Transforming growth factor beta mediates hepatocyte apoptosis through Smad3 generation of reactive oxygen species

Biochimie

Volumn 89, Issue 12, 2007, Pages 1464-1473

  Black, Dalliah ^a   Lyman, Suzanne ^a   Qian, Ting ^b   Lemasters, John J ^a,b   Rippe, Richard A ^a   Nitta, Takashi ^c   Kim, Jae Sung ^a,c   Behrns, Kevin E ^a,c  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Apoptosis; Hepatocyte; Reactive oxygen species; Smad3; Transforming growth factor beta

Indexed keywords

CASPASE; DIPHENYLIODONIUM SALT; REACTIVE OXYGEN METABOLITE; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TROLOX C;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; KNOCKOUT MOUSE; LIVER CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 8; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; HEPATOCYTES; MICE; MICE, KNOCKOUT; MITOCHONDRIA, LIVER; PLASMIDS; REACTIVE OXYGEN SPECIES; SMAD3 PROTEIN; STATISTICS AS TOPIC; TIME FACTORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TRYPAN BLUE;

MUS;

EID: 36248990744     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2007.09.001     Document Type: Article

References (24)

1. Massague J. TGF-beta signal transduction. Annu. Rev. Biochem 67 (1998) 753-791
2. Kim B.C., Mamura M., Choi K.S., Calabretta B., and Kim S.J. Transforming growth factor beta 1 induces apoptosis through cleavage of BAD in a Smad3-dependent mechanism in FaO hepatoma cells. Mol. Cell. Biol. 22 (2002) 1369-1378
3. Schrum L.W., Bird M.A., Salcher O., Burchardt E.R., Grisham J.W., Brenner D.A., Rippe R.A., and Behrns K.E. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver, Am. J. Physiol Gastrointest. Liver Physiol 280 (2001) G139-G148
4. Shima Y., Nakao K., Nakashima T., Kawakami A., Nakata K., Hamasaki K., Kato Y., Eguchi K., and Ishii N. Activation of caspase-8 in transforming growth factor-beta-induced apoptosis of human hepatoma cells. Hepatology 30 (1999) 1215-1222
5. Black D., Bird M.A., Samson C.M., Lyman S., Lange P.A., Schrum L.W., Qian T., Lemasters J.J., Brenner D.A., Rippe R.A., and Behrns K.E. Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism. J. Hepatol 40 (2004) 942-951
6. Yoo J., Ghiassi M., Jirmanova L., Balliet A.G., Hoffman B., Fornace Jr. A.J., Liebermann D.A., Bottinger E.P., and Roberts A.B. Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation. J. Biol. Chem. 278 (2003) 43001-43007
7. Major M.B., and Jones D.A. Identification of a gadd45beta 3′ enhancer that mediates SMAD3- and SMAD4-dependent transcriptional induction by transforming growth factor beta. J. Biol. Chem. 279 (2004) 5278-5287
8. Yang Y.A., Zhang G.M., Feigenbaum L., and Zhang Y.E. Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2. Cancer Cell 9 (2006) 445-457
9. Conery A.R., Cao Y., Thompson E.A., Townsend Jr. C.M., Ko T.C., and Luo K. Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis. Nat. Cell Biol. 6 (2004) 366-372
10. Thannickal V.J., and Fanburg B.L. Activation of an H2O2-generating NADH oxidase in human lung fibroblasts by transforming growth factor beta 1. J. Biol. Chem. 270 (1995) 30334-30338
11. Sanchez A., Alvarez A.M., Benito M., and Fabregat I. Cycloheximide prevents apoptosis, reactive oxygen species production, and glutathione depletion induced by transforming growth factor beta in fetal rat hepatocytes in primary culture. Hepatology 26 (1997) 935-943
12. Ju W., Ogawa A., Heyer J., Nierhof D., Yu L., Kucherlapati R., Shafritz D.A., and Bottinger E.P. Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation. Mol. Cell. Biol. 26 (2006) 654-667
13. Schnabl B., Kweon Y.O., Frederick J.P., Wang X.F., Rippe R.A., and Brenner D.A. The role of Smad3 in mediating mouse hepatic stellate cell activation. Hepatology 34 (2001) 89-100
14. Datto M.B., Frederick J.P., Pan L., Borton A.J., Zhuang Y., and Wang X.F. Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol. Cell. Biol. 19 (1999) 2495-2504
15. Arias I., Boyer J., and Fausto N. The Liver: Biology and Pathobiology (1994), Raven Press, New York
16. Pattillo R.A., Ruchert A., Hussa R., Bernstein R., and Des E. The Jar cell line-continuous human multihormone production and control. In Vitro 6 (1971) 398-399
17. Sit K.H., Yin L., and Paramanantham R. Apoptotic condensations in M-phase cells. Anat. Rec 248 (1997) 149-158
18. Hatano E., Bradham C.A., Stark A., Iimuro Y., Lemasters J.J., and Brenner D.A. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. J. Biol. Chem. 275 (2000) 11814-11823
19. Leist M., Gantner F., Bohlinger I., Germann P.G., Tiegs G., and Wendel A. Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-alpha requires transcriptional arrest. J. Immunol 153 (1994) 1778-1788
20. Herrera B., Murillo M.M., varez-Barrientos A., Beltran J., Fernandez M., and Fabregat I. Source of early reactive oxygen species in the apoptosis induced by transforming growth factor-beta in fetal rat hepatocytes. Free Radic. Biol. Med 36 (2004) 16-26
21. Jang C.W., Chen C.H., Chen C.C., Chen J.Y., Su Y.H., and Chen R.H. TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase. Nat. Cell Biol. 4 (2002) 51-58
22. Sturrock A., Cahill B., Norman K., Huecksteadt T.P., Hill K., Sanders K., Karwande S.V., Stringham J.C., Bull D.A., Gleich M., Kennedy T.P., and Hoidal J.R. Transforming growth factor-beta1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells, Am. J. Physiol Lung Cell Mol. Physiol 290 (2006) L661-L673
23. Schuster N., and Krieglstein K. Mechanisms of TGF-beta-mediated apoptosis. Cell Tissue Res. 307 (2002) 1-14
24. Herrera B., Alvarez A.M., Sanchez A., Fernandez M., Roncero C., Benito M., and Fabregat I. Reactive oxygen species (ROS) mediates the mitochondrial-dependent apoptosis induced by transforming growth factor (beta) in fetal hepatocytes. FASEB J 15 (2001) 741-751