P53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice

Journal of Hepatology

Volumn 57, Issue 4, 2012, Pages 837-843

  Tomita, Kengo ^a,b   Teratani, Toshiaki ^b   Suzuki, Takahiro ^b   Oshikawa, Tetsuya ^b   Yokoyama, Hirokazu ^b   Shimamura, Katsuyoshi ^b   Nishiyama, Kiyoshi ^a   Mataki, Norikazu ^a   Irie, Rie ^c   Minamino, Tohru ^d   Okada, Yoshikiyo ^a   Kurihara, Chie ^a   Ebinuma, Hirotoshi ^b   Saito, Hidetsugu ^e   Shimizu, Ippei ^d   Yoshida, Yohko ^d   Hokari, Ryota ^a   Sugiyama, Kazuo ^b   Hatsuse, Kazuo ^a   Yamamoto, Junji ^a   Kanai, Takanori ^b   Miura, Soichiro ^a   Hibi, Toshifumi ^b   more..

^a NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c KAWASAKI MUNICIPAL HOSPITAL   (Japan)

^d CHIBA UNIVERSITY   (Japan)

^e KEIO UNIVERSITY   (Japan)

Author keywords

Non alcoholic steatohepatitis; P53; P66Shc; Reactive oxygen species; Transforming growth factor

Indexed keywords

PROTEIN P53; REACTIVE OXYGEN METABOLITE; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; HUMAN; HUMAN TISSUE; LIPID PEROXIDATION; LIVER CELL; MALE; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CASPASE 3; CHOLINE DEFICIENCY; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FATTY LIVER; HEPATOCYTES; HUMANS; MALE; METHIONINE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PRIMARY CELL CULTURE; PROTO-ONCOGENE PROTEINS P21(RAS); REACTIVE OXYGEN SPECIES; RNA, MESSENGER; SHC SIGNALING ADAPTOR PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84866348839     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.05.013     Document Type: Article

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