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Guarantors of the article: E. M. Hennes, M.D., and A. W. Lohse, M.D. Specific author contributions: E. M. Hennes, A. W. Lohse, Y. H. Oo and D. H. Adams were prominent in the design of the study, contribution of patient data and in the writing of the paper, C. Schramm, U. Denzer, P. Buggisch, C. Wiegard, S. Kanzler, M. Schuchmann, W. Boecher and P. R. Galle contributed patient data and fruitful discussions in the writing of the paper. Financial support: No financial support was received by any of the authors. Potential competing interests: There were no potential competing interests for any of the authors.
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