The sweet taste of true synergy: Positive allosteric modulation of the human sweet taste receptor

Trends in Pharmacological Sciences

Volumn 32, Issue 11, 2011, Pages 631-636

  Servant, Guy ^a   Tachdjian, Catherine ^a   Li, Xiaodong ^b   Karanewsky, Donald S ^a  

^a Senomyx Inc   (United States)

^b INTERNATIONAL FLAVORS AND FRAGRANCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CARBOXYBENZENESELENIC ACID; CINACALCET; COMPLEMENTARY DNA; G PROTEIN COUPLED RECEPTOR; ORGANOLEPTIC MODIFIER; POSITIVE ALLOSTERIC MODULATOR; REBAUDIOSIDE C; SE 3; SE 4; SUGAR; SWEETENING AGENT; TRILOBATIN; UNCLASSIFIED DRUG;

ALLOSTERISM; CALORIC INTAKE; CALORIC RESTRICTION; CHEMICAL STRUCTURE; DNA LIBRARY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; FAT INTAKE; GENE FUNCTION; GENOME ANALYSIS; HUMAN; HYPERCALCEMIA; LOW CARBOHYDRATE DIET; NONHUMAN; PRIORITY JOURNAL; REVIEW; SECONDARY HYPERPARATHYROIDISM; SEDENTARY LIFESTYLE; SWEETNESS; TASTE BUD; TASTE DISCRIMINATION;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; CARBOHYDRATES; ENERGY INTAKE; HUMANS; RECEPTORS, G-PROTEIN-COUPLED; SWEETENING AGENTS; TASTE; TASTE BUDS; TASTE PERCEPTION;

EID: 80054799073     PISSN: 01656147     EISSN: 18733735     Source Type: Journal    
DOI: 10.1016/j.tips.2011.06.007     Document Type: Review

References (52)

1. C.L. Ogden Prevalence and trends in overweight among US children and adolescents, 1999-2000 JAMA 288 2002 1728 1732
2. E.A. Finkelstein Annual medical spending attributable to obesity: payer-and service-specific estimates Health Aff. (Millwood) 28 2009 w822 w831
3. G. Danaei The preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors PLoS Med. 6 2009 e1000058
4. G.E. DuBois Validity of early indirect models of taste active sites and advances in new taste technologies enabled by improved models Flavour Fragrance J. 26 2011 239 253
5. S.S. Schiffman, and C.A. Gatlin Sweeteners: state of knowledge review Neurosci. Biobehav. Rev. 17 1993 313 345 (Pubitemid 23306319)
6. S.S. Schiffman Bitterness of sweeteners as a function of concentration Brain Res. Bull. 36 1995 505 513
7. L. O'Brien Nabors Alternative Sweeteners 2001 Marcel Dekker
8. Foguet, R. et al. Zoster, S.A. Body and mouthfeel potentiated food and beverages containing neohesperidin dihydrochalcone, US Patent 5,300,309
9. Renkens, A.J.M. Sara Lee. Sweetening tablet, European Patent 0988796A1
10. Gelin, J.-L. et al. Firmenich S.A. Natural sweetener composition, World Patent 2008/149253A2
11. Renkens, A.J.M. Sara Lee. Sweetener, World Patent 01/06872A1
12. S.S. Schiffman Synergism among ternary mixtures of fourteen sweeteners Chem. Senses 25 2000 131 140 (Pubitemid 30199289)
13. S.S. Schiffman Investigation of synergism in binary mixtures of sweeteners Brain Res. Bull. 38 1995 105 120
14. M.A. Hoon Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity Cell 96 1999 541 551 (Pubitemid 29106841)
15. M. Max Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac Nat. Genet. 28 2001 58 63 (Pubitemid 32405818)
16. J.P. Montmayeur A candidate taste receptor gene near a sweet taste locus Nat. Neurosci. 4 2001 492 498
17. G. Nelson Mammalian sweet taste receptors Cell 106 2001 381 390 (Pubitemid 32772621)
18. X. Li Human receptors for sweet and umami taste Proc. Natl. Acad. Sci. U.S A. 99 2002 4692 4696 (Pubitemid 34286046)
19. E. Sainz Identification of a novel member of the T1R family of putative taste receptors J. Neurochem. 77 2001 896 903 (Pubitemid 32466786)
20. A.A. Bachmanov Positional cloning of the mouse saccharin preference (Sac) locus Chem. Senses 26 2001 925 933 (Pubitemid 32899110)
21. M. Kitagawa Molecular genetic identification of a candidate receptor gene for sweet taste Biochem. Biophys. Res. Commun. 283 2001 236 242 (Pubitemid 32912563)
22. G. Nelson An amino-acid taste receptor Nature 416 2002 199 202 (Pubitemid 34246480)
23. G.Q. Zhao The receptors for mammalian sweet and umami taste Cell 115 2003 255 266 (Pubitemid 37487700)
24. M. Behrens Sweet and umami taste: natural products, their chemosensory targets, and beyond Angew. Chem. Int. Ed. Engl. 50 2011 2220 2242
25. W. Meyerhof Molecular biology of mammalian bitter taste receptors. A review Flavour Fragrance J. 26 2011 260 268
26. Slack, J.P. and Givaudan, S.A. Functional method to identify tastants, US Patent Application 2009/0176266A1
27. F. Zhang Molecular mechanism for the umami taste synergism Proc. Natl. Acad. Sci. U.S.A. 105 2008 20930 20934
28. H. Xu Different functional roles of T1R subunits in the heteromeric taste receptors Proc. Natl. Acad. Sci. U.S.A. 101 2004 14258 14263 (Pubitemid 39305062)
29. Y. Nie Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli Curr. Biol. 15 2005 1948 1952 (Pubitemid 41566143)
30. P. Jiang Molecular mechanisms of sweet receptor function Chem. Senses 30 Suppl. 1 2005 i17 i18
31. P. Jiang Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3 J. Biol. Chem. 280 2005 34296 34305 (Pubitemid 41443155)
32. M. Winnig The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor BMC Struct. Biol. 7 2007 66
33. M. Winnig Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor BMC Neurosci. 6 2005 22
34. P. Jiang The cysteine-rich region of T1R3 determines responses to intensely sweet proteins J. Biol. Chem. 279 2004 45068 45075 (Pubitemid 39430921)
35. P.J. Conn Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders Nat. Rev. Drug Discov. 8 2009 41 54
36. K.J. Gregory Allosteric modulation of metabotropic glutamate receptors: structural insights and therapeutic potential Neuropharmacology 60 2011 66 81
37. H. Brauner-Osborne Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors Curr. Drug Targets 8 2007 169 184 (Pubitemid 46049458)
38. T.W. Schwartz, and B. Holst Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors J. Recept. Signal. Transduct. Res. 26 2006 107 128
39. D.W. Engers Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273 ChemMedChem 4 2009 505 511
40. G. Servant Positive allosteric modulators of the human sweet taste receptor enhance sweet taste Proc. Natl. Acad. Sci. U.S.A. 107 2010 4746 4751
41. Shigemura, R. et al. Senomyx, Inc. Composition comprising sweetness enhancers and methods of making them, World Patent 2010/014813A2
42. Shigemura, R. et al. Senomyx, Inc. Sweetener compositions and methods of making them, World Patent 2009/100333A2
43. F. Zhang Molecular mechanism of the sweet taste enhancers Proc. Natl. Acad. Sci. U.S.A. 107 2010 4752 4757
44. Zhonghua, J. et al. Givaudan S.A. Consumables, World Patent 2008/148239A1
45. Stroz, J.J. et al. Sweetener composition, US Patent 4,758,438
46. Zhonghua, J. et al. Givaudan S.A. Compositions and their use, World Patent 2009/023975A2
47. J.H. Kroeze Neohesperidin dihydrochalcone is not a taste enhancer in aqueous sucrose solutions Chem. Senses 25 2000 555 559
48. I. Prakash Development of rebiana, a natural, non-caloric sweetener Food Chem. Toxicol. 46 Suppl. 7 2008 S75 S82
49. Palmer, K.R. et al. RedPoint Bio Corporation, Natural product sweetness enhancers, World Patent 2011/009081A1
50. V. Galindo-Cuspinera A TAS1R receptor-based explanation of sweet 'water-taste' Nature 441 2006 354 357 (Pubitemid 44050200)
51. P. Jiang Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste J. Biol. Chem. 280 2005 15238 15246 (Pubitemid 40562880)
52. M.L. Parmentier A model for the functioning of family 3 GPCRs Trends Pharmacol. Sci. 23 2002 268 274