Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-Candida activity, and quantitative structure-analysis relationship studies

Journal of Medicinal Chemistry

Volumn 45, Issue 13, 2002, Pages 2720-2732

  Tafi, Andrea ^a   Costi, Roberta ^b   Botta, Maurizio ^a   Di Santo, Roberto ^b   Corelli, Federico ^a   Massa, Silvio ^a   Ciacci, Andrea ^a   Manetti, Fabrizio ^a   Artico, Marino ^b  

^a UNIVERSITY OF SIENA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 [(2,4 DICHLOROPHENYL)[4 (4 HYDROXYPHENYL) 1H PYRROL 3 YL]METHYL] 1H IMIDAZOLE; 1 [(2,4 DICHLOROPHENYL)[4 (4 TRIFLUOROMETHYLPHENYL) 1H PYRROL 3 YL]METHYL] 1H IMIDAZOLE; 1 [[4 (4 AMINOPHENYL) 1H PYRROL 3 YL](2,4 DICHLOROPHENYL)METHYL] 1H IMIDAZOLE; 14 ALPHA LANOSTEROL DEMETHYLASE; ANTIFUNGAL AGENT; BIFONAZOLE; CYTOCHROME P450 ISOENZYME; HYDROXYL GROUP; IMIDAZOLE DERIVATIVE; PHENYL GROUP; PORPHYRIN; PYRROLNITRIN; UNCLASSIFIED DRUG;

ALKALINITY; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CHEMICAL MODIFICATION; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG CONFORMATION; DRUG MECHANISM; DRUG SYNTHESIS; HYDROGEN BOND; HYDROPHOBICITY; IN VITRO STUDY; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PH; PHARMACOPHORE; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STEREOISOMERISM;

ANTIFUNGAL AGENTS; CANDIDA; IMIDAZOLES; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRROLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; STEREOISOMERISM;

EID: 0037142376     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm011087h     Document Type: Article

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