메뉴 건너뛰기




Volumn 55, Issue 3, 2011, Pages 636-646

Mycophenolate for the treatment of autoimmune hepatitis: Prospective assessment of its efficacy and safety for induction and maintenance of remission in a large cohort of treatment-naïve patients

Author keywords

Autoimmune hepatitis; Cirrhosis; Liver autoimmunity; Mycophenolate mofetil

Indexed keywords

AMINOTRANSFERASE; CORTICOSTEROID; IMMUNOGLOBULIN; MYCOPHENOLIC ACID; PREDNISOLONE; STEROID;

EID: 84860389502     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2010.12.032     Document Type: Article
Times cited : (158)

References (49)
  • 1
    • 53849104741 scopus 로고    scopus 로고
    • Enzymes as target antigens of liver specific autoimmunity: The case of cytochromes P450s
    • D.P. Bogdanos, and G.N. Dalekos Enzymes as target antigens of liver specific autoimmunity: the case of cytochromes P450s Curr Med Chem 15 2008 2285 2292
    • (2008) Curr Med Chem , vol.15 , pp. 2285-2292
    • Bogdanos, D.P.1    Dalekos, G.N.2
  • 2
  • 3
    • 15544372202 scopus 로고    scopus 로고
    • Autoantibodies and autoantigens in autoimmune hepatitis: Important tools in clinical practice and to study pathogenesis of the disease
    • K. Zachou, E. Rigopoulou, and G.N. Dalekos Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease J Autoimm Dis 1 2004 2
    • (2004) J Autoimm Dis , vol.1 , pp. 2
    • Zachou, K.1    Rigopoulou, E.2    Dalekos, G.N.3
  • 4
    • 0015432456 scopus 로고
    • Clinical, biochemical, and histological remission of severe chronic active liver disease: A controlled study of treatments and early prognosis
    • R.D. Soloway, W.H. Summerskill, and A.H. Baggenstoss Clinical, biochemical, and histological remission of severe chronic active liver disease: a controlled study of treatments and early prognosis Gastroenterology 63 1972 820 833
    • (1972) Gastroenterology , vol.63 , pp. 820-833
    • Soloway, R.D.1    Summerskill, W.H.2    Baggenstoss, A.H.3
  • 5
    • 0018866458 scopus 로고
    • Late results of the Royal Free Hospital prospective controlled trial of prednisolone therapy in hepatitis B surface antigen negative chronic active hepatitis
    • A.P. Kirk, S. Jain, and S. Pocock Late results of the Royal Free Hospital prospective controlled trial of prednisolone therapy in hepatitis B surface antigen negative chronic active hepatitis Gut 21 1980 78 83 (Pubitemid 10157086)
    • (1980) Gut , vol.21 , Issue.1 , pp. 78-83
    • Kirk, A.P.1    Jain, S.2    Pocock, S.3
  • 6
    • 0015051285 scopus 로고
    • Controlled prospective trial of corticosteroid therapy in active chronic hepatitis
    • G.C. Cook, R. Mulligan, and S. Sherlock Controlled prospective trial of corticosteroid therapy in active chronic hepatitis Q J Med 158 1971 159 185
    • (1971) Q J Med , vol.158 , pp. 159-185
    • Cook, G.C.1    Mulligan, R.2    Sherlock, S.3
  • 7
    • 0015916642 scopus 로고
    • Controlled trial of prednisone and azathioprine in active chronic hepatitis
    • I.M. Murray-Lyon, R.B. Stern, and R. Williams Controlled trial of prednisone and azathioprine in active chronic hepatitis Lancet 1 1973 735 737
    • (1973) Lancet , vol.1 , pp. 735-737
    • Murray-Lyon, I.M.1    Stern, R.B.2    Williams, R.3
  • 8
    • 0016802724 scopus 로고
    • Prednisone for chronic active liver disease: Dose titration, standard dose, and combination with azathioprine compared
    • W.H.J. Summerskill, M.G. Korman, H.V. Ammon, and A.H. Baggenstoss Prednisone for chronic active liver disease: dose titration, standard dose, and combination with azathioprine compared Gut 16 1975 876 883
    • (1975) Gut , vol.16 , pp. 876-883
    • Summerskill, W.H.J.1    Korman, M.G.2    Ammon, H.V.3    Baggenstoss, A.H.4
  • 9
    • 68149089466 scopus 로고    scopus 로고
    • Current and future treatments of autoimmune hepatitis
    • A.J. Czaja Current and future treatments of autoimmune hepatitis Expert Rev Gastroenterol Hepatol 3 2009 269 291
    • (2009) Expert Rev Gastroenterol Hepatol , vol.3 , pp. 269-291
    • Czaja, A.J.1
  • 10
    • 22844437295 scopus 로고    scopus 로고
    • Autoimmune hepatitis type 1: Safety and efficacy of prolonged medical therapy
    • DOI 10.1111/j.1478-3231.2005.01141.x
    • S. Seela, H. Sheela, and J.L. Boyer Autoimmune hepatitis type 1: safety and efficacy of prolonged medical therapy Liver Int 25 2005 734 739 (Pubitemid 41038654)
    • (2005) Liver International , vol.25 , Issue.4 , pp. 734-739
    • Seela, S.1    Sheela, H.2    Boyer, J.L.3
  • 11
    • 0023242606 scopus 로고
    • Sustained remission after corticosteroid therapy of severe hepatitis B surface antigen-negative chronic active hepatitis
    • A.J. Czaja, S.J. Beaver, and M.T. Shiels Sustained remission following corticosteroid therapy of severe HBsAg-negative chronic active hepatitis Gastroenterology 92 1987 215 219 (Pubitemid 17207684)
    • (1987) Gastroenterology , vol.92 , Issue.1 , pp. 215-219
    • Czaja, A.J.1    Beaver, S.J.2    Shiels, M.T.3
  • 12
    • 34047223229 scopus 로고    scopus 로고
    • Consequences of treatment withdrawal in type 1 autoimmune hepatitis
    • DOI 10.1111/j.1478-3231.2007.01444.x
    • A.J. Montano-Loza, H.A. Carpenter, and A.J. Czaja Consequences of treatment withdrawal in type 1 autoimmune hepatitis Liver Int 27 2007 507 515 (Pubitemid 46534573)
    • (2007) Liver International , vol.27 , Issue.4 , pp. 507-515
    • Montano-loza, A.J.1    Carpenter, H.A.2    Czaja, A.J.3
  • 13
    • 0029130857 scopus 로고
    • Azathioprine for long-term maintenance of remission in autoimmune hepatitis
    • P.J. Johnson, I.G. McJFarlane, and R. Williams Azathioprine for long-term maintenance of remission in autoimmune hepatitis N Engl J Med 333 1995 958 963
    • (1995) N Engl J Med , vol.333 , pp. 958-963
    • Johnson, P.J.1    McJfarlane, I.G.2    Williams, R.3
  • 14
    • 44949148177 scopus 로고    scopus 로고
    • Safety issues in the management of autoimmune hepatitis
    • DOI 10.1517/14740338.7.3.319
    • A.J. Czaja Safety issues in the management of autoimmune hepatitis Expert Opin Drug Saf 7 2008 319 333 (Pubitemid 351802831)
    • (2008) Expert Opinion on Drug Safety , vol.7 , Issue.3 , pp. 319-333
    • Czaja, A.J.1
  • 15
    • 45849107951 scopus 로고    scopus 로고
    • Clinical pharmacology and pharmacogenetics of thiopurines
    • S. Sahasranaman, D. Howard, and S. Roy Clinical pharmacology and pharmacogenetics of thiopurines Eur J Clin Pharmacol 64 2008 753 767
    • (2008) Eur J Clin Pharmacol , vol.64 , pp. 753-767
    • Sahasranaman, S.1    Howard, D.2    Roy, S.3
  • 18
    • 22844449643 scopus 로고    scopus 로고
    • Use of mycophenolate in the treatment of autoimmune hepatitis
    • DOI 10.1111/j.1478-3231.2005.01123.x
    • Y.H. Oo, and J. Neuberger Use of mycophanolate in the treatment of autoimmune hepatitis Liver Int 25 2005 687 691 (Pubitemid 41038648)
    • (2005) Liver International , vol.25 , Issue.4 , pp. 687-691
    • Oo, Y.H.1    Neuberger, J.2
  • 19
    • 0028656460 scopus 로고
    • Cyclosporine in the management of corticosteroid-resistant type 1 autoimmune chronic active hepatitis
    • K.E. Sherman, M. Narkewicz, and C.P. Pinto Cyclosporine in the management of corticosteroid-resistant type 1 autoimmune chronic active hepatitis J Ηepatol 21 1994 1040 1047
    • (1994) J Ηepatol , vol.21 , pp. 1040-1047
    • Sherman, K.E.1    Narkewicz, M.2    Pinto, C.P.3
  • 20
    • 0029024492 scopus 로고
    • Tacrolimus: A potential new treatment for autoimmune chronic hepatitis: Results of an open-label preliminary trial
    • D.H. Van Thiel, H. Wright, and P. Carrol Tacrolimus: a potential new treatment for autoimmune chronic hepatitis: results of an open-label preliminary trial Am J Gastroenterol 90 1995 771 777
    • (1995) Am J Gastroenterol , vol.90 , pp. 771-777
    • Van Thiel, D.H.1    Wright, H.2    Carrol, P.3
  • 22
    • 16244397067 scopus 로고    scopus 로고
    • Mechanisms of action of mycophenolate mofetil
    • A.C. Allison Mechanisms of action of mycophenolate mofetil Lupus 14 2005 s2 s8 (Pubitemid 40460509)
    • (2005) Lupus , vol.14 , Issue.SUPPL. 1
    • Allison, A.C.1
  • 23
    • 33846648650 scopus 로고    scopus 로고
    • Mycophenolate mofetil: What is its place in the treatment of autoimmune rheumatic diseases?
    • DOI 10.1016/j.autrev.2006.11.001, PII S1568997206002114
    • L. Iaccarino, M. Rampudda, M. Canova, S. Della Libera, P. Sarzi-Puttinic, and A. Doria Mycophenolate mofetil: what is its place in the treatment of autoimmune rheumatic diseases? Autoimmunity Rev 6 2007 190 195 (Pubitemid 46187338)
    • (2007) Autoimmunity Reviews , vol.6 , Issue.3 , pp. 190-195
    • Iaccarino, L.1    Rampudda, M.2    Canova, M.3    Della Libera, S.4    Sarzi-Puttinic, P.5    Doria, A.6
  • 24
    • 0033845138 scopus 로고    scopus 로고
    • Mycophenolate mofetil for maintenance of remission in autoimmune hepatitis in patients resistant to or intolerant of azathioprine
    • DOI 10.1016/S0168-8278(00)80271-8
    • P.D. Richardson, P.D. James, and S.D. Ryder Mycophenolate mofetil for maintenance of remission in autoimmune hepatitis in patients resistant to or intolerant of azathioprine J Hepatol 33 2000 371 375 (Pubitemid 30663373)
    • (2000) Journal of Hepatology , vol.33 , Issue.3 , pp. 371-375
    • Richardson, P.D.1    James, P.D.2    Ryder, S.D.3
  • 25
    • 3042646320 scopus 로고    scopus 로고
    • Mycophenolate mofetil for the treatment of autoimmune hepatitis in patients refractory to standard therapy
    • S.M. Devlin, M.G. Swain, S.J. Urbanski, and K.W. Burak Mycophenolate mofetil for the treatment of autoimmune hepatitis in patients refractory to standard therapy Can J Gastroenterol 18 2004 321 326 (Pubitemid 38801788)
    • (2004) Canadian Journal of Gastroenterology , vol.18 , Issue.5 , pp. 321-326
    • Devlin, S.M.1    Swain, M.G.2    Urbanski, S.J.3    Burak, K.W.4
  • 27
    • 25444468309 scopus 로고    scopus 로고
    • Empiric therapy of autoimmune hepatitis with mycophenolate mofetil: Comparison with conventional treatment for refractory disease
    • DOI 10.1097/01.mcg.0000177260.72692.e8
    • A.J. Czaja, and H.A. Carpenter Empiric therapy of autoimmune hepatitis with mycophenolate mofetil: comparison with conventional treatment for refractory disease J Clin Gastroenterol 39 2005 819 825 (Pubitemid 41361901)
    • (2005) Journal of Clinical Gastroenterology , vol.39 , Issue.9 , pp. 819-825
    • Czaja, A.J.1    Carpenter, H.A.2
  • 29
    • 58149390145 scopus 로고    scopus 로고
    • Mycophenolate mofetil as second line therapy in autoimmune hepatitis?
    • E.M. Hennes, Y.H. Oo, and C. Schramm Mycophenolate mofetil as second line therapy in autoimmune hepatitis? Am J Gastroenterol 103 2008 3063 3070
    • (2008) Am J Gastroenterol , vol.103 , pp. 3063-3070
    • Hennes, E.M.1    Oo, Y.H.2    Schramm, C.3
  • 30
    • 67349142573 scopus 로고    scopus 로고
    • Mycophenolate mofetil as rescue treatment for autoimmune liver disease in children: A 5-year follow-up
    • M.M. Aw, A. Dhawan, M. Samyn, A. Bargiota, and G. Mieli-Vergani Mycophenolate mofetil as rescue treatment for autoimmune liver disease in children: a 5-year follow-up J Hepatol 51 2009 156 160
    • (2009) J Hepatol , vol.51 , pp. 156-160
    • Aw, M.M.1    Dhawan, A.2    Samyn, M.3    Bargiota, A.4    Mieli-Vergani, G.5
  • 31
    • 70350218797 scopus 로고    scopus 로고
    • Mycophenolate Mofetil for autoimmune hepatitis: A single practice experience
    • D.C. Wolf, L. Bojito, M. Facciuto, and E. Lebovics Mycophenolate Mofetil for autoimmune hepatitis: a single practice experience Dig Dis Sci 54 2009 2519 2522
    • (2009) Dig Dis Sci , vol.54 , pp. 2519-2522
    • Wolf, D.C.1    Bojito, L.2    Facciuto, M.3    Lebovics, E.4
  • 32
    • 50649118076 scopus 로고    scopus 로고
    • A single center review of the use of mycophenolate mofetil in the treatment of autoimmune hepatitis
    • J.T. Hlivko, M.L. Shiffman, and R.T. Stravitz A single center review of the use of mycophenolate mofetil in the treatment of autoimmune hepatitis Clin Gastroenterol Hepatol 6 2008 1036 1040
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 1036-1040
    • Hlivko, J.T.1    Shiffman, M.L.2    Stravitz, R.T.3
  • 35
    • 0035117791 scopus 로고    scopus 로고
    • Duration of immunosuppressive therapy in autoimmune hepatitis
    • S. Kanzler, G. Gerken, and H. Lohr Duration of immunosuppressive therapy in autoimmune hepatitis J Hepatol 34 2001 354 355
    • (2001) J Hepatol , vol.34 , pp. 354-355
    • Kanzler, S.1    Gerken, G.2    Lohr, H.3
  • 36
    • 0019813866 scopus 로고
    • Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
    • R.G. Knodell, K.G. Ishak, and W.C. Black Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis Hepatology 1 1981 431 435 (Pubitemid 12218164)
    • (1981) Hepatology , vol.1 , Issue.5 , pp. 431-435
    • Knodell, R.G.1    Ishak, K.G.2    Black, W.C.3
  • 38
    • 32944462909 scopus 로고    scopus 로고
    • Prevalence and clinical significance of immunoglobulin A antibodies against tissue transglutaminase in patients with diverse chronic liver diseases
    • A.E. Germenis, E.E. Yiannaki, and K. Zachou Prevalence and clinical significance of immunoglobulin A antibodies against tissue transglutaminase in patients with diverse chronic liver diseases Clin Diagn Lab Immunol 12 2005 941 948
    • (2005) Clin Diagn Lab Immunol , vol.12 , pp. 941-948
    • Germenis, A.E.1    Yiannaki, E.E.2    Zachou, K.3
  • 39
    • 33645764198 scopus 로고    scopus 로고
    • Alterations of leptin during IFN-alpha therapy in patients with chronic viral hepatitis
    • T.A. Zografos, E.I. Rigopoulou, and C. Liaskos Alterations of leptin during IFN-alpha therapy in patients with chronic viral hepatitis J Hepatol 44 2006 848 855
    • (2006) J Hepatol , vol.44 , pp. 848-855
    • Zografos, T.A.1    Rigopoulou, E.I.2    Liaskos, C.3
  • 40
    • 67349254165 scopus 로고    scopus 로고
    • Autoimmune hepatitis in Italy: The Bologna experience
    • P. Muratori, A. Granito, and C. Quarneti Autoimmune hepatitis in Italy: the Bologna experience J Hepatol 50 2009 1210 1218
    • (2009) J Hepatol , vol.50 , pp. 1210-1218
    • Muratori, P.1    Granito, A.2    Quarneti, C.3
  • 41
    • 77953120859 scopus 로고    scopus 로고
    • Treatment options for autoimmune hepatitis: A systematic review of randomized controlled trials
    • M.H.M. Lamers, M.G.H. van Oijen, and M. Pronk Treatment options for autoimmune hepatitis: a systematic review of randomized controlled trials J Hepatol 53 2010 191 198
    • (2010) J Hepatol , vol.53 , pp. 191-198
    • Lamers, M.H.M.1    Van Oijen, M.G.H.2    Pronk, M.3
  • 42
    • 67349145925 scopus 로고    scopus 로고
    • Rapidity of treatment response and outcome in type 1 autoimmune hepatitis
    • A.J. Czaja Rapidity of treatment response and outcome in type 1 autoimmune hepatitis J Hepatol 51 2009 161 167
    • (2009) J Hepatol , vol.51 , pp. 161-167
    • Czaja, A.J.1
  • 44
    • 59649086033 scopus 로고    scopus 로고
    • Features and consequences of untreated autoimmune hepatitis
    • A. Czaja Features and consequences of untreated autoimmune hepatitis Liver Int 29 2009 816 823
    • (2009) Liver Int , vol.29 , pp. 816-823
    • Czaja, A.1
  • 45
    • 77952711598 scopus 로고    scopus 로고
    • Diagnosis and management of autoimmune hepatitis
    • M.P. Manns, A.J. Czaja, and J.D. Gorham Diagnosis and management of autoimmune hepatitis Hepatology 51 2010 2193 2213
    • (2010) Hepatology , vol.51 , pp. 2193-2213
    • Manns, M.P.1    Czaja, A.J.2    Gorham, J.D.3
  • 46
    • 22144442065 scopus 로고    scopus 로고
    • Mycophenolate mofetil combination therapy improves long-term outcomes after liver transplantation in patients with and without hepatitis C
    • DOI 10.1002/lt.20453
    • R.H. Wiesner, J.S. Shorr, B.J. Steffen, A.H. Chu, R.D. Gordon, and J.R. Lake Mycophenolate mofetil combination therapy improves longterm outcomes after liver transplantation in patients with and without hepatitis C Liver Transpl 11 2005 750 759 (Pubitemid 40975576)
    • (2005) Liver Transplantation , vol.11 , Issue.7 , pp. 750-759
    • Wiesner, R.H.1    Shorr, J.S.2    Steffen, B.J.3    Chu, A.H.4    Gordon, R.D.5    Lake, J.R.6
  • 47
    • 0029006409 scopus 로고
    • Placebo-controlled study of mycophenolate mofetil combined with cyclosporine and corticosteroids for prevention of acute rejection
    • European Mycophenolate Mofetil Cooperative Study Group
    • European Mycophenolate Mofetil Cooperative Study Group Placebo-controlled study of mycophenolate mofetil combined with cyclosporine and corticosteroids for prevention of acute rejection Lancet 345 1995 1321 1325
    • (1995) Lancet , vol.345 , pp. 1321-1325
  • 48
    • 21344453508 scopus 로고    scopus 로고
    • Autoimmune hepatitis: Effect of symptoms and cirrhosis on natural history and outcome
    • DOI 10.1002/hep.20732
    • J.J. Feld, H. Dinh, T. Arenovich, V.A. Marcus, I.R. Wanless, and E.J. Heathcote Autoimmune hepatitis: effect of symptoms and cirrhosis on natural history and outcome Hepatology 42 2005 53 62 (Pubitemid 40911311)
    • (2005) Hepatology , vol.42 , Issue.1 , pp. 53-62
    • Feld, J.J.1    Dinh, H.2    Arenovich, T.3    Marcus, V.A.4    Wanless, I.R.5    Heathcote, E.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.