P66Shc has a pivotal function in impaired liver regeneration in aged mice by a redox-dependent mechanism

Laboratory Investigation

Volumn 90, Issue 12, 2010, Pages 1717-1726

  Haga, Sanae ^a,b   Morita, Naoki ^c   Irani, Kaikobad ^d   Fujiyoshi, Masato ^a   Ogino, Tetsuya ^e   Ozawa, Takeaki ^f   Ozaki, Michitaka ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^e OKAYAMA UNIVERSITY   (Japan)

^f UNIVERSITY OF TOKYO   (Japan)

Author keywords

Akt; apoptosis; caspase 3; in vivo imaging; oxidative stress; p66Shc

Indexed keywords

CATALASE; GLUTATHIONE PEROXIDASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN P46; PROTEIN P52; PROTEIN P66; PROTEIN P66 SHC; REDOX EFFECTOR FACTOR 1; STAT3 PROTEIN; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; PROTEIN SHC; SHC1 PROTEIN, MOUSE; SHC4 PROTEIN, HUMAN;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; C57BL 6 MOUSE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE DELETION; LIVER CELL; LIVER INJURY; LIVER REGENERATION; LIVER RESECTION; MALE; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REDOX STRESS; ANIMAL; C57BL MOUSE; COMPARATIVE STUDY; GENETICS; LIVER; METABOLISM; MOUSE MUTANT; OXIDATION REDUCTION REACTION; PHOSPHORYLATION; PHYSIOLOGY;

AGING; ANIMALS; APOPTOSIS; CELL PROLIFERATION; DNA-(APURINIC OR APYRIMIDINIC SITE) LYASE; HEPATECTOMY; HEPATOCYTES; LIVER; LIVER REGENERATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SHC SIGNALING ADAPTOR PROTEINS; STAT3 TRANSCRIPTION FACTOR; SUPEROXIDE DISMUTASE;

EID: 78649676709     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2010.119     Document Type: Article

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