메뉴 건너뛰기




Volumn 41, Issue 5, 2005, Pages 1074-1084

Oxidative stress stimulates proliferation and invasiveness of hepatic stellate cells via a MMP2-mediated mechanism

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA TOCOPHEROL; ANTIOXIDANT; GELATINASE A; HYDROXAMIC ACID DERIVATIVE; ILOMASTAT; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE MACROGOL; TISSUE INHIBITOR OF METALLOPROTEINASE 2; WORTMANNIN; XANTHINE; XANTHINE OXIDASE;

EID: 20944451594     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20683     Document Type: Article
Times cited : (220)

References (50)
  • 1
    • 0024411821 scopus 로고
    • In situ hybridization for procollagen type I, III, and IV mRNA in normal and fibrotic rat liver: Evidence for predominant expression in non-parenchymal liver cells
    • Milani S, Herbst H, Schuppan D, Hahn EG, Stein H. In situ hybridization for procollagen type I, III, and IV mRNA in normal and fibrotic rat liver: evidence for predominant expression in non-parenchymal liver cells. HEPATOLOGY 1989;10:84-92.
    • (1989) Hepatology , vol.10 , pp. 84-92
    • Milani, S.1    Herbst, H.2    Schuppan, D.3    Hahn, E.G.4    Stein, H.5
  • 2
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 2000;275:2247-2250.
    • (2000) J Biol Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 3
    • 0034808310 scopus 로고    scopus 로고
    • History, heterogeniry, developmental biology and functions of quiescent hepatic stellate cells
    • Geerts A. History, heterogeniry, developmental biology and functions of quiescent hepatic stellate cells. Semin Liver Dis 2001;21:311-335.
    • (2001) Semin Liver Dis , vol.21 , pp. 311-335
    • Geerts, A.1
  • 4
    • 0028181393 scopus 로고
    • Stimulation of collagen α1 (I) gene expression is associated with lipid peroxidation in hepatocellular injury: A link to tissue fibrosis?
    • Bedossa P, Houglum K, Trautwein C Holstage A, Chojkier M. Stimulation of collagen α1 (I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis? HEPATOLOGY 1994;19:1262-1271.
    • (1994) Hepatology , vol.19 , pp. 1262-1271
    • Bedossa, P.1    Houglum, K.2    Holstage A, T.C.3    Chojkier, M.4
  • 5
    • 0034869459 scopus 로고    scopus 로고
    • Oxidative stress-related molecules and liver fibrosis
    • Parola M, Robino G. Oxidative stress-related molecules and liver fibrosis. J Hepatol 2001;35:297-306.
    • (2001) J Hepatol , vol.35 , pp. 297-306
    • Parola, M.1    Robino, G.2
  • 6
    • 12644298684 scopus 로고    scopus 로고
    • Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells: Role of nitric oxide
    • Casini A, Ceni E, Salzano R, Biondi P, Parola M, Galli A, et al. Neutrophil-derived superoxide anion induces lipid peroxidation and stimulates collagen synthesis in human hepatic stellate cells: role of nitric oxide. HEPATOLOGY 1997;25:361-367.
    • (1997) Hepatology , vol.25 , pp. 361-367
    • Casini, A.1    Ceni, E.2    Salzano, R.3    Biondi, P.4    Parola, M.5    Galli, A.6
  • 7
    • 0037155835 scopus 로고    scopus 로고
    • Cytochrome P450 2E1-derived oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells
    • Nieto N, Friedman SL, Cederbaum AI. Cytochrome P450 2E1-derived oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells. J Biol Chem 2002;277:9853-9864.
    • (2002) J Biol Chem , vol.277 , pp. 9853-9864
    • Nieto, N.1    Friedman, S.L.2    Cederbaum, A.I.3
  • 9
    • 0037693895 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tissue inhibitors of metalloproreinases, structure, functions and biochemistry
    • Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloproreinases, structure, functions and biochemistry. Circ Res 2003; 92:827-839.
    • (2003) Circ Res , vol.92 , pp. 827-839
    • Visse, R.1    Nagase, H.2
  • 10
    • 0031656460 scopus 로고    scopus 로고
    • Matrix metalloproteinases: Structures, evolution, and diversification
    • Massova I, Kotra LP, Fridman R, Mobashery S. Matrix metalloproteinases: structures, evolution, and diversification. FASEB J 1998;12:1075-1095.
    • (1998) FASEB J , vol.12 , pp. 1075-1095
    • Massova, I.1    Kotra, L.P.2    Fridman, R.3    Mobashery, S.4
  • 11
    • 0344861306 scopus 로고    scopus 로고
    • Surface association of secreted matrix meralloproteinases
    • Fridman R. Surface association of secreted matrix meralloproteinases. Curr Top Dev Biol 2003;54:75-100.
    • (2003) Curr Top Dev Biol , vol.54 , pp. 75-100
    • Fridman, R.1
  • 12
    • 0028291795 scopus 로고
    • Differential expression of matrix-metalloproteinases-1 and -2 genes in normal and fibrotic human liver
    • Milani S, Herbsr H, Shuppan D, Grappone C, Pellegrini G, Pinzani M, et al. Differential expression of matrix-metalloproteinases-1 and -2 genes in normal and fibrotic human liver. Am J Pathol 1994;144:528-537.
    • (1994) Am J Pathol , vol.144 , pp. 528-537
    • Milani, S.1    Herbsr, H.2    Shuppan, D.3    Grappone, C.4    Pellegrini, G.5    Pinzani, M.6
  • 13
    • 0032835380 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 activation in human hepatic fibrosis by cell-matrix interaction
    • Preaux AM, Mallat A, Nhieu JT, D'Ortho MP, Hembry RM, Mavier P. Matrix metalloproteinase-2 activation in human hepatic fibrosis by cell-matrix interaction. HEPATOLOGY 1999;30:944-950.
    • (1999) Hepatology , vol.30 , pp. 944-950
    • Preaux, A.M.1    Mallat, A.2    Nhieu, J.T.3    D'Ortho, M.P.4    Hembry, R.M.5    Mavier, P.6
  • 14
    • 0035328844 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinase-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase
    • Bigg HF, Morrison CJ, Butler GS, Bogoyevitch MA, Wang Z, Soloway PD, et al. Tissue inhibitor of metalloproteinase-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase. Cancer Res 2001;61:3610-3618.
    • (2001) Cancer Res , vol.61 , pp. 3610-3618
    • Bigg, H.F.1    Morrison, C.J.2    Butler, G.S.3    Bogoyevitch, M.A.4    Wang, Z.5    Soloway, P.D.6
  • 15
    • 0031708377 scopus 로고    scopus 로고
    • Differential expression and origin of membrane-type 1 and 2 matrix metalloproteinases (MT-MMPs) in association with MMP2 activation in injured human livers
    • Theret N, Musso O, L'Helgoualc'h A, Champion J-P, Clement B. Differential expression and origin of membrane-type 1 and 2 matrix metalloproteinases (MT-MMPs) in association with MMP2 activation in injured human livers. Am J Pathol 1998;153:945-954.
    • (1998) Am J Pathol , vol.153 , pp. 945-954
    • Theret, N.1    Musso, O.2    L'Helgoualc'h, A.3    Champion, J.-P.4    Clement, B.5
  • 16
    • 0030724689 scopus 로고    scopus 로고
    • Dual expression of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase in fibrotic human liver
    • Takahara T, Furui K, Yata Y, Jin B, Zhang LP, Nambu S, et al. Dual expression of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase in fibrotic human liver. HEPATOLOGY 1997;26:1521-1529.
    • (1997) Hepatology , vol.26 , pp. 1521-1529
    • Takahara, T.1    Furui, K.2    Yata, Y.3    Jin, B.4    Zhang, L.P.5    Nambu, S.6
  • 17
    • 0034814405 scopus 로고    scopus 로고
    • Extracellular matrix degradation and role of hepatic stellate cells
    • Benyon RC, Arthur MJP. Extracellular matrix degradation and role of hepatic stellate cells. Semin Liver Dis 2001;21:373-384.
    • (2001) Semin Liver Dis , vol.21 , pp. 373-384
    • Benyon, R.C.1    Arthur, M.J.P.2
  • 18
    • 20644465610 scopus 로고    scopus 로고
    • Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation
    • Benyon RC, Horell CJ, Da Gaca M, Jones EH, Iredale JP, Arthur MJP. Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation. HEPATOLOGY 1999;30:977-986.
    • (1999) Hepatology , vol.30 , pp. 977-986
    • Benyon, R.C.1    Horell, C.J.2    Da Gaca, M.3    Jones, E.H.4    Iredale, J.P.5    Arthur, M.J.P.6
  • 19
    • 0033962940 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ transcriptional regulation is involved in platelet-derived growth factor-induced proliferation in human hepatic stellate cells
    • Galli A, Crabb D, Price D, Ceni E, Salzano R, Surrenti C, et al. Peroxisome proliferator-activated receptor γ transcriptional regulation is involved in platelet-derived growth factor-induced proliferation in human hepatic stellate cells. HEPATOLOGY 2000;31:101-108.
    • (2000) Hepatology , vol.31 , pp. 101-108
    • Galli, A.1    Crabb, D.2    Price, D.3    Ceni, E.4    Salzano, R.5    Surrenti, C.6
  • 20
    • 0023187867 scopus 로고
    • A rapid in vitro assay for quantitating the invasive potential of tumor cells
    • Albini A, Iwamoto Y, Kleinman HK. A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res 1987;47:3239-3245.
    • (1987) Cancer Res , vol.47 , pp. 3239-3245
    • Albini, A.1    Iwamoto, Y.2    Kleinman, H.K.3
  • 21
    • 0030934411 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinases-1 and -2 RNA expression in rat and human liver fibrosis
    • Herbst H, Wege T, Milani S, Pellegrini G, Orzechowski H-D, Bauer M, et al. Tissue inhibitor of metalloproteinases-1 and -2 RNA expression in rat and human liver fibrosis. Am J Pathol 1997;150:1647-1659.
    • (1997) Am J Pathol , vol.150 , pp. 1647-1659
    • Herbst, H.1    Wege, T.2    Milani, S.3    Pellegrini, G.4    Orzechowski, H.-D.5    Bauer, M.6
  • 22
    • 0142089835 scopus 로고    scopus 로고
    • Galardin (GM 6001), a broad-spectrum matrix-metalloproteinase inhibitor, blocks bombesin- and LPA-induced EGF receptor transactivation and DNA synthesis in Rat-1 cells
    • Santiskulvong C, Rozengurt E, Galardin (GM 6001), a broad-spectrum matrix-metalloproteinase inhibitor, blocks bombesin- and LPA-induced EGF receptor transactivation and DNA synthesis in Rat-1 cells. Exp Cell Res 2003;290:437-446.
    • (2003) Exp Cell Res , vol.290 , pp. 437-446
    • Santiskulvong, C.1    Rozengurt, E.2
  • 23
    • 0038561224 scopus 로고    scopus 로고
    • Androgen stimulates matrix metalloproteinese-2 expression in human prostate cancer
    • Liao X, Thrasher BJ, Felling J, Holzbeierlein J, Li B. Androgen stimulates matrix metalloproteinese-2 expression in human prostate cancer. Endocrinology 2003;144:1656-1663.
    • (2003) Endocrinology , vol.144 , pp. 1656-1663
    • Liao, X.1    Thrasher, B.J.2    Felling, J.3    Holzbeierlein, J.4    Li, B.5
  • 24
    • 2442421050 scopus 로고    scopus 로고
    • Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor
    • Zhang D, Bar-Eli M, Meloche S, Brodt P. Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor. J Biol Chem 2004;279:19683-19690.
    • (2004) J Biol Chem , vol.279 , pp. 19683-19690
    • Zhang, D.1    Bar-Eli, M.2    Meloche, S.3    Brodt, P.4
  • 25
    • 0032975552 scopus 로고    scopus 로고
    • Constitutively active mitogen-activated protein kinase MEK1 disrupts morphogenesis and induces an invasive phenotype in madin-darby canine kidney epithelial cells
    • Montesano R, Soriano JV, Hosseini G, Pepper MS, Schramek H. Constitutively active mitogen-activated protein kinase MEK1 disrupts morphogenesis and induces an invasive phenotype in madin-darby canine kidney epithelial cells. Cell Growth Differ 1999;10:317-332.
    • (1999) Cell Growth Differ , vol.10 , pp. 317-332
    • Montesano, R.1    Soriano, J.V.2    Hosseini, G.3    Pepper, M.S.4    Schramek, H.5
  • 26
    • 0032946712 scopus 로고    scopus 로고
    • Intracellular pathways mediating Na+/H+ exchange activation by platelet-derived growth factor in rat hepatic stellate cells
    • Di Sario A, Bendia E, Svegliati-Baroni G, Ridolfi F, Bolognini L, Feliciangeli G, et al. Intracellular pathways mediating Na+/H+ exchange activation by platelet-derived growth factor in rat hepatic stellate cells. Gastroenterology 1999;116:1155-1166.
    • (1999) Gastroenterology , vol.116 , pp. 1155-1166
    • Di Sario, A.1    Bendia, E.2    Svegliati-Baroni, G.3    Ridolfi, F.4    Bolognini, L.5    Feliciangeli, G.6
  • 27
    • 0033968019 scopus 로고    scopus 로고
    • Phosphatidylinositol-3 kinase and extracellular signal-regulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-1 in human hepatic stellate cells
    • Gentilini A, Marra F, Gentilini P, Pinzani M. Phosphatidylinositol-3 kinase and extracellular signal-regulated kinase mediate the chemotactic and mitogenic effects of insulin-like growth factor-1 in human hepatic stellate cells. J Hepatol 2000;32:227-234.
    • (2000) J Hepatol , vol.32 , pp. 227-234
    • Gentilini, A.1    Marra, F.2    Gentilini, P.3    Pinzani, M.4
  • 28
    • 0036172218 scopus 로고    scopus 로고
    • Rearrangement of the cytoskeletal network induced by platelet-derived growth factor in rat hepatic stellate cells: Role of different intracellular signalling pathways
    • Di Sario A, Bendia E, Svegliati-Baroni G, Marzioni M, Ridolfi F, Trozzi L, et al. Rearrangement of the cytoskeletal network induced by platelet-derived growth factor in rat hepatic stellate cells: role of different intracellular signalling pathways. J Hepatol 2002;36:179-190.
    • (2002) J Hepatol , vol.36 , pp. 179-190
    • Di Sario, A.1    Bendia, E.2    Svegliati-Baroni, G.3    Marzioni, M.4    Ridolfi, F.5    Trozzi, L.6
  • 29
    • 0028178928 scopus 로고
    • PDGF- and insulin-dependent pp70S6K activation mediated by phosphatidylinositol-3-OH kinase
    • Chung J, Grammer TC, Lemon KP, Kazlauskas A, Blenis J. PDGF- and insulin-dependent pp70S6K activation mediated by phosphatidylinositol-3-OH kinase. Nature 1994;370:71-75.
    • (1994) Nature , vol.370 , pp. 71-75
    • Chung, J.1    Grammer, T.C.2    Lemon, K.P.3    Kazlauskas, A.4    Blenis, J.5
  • 30
    • 0030220365 scopus 로고    scopus 로고
    • Effect of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis
    • Gasso M, Rubio M, Varela G, Cabre M, Caballeria J, Alonso E, et al. Effect of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis. J Hepatol 1996;25:200-205.
    • (1996) J Hepatol , vol.25 , pp. 200-205
    • Gasso, M.1    Rubio, M.2    Varela, G.3    Cabre, M.4    Caballeria, J.5    Alonso, E.6
  • 31
    • 0030854425 scopus 로고    scopus 로고
    • A pilot study of the effects of D-α-tocopherol and hepatic stellate cell activation in chronic hepatitis C
    • Houglum K, Venkaterami A, Lyche K, Chojkier M. A pilot study of the effects of D-α-tocopherol and hepatic stellate cell activation in chronic hepatitis C. Gastroenterology 1997;113:1069-1073.
    • (1997) Gastroenterology , vol.113 , pp. 1069-1073
    • Houglum, K.1    Venkaterami, A.2    Lyche, K.3    Chojkier, M.4
  • 32
    • 0035179839 scopus 로고    scopus 로고
    • DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells
    • Olaso E, Ikeda K, Eng FJ, Xu Lieming, Wang L-H, Lin HC, et al. DDR2 receptor promotes MMP-2-mediated proliferation and invasion by hepatic stellate cells. J Clin Invest 2001;108:1369-1378.
    • (2001) J Clin Invest , vol.108 , pp. 1369-1378
    • Olaso, E.1    Ikeda, K.2    Eng, F.J.3    Lieming, X.4    Wang, L.-H.5    Lin, H.C.6
  • 33
    • 0031659907 scopus 로고    scopus 로고
    • Galatinase A and B are up-regulated in rat lungs by sub acute hyperoxia: Pathogenic implication
    • Prado A, Barrios R, Maldonado V, Melendez J, Perez J, Ruiz V, et al. Galatinase A and B are up-regulated in rat lungs by sub acute hyperoxia: pathogenic implication. Am J Pathol 1998;153:833-844.
    • (1998) Am J Pathol , vol.153 , pp. 833-844
    • Prado, A.1    Barrios, R.2    Maldonado, V.3    Melendez, J.4    Perez, J.5    Ruiz, V.6
  • 34
    • 0030033405 scopus 로고    scopus 로고
    • The effect of ultraviolet a and reactive oxygen species on the mRNA expression of 72-kDa type IV collagenase and its tissue inhibitor in cultured human dermal fibroblasts
    • Kawaguchi Y, Tanaka H, Okada T, Konishi H, Takahaschi M, Ito M, et al. The effect of ultraviolet A and reactive oxygen species on the mRNA expression of 72-kDa type IV collagenase and its tissue inhibitor in cultured human dermal fibroblasts. Arch Dermatol Res 1996;288:39-44.
    • (1996) Arch Dermatol Res , vol.288 , pp. 39-44
    • Kawaguchi, Y.1    Tanaka, H.2    Okada, T.3    Konishi, H.4    Takahaschi, M.5    Ito, M.6
  • 35
    • 0034995893 scopus 로고    scopus 로고
    • Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts
    • Siwik DA, Pagano PJ, Colucci WS. Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts. Am J Physiol 2001;280:C53-C60.
    • (2001) Am J Physiol , vol.280
    • Siwik, D.A.1    Pagano, P.J.2    Colucci, W.S.3
  • 36
    • 0036260697 scopus 로고    scopus 로고
    • Cellular response to oxidative stress: Signaling for suicide and survival
    • Martindale JL, Holbrook NJ. Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 2002;192:1-15.
    • (2002) J Cell Physiol , vol.192 , pp. 1-15
    • Martindale, J.L.1    Holbrook, N.J.2
  • 37
    • 0033865692 scopus 로고    scopus 로고
    • Glutatione oxidation and PTPase inhibition by hydrogen peroxide in Caco-2 cell monolayer
    • Rao RK, Li L, Baker RD, Baker SS, Gupta A. Glutatione oxidation and PTPase inhibition by hydrogen peroxide in Caco-2 cell monolayer. Am J Physiol 2000;279:G332-G340.
    • (2000) Am J Physiol , vol.279
    • Rao, R.K.1    Li, L.2    Baker, R.D.3    Baker, S.S.4    Gupta, A.5
  • 38
    • 0034640524 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival
    • Wang X, McCullough KD, Franke TF, Holbrook NJ. Epidermal growth factor receptor-dependent Akt activation by oxidative stress enhances cell survival. J Biol Chem 2000;273:14624-14631.
    • (2000) J Biol Chem , vol.273 , pp. 14624-14631
    • Wang, X.1    McCullough, K.D.2    Franke, T.F.3    Holbrook, N.J.4
  • 39
    • 0034810089 scopus 로고    scopus 로고
    • Cytokine receptors and signalling in hepatic stellate cells
    • Pinzani M, Marra F. Cytokine receptors and signalling in hepatic stellate cells. Semin Liver Dis 2001;21:397-416.
    • (2001) Semin Liver Dis , vol.21 , pp. 397-416
    • Pinzani, M.1    Marra, F.2
  • 40
    • 0037031833 scopus 로고    scopus 로고
    • Non steroidal anti-inflammatory drugs inhibit matrix metalloproteinase-2 via suppression of the ERK/Sp1-mediated transcription
    • Pan M-R, Hung W-C. Non steroidal anti-inflammatory drugs inhibit matrix metalloproteinase-2 via suppression of the ERK/Sp1-mediated transcription. J Biol Chem 2002;277:32775-32780.
    • (2002) J Biol Chem , vol.277 , pp. 32775-32780
    • Pan, M.-R.1    Hung, W.-C.2
  • 41
    • 0034627774 scopus 로고    scopus 로고
    • Constitutive activation of MAP kinase (MEK1) is critical and sufficient for the activation of MMP-2
    • Kurata H, Thant AA, Matsuo S, Senga T, Okazaki K, Hotta N, et al. Constitutive activation of MAP kinase (MEK1) is critical and sufficient for the activation of MMP-2. Exp Cell Res 2000;254:180-188.
    • (2000) Exp Cell Res , vol.254 , pp. 180-188
    • Kurata, H.1    Thant, A.A.2    Matsuo, S.3    Senga, T.4    Okazaki, K.5    Hotta, N.6
  • 42
    • 0037113915 scopus 로고    scopus 로고
    • Eph B4 receptor signaling mediates endothelial cell migration and proliferation via phoshatidylinositol 3-kinase pathway
    • Steinle JJ, Meinninger CJ, Forough R, Wu G, Wu MH, Granger HJ. Eph B4 receptor signaling mediates endothelial cell migration and proliferation via phoshatidylinositol 3-kinase pathway. J Biol Chem 2002;277:43830-43835.
    • (2002) J Biol Chem , vol.277 , pp. 43830-43835
    • Steinle, J.J.1    Meinninger, C.J.2    Forough, R.3    Wu, G.4    Wu, M.H.5    Granger, H.J.6
  • 43
    • 0037455716 scopus 로고    scopus 로고
    • Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI3-kinase/Akt signaling
    • Zhang D, Brodt P. Type 1 insulin-like growth factor regulates MT1-MMP synthesis and tumor invasion via PI3-kinase/Akt signaling. Oncogene 2003;22:974-982.
    • (2003) Oncogene , vol.22 , pp. 974-982
    • Zhang, D.1    Brodt, P.2
  • 44
    • 0038784546 scopus 로고    scopus 로고
    • Membrane type I matrix metalloproteinase usurps tumor growth control imposed by three-dimensional extracellular matrix
    • Hotary KB, Allen ED, Brooks PC, Datta NS, Long MW, Weiss SJ. Membrane type I matrix metalloproteinase usurps tumor growth control imposed by three-dimensional extracellular matrix. Cell 2003;114:33-45.
    • (2003) Cell , vol.114 , pp. 33-45
    • Hotary, K.B.1    Allen, E.D.2    Brooks, P.C.3    Datta, N.S.4    Long, M.W.5    Weiss, S.J.6
  • 45
    • 0842304200 scopus 로고    scopus 로고
    • Membrane type 1 matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-related kinase activation and cell migration
    • Takino T, Miyamori H, Watanabe Y, Yoshioka K, Seiki M, Sato H. Membrane type 1 matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-related kinase activation and cell migration. Cancer Res 2004;64:1044-1049.
    • (2004) Cancer Res , vol.64 , pp. 1044-1049
    • Takino, T.1    Miyamori, H.2    Watanabe, Y.3    Yoshioka, K.4    Seiki, M.5    Sato, H.6
  • 46
    • 0032994264 scopus 로고    scopus 로고
    • Insulin and insulin-like growth faccor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: Differential effects on signal transduction pathways
    • Svegliati Baroni G, Ridolfi F, Di Sario A, Casini A, Marucci L, Gaggiotti G, et al. Insulin and insulin-like growth faccor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: differential effects on signal transduction pathways. HEPATOLOGY 1999;29:1743-1751.
    • (1999) Hepatology , vol.29 , pp. 1743-1751
    • Svegliati Baroni, G.1    Ridolfi, F.2    Di Sario, A.3    Casini, A.4    Marucci, L.5    Gaggiotti, G.6
  • 47
    • 0028882512 scopus 로고
    • Involvement of phosphatidylinositol 3-kinase in the activation of extracellular signal regulated kinase by PDGF in hepatic stellate cells
    • Marra F, Pinzani M, De Franco R, Laffi G, Gentilini P. Involvement of phosphatidylinositol 3-kinase in the activation of extracellular signal regulated kinase by PDGF in hepatic stellate cells. FEBS Lett 1995;376:141-145.
    • (1995) FEBS Lett , vol.376 , pp. 141-145
    • Marra, F.1    Pinzani, M.2    De Franco, R.3    Laffi, G.4    Gentilini, P.5
  • 48
    • 0029761702 scopus 로고    scopus 로고
    • Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: The potential for multiplex signalling
    • Denhardt DT. Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling. Biochem J 1996;318:729-747.
    • (1996) Biochem J , vol.318 , pp. 729-747
    • Denhardt, D.T.1
  • 49
    • 2342562556 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases in apoptosis regulation
    • Wada T, Penninger JM. Mitogen-activated protein kinases in apoptosis regulation. Oncogene 2004;23:2838-2849.
    • (2004) Oncogene , vol.23 , pp. 2838-2849
    • Wada, T.1    Penninger, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.