Central pontine myelinolysis (CPM) associated with tacrolimus (FK506) after liver transplantation

Annals of Transplantation

Volumn 16, Issue 3, 2011, Pages 139-142

  Fukazawa, Kyota ^a   Nishida, Seigo ^a   Aguina, Luz M ^a   Pretto Jr , Ernesto A ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Central pontine myelinolysis; Liver transplantation; Morbidity; Neurologic complications

Indexed keywords

ELECTROLYTE; TACROLIMUS;

ADULT; ANAMNESIS; ARTERIAL GAS; ARTICLE; CASE REPORT; CENTRAL PONTINE MYELINOLYSIS; DYSARTHRIA; FEMALE; FOLLOW UP; HOSPITAL ADMISSION; HUMAN; LIVER TRANSPLANTATION; NEUROLOGIC DISEASE; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE IMAGING; THROMBOELASTOGRAPHY;

EID: 80054864189     PISSN: 14259524     EISSN: None     Source Type: Journal    
DOI: 10.12659/AOT.882008     Document Type: Article

References (18)

1. Kumar S, Fowler M, Gonzalez-Toledo E, Jaffe SL: Central pontine myelinolysis, an update. Neurol Res, 2006; 28(3): 360-66
2. Lampl C, Yazdi K: Central pontine myelinolysis. Eur Neurol, 2002; 47(1): 3-10
3. Lee EM, Kang JK, Yun SC et al: Risk factors for central pontine and extrapontine myelinolysis following orthotopic liver transplantation. Eur Neurol, 2009; 62(6): 362-68
4. de Groen PC, Aksamit AJ, Rakela J et al: Central nervous system toxicity after liver transplantation. The role of cyclosporine and cholesterol. N Engl J Med, 1987; 317(14): 861-66
5. Truwit CL, Denaro CP, Lake JR, DeMarco T: MR imaging of reversible cyclosporin A-induced neurotoxicity. AJNR Am J Neuroradiol. 1991; 12(4): 651-59
6. Ravaioli M, Guarino M, Stracciari A et al: Speech disorder related to tacrolimus-induced pontine myelinolysis after orthotopic liver transplantation. Transpl Int, 2003; 16(8): 507-9
7. Gocht A, Colmant HJ: Central pontine and extrapontine myelinolysis: a report of 58 cases. Clin Neuropathol, 1987; 6(6): 262-70
8. Odier C, Nguyen DK, Panisset M: Central pontine and extrapontine myelinolysis: from epileptic and other manifestations to cognitive prognosis. J Neurol, 2010; 257(7): 1176-80
9. A comparison of tacrolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation. The U.S. Multicenter FK506 Liver Study Group. N Engl J Med, 1994; 331(17): 1110-15
10. Appignani BA, Bhadelia RA, Blacklow SC et al: Neuroimaging findings in patients on immunosuppressive therapy: experience with tacrolimus toxicity. AJR Am J Roentgenol, 1996; 166(3): 683-88
11. Fruhauf NR, Koeppen Dagger S, Saner FH et al: Late onset of tacrolimus-related posterior leukoencephalopathy after living donor liver transplantation. Liver Transpl, 2003; 9(9): 983-85
12. Grimbert P, Azema C, Pastural M et al: Tacrolimus (FK506)-induced severe and late encephalopathy in a renal transplant recipient. Nephrol Dial Transplant, 1999; 14(10): 2489-91
13. Todo S, Fung JJ, Starzl TE et al: Liver, kidney, and thoracic organ transplantation under FK 506. Ann Surg, 1990; 212(3): 295-305; discussion 6-7
14. Starzl TE, Schneck SA, Mazzoni G et al: Acute neurological complications after liver transplantation with particular reference to intraoperative cerebral air embolus. Ann Surg, 1978; 187(3): 236-40
15. Shutter LA, Green JP, Newman NJ et al: Cortical blindness and white matter lesions in a patient receiving FK506 after liver transplantation. Neurology, 1993; 43(11): 2417-18
16. Reyes J, Gayowski T, Fung J et al: Expressive dysphasia possibly related to FK506 in two liver transplant recipients. Transplantation, 1990; 50(6): 1043-45
17. Lad RP, Smith MA, Hilt DC: Molecular cloning and regional distribution of rat brain cyclophilin. Brain Res Mol Brain Res, 1991; 9(3): 239-44
18. Norenberg MD: Central pontine myelinolysis: historical and mechanistic considerations. Metab Brain Dis, 2010; 25(1): 97-106