Issue.SUPPL. 2 , pp. 81-90
    • Brattsand, R.1    Linden, M.2
  • 51
    • 0034284349 scopus 로고    scopus 로고
    • Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: Negative interference of activated glucocorticoid receptor with transcription factors
    • De Bosscher, K.; Vanden Berghe, W.; Haegeman, G. Mechanisms of anti-inflammatory action and of immunosuppression by glucocorticoids: negative interference of activated glucocorticoid receptor with transcription factors. J. Neuroimmunol., 2000, 109 (1), 16-22.
    • (2000) J. Neuroimmunol. , vol.109 , Issue.1 , pp. 16-22
    • de Bosscher, K.1    Vanden Berghe, W.2    Haegeman, G.3
  • 52
    • 0029801742 scopus 로고    scopus 로고
    • Regulation of cytokine and cytokine receptor expression by glucocorticoids
    • Almawi, W.Y.; Beyhum, H.N.; Rahme, A.A.; Rieder, M.J. Regulation of cytokine and cytokine receptor expression by glucocorticoids. J. Leukoc. Biol., 1996, 60 (5), 563-572.
    • (1996) J. Leukoc. Biol. , vol.60 , Issue.5 , pp. 563-572
    • Almawi, W.Y.1    Beyhum, H.N.2    Rahme, A.A.3    Rieder, M.J.4
  • 53
    • 0001853291 scopus 로고    scopus 로고
    • Molecular mechanisms of glucocorticoid effects
    • Almawi, W.Y. Molecular mechanisms of glucocorticoid effects. Mod. Asp. Immunobiol., 2001, 2, 78-82.
    • (2001) Mod. Asp. Immunobiol. , vol.2 , pp. 78-82
    • Almawi, W.Y.1
  • 54
    • 0027452579 scopus 로고
    • Oral pulse prednisone therapy after relapse of severe autoimmune chronic active hepatitis. A prospective randomized treatment trial evaluating clinical, biochemical, and lymphocyte subset responses
    • Czaja, A.J.; Wang, K.K.; Shiels, M.T.; Katzmann, J.A. Oral pulse prednisone therapy after relapse of severe autoimmune chronic active hepatitis. A prospective randomized treatment trial evaluating clinical, biochemical, and lymphocyte subset responses. J. Hepatol., 1993, 17 (2), 180-186.
    • (1993) J. Hepatol. , vol.17 , Issue.2 , pp. 180-186
    • Czaja, A.J.1    Wang, K.K.2    Shiels, M.T.3    Katzmann, J.A.4
  • 55
    • 0024442393 scopus 로고
    • A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin
    • Siekierka, J.J.; Hung, S.H.; Poe, M.; Lin, C.S.; Sigal, N.H. A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin. Nature, 1989, 341 (6244), 755-757.
    • (1989) Nature , vol.341 , Issue.6244 , pp. 755-757
    • Siekierka, J.J.1    Hung, S.H.2    Poe, M.3    Lin, C.S.4    Sigal, N.H.5
  • 56
    • 0025893168 scopus 로고
    • Calcineurin is a common target of cyclophilincyclosporin A and FKBP-FK506 complexes
    • Liu, J.; Farmer, J.D., Jr.; Lane, W.S.; Friedman, J.; Weissman, I.; Schreiber, S.L. Calcineurin is a common target of cyclophilincyclosporin A and FKBP-FK506 complexes. Cell, 1991, 66 (4), 807-815.
    • (1991) Cell , vol.66 , Issue.4 , pp. 807-815
    • Liu, J.1    Farmer Jr., J.D.2    Lane, W.S.3    Friedman, J.4    Weissman, I.5    Schreiber, S.L.6
  • 57
    • 38449094179 scopus 로고    scopus 로고
    • Metabolism of tacrolimus (FK506) and recent topics in clinical pharmacokinetics
    • Iwasaki, K. Metabolism of tacrolimus (FK506) and recent topics in clinical pharmacokinetics. Drug Metab. Pharmacokinet., 2007, 22 (5), 328-335.
    • (2007) Drug Metab. Pharmacokinet. , vol.22 , Issue.5 , pp. 328-335
    • Iwasaki, K.1
  • 58
    • 1842534887 scopus 로고    scopus 로고
    • Inhibitors of the calcineurin/NFAT pathway
    • Martinez-Martinez, S.; Redondo, J.M. Inhibitors of the calcineurin/NFAT pathway. Curr. Med. Chem., 2004, 11 (8), 997-1007.
    • (2004) Curr. Med. Chem. , vol.11 , Issue.8 , pp. 997-1007
    • Martinez-Martinez, S.1    Redondo, J.M.2
  • 59
    • 20644466433 scopus 로고    scopus 로고
    • NFAT proteins: Key regulators of T-cell development and function
    • Macian, F. NFAT proteins: key regulators of T-cell development and function. Nat. Rev. Immunol., 2005, 5 (6), 472-484.
    • (2005) Nat. Rev. Immunol. , vol.5 , Issue.6 , pp. 472-484
    • Macian, F.1
  • 60
    • 0028102027 scopus 로고
    • Molecular and biological actions of cyclosporin A and FK506 on T cell development and function
    • Hollander, G.A.; Bierer, B.E.; Burakoff, S.J. Molecular and biological actions of cyclosporin A and FK506 on T cell development and function. Transfus. Sci., 1994, 15 (3), 207-220.
    • (1994) Transfus. Sci. , vol.15 , Issue.3 , pp. 207-220
    • Hollander, G.A.1    Bierer, B.E.2    Burakoff, S.J.3
  • 61
    • 0036054540 scopus 로고    scopus 로고
    • Distribution of cyclosporin in organ transplant recipients
    • Akhlaghi, F.; Trull, A.K. Distribution of cyclosporin in organ transplant recipients. Clin. Pharmacokinet., 2002, 41 (9), 615-637.
    • (2002) Clin. Pharmacokinet. , vol.41 , Issue.9 , pp. 615-637
    • Akhlaghi, F.1    Trull, A.K.2
  • 62
    • 0037323992 scopus 로고    scopus 로고
    • Calcineurin phosphatase activity and immunosuppression. A review on the role of calcineurin phosphatase activity and the immunosuppressive effect of cyclosporin A and tacrolimus
    • Jorgensen, K.A.; Koefoed-Nielsen, P.B.; Karamperis, N. Calcineurin phosphatase activity and immunosuppression. A review on the role of calcineurin phosphatase activity and the immunosuppressive effect of cyclosporin A and tacrolimus. Scand. J. Immunol., 2003, 57 (2), 93-98.
    • (2003) Scand. J. Immunol. , vol.57 , Issue.2 , pp. 93-98
    • Jorgensen, K.A.1    Koefoed-Nielsen, P.B.2    Karamperis, N.3
  • 63
    • 0036270285 scopus 로고    scopus 로고
    • Autoimmune hepatitis after liver transplantation and other lessons of self-intolerance
    • Czaja, A.J. Autoimmune hepatitis after liver transplantation and other lessons of self-intolerance. Liver Transpl., 2002, 8 (6), 505-513.
    • (2002) Liver Transpl. , vol.8 , Issue.6 , pp. 505-513
    • Czaja, A.J.1
  • 64
    • 0027489719 scopus 로고
    • Cyclosporineinduced autoimmunity: Critical role of autoregulation in the prevention of major histocompatibility class II-dependent autoaggression
    • Hess, A.D.; Fischer, A.C.; Horwitz, L.R.; Laulis, M.K. Cyclosporineinduced autoimmunity: critical role of autoregulation in the prevention of major histocompatibility class II-dependent autoaggression. Transplant. Proc., 1993, 25 (5), 2811-2813.
    • (1993) Transplant. Proc. , vol.25 , Issue.5 , pp. 2811-2813
    • Hess, A.D.1    Fischer, A.C.2    Horwitz, L.R.3    Laulis, M.K.4
  • 65
    • 0022403571 scopus 로고
    • Cyclosporin, a new treatment for autoimmune chronic active hepatitis
    • Mistilis, S.P.; Vickers, C.R.; Darroch, M.H.; McCarthy, S.W. Cyclosporin, a new treatment for autoimmune chronic active hepatitis. Med. J. Aust., 1985, 143 (10), 463-465.
    • (1985) Med. J. Aust. , vol.143 , Issue.10 , pp. 463-465
    • Mistilis, S.P.1    Vickers, C.R.2    Darroch, M.H.3    McCarthy, S.W.4
  • 67
    • 0027170712 scopus 로고
    • Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders
    • Faulds, D.; Goa, K.L.; Benfield, P. Cyclosporin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in immunoregulatory disorders. Drugs, 1993, 45 (6), 953-1040.
    • (1993) Drugs , vol.45 , Issue.6 , pp. 953-1040
    • Faulds, D.1    Goa, K.L.2    Benfield, P.3
  • 68
    • 0023630918 scopus 로고
    • Central nervous system toxicity after liver transplantation. The role of cyclosporine and cholesterol
    • de Groen, P.C.; Aksamit, A.J.; Rakela, J.; Forbes, G.S.; Krom, R.A. Central nervous system toxicity after liver transplantation. The role of cyclosporine and cholesterol. N. Eng. J. Med., 1987, 317 (14), 861-866.
    • (1987) N. Eng. J. Med. , vol.317 , Issue.14 , pp. 861-866
    • de Groen, P.C.1    Aksamit, A.J.2    Rakela, J.3    Forbes, G.S.4    Krom, R.A.5
  • 69
    • 0033803718 scopus 로고    scopus 로고
    • Neurotoxicity of calcineurin inhibitors: Impact and clinical management
    • Bechstein, W.O. Neurotoxicity of calcineurin inhibitors: impact and clinical management. Transpl. Int., 2000, 13 (5), 313-326.
    • (2000) Transpl. Int. , vol.13 , Issue.5 , pp. 313-326
    • Bechstein, W.O.1
  • 70
    • 2342560435 scopus 로고    scopus 로고
    • Biochemical mechanisms of cyclosporine neurotoxicity
    • Serkova, N.J.; Christians, U.; Benet, L.Z. Biochemical mechanisms of cyclosporine neurotoxicity. Mol. Interv., 2004, 4 (2), 97-107.
    • (2004) Mol. Interv. , vol.4 , Issue.2 , pp. 97-107
    • Serkova, N.J.1    Christians, U.2    Benet, L.Z.3
  • 72
    • 44949206987 scopus 로고    scopus 로고
    • De novo autoimmune hepatitis after liver transplantation
    • Lohse, A.W.; Weiler-Norman, C.; Burdelski, M. De novo autoimmune hepatitis after liver transplantation. Hepatol. Res., 2007, 37 (Suppl 3), S462.
    • (2007) Hepatol. Res. , vol.37 , Issue.SUPPL. 3
    • Lohse, A.W.1    Weiler-Norman, C.2    Burdelski, M.3
  • 73
    • 0016802724 scopus 로고
    • Prednisone for chronic active liver disease: Dose titration, standard dose, and combination with azathioprine compared
    • Summerskill, W.H.; Korman, M.G.; Ammon, H.V.; Baggenstoss, A.H. Prednisone for chronic active liver disease: dose titration, standard dose, and combination with azathioprine compared. Gut, 1975, 16 (11), 876-883.
    • (1975) Gut , vol.16 , Issue.11 , pp. 876-883
    • Summerskill, W.H.1    Korman, M.G.2    Ammon, H.V.3    Baggenstoss, A.H.4
  • 74
    • 0025034447 scopus 로고
    • Azathioprine metabolism: Pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients
    • Chan, G.L.; Erdmann, G.R.; Gruber, S.A.; Matas, A.J.; Canafax, D.M. Azathioprine metabolism: pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients. J. Clin. Pharmacol., 1990, 30 (4), 358-363.
    • (1990) J. Clin. Pharmacol. , vol.30 , Issue.4 , pp. 358-363
    • Chan, G.L.1    Erdmann, G.R.2    Gruber, S.A.3    Matas, A.J.4    Canafax, D.M.5
  • 75
    • 0026758498 scopus 로고
    • The clinical pharmacology of 6-mercaptopurine
    • Lennard, L. The clinical pharmacology of 6-mercaptopurine. Eur. J. Clin. Pharmacol., 1992, 43 (4), 329-339.
    • (1992) Eur. J. Clin. Pharmacol. , vol.43 , Issue.4 , pp. 329-339
    • Lennard, L.1
  • 76
    • 0034098326 scopus 로고    scopus 로고
    • Immunosuppressive drugs: The first 50 years and a glance forward
    • Allison, A.C. Immunosuppressive drugs: the first 50 years and a glance forward. Immunopharmacology, 2000, 47 (2-3), 63-83.
    • (2000) Immunopharmacology , vol.47 , Issue.2-3 , pp. 63-83
    • Allison, A.C.1
  • 78
    • 49149091001 scopus 로고    scopus 로고
    • Azathioprine in inflammatory bowel disease: Improved molecular insights and resulting clinical implications
    • Atreya, I.; Neurath, M.F. Azathioprine in inflammatory bowel disease: improved molecular insights and resulting clinical implications. Expert Rev. Gastroenterol. Hepatol., 2008, 2 (1), 23-34.
    • (2008) Expert Rev. Gastroenterol. Hepatol. , vol.2 , Issue.1 , pp. 23-34
    • Atreya, I.1    Neurath, M.F.2
  • 79
    • 0023748255 scopus 로고
    • Maintenance of remission in autoimmune chronic active hepatitis with azathioprine after corticosteroid withdrawal
    • Stellon, A.J.; Keating, J.J.; Johnson, P.J.; McFarlane, I.G.; Williams, R. Maintenance of remission in autoimmune chronic active hepatitis with azathioprine after corticosteroid withdrawal. Hepatology, 1988, 8 (4), 781-784.
    • (1988) Hepatology , vol.8 , Issue.4 , pp. 781-784
    • Stellon, A.J.1    Keating, J.J.2    Johnson, P.J.3    McFarlane, I.G.4    Williams, R.5
  • 80
    • 0029130857 scopus 로고
    • Azathioprine for longterm maintenance of remission in autoimmune hepatitis
    • Johnson, P.J.; McFarlane, I.G.; Williams, R. Azathioprine for longterm maintenance of remission in autoimmune hepatitis. N. Engl. J. Med., 1995, 333 (15), 958-963.
    • (1995) N. Engl. J. Med. , vol.333 , Issue.15 , pp. 958-963
    • Johnson, P.J.1    McFarlane, I.G.2    Williams, R.3
  • 81
    • 33745831588 scopus 로고    scopus 로고
    • Thiopurine methyltransferase deficiency and azathioprine intolerance in autoimmune hepatitis
    • Czaja, A.J.; Carpenter, H.A. Thiopurine methyltransferase deficiency and azathioprine intolerance in autoimmune hepatitis. Dig. Dis. Sci., 2006, 51 (5), 968-975.
    • (2006) Dig. Dis. Sci. , vol.51 , Issue.5 , pp. 968-975
    • Czaja, A.J.1    Carpenter, H.A.2
  • 82
    • 0019461085 scopus 로고
    • Azathioprine-induced pancytopenia. Occurrence in two patients with connective-tissue diseases
    • Bacon, B.R.; Treuhaft, W.H.; Goodman, A.M. Azathioprine-induced pancytopenia. Occurrence in two patients with connective-tissue diseases. Arch. Intern. Med., 1981, 141 (2), 223-226.
    • (1981) Arch. Intern. Med. , vol.141 , Issue.2 , pp. 223-226
    • Bacon, B.R.1    Treuhaft, W.H.2    Goodman, A.M.3
  • 83
    • 0029160172 scopus 로고
    • Azathioprineinduced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis
    • Ben Ari, Z.; Mehta, A.; Lennard, L.; Burroughs, A.K. Azathioprineinduced myelosuppression due to thiopurine methyltransferase deficiency in a patient with autoimmune hepatitis. J. Hepatol., 1995, 23 (3), 351-354.
    • (1995) J. Hepatol. , vol.23 , Issue.3 , pp. 351-354
    • Ben Ari, Z.1    Mehta, A.2    Lennard, L.3    Burroughs, A.K.4
  • 84
    • 0021332884 scopus 로고
    • Azathioprine and the liver. Evidence favoring idiosyncratic, mixed cholestatichepatocellular injury in humans
    • DePinho, R.A.; Goldberg, C.S.; Lefkowitch, J.H. Azathioprine and the liver. Evidence favoring idiosyncratic, mixed cholestatichepatocellular injury in humans. Gastroenterology, 1984, 86 (1), 162-165.
    • (1984) Gastroenterology , vol.86 , Issue.1 , pp. 162-165
    • DePinho, R.A.1    Goldberg, C.S.2    Lefkowitch, J.H.3
  • 86
    • 3142557936 scopus 로고    scopus 로고
    • Acute and clinically relevant drug-induced liver injury: A population based case-control study
    • de Abajo, F.J.; Montero, D.; Madurga, M.; Garcia Rodriguez, L.A. Acute and clinically relevant drug-induced liver injury: a population based case-control study. Br. J. Clin. Pharmacol., 2004, 58 (1), 71-80.
    • (2004) Br. J. Clin. Pharmacol. , vol.58 , Issue.1 , pp. 71-80
    • de Abajo, F.J.1    Montero, D.2    Madurga, M.3    Garcia Rodriguez, L.A.4
  • 87
    • 4444224484 scopus 로고    scopus 로고
    • Azathioprine, 6-mercaptopurine in inflammatory bowel disease: Pharmacology, efficacy, and safety
    • Dubinsky, M.C. Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin. Gastroenterol. Hepatol., 2004, 2 (9), 731-743.
    • (2004) Clin. Gastroenterol. Hepatol. , vol.2 , Issue.9 , pp. 731-743
    • Dubinsky, M.C.1
  • 91
    • 33847000579 scopus 로고    scopus 로고
    • Apoptosis of T cells and the control of inflammatory bowel disease: Therapeutic implications
    • Mudter, J.; Neurath, M.F. Apoptosis of T cells and the control of inflammatory bowel disease: therapeutic implications. Gut, 2007, 56 (2), 293-303.
    • (2007) Gut , vol.56 , Issue.2 , pp. 293-303
    • Mudter, J.1    Neurath, M.F.2
  • 92
    • 78650029386 scopus 로고    scopus 로고
    • Increased proportion of CD16(+) NK cells in the colonic lamina propria of inflammatory bowel disease patients, but not after azathioprine treatment
    • Steel, A.W.; Mela, C.M.; Lindsay, J.O.; Gazzard, B.G.; Goodier, M.R. Increased proportion of CD16(+) NK cells in the colonic lamina propria of inflammatory bowel disease patients, but not after azathioprine treatment. Aliment. Pharmacol. Ther., 2011, 33 (1), 115-126.
    • (2011) Aliment. Pharmacol. Ther. , vol.33 , Issue.1 , pp. 115-126
    • Steel, A.W.1    Mela, C.M.2    Lindsay, J.O.3    Gazzard, B.G.4    Goodier, M.R.5
  • 93
    • 0031748776 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of mycophenolate mofetil
    • Bullingham, R.E.; Nicholls, A.J.; Kamm, B.R. Clinical pharmacokinetics of mycophenolate mofetil. Clin. Pharmacokinet., 1998, 34 (6), 429-455.
    • (1998) Clin. Pharmacokinet. , vol.34 , Issue.6 , pp. 429-455
    • Bullingham, R.E.1    Nicholls, A.J.2    Kamm, B.R.3
  • 94
    • 0034045586 scopus 로고    scopus 로고
    • Mycophenolate mofetil and its mechanisms of action
    • Allison, A.C.; Eugui, E.M. Mycophenolate mofetil and its mechanisms of action. Immunopharmacology, 2000, 47 (2-3), 85-118.
    • (2000) Immunopharmacology , vol.47 , Issue.2-3 , pp. 85-118
    • Allison, A.C.1    Eugui, E.M.2
  • 95
    • 16244397067 scopus 로고    scopus 로고
    • Mechanisms of action of mycophenolate mofetil
    • Allison, A.C. Mechanisms of action of mycophenolate mofetil. Lupus, 2005, 14 (Suppl 1), s2-8.
    • (2005) Lupus , vol.14 , Issue.SUPPL. 1
    • Allison, A.C.1
  • 96
    • 42049116103 scopus 로고    scopus 로고
    • Pharmacokinetics of mycophenolate mofetil and sirolimus in children
    • Filler, G.; Bendrick-Peart, J.; Christians, U. Pharmacokinetics of mycophenolate mofetil and sirolimus in children. Ther. Drug Monit., 2008, 30 (2), 138-142.
    • (2008) Ther. Drug Monit. , vol.30 , Issue.2 , pp. 138-142
    • Filler, G.1    Bendrick-Peart, J.2    Christians, U.3
  • 99
    • 84860389502 scopus 로고    scopus 로고
    • Mycophenolate for the treatment of autoimmune hepatitis: Prospective assessment of its efficacy and safety for induction and maintenance of remission in a large cohort of treatment-naive patients
    • Zachou, K.; Gatselis, N.; Papadamou, G.; Rigopoulou, E.I.; Dalekos, G.N. Mycophenolate for the treatment of autoimmune hepatitis: prospective assessment of its efficacy and safety for induction and maintenance of remission in a large cohort of treatment-naive patients. J. Hepatol., 2011, 55 (3), 636-646.
    • (2011) J. Hepatol. , vol.55 , Issue.3 , pp. 636-646
    • Zachou, K.1    Gatselis, N.2    Papadamou, G.3    Rigopoulou, E.I.4    Dalekos, G.N.5
  • 101
    • 77958508170 scopus 로고    scopus 로고
    • Mycophenolate mofetil for the treatment of autoimmune hepatitis in patients refractory or intolerant to conventional therapy
    • Sharzehi, K.; Huang, M.A.; Schreibman, I.R.; Brown, K.A. Mycophenolate mofetil for the treatment of autoimmune hepatitis in patients refractory or intolerant to conventional therapy. Can. J. Gastroenterol., 2010, 24 (10), 588-592.
    • (2010) Can. J. Gastroenterol. , vol.24 , Issue.10 , pp. 588-592
    • Sharzehi, K.1    Huang, M.A.2    Schreibman, I.R.3    Brown, K.A.4
  • 103
    • 22844442303 scopus 로고    scopus 로고
    • Transplant immunosuppressive agents in non-transplant chronic autoimmune hepatitis: The Canadian association for the study of liver (CASL) experience with mycophenolate mofetil and tacrolimus
    • Chatur, N.; Ramji, A.; Bain, V.G.; Ma, M.M.; Marotta, P.J.; Ghent, C.N.; Lilly, L.B.; Heathcote, E.J.; Deschenes, M.; Lee, S.S.; Steinbrecher, U.P.; Yoshida, E.M. Transplant immunosuppressive agents in non-transplant chronic autoimmune hepatitis: the Canadian association for the study of liver (CASL) experience with mycophenolate mofetil and tacrolimus. Liver Int., 2005, 25 (4), 723-727.
    • (2005) Liver Int. , vol.25 , Issue.4 , pp. 723-727
    • Chatur, N.1    Ramji, A.2    Bain, V.G.3    Ma, M.M.4    Marotta, P.J.5    Ghent, C.N.6    Lilly, L.B.7    Heathcote, E.J.8    Deschenes, M.9    Lee, S.S.10    Steinbrecher, U.P.11    Yoshida, E.M.12
  • 104
    • 34447096274 scopus 로고    scopus 로고
    • Mycophenolate mofetil in autoimmune hepatitis patients not responsive or intolerant to standard immunosuppressive therapy
    • Inductivo-Yu, I.; Adams, A.; Gish, R.G.; Wakil, A.; Bzowej, N.H.; Frederick, R.T.; Bonacini, M. Mycophenolate mofetil in autoimmune hepatitis patients not responsive or intolerant to standard immunosuppressive therapy. Clin. Gastroenterol. Hepatol., 2007, 5 (7), 799-802.
    • (2007) Clin. Gastroenterol. Hepatol. , vol.5 , Issue.7 , pp. 799-802
    • Inductivo-Yu, I.1    Adams, A.2    Gish, R.G.3    Wakil, A.4    Bzowej, N.H.5    Frederick, R.T.6    Bonacini, M.7
  • 106
    • 67349142573 scopus 로고    scopus 로고
    • Mycophenolate mofetil as rescue treatment for autoimmune liver disease in children: A 5-year follow-up
    • Aw, M.M.; Dhawan, A.; Samyn, M.; Bargiota, A.; Mieli-Vergani, G. Mycophenolate mofetil as rescue treatment for autoimmune liver disease in children: a 5-year follow-up. J. Hepatol., 2009, 51 (1), 156-160.
    • (2009) J. Hepatol. , vol.51 , Issue.1 , pp. 156-160
    • Aw, M.M.1    Dhawan, A.2    Samyn, M.3    Bargiota, A.4    Mieli-Vergani, G.5
  • 107
    • 70350218797 scopus 로고    scopus 로고
    • Mycophenolate mofetil for autoimmune hepatitis: A single practice experience
    • Wolf, D.C.; Bojito, L.; Facciuto, M.; Lebovics, E. Mycophenolate mofetil for autoimmune hepatitis: a single practice experience. Dig. Dis. Sci., 2009, 54 (11), 2519-2522.
    • (2009) Dig. Dis. Sci. , vol.54 , Issue.11 , pp. 2519-2522
    • Wolf, D.C.1    Bojito, L.2    Facciuto, M.3    Lebovics, E.4
  • 108
    • 0032938954 scopus 로고    scopus 로고
    • Mycophenolate mofetil--is it worth the cost? The infavor opinion
    • Seikaly, M.G. Mycophenolate mofetil--is it worth the cost? The infavor opinion. Pediatr. Transplant., 1999, 3 (1), 79-82.
    • (1999) Pediatr. Transplant. , vol.3 , Issue.1 , pp. 79-82
    • Seikaly, M.G.1
  • 109
    • 0033149863 scopus 로고    scopus 로고
    • Pathogenesis of autoimmune hepatitis
    • McFarlane, I.G. Pathogenesis of autoimmune hepatitis. Biomed. Pharmacother., 1999, 53 (5-6), 255-263.
    • (1999) Biomed. Pharmacother. , vol.53 , Issue.5-6 , pp. 255-263
    • McFarlane, I.G.1
  • 110
    • 0035053568 scopus 로고    scopus 로고
    • Understanding the pathogenesis of autoimmune hepatitis
    • Czaja, A.J. Understanding the pathogenesis of autoimmune hepatitis. Am. J. Gastroenterol., 2001, 96 (4), 1224-1231.
    • (2001) Am. J. Gastroenterol. , vol.96 , Issue.4 , pp. 1224-1231
    • Czaja, A.J.1
  • 111
    • 34250832713 scopus 로고    scopus 로고
    • Evolving concepts in the diagnosis, pathogenesis and treatment of autoimmune hepatitis
    • Czaja, A.J. Evolving concepts in the diagnosis, pathogenesis and treatment of autoimmune hepatitis. Minerva Gastroenterol. Dietol., 2007, 53 (1), 43-78.
    • (2007) Minerva Gastroenterol. Dietol. , vol.53 , Issue.1 , pp. 43-78
    • Czaja, A.J.1
  • 113
    • 0032930417 scopus 로고    scopus 로고
    • Mammalian nitric oxide synthases
    • Stuehr, D.J. Mammalian nitric oxide synthases. Biochim. Biophys. Acta, 1999, 1411 (2-3), 217-230.
    • (1999) Biochim. Biophys. Acta , vol.1411 , Issue.2-3 , pp. 217-230
    • Stuehr, D.J.1
  • 114
    • 67349236642 scopus 로고    scopus 로고
    • Mycophenolate mofetil to the rescue in autoimmune hepatitis: A fresh sprout on the decision tree
    • Czaja, A.J. Mycophenolate mofetil to the rescue in autoimmune hepatitis: a fresh sprout on the decision tree. J. Hepatol., 2009, 51 (1), 8-10.
    • (2009) J. Hepatol. , vol.51 , Issue.1 , pp. 8-10
    • Czaja, A.J.1
  • 115
    • 0033845138 scopus 로고    scopus 로고
    • Mycophenolate mofetil for maintenance of remission in autoimmune hepatitis in patients resistant to or intolerant of azathioprine
    • Richardson, P.D.; James, P.D.; Ryder, S.D. Mycophenolate mofetil for maintenance of remission in autoimmune hepatitis in patients resistant to or intolerant of azathioprine. J. Hepatol., 2000, 33 (3), 371-375.
    • (2000) J. Hepatol. , vol.33 , Issue.3 , pp. 371-375
    • Richardson, P.D.1    James, P.D.2    Ryder, S.D.3
  • 116
    • 3042646320 scopus 로고    scopus 로고
    • Mycophenolate mofetil for the treatment of autoimmune hepatitis in patients refractory to standard therapy
    • Devlin, S.M.; Swain, M.G.; Urbanski, S.J.; Burak, K.W. Mycophenolate mofetil for the treatment of autoimmune hepatitis in patients refractory to standard therapy. Can. J. Gastroenterol., 2004, 18 (5), 321-326.
    • (2004) Can. J. Gastroenterol. , vol.18 , Issue.5 , pp. 321-326
    • Devlin, S.M.1    Swain, M.G.2    Urbanski, S.J.3    Burak, K.W.4
  • 117
    • 25444468309 scopus 로고    scopus 로고
    • Empiric therapy of autoimmune hepatitis with mycophenolate mofetil: Comparison with conventional treatment for refractory disease
    • Czaja, A.J.; Carpenter, H.A. Empiric therapy of autoimmune hepatitis with mycophenolate mofetil: comparison with conventional treatment for refractory disease. J. Clin. Gastroenterol., 2005, 39 (9), 819-825.
    • (2005) J. Clin. Gastroenterol. , vol.39 , Issue.9 , pp. 819-825
    • Czaja, A.J.1    Carpenter, H.A.2
  • 118
    • 77955482973 scopus 로고    scopus 로고
    • Iatrogenic immunodeficiencyassociated lymphoproliferative disease of the Hodgkin lymphomalike variant in a patient treated with mycophenolate mofetil for autoimmune hepatitis
    • Adams, B.; Lazarchick, J.; Medina, A.M.; Willner, I.R.; Neville, B.; Murphy, E.; Stuart, R.; Costa, L.J. Iatrogenic immunodeficiencyassociated lymphoproliferative disease of the Hodgkin lymphomalike variant in a patient treated with mycophenolate mofetil for autoimmune hepatitis. Am. J. Hematol., 2010, 85 (8), 627-629.
    • (2010) Am. J. Hematol. , vol.85 , Issue.8 , pp. 627-629
    • Adams, B.1    Lazarchick, J.2    Medina, A.M.3    Willner, I.R.4    Neville, B.5    Murphy, E.6    Stuart, R.7    Costa, L.J.8
  • 120
    • 66349089572 scopus 로고    scopus 로고
    • Reviewing the evidence for mycophenolate mofetil as a new teratogen: Case report and review of the literature
    • Anderka, M.T.; Lin, A.E.; Abuelo, D.N.; Mitchell, A.A.; Rasmussen, S.A. Reviewing the evidence for mycophenolate mofetil as a new teratogen: case report and review of the literature. Am. J. Med. Genet. A., 2009, 149A (6), 1241-1248.
    • (2009) Am. J. Med. Genet. A. , vol.149 A , Issue.6 , pp. 1241-1248
    • Anderka, M.T.1    Lin, A.E.2    Abuelo, D.N.3    Mitchell, A.A.4    Rasmussen, S.A.5
  • 122
    • 79953324901 scopus 로고    scopus 로고
    • An additional patient with mycophenolate mofetil embryopathy: Cardiac and facial analyses
    • Lin, A.E.; Singh, K.E.; Strauss, A.; Nguyen, S.; Rawson, K.; Kimonis, V.E. An additional patient with mycophenolate mofetil embryopathy: cardiac and facial analyses. Am. J. Med. Genet. A., 2011, 155A (4), 748-756.
    • (2011) Am. J. Med. Genet. A. , vol.155 A , Issue.4 , pp. 748-756
    • Lin, A.E.1    Singh, K.E.2    Strauss, A.3    Nguyen, S.4    Rawson, K.5    Kimonis, V.E.6
  • 124
    • 0021702476 scopus 로고
    • Budesonide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in asthma and rhinitis
    • Clissold, S.P.; Heel, R.C. Budesonide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy in asthma and rhinitis. Drugs, 1984, 28 (6), 485-518.
    • (1984) Drugs , vol.28 , Issue.6 , pp. 485-518
    • Clissold, S.P.1    Heel, R.C.2
  • 125
    • 0038121959 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamic action of budesonide in early-and late-stage primary biliary cirrhosis
    • Hempfling, W.; Grunhage, F.; Dilger, K.; Reichel, C.; Beuers, U.; Sauerbruch, T. Pharmacokinetics and pharmacodynamic action of budesonide in early-and late-stage primary biliary cirrhosis. Hepatology, 2003, 38 (1), 196-202.
    • (2003) Hepatology , vol.38 , Issue.1 , pp. 196-202
    • Hempfling, W.1    Grunhage, F.2    Dilger, K.3    Reichel, C.4    Beuers, U.5    Sauerbruch, T.6
  • 126
    • 6044261115 scopus 로고    scopus 로고
    • Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease
    • Edsbacker, S.; Andersson, T. Pharmacokinetics of budesonide (Entocort EC) capsules for Crohn's disease. Clin. Pharmacokinet., 2004, 43 (12), 803-821.
    • (2004) Clin. Pharmacokinet. , vol.43 , Issue.12 , pp. 803-821
    • Edsbacker, S.1    Andersson, T.2
  • 128
    • 0028080375 scopus 로고
    • Oral budesonide for treatment of autoimmune chronic active hepatitis
    • Danielsson, A.; Prytz, H. Oral budesonide for treatment of autoimmune chronic active hepatitis. Aliment. Pharmacol. Ther., 1994, 8 (6), 585-590.
    • (1994) Aliment. Pharmacol. Ther. , vol.8 , Issue.6 , pp. 585-590
    • Danielsson, A.1    Prytz, H.2
  • 133
    • 80052435492 scopus 로고    scopus 로고
    • Budesonide for the treatment of autoimmune hepatitis
    • Snider, K.R.; Potter, T.G. Budesonide for the treatment of autoimmune hepatitis. Ann. Pharmacother., 2011, 45 (9), 1144-1150.
    • (2011) Ann. Pharmacother. , vol.45 , Issue.9 , pp. 1144-1150
    • Snider, K.R.1    Potter, T.G.2
  • 134
    • 33749068715 scopus 로고    scopus 로고
    • Antiproliferative and apoptotic potencies of glucocorticoids: Nonconcordance with their antiinflammatory and immunosuppressive properties
    • Longui, C.A.; Santos, M.C.; Formiga, C.B.; Oliveira, D.V.; Rocha, M.N.; Faria, C.D.; Kochi, C.; Monte, O. Antiproliferative and apoptotic potencies of glucocorticoids: nonconcordance with their antiinflammatory and immunosuppressive properties. Arq. Bras. Endocrinol. Metabol., 2005, 49 (3), 378-383.
    • (2005) Arq. Bras. Endocrinol. Metabol. , vol.49 , Issue.3 , pp. 378-383
    • Longui, C.A.1    Santos, M.C.2    Formiga, C.B.3    Oliveira, D.V.4    Rocha, M.N.5    Faria, C.D.6    Kochi, C.7    Monte, O.8
  • 135
    • 0030423740 scopus 로고    scopus 로고
    • Budesonide inhibits T cell-initiated epithelial pathophysiology in an in vitro model of inflammation
    • McKay, D.M.; Brattsand, R.; Wieslander, E.; Fung, M.; Croitoru, K.; Perdue, M.H. Budesonide inhibits T cell-initiated epithelial pathophysiology in an in vitro model of inflammation. J. Pharmacol. Exp. Ther., 1996, 277 (1), 403-410.
    • (1996) J. Pharmacol. Exp. Ther. , vol.277 , Issue.1 , pp. 403-410
    • McKay, D.M.1    Brattsand, R.2    Wieslander, E.3    Fung, M.4    Croitoru, K.5    Perdue, M.H.6
  • 136
    • 77953123628 scopus 로고    scopus 로고
    • Effect of formoterol and budesonide on chemokine release, chemokine receptor expression and chemotaxis in human neutrophils
    • Strandberg, K.; Blidberg, K.; Sahlander, K.; Palmberg, L.; Larsson, K. Effect of formoterol and budesonide on chemokine release, chemokine receptor expression and chemotaxis in human neutrophils. Pulm. Pharmacol. Ther., 2010, 23 (4), 316-323.
    • (2010) Pulm. Pharmacol. Ther. , vol.23 , Issue.4 , pp. 316-323
    • Strandberg, K.1    Blidberg, K.2    Sahlander, K.3    Palmberg, L.4    Larsson, K.5
  • 137
  • 138
    • 0347598081 scopus 로고    scopus 로고
    • Side effects of budesonide in liver cirrhosis due to chronic autoimmune hepatitis: Influence of hepatic metabolism versus portosystemic shunts on a patient complicated with HCC
    • Geier, A.; Gartung, C.; Dietrich, C.G.; Wasmuth, H.E.; Reinartz, P.; Matern, S. Side effects of budesonide in liver cirrhosis due to chronic autoimmune hepatitis: influence of hepatic metabolism versus portosystemic shunts on a patient complicated with HCC. World J. Gastroenterol., 2003, 9 (12), 2681-2685.
    • (2003) World J. Gastroenterol. , vol.9 , Issue.12 , pp. 2681-2685
    • Geier, A.1    Gartung, C.2    Dietrich, C.G.3    Wasmuth, H.E.4    Reinartz, P.5    Matern, S.6
  • 139
    • 0034321507 scopus 로고    scopus 로고
    • Failure of budesonide in a pilot study of treatment-dependent autoimmune hepatitis
    • Czaja, A.J.; Lindor, K.D. Failure of budesonide in a pilot study of treatment-dependent autoimmune hepatitis. Gastroenterology, 2000, 119 (5), 1312-1316.
    • (2000) Gastroenterology , vol.119 , Issue.5 , pp. 1312-1316
    • Czaja, A.J.1    Lindor, K.D.2
  • 140
    • 79952706982 scopus 로고    scopus 로고
    • Reactivation of autoimmune hepatitis during budesonide monotherapy, and response to standard treatment
    • Lohse, A.W.; Gil, H. Reactivation of autoimmune hepatitis during budesonide monotherapy, and response to standard treatment. J. Hepatol., 2011, 54 (4), 837-839.
    • (2011) J. Hepatol. , vol.54 , Issue.4 , pp. 837-839
    • Lohse, A.W.1    Gil, H.2
  • 141
    • 59649086033 scopus 로고    scopus 로고
    • Features and consequences of untreated type 1 autoimmune hepatitis
    • Czaja, A.J. Features and consequences of untreated type 1 autoimmune hepatitis. Liver Int., 2009, 29 (6), 816-823.
    • (2009) Liver Int. , vol.29 , Issue.6 , pp. 816-823
    • Czaja, A.J.1
  • 142
    • 83055165825 scopus 로고    scopus 로고
    • Budd-Chiari syndrome after treatment with budesonide in a cirrhotic patient with autoimmune hepatitis
    • Mederacke, I.; Helfritz, F.; Puls, F.; Ringe, K.I.; Klempnauer, J.; Manns, M.P.; Strassburg, C.P. Budd-Chiari syndrome after treatment with budesonide in a cirrhotic patient with autoimmune hepatitis. Ann. Hepatol., 2012, 11 (1), 143-144.
    • (2012) Ann. Hepatol. , vol.11 , Issue.1 , pp. 143-144
    • Mederacke, I.1    Helfritz, F.2    Puls, F.3    Ringe, K.I.4    Klempnauer, J.5    Manns, M.P.6    Strassburg, C.P.7
  • 144
    • 0028939627 scopus 로고
    • Cyclosporin in the treatment of corticosteroid resistant autoimmune chronic active hepatitis
    • Jackson, L.D.; Song, E. Cyclosporin in the treatment of corticosteroid resistant autoimmune chronic active hepatitis. Gut, 1995, 36 (3), 459-461.
    • (1995) Gut , vol.36 , Issue.3 , pp. 459-461
    • Jackson, L.D.1    Song, E.2
  • 146
    • 78751694482 scopus 로고    scopus 로고
    • Immunosuppressive therapy allows recovery from liver failure in children with autoimmune hepatitis
    • Cuarterolo, M.L.; Ciocca, M.E.; Lopez, S.I.; de Davila, M.T.; Alvarez, F. Immunosuppressive therapy allows recovery from liver failure in children with autoimmune hepatitis. Clin. Gastroenterol. Hepatol., 2011, 9 (2), 145-149.
    • (2011) Clin. Gastroenterol. Hepatol. , vol.9 , Issue.2 , pp. 145-149
    • Cuarterolo, M.L.1    Ciocca, M.E.2    Lopez, S.I.3    de Davila, M.T.4    Alvarez, F.5
  • 147
    • 34447521577 scopus 로고    scopus 로고
    • Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis
    • Larsen, F.S.; Vainer, B.; Eefsen, M.; Bjerring, P.N.; Adel Hansen, B. Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis. World J. Gastroenterol., 2007, 13 (23), 3232-3236.
    • (2007) World J. Gastroenterol. , vol.13 , Issue.23 , pp. 3232-3236
    • Larsen, F.S.1    Vainer, B.2    Eefsen, M.3    Bjerring, P.N.4    Adel Hansen, B.5
  • 148
    • 0036853179 scopus 로고    scopus 로고
    • Transplantation for autoimmune hepatitis
    • Neuberger, J. Transplantation for autoimmune hepatitis. Semin. Liver Dis., 2002, 22 (4), 379-386.
    • (2002) Semin. Liver Dis. , vol.22 , Issue.4 , pp. 379-386
    • Neuberger, J.1
  • 152
    • 0023205295 scopus 로고
    • Cyclosporine treatment of autoimmune chronic active hepatitis
    • Hyams, J.S.; Ballow, M.; Leichtner, A.M. Cyclosporine treatment of autoimmune chronic active hepatitis. Gastroenterology, 1987, 93 (4), 890-893.
    • (1987) Gastroenterology , vol.93 , Issue.4 , pp. 890-893
    • Hyams, J.S.1    Ballow, M.2    Leichtner, A.M.3
  • 153
    • 0027442411 scopus 로고
    • A case of cyclosporine-sensitive, steroid-resistant, autoimmune chronic active hepatitis
    • Person, J.L.; McHutchison, J.G.; Fong, T.L.; Redeker, A.G. A case of cyclosporine-sensitive, steroid-resistant, autoimmune chronic active hepatitis. J. Clin. Gastroenterol., 1993, 17 (4), 317-320.
    • (1993) J. Clin. Gastroenterol. , vol.17 , Issue.4 , pp. 317-320
    • Person, J.L.1    McHutchison, J.G.2    Fong, T.L.3    Redeker, A.G.4
  • 154
    • 0028656460 scopus 로고
    • Cyclosporine in the management of corticosteroid-resistant type I autoimmune chronic active hepatitis
    • Sherman, K.E.; Narkewicz, M.; Pinto, P.C. Cyclosporine in the management of corticosteroid-resistant type I autoimmune chronic active hepatitis. J. Hepatol., 1994, 21 (6), 1040-1047.
    • (1994) J. Hepatol. , vol.21 , Issue.6 , pp. 1040-1047
    • Sherman, K.E.1    Narkewicz, M.2    Pinto, P.C.3
  • 155
    • 0033511303 scopus 로고    scopus 로고
    • Efficacy of cyclosporin A in children with type 2 autoimmune hepatitis
    • Debray, D.; Maggiore, G.; Girardet, J.P.; Mallet, E.; Bernard, O. Efficacy of cyclosporin A in children with type 2 autoimmune hepatitis. J. Pediatr., 1999, 135 (1), 111-114.
    • (1999) J. Pediatr. , vol.135 , Issue.1 , pp. 111-114
    • Debray, D.1    Maggiore, G.2    Girardet, J.P.3    Mallet, E.4    Bernard, O.5
  • 157
    • 0032882580 scopus 로고    scopus 로고
    • Successful withdrawal of prednisone after adult liver transplantation for autoimmune hepatitis
    • Trouillot, T.E.; Shrestha, R.; Kam, I.; Wachs, M.; Everson, G.T. Successful withdrawal of prednisone after adult liver transplantation for autoimmune hepatitis. Liver Transpl. Surg., 1999, 5 (5), 375-380.
    • (1999) Liver Transpl. Surg. , vol.5 , Issue.5 , pp. 375-380
    • Trouillot, T.E.1    Shrestha, R.2    Kam, I.3    Wachs, M.4    Everson, G.T.5
  • 160
    • 33745487508 scopus 로고    scopus 로고
    • Active drug transport of immunosuppressants: New insights for pharmacokinetics and pharmacodynamics
    • Christians, U.; Strom, T.; Zhang, Y.L.; Steudel, W.; Schmitz, V.; Trump, S.; Haschke, M. Active drug transport of immunosuppressants: new insights for pharmacokinetics and pharmacodynamics. Ther. Drug Monit., 2006, 28 (1), 39-44.
    • (2006) Ther. Drug Monit. , vol.28 , Issue.1 , pp. 39-44
    • Christians, U.1    Strom, T.2    Zhang, Y.L.3    Steudel, W.4    Schmitz, V.5    Trump, S.6    Haschke, M.7
  • 162
    • 33845232219 scopus 로고    scopus 로고
    • Effects of genetic polymorphisms on the pharmacokinetics of calcineurin inhibitors
    • Utecht, K.N.; Hiles, J.J.; Kolesar, J. Effects of genetic polymorphisms on the pharmacokinetics of calcineurin inhibitors. Am. J. Health Syst. Pharm., 2006, 63 (23), 2340-2348.
    • (2006) Am. J. Health Syst. Pharm. , vol.63 , Issue.23 , pp. 2340-2348
    • Utecht, K.N.1    Hiles, J.J.2    Kolesar, J.3
  • 163
    • 77249158801 scopus 로고    scopus 로고
    • Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part I
    • Staatz, C.E.; Goodman, L.K.; Tett, S.E. Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part I. Clin. Pharmacokinet., 2010, 49 (3), 141-175.
    • (2010) Clin. Pharmacokinet. , vol.49 , Issue.3 , pp. 141-175
    • Staatz, C.E.1    Goodman, L.K.2    Tett, S.E.3
  • 164
    • 77249125964 scopus 로고    scopus 로고
    • Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part II
    • Staatz, C.E.; Goodman, L.K.; Tett, S.E. Effect of CYP3A and ABCB1 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of calcineurin inhibitors: Part II. Clin. Pharmacokinet., 2010, 49 (4), 207-221.
    • (2010) Clin. Pharmacokinet. , vol.49 , Issue.4 , pp. 207-221
    • Staatz, C.E.1    Goodman, L.K.2    Tett, S.E.3
  • 165
    • 0023270178 scopus 로고
    • Impairment of prednisolone metabolism by cyclosporine treatment in renal graft recipients
    • Ost, L. Impairment of prednisolone metabolism by cyclosporine treatment in renal graft recipients. Transplantation, 1987, 44 (4), 533-535.
    • (1987) Transplantation , vol.44 , Issue.4 , pp. 533-535
    • Ost, L.1
  • 166
    • 10344264967 scopus 로고    scopus 로고
    • Pharmacokinetics of immunosuppressants: A perspective on ethnic differences
    • Dirks, N.L.; Huth, B.; Yates, C.R.; Meibohm, B. Pharmacokinetics of immunosuppressants: a perspective on ethnic differences. Int. J. Clin. Pharmacol. Ther., 2004, 42 (12), 701-718.
    • (2004) Int. J. Clin. Pharmacol. Ther. , vol.42 , Issue.12 , pp. 701-718
    • Dirks, N.L.1    Huth, B.2    Yates, C.R.3    Meibohm, B.4
  • 167
    • 1442314112 scopus 로고    scopus 로고
    • From pharmacokinetics to pharmacogenomics: A new approach to tailor immunosuppressive therapy
    • Cattaneo, D.; Perico, N.; Remuzzi, G. From pharmacokinetics to pharmacogenomics: a new approach to tailor immunosuppressive therapy. Am. J. Transplant., 2004, 4 (3), 299-310.
    • (2004) Am. J. Transplant. , vol.4 , Issue.3 , pp. 299-310
    • Cattaneo, D.1    Perico, N.2    Remuzzi, G.3
  • 168
    • 2442595887 scopus 로고    scopus 로고
    • C2 monitoring of cyclosporine in de novo liver transplant recipients: The clinician's perspective
    • Villamil, F.; Pollard, S. C2 monitoring of cyclosporine in de novo liver transplant recipients: the clinician's perspective. Liver Transpl., 2004, 10 (5), 577-583.
    • (2004) Liver Transpl. , vol.10 , Issue.5 , pp. 577-583
    • Villamil, F.1    Pollard, S.2
  • 169
    • 68449084545 scopus 로고    scopus 로고
    • New insights into the pharmacokinetics and pharmacodynamics of the calcineurin inhibitors and mycophenolic acid: Possible consequences for therapeutic drug monitoring in solid organ transplantation
    • de Jonge, H.; Naesens, M.; Kuypers, D.R. New insights into the pharmacokinetics and pharmacodynamics of the calcineurin inhibitors and mycophenolic acid: possible consequences for therapeutic drug monitoring in solid organ transplantation. Ther. Drug Monit., 2009, 31 (4), 416-435.
    • (2009) Ther. Drug Monit. , vol.31 , Issue.4 , pp. 416-435
    • de Jonge, H.1    Naesens, M.2    Kuypers, D.R.3
  • 170
    • 0017035213 scopus 로고
    • Development of radioimmunoassays for prednisone and prednisolone. Application to studies of hepatic metabolism of prednisone
    • Schalm, S.W.; Summerskill, W.H.; Go, V.L. Development of radioimmunoassays for prednisone and prednisolone. Application to studies of hepatic metabolism of prednisone. Mayo Clin. Proc., 1976, 51 (12), 761-766.
    • (1976) Mayo Clin. Proc. , vol.51 , Issue.12 , pp. 761-766
    • Schalm, S.W.1    Summerskill, W.H.2    Go, V.L.3
  • 172
    • 75649088107 scopus 로고    scopus 로고
    • Pharmacodynamic monitoring of calcineurin inhibition therapy: Principles, performance, and perspectives
    • van Rossum, H.H.; de Fijter, J.W.; van Pelt, J. Pharmacodynamic monitoring of calcineurin inhibition therapy: principles, performance, and perspectives. Ther. Drug Monit., 2010, 32 (1), 3-10.
    • (2010) Ther. Drug Monit. , vol.32 , Issue.1 , pp. 3-10
    • van Rossum, H.H.1    de Fijter, J.W.2    van Pelt, J.3
  • 173
    • 0038237028 scopus 로고    scopus 로고
    • Tacrolimus: A further update of its use in the management of organ transplantation
    • Scott, L.J.; McKeage, K.; Keam, S.J.; Plosker, G.L. Tacrolimus: a further update of its use in the management of organ transplantation. Drugs, 2003, 63 (12), 1247-1297.
    • (2003) Drugs , vol.63 , Issue.12 , pp. 1247-1297
    • Scott, L.J.1    McKeage, K.2    Keam, S.J.3    Plosker, G.L.4
  • 174
    • 77955301448 scopus 로고    scopus 로고
    • Tacrolimus-associated posterior reversible encephalopathy syndrome after solid organ transplantation
    • Wu, Q.; Marescaux, C.; Wolff, V.; Jeung, M.Y.; Kessler, R.; Lauer, V.; Chen, Y. Tacrolimus-associated posterior reversible encephalopathy syndrome after solid organ transplantation. Eur. Neurol., 2010, 64 (3), 169-177.
    • (2010) Eur. Neurol. , vol.64 , Issue.3 , pp. 169-177
    • Wu, Q.1    Marescaux, C.2    Wolff, V.3    Jeung, M.Y.4    Kessler, R.5    Lauer, V.6    Chen, Y.7
  • 176
    • 80054864189 scopus 로고    scopus 로고
    • Central pontine myelinolysis (CPM) associated with tacrolimus (FK506) after liver transplantation
    • Fukazawa, K.; Nishida, S.; Aguina, L.; Pretto, E., Jr. Central pontine myelinolysis (CPM) associated with tacrolimus (FK506) after liver transplantation. Ann. Transplant., 2011, 16 (3), 139-142.
    • (2011) Ann. Transplant. , vol.16 , Issue.3 , pp. 139-142
    • Fukazawa, K.1    Nishida, S.2    Aguina, L.3    Pretto Jr., E.4
  • 179
    • 0024502109 scopus 로고
    • Pharmacokinetics of 6-thiouric acid and 6-mercaptopurine in renal allograft recipients after oral administration of azathioprine
    • Chan, G.L.; Erdmann, G.R.; Gruber, S.A.; Stock, P.; Chen, S.; Ascher, N.L.; Canafax, D.M. Pharmacokinetics of 6-thiouric acid and 6-mercaptopurine in renal allograft recipients after oral administration of azathioprine. Eur J Clin Pharmacol, 1989, 36 (3), 265-271.
    • (1989) Eur J Clin Pharmacol , vol.36 , Issue.3 , pp. 265-271
    • Chan, G.L.1    Erdmann, G.R.2    Gruber, S.A.3    Stock, P.4    Chen, S.5    Ascher, N.L.6    Canafax, D.M.7
  • 180
    • 0028054901 scopus 로고
    • Kinetics of mercaptopurine and thioguanine nucleotides in renal transplant recipients during azathioprine treatment
    • Bergan, S.; Rugstad, H.E.; Bentdal, O.; Endresen, L.; Stokke, O. Kinetics of mercaptopurine and thioguanine nucleotides in renal transplant recipients during azathioprine treatment. Ther. Drug Monit., 1994, 16 (1), 13-20.
    • (1994) Ther. Drug Monit. , vol.16 , Issue.1 , pp. 13-20
    • Bergan, S.1    Rugstad, H.E.2    Bentdal, O.3    Endresen, L.4    Stokke, O.5
  • 184
    • 30344466643 scopus 로고    scopus 로고
    • Chronic liver disease related to 6-thioguanine in children with acute lymphoblastic leukaemia
    • De Bruyne, R.; Portmann, B.; Samyn, M.; Bansal, S.; Knisely, A.; Mieli-Vergani, G.; Dhawan, A. Chronic liver disease related to 6-thioguanine in children with acute lymphoblastic leukaemia. J. Hepatol., 2006, 44 (2), 407-410.
    • (2006) J. Hepatol. , vol.44 , Issue.2 , pp. 407-410
    • de Bruyne, R.1    Portmann, B.2    Samyn, M.3    Bansal, S.4    Knisely, A.5    Mieli-Vergani, G.6    Dhawan, A.7
  • 185
    • 33749515604 scopus 로고    scopus 로고
    • Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: A randomised trial
    • Vora, A.; Mitchell, C.D.; Lennard, L.; Eden, T.O.; Kinsey, S.E.; Lilleyman, J.; Richards, S.M. Toxicity and efficacy of 6-thioguanine versus 6-mercaptopurine in childhood lymphoblastic leukaemia: a randomised trial. Lancet, 2006, 368 (9544), 1339-1348.
    • (2006) Lancet , vol.368 , Issue.9544 , pp. 1339-1348
    • Vora, A.1    Mitchell, C.D.2    Lennard, L.3    Eden, T.O.4    Kinsey, S.E.5    Lilleyman, J.6    Richards, S.M.7
  • 186
    • 33846266585 scopus 로고    scopus 로고
    • Toxicity of 6-thioguanine: No hepatotoxicity in a series of IBD patients treated with long-term, low dose 6-thioguanine. Some evidence for dose or metabolite level dependent effects?
    • Gilissen, L.P.; Derijks, L.J.; Driessen, A.; Bos, L.P.; Hooymans, P.M.; Stockbrugger, R.W.; Engels, L.G. Toxicity of 6-thioguanine: no hepatotoxicity in a series of IBD patients treated with long-term, low dose 6-thioguanine. Some evidence for dose or metabolite level dependent effects? Dig. Liver Dis., 2007, 39 (2), 156-159.
    • (2007) Dig. Liver Dis. , vol.39 , Issue.2 , pp. 156-159
    • Gilissen, L.P.1    Derijks, L.J.2    Driessen, A.3    Bos, L.P.4    Hooymans, P.M.5    Stockbrugger, R.W.6    Engels, L.G.7
  • 190
    • 84855950727 scopus 로고    scopus 로고
    • Hepatotoxicity associated with 6-methyl mercaptopurine formation during azathioprine and 6-mercaptopurine therapy does not occur on the short-term during 6-thioguanine therapy in IBD treatment
    • van Asseldonk, D.P.; Seinen, M.L.; de Boer, N.K.; van Bodegraven, A.A.; Mulder, C.J. Hepatotoxicity associated with 6-methyl mercaptopurine formation during azathioprine and 6-mercaptopurine therapy does not occur on the short-term during 6-thioguanine therapy in IBD treatment. J. Crohns Colitis, 2012, 6 (1), 95-101.
    • (2012) J. Crohns Colitis , vol.6 , Issue.1 , pp. 95-101
    • van Asseldonk, D.P.1    Seinen, M.L.2    de Boer, N.K.3    van Bodegraven, A.A.4    Mulder, C.J.5
  • 192
    • 78650166432 scopus 로고    scopus 로고
    • Dosing 6-thioguanine in inflammatory bowel disease: Expert-based guidelines for daily practice
    • Seinen, M.L.; van Asseldonk, D.P.; Mulder, C.J.; de Boer, N.K. Dosing 6-thioguanine in inflammatory bowel disease: expert-based guidelines for daily practice. J. Gastrointestin. Liver Dis., 2010, 19 (3), 291-294.
    • (2010) J. Gastrointestin. Liver Dis. , vol.19 , Issue.3 , pp. 291-294
    • Seinen, M.L.1    van Asseldonk, D.P.2    Mulder, C.J.3    de Boer, N.K.4
  • 193
    • 10344247722 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis
    • Wusk, B.; Kullak-Ublick, G.A.; Rammert, C.; von Eckardstein, A.; Fried, M.; Rentsch, K.M. Therapeutic drug monitoring of thiopurine drugs in patients with inflammatory bowel disease or autoimmune hepatitis. Eur. J. Gastroenterol. Hepatol., 2004, 16 (12), 1407-1413.
    • (2004) Eur. J. Gastroenterol. Hepatol. , vol.16 , Issue.12 , pp. 1407-1413
    • Wusk, B.1    Kullak-Ublick, G.A.2    Rammert, C.3    von Eckardstein, A.4    Fried, M.5    Rentsch, K.M.6
  • 194
    • 79952260306 scopus 로고    scopus 로고
    • Azathioprine metabolite measurements are not useful in following treatment of autoimmune hepatitis in Alaska Native and other non-Caucasian people
    • Ferucci, E.D.; Hurlburt, K.J.; Mayo, M.J.; Livingston, S.; Deubner, H.; Gove, J.; Plotnik, J.; McMahon, B.J. Azathioprine metabolite measurements are not useful in following treatment of autoimmune hepatitis in Alaska Native and other non-Caucasian people. Can. J. Gastroenterol., 2011, 25 (1), 21-27.
    • (2011) Can. J. Gastroenterol. , vol.25 , Issue.1 , pp. 21-27
    • Ferucci, E.D.1    Hurlburt, K.J.2    Mayo, M.J.3    Livingston, S.4    Deubner, H.5    Gove, J.6    Plotnik, J.7    McMahon, B.J.8
  • 197
    • 4043171462 scopus 로고    scopus 로고
    • Upstream and downstream of mTOR
    • Hay, N.; Sonenberg, N. Upstream and downstream of mTOR. Genes Dev., 2004, 18 (16), 1926-1945.
    • (2004) Genes Dev. , vol.18 , Issue.16 , pp. 1926-1945
    • Hay, N.1    Sonenberg, N.2
  • 198
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger, S.; Loewith, R.; Hall, M.N. TOR signaling in growth and metabolism. Cell, 2006, 124 (3), 471-484.
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 199
    • 81855224569 scopus 로고    scopus 로고
    • High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1
    • Yellen, P.; Saqcena, M.; Salloum, D.; Feng, J.; Preda, A.; Xu, L.; Rodrik-Outmezguine, V.; Foster, D.A. High-dose rapamycin induces apoptosis in human cancer cells by dissociating mTOR complex 1 and suppressing phosphorylation of 4E-BP1. Cell Cycle, 2011, 10 (22), 3948-3956.
    • (2011) Cell Cycle , vol.10 , Issue.22 , pp. 3948-3956
    • Yellen, P.1    Saqcena, M.2    Salloum, D.3    Feng, J.4    Preda, A.5    Xu, L.6    Rodrik-Outmezguine, V.7    Foster, D.A.8
  • 200
    • 79957509564 scopus 로고    scopus 로고
    • The emerging role of mammalian target of rapamycin inhibitors in the treatment of sarcomas
    • Vemulapalli, S.; Mita, A.; Alvarado, Y.; Sankhala, K.; Mita, M. The emerging role of mammalian target of rapamycin inhibitors in the treatment of sarcomas. Target. Oncol., 2011, 6 (1), 29-39.
    • (2011) Target. Oncol. , vol.6 , Issue.1 , pp. 29-39
    • Vemulapalli, S.1    Mita, A.2    Alvarado, Y.3    Sankhala, K.4    Mita, M.5
  • 201
    • 80052828293 scopus 로고    scopus 로고
    • Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells
    • Marzec, M.; Liu, X.; Wysocka, M.; Rook, A.H.; Odum, N.; Wasik, M.A. Simultaneous inhibition of mTOR-containing complex 1 (mTORC1) and MNK induces apoptosis of cutaneous T-cell lymphoma (CTCL) cells. PLoS One, 2011, 6 (9), e24849.
    • (2011) PLoS One , vol.6 , Issue.9
    • Marzec, M.1    Liu, X.2    Wysocka, M.3    Rook, A.H.4    Odum, N.5    Wasik, M.A.6
  • 203
    • 53149105145 scopus 로고    scopus 로고
    • Rapamycin-induced cytotoxic signal transduction pathway
    • Choi, S.J.; You, H.S.; Chung, S.Y. Rapamycin-induced cytotoxic signal transduction pathway. Transplant. Proc., 2008, 40 (8), 2737-2739.
    • (2008) Transplant. Proc. , vol.40 , Issue.8 , pp. 2737-2739
    • Choi, S.J.1    You, H.S.2    Chung, S.Y.3
  • 204
    • 0034060334 scopus 로고    scopus 로고
    • Apoptosis and liver disease
    • Rust, C.; Gores, G.J. Apoptosis and liver disease. Am. J. Med., 2000, 108 (7), 567-574.
    • (2000) Am. J. Med. , vol.108 , Issue.7 , pp. 567-574
    • Rust, C.1    Gores, G.J.2
  • 205
    • 0041880709 scopus 로고    scopus 로고
    • Apoptosis and the liver: Relation to autoimmunity and related conditions
    • Bai, J.; Odin, J.A. Apoptosis and the liver: relation to autoimmunity and related conditions. Autoimmun. Rev., 2003, 2 (1), 36-42.
    • (2003) Autoimmun. Rev. , vol.2 , Issue.1 , pp. 36-42
    • Bai, J.1    Odin, J.A.2
  • 206
    • 84863273482 scopus 로고    scopus 로고
    • Effects of STAT3 Gene Silencing and Rapamycin on Apoptosis in Hepatocarcinoma Cells
    • Zhang, Y.; Zhang, J.W.; Lv, G.Y.; Xie, S.L.; Wang, G.Y. Effects of STAT3 Gene Silencing and Rapamycin on Apoptosis in Hepatocarcinoma Cells. Int. J. Med. Sci., 2012, 9 (3), 216-224.
    • (2012) Int. J. Med. Sci. , vol.9 , Issue.3 , pp. 216-224
    • Zhang, Y.1    Zhang, J.W.2    Lv, G.Y.3    Xie, S.L.4    Wang, G.Y.5
  • 207
    • 63949085355 scopus 로고    scopus 로고
    • Apoptosis of CD4(+)CD25(high) T cells in response to Sirolimus requires activation of T cell receptor and is modulated by IL-2
    • Molhoek, K.R.; McSkimming, C.C.; Olson, W.C.; Brautigan, D.L.; Slingluff, C.L., Jr. Apoptosis of CD4(+)CD25(high) T cells in response to Sirolimus requires activation of T cell receptor and is modulated by IL-2. Cancer Immunol. Immunother., 2009, 58 (6), 867-876.
    • (2009) Cancer Immunol. Immunother. , vol.58 , Issue.6 , pp. 867-876
    • Molhoek, K.R.1    McSkimming, C.C.2    Olson, W.C.3    Brautigan, D.L.4    Slingluff Jr., C.L.5
  • 208
    • 32844466881 scopus 로고    scopus 로고
    • Rapamycin does not induce anergy but inhibits expansion and differentiation of alloreactive human T cells
    • Nikolaeva, N.; Bemelman, F.J.; Yong, S.L.; van Lier, R.A.; ten Berge, I.J. Rapamycin does not induce anergy but inhibits expansion and differentiation of alloreactive human T cells. Transplantation, 2006, 81 (3), 445-454.
    • (2006) Transplantation , vol.81 , Issue.3 , pp. 445-454
    • Nikolaeva, N.1    Bemelman, F.J.2    Yong, S.L.3    van Lier, R.A.4    ten Berge, I.J.5
  • 209
    • 33845915103 scopus 로고    scopus 로고
    • Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin
    • Strauss, L.; Whiteside, T.L.; Knights, A.; Bergmann, C.; Knuth, A.; Zippelius, A. Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin. J. Immunol., 2007, 178 (1), 320-329.
    • (2007) J. Immunol. , vol.178 , Issue.1 , pp. 320-329
    • Strauss, L.1    Whiteside, T.L.2    Knights, A.3    Bergmann, C.4    Knuth, A.5    Zippelius, A.6
  • 213
    • 81155162619 scopus 로고    scopus 로고
    • De-novo calcineurininhibitor-free immunosuppression with sirolimus and mycophenolate mofetil after heart transplantation: 5-year results
    • Meiser, B.; Buchholz, S.; Kaczmarek, I. De-novo calcineurininhibitor-free immunosuppression with sirolimus and mycophenolate mofetil after heart transplantation: 5-year results. Curr. Opin. Organ Transplant., 2011, 16 (5), 522-528.
    • (2011) Curr. Opin. Organ Transplant. , vol.16 , Issue.5 , pp. 522-528
    • Meiser, B.1    Buchholz, S.2    Kaczmarek, I.3
  • 217
    • 84864284947 scopus 로고    scopus 로고
    • Interstitial pneumonitis is a frequent complication in liver transplant recipients treated with sirolimus
    • Morcos, A.; Nair, S.; Keane, M.P.; McElvaney, N.G.; McCormick, P.A. Interstitial pneumonitis is a frequent complication in liver transplant recipients treated with sirolimus. Ir. J. Med. Sci., 2012.
    • (2012) Ir. J Med Sci.
    • Morcos, A.1    Nair, S.2    Keane, M.P.3    McElvaney, N.G.4    McCormick, P.A.5
  • 218
    • 81855173480 scopus 로고    scopus 로고
    • Sirolimus in solid organ transplantation: Current therapies and new frontiers
    • Veroux, M.; Tallarita, T.; Corona, D.; D'Assoro, A.; Gurrieri, C.; Veroux, P. Sirolimus in solid organ transplantation: current therapies and new frontiers. Immunotherapy, 2011, 3 (12), 1487-1497.
    • (2011) Immunotherapy , vol.3 , Issue.12 , pp. 1487-1497
    • Veroux, M.1    Tallarita, T.2    Corona, D.3    D'Assoro, A.4    Gurrieri, C.5    Veroux, P.6
  • 219
    • 84856212971 scopus 로고    scopus 로고
    • The risk of skin rash and stomatitis with the mammalian target of rapamycin inhibitor temsirolimus: A systematic review of the literature and meta-analysis
    • Gomez-Fernandez, C.; Garden, B.C.; Wu, S.; Feldman, D.R.; Lacouture, M.E. The risk of skin rash and stomatitis with the mammalian target of rapamycin inhibitor temsirolimus: a systematic review of the literature and meta-analysis. Eur. J. Cancer, 2012, 48 (3), 340-346.
    • (2012) Eur. J. Cancer , vol.48 , Issue.3 , pp. 340-346
    • Gomez-Fernandez, C.1    Garden, B.C.2    Wu, S.3    Feldman, D.R.4    Lacouture, M.E.5
  • 220
    • 0036695065 scopus 로고    scopus 로고
    • Treatment strategies in autoimmune hepatitis
    • Czaja, A.J. Treatment strategies in autoimmune hepatitis. Clin. Liver Dis., 2002, 6 (3), 799-824.
    • (2002) Clin. Liver Dis. , vol.6 , Issue.3 , pp. 799-824
    • Czaja, A.J.1
  • 221
    • 0036322130 scopus 로고    scopus 로고
    • Diagnosis and treatment of autoimmune hepatitis
    • Czaja, A.J.; Freese, D.K. Diagnosis and treatment of autoimmune hepatitis. Hepatology, 2002, 36 (2), 479-497.
    • (2002) Hepatology , vol.36 , Issue.2 , pp. 479-497
    • Czaja, A.J.1    Freese, D.K.2
  • 223
    • 0026571063 scopus 로고
    • Prognostic features and role of liver transplantation in severe corticosteroid-treated autoimmune chronic active hepatitis
    • Sanchez-Urdazpal, L.; Czaja, A.J.; van Hoek, B.; Krom, R.A.; Wiesner, R.H. Prognostic features and role of liver transplantation in severe corticosteroid-treated autoimmune chronic active hepatitis. Hepatology, 1992, 15 (2), 215-221.
    • (1992) Hepatology , vol.15 , Issue.2 , pp. 215-221
    • Sanchez-Urdazpal, L.1    Czaja, A.J.2    van Hoek, B.3    Krom, R.A.4    Wiesner, R.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.