A combination of 2-deoxy-d-glucose and 6-aminonicotinamide induces oxidative stress mediated selective radiosensitization of malignant cells via mitochondrial dysfunction

Tumor Biology

Volumn 32, Issue 5, 2011, Pages 951-964

  Bhardwaj, Richa ^a   Sharma, Pradeep Kumar ^a,c   Jadon, Suryaprakash Singh ^b   Varshney, Rajeev ^a,d  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^b Shri Varshneya College   (India)

^c GURU GOBIND SINGH INDRAPRASTHA UNIVERSITY   (India)

^d DRDO   (India)

Author keywords

2 Deoxy D glucose; 6 Aminonicotinamide; Mitochondrial dysfunction; Oxidative stress; Radiosensitization

Indexed keywords

6 AMINONICOTINAMIDE; CYTOCHROME C; DEOXYGLUCOSE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIPID PEROXIDATION; MICRONUCLEUS; MITOCHONDRIAL DYSFUNCTION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; RADIOSENSITIZATION;

EID: 80052310072     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-011-0197-y     Document Type: Article

References (40)

1. R Varshney BS Dwarakanath V Jain 2005 Radiosensitization by 6-aminonicotinamide and 2-deoxy-d-glucose in human cancer cells Int J Radiat Biol 81 397 408 16076755 10.1080/09553000500148590 1:CAS:528: DC%2BD2MXps1GqsLc%3D (Pubitemid 41117010)
2. DR Spitz JE Sim LA Ridnour SS Galoforo YJ Lee 2000 Glucose deprivation-induced oxidative stress in human tumor cells: a fundamental defect in metabolism? Ann NY Acad Sci 899 349 362 10863552 10.1111/j.1749-6632.2000. tb06199.x 1:CAS:528:DC%2BD3cXks1Shsbw%3D (Pubitemid 30352799)
3. PK Sharma R Bhardwaj BS Dwarakanath R Varshney 2010 Metabolic oxidative stress induced by a combination of 2-DG and 6-AN enhances radiation damage selectively in malignant cells via non coordinated expression of antioxidant enzymes Cancer Lett 295 154 166 20363070 10.1016/j.canlet.2010.02.021 1:CAS:528:DC%2BC3cXotVWlur4%3D
4. K England C O'Driscoll TG Cotter 2004 Carbonylation of glycolytic proteins is a key response to drug-induced oxidative stress and apoptosis Cell Death Differ 11 252 260 14631408 10.1038/sj.cdd.4401338 1:CAS:528: DC%2BD2cXht1CntLo%3D (Pubitemid 38313134)
5. UN Das 1999 Essential fatty acids, lipid peroxidation and apoptosis Prostaglandins Leukot Essent Fatty Acids 61 157 163 10582655 10.1054/plef.1999.0085 1:CAS:528:DyaK1MXntVWlurc%3D (Pubitemid 29520805)
6. G Stark 1991 The effect of ionizing radiation on lipid membranes Biochim Biophys Acta 1071 103 122 1854791 1:CAS:528:DyaK3MXltlSlurY%3D (Pubitemid 121002406)
7. BN Pandey KP Mishra 2003 In vitro studies on radiation induced membrane oxidative damage in apoptotic death of mouse thymocytes Intl J Low Radiat 1 113 119 10.1504/IJLR.2003.003478 1:CAS:528:DC%2BD2cXhsVymtrs%3D
8. JF Kalinich R Ramakrishnan DE McClain N Ramakrishnan 2000 4-Hydroxynonenal, an end-product of lipid peroxidation, induces apoptosis in human leukemic T- and B-cell lines Free Radic Res 33 349 358 11022844 10.1080/10715760000300891 1:CAS:528:DC%2BD3cXns1ert78%3D
9. DR Green JC Reed 1998 Mitochondria and apoptosis Science 281 1309 1312 9721092 10.1126/science.281.5381.1309 1:CAS:528:DyaK1cXlvVegsLo%3D (Pubitemid 28406816)
10. JF Turrens 2003 Mitochondrial formation of reactive oxygen species J Physiol 552 335 344 14561818 10.1113/jphysiol.2003.049478 1:CAS:528: DC%2BD3sXps1ehtLc%3D (Pubitemid 37321833)
11. YH Ling L Liebes Y Zou R Perez-Soler 2003 Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells J Biol Chem 278 33714 33723 12821677 10.1074/jbc.M302559200 1:CAS:528:DC%2BD3sXmvVCrt7s%3D (Pubitemid 37553204)
12. DM Hockenbery ZN Oltvai XM Yin CL Milliman SJ Korsmeyer 1993 Bcl-2 functions in an antioxidant pathway to prevent apoptosis Cell 75 241 251 7503812 10.1016/0092-8674(93)80066-N 1:CAS:528:DyaK3sXms1Omtr8%3D (Pubitemid 23320288)
13. MC Wei WX Zong EH Cheng T Lindsten V Panoutsakopoulou 2001 Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death Science 292 727 730 11326099 10.1126/science.1059108 1:CAS:528:DC%2BD3MXjt1eltr0%3D (Pubitemid 32385543)
14. WX Zong T Lindsten AJ Ross GR MacGregor CB Thompson 2001 BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak Genes Dev 15 1481 1486 11410528 10.1101/gad.897601 1:CAS:528:DC%2BD3MXksFKgtbg%3D (Pubitemid 32552527)
15. SW Ryter HP Kim A Hoetzel, et al. 2007 Mechanisms of cell death in oxidative stress Antioxid Redox Signaling 9 49 89 10.1089/ars.2007.9.49 1:CAS:528:DC%2BD28Xht1Wqur3L (Pubitemid 44901874)
16. P Marchetti M Castedo SA Susin, et al. 1996 Mitochondrial permeability transition is a central coordinating event of apoptosis J Exp Med 184 1155 1160 9064332 10.1084/jem.184.3.1155 1:CAS:528:DyaK28XlsFartLY%3D (Pubitemid 26313572)
17. J Cao Y Liu J Li, et al. 2007 Curcumin induces apoptosis through mitochondrial hyperpolarization and mtDNA damage in human hepatoma G2 cells Free Radic Biol Med 43 968 975 17697941 10.1016/j.freeradbiomed.2007.06.006 1:CAS:528:DC%2BD2sXovFOqurk%3D (Pubitemid 47223632)
18. R Varshney S Gupta BS Dwarakanath 2004 Radiosensitization of Murine Ehrlich ascites tumor by a combination of 2-deoxy-d-glucose and 6-aminonicotinamide Technol Cancer Res 3 659 663 1:CAS:528: DC%2BD2MXmtVaksw%3D%3D (Pubitemid 40023556)
19. V Jain 1996 Modifications of radiation responses by 2-deoxy-d-glucose in normal and cancer cells Ind J Nucl Med 11 8 17
20. BS Dwarakanath F Zolzer S Chandna, et al. 2001 Heterogeneity in 2-deoxy-d-glucose induced modifications in energetic and radiation responses of human tumor cell lines Int J Radiat Oncol Biol Phys 51 1151 1161
21. BN Pandey KP Mishra 2003 Oxidative membrane damage and its involvement in radiation induced apoptotic cell death Iran J Radiat Res 1 17 22
22. S Kantengwa L Jornot C Devenoges LP Nicod 2003 Superoxide anions induce the maturation of human dendritic cells Am J Respir Crit Care Med 167 431 437 12554628 10.1164/rccm.200205-425OC (Pubitemid 36216428)
23. R Varshney RK Kale 1990 Effects of calmodulin antagonists on radiation induced lipid peroxidation in microsomes Int J Rad Biol 58 733 743 1977818 10.1080/09553009014552121 1:CAS:528:DyaK3MXitVaiuw%3D%3D (Pubitemid 20346842)
24. RL Levine 1984 Mixed-function oxidation of histidine residues Methods Enzymol 107 370 376 6503718 10.1016/0076-6879(84)07025-7 1:CAS:528:DyaL2MXitlWh (Pubitemid 14053816)
25. M Athar NK Chaudhury ME Hussain R Varshney 2010 Hoechst 33342 enhances radiosensitization of malignant glioma cells via increase in mitochondrial ROS Free Radic Res 44 936 949 20540663 10.3109/10715762.2010.492829 1:CAS:528:DC%2BC3cXhtVClu73I
26. A Maftah M Ratinaud M Dumas F Bonte A Meybeck R Julien 1994 Human epidermal cells progressively lose their cardiolipins during ageing without change in mitochondrial transmembrane potential Mech Ageing Dev 77 83 96 7745994 10.1016/0047-6374(94)90017-5 1:CAS:528:DyaK2MXktlygtLo%3D
27. O Warburg K Posener E Negelein 1924 On the metabolism of cancer cells Biochemistry 152 319 344
28. DA Averill-Bates E Przybytkowski 1994 The role of glucose in cellular defenses against cytotoxicity of hydrogen peroxide in Chinese hamster ovary cells Arch Biochem Biophys 312 52 58 8031146 10.1006/abbi.1994.1279 1:CAS:528:DyaK2cXltVWmsr0%3D
29. N Jelluma X Yang D Stokoe GI Evan TB Dansen DA Haas-Kogan 2006 Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes Mol Cancer Res 4 319 330 16687487 10.1158/1541-7786.MCR-05-0061 1:CAS:528:DC%2BD28XktlymsLc%3D (Pubitemid 43837333)
30. YJ Lee SS Galoforo CM Berns WP Tong HRC Kim PM Corry 1997 Glucose deprivation-induced cytotoxicity in drug resistant human breast carcinoma MCF-7/ADR cells: role of c-myc and bcl-2 in apoptotic cell death J Cell Sci 110 681 686 9092950 1:CAS:528:DyaK2sXitlams74%3D (Pubitemid 27153982)
31. MC Coleman CR Asbury D Daniels, et al. 2008 2-Deoxy-d-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer Free Rad Biol Med 44 322 331 18215740 10.1016/j.freeradbiomed.2007.08.032 1:CAS:528:DC%2BD1cXpt1KltA%3D%3D
32. RH Xu H Pelicano Y Zhou, et al. 2005 Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia Cancer Res 65 613 621 15695406 10.1158/0008-5472.CAN-04-4313 1:CAS:528:DC%2BD2MXns1Ojuw%3D%3D (Pubitemid 40911174)
33. 2 mediate glucose deprivation-induced cytotoxicity and oxidative stress in human cancer cells J Biol Chem 280 4254 4263 15561720 10.1074/jbc.M411662200
34. KM Choi CM Kang ES Cho SM Kang SB Lee HD Um 2007 Ionizing radiation-induced micronucleus formation is mediated by reactive oxygen species that are produced in a manner dependent on mitochondria, Nox1, and JNK Oncol Rep 17 1183 1188 17390063 1:CAS:528:DC%2BD2sXlsVyms7s%3D
35. M Widel S Jedrus B Lukaszczyk K Raczek-Zwierzycka A Swierniak 2003 Radiation-induced micronucleus frequency in peripheral blood lymphocytes is correlated with normal tissue damage in patients with cervical carcinoma undergoing radiotherapy Radiat Res 159 6 713 721 12751953 10.1667/0033- 7587(2003)159[0713:RMFIPB]2.0.CO;2 1:CAS:528:DC%2BD3sXks1Gntbo%3D (Pubitemid 36676863)
36. S Paglin T Delohery R Erlandson J Yahalom 1997 Radiation induced micronuclei formation in human breast cancer cells: dependence on serum and cell cycle distribution Biochem Biophys Res Comm 237 678 684 9299426 10.1006/bbrc.1997.7117 1:CAS:528:DyaK2sXmtV2gtrw%3D (Pubitemid 27434747)
37. Y Liu S Xiao-Dong W Liu Z Tian-Yi J Zuo 2003 Glucose deprivation induces mitochondrial dysfunction and oxidative stress in PC12 cell line J Cell Mol Med 7 49 56 12767261 10.1111/j.1582-4934.2003.tb00202.x 1:CAS:528: DC%2BD3sXksFeitr0%3D (Pubitemid 37123376)
38. RA Kirkland JL Frankiin 2001 Evidence for redox regulation of cytochrome c release during programmed neuronal death: antioxidant effects of protein synthesis and caspase inhibition J Neurosci 21 1949 1963 11245680 1:CAS:528:DC%2BD3MXjslCltr4%3D (Pubitemid 32221379)
39. K Gottlob N Majewski S Kennedy E Kandel RB Robey N Hay 2001 Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase Genes Dev 15 1406 1418 11390360 10.1101/gad.889901 1:CAS:528:DC%2BD3MXktlSntbc%3D (Pubitemid 32524647)
40. MG Vander Heiden NS Chandel XX Li PT Schumacker M Colombini CB Thompson 2000 Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival Proc Natl Acad Sci USA 97 4666 4671 10781072 10.1073/pnas.090082297 1:CAS:528:DC%2BD3cXivFKjt7Y%3D (Pubitemid 30238615)