Acute and subchronic toxicity of sucralose

Food and Chemical Toxicology

Volumn 38, Issue SUPPL.2, 2000, Pages 53-69

  Goldsmith, L A ^a  

^a McNeil Specialty Products Company   (United States)

Author keywords

Beagle dog; Gavage; Rodents; Sucralose; Sweeteners; Toxicity

Indexed keywords

SUCRALOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DOG; FEMALE; FLUID INTAKE; FOOD CONTROL; FOOD INTAKE; FOOD SAFETY; MALE; NONHUMAN; TOXICITY TESTING; URINALYSIS;

ADMINISTRATION, ORAL; ALANINE TRANSAMINASE; ANIMALS; BODY WEIGHT; CALCIUM; DOGS; EATING; FEMALE; HEMATOLOGIC TESTS; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MAGNESIUM; MALE; MICE; ORGAN SIZE; PHOSPHATES; RATS; RATS, SPRAGUE-DAWLEY; SUCROSE; SWEETENING AGENTS; URINALYSIS;

EID: 0034084641     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0278-6915(00)00028-4     Document Type: Article

References (12)

1. Federal Register (1998) Food Additives Permitted for Direct Addition to Food for Human Consumption; Sucralose. Federal Register 63 (64), 16417-16433.
2. Gettys T. W., Mills S. and Henricks D. M. (1988) An evaluation of the relation between food consumption rate and equilibrium body-weight in male rats. British Journal of Nutrition 60, 151-160.
3. Leegwater D. C., deGroot A. P. and VanKalmthout-Kuyper M. (1974) The aetiology of caecal enlargement in the rat. Food and Cosmetics Toxicology 12, 687-697.
4. Lord G. H. and Newberne P. M. (1990) Renal mineralization - A ubiquitous lesion in chronic rat studies. Food and Chemical Toxicology 28, 449-455.
5. Lu F. C. (1988) Acceptable daily intake: Inception, evolution and application. Regulatory Toxicology and Pharmacology 8, 45-60.
6. Lu F. C. and Sielken R. L. (1991) Assessment of safety/ risk of chemicals: inception and evolution of the ADI and dose-response modeling procedures. Toxicology Letters 59, 5-40.
7. McNeil Specialty Products Food Additive Petition 7A3987 (1987) (Sucralose).
8. Oishi S., Oishi H. and Hiraga K. (1979) The effect of food restriction for four weeks on common toxicity parameters in male rats. Toxicology and Applied Pharmacology 47, 15-22.
9. Pfeiffer C. J. (1968) A mathematical evaluation of the thymic weight parameter. Toxicology and Applied Pharmacology 13, 220-227.
10. Scharer K. (1977) The effect of chronic underfeeding on organ weights of rats. How to interpret organ weight changes in cases of marked growth retardation in toxicity tests? Toxicology 7, 45-56.
11. Weil C. S. (1970) Significance of organ-weight changes in food safety evaluation. In Metabolic Aspects of Food Safety, ed. F. J. C. Roe, pp. 419. Blackwell, Oxford.
12. WHO (1987) Principles for the safety assessment of food additives and contaminants in food, p. 70. World Health Organization Environmental Health Criteria.