Metabolic oxidative stress induced by a combination of 2-DG and 6-AN enhances radiation damage selectively in malignant cells via non-coordinated expression of antioxidant enzymes

Cancer Letters

Volumn 295, Issue 2, 2010, Pages 154-166

  Sharma, Pradeep K ^a   Bhardwaj, Richa ^a   Dwarakanath, Bilikere S ^a   Varshney, Rajeev ^a,b  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^b DRDO   (India)

Author keywords

2 Deoxy d glucose; 6 Aminonicotinamide; GSH; Metabolic oxidative stress; Radiosensitization; Reactive oxygen species; Redox status

Indexed keywords

6 AMINONICOTINAMIDE; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; DEOXYGLUCOSE; GLUTATHIONE; GLUTATHIONE DISULFIDE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; MANGANESE SUPEROXIDE DISMUTASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; CANCER CELL CULTURE; CANCER RADIOTHERAPY; CELL VIABILITY; CLONOGENESIS; CONTROLLED STUDY; CYTOTOXICITY; DRUG SELECTIVITY; EMBRYO; ENZYME ACTIVITY; GLIOMA; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; METABOLIC STRESS; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIZATION; SQUAMOUS CELL CARCINOMA; THERAPY EFFECT;

6-AMINONICOTINAMIDE; ANTIOXIDANTS; CATALASE; CELL LINE, TUMOR; DEOXYGLUCOSE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HUMANS; NADP; NEOPLASMS; OXIDATIVE STRESS; RADIATION TOLERANCE; SUPEROXIDE DISMUTASE;

EID: 77954028765     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2010.02.021     Document Type: Article

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