Both decorin-binding proteins A and B are critical for the overall virulence of Borrelia burgdorferi

Infection and Immunity

Volumn 76, Issue 3, 2008, Pages 1239-1246

  Shi, Yanlin ^a   Xu, Qilong ^a   McShan, Kristy ^a   Fang, Ting Liang ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DECORIN; DECORIN BINDING PROTEIN A; DECORIN BINDING PROTEIN B; GLYCOSAMINOGLYCAN; LIGAND; PROTEOGLYCAN; UNCLASSIFIED DRUG; ADHESIN; DDPB PROTEIN, BORRELIA BURGDORFERI; OUTER MEMBRANE PROTEIN; VIRULENCE FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL GENE; BACTERIAL VIRULENCE; BORRELIA BURGDORFERI; CONNECTIVE TISSUE; CONTROLLED STUDY; DBPA GENE; DBPB GENE; EXTRACELLULAR MATRIX; GENE LOCUS; GENETIC COMPLEMENTATION; HOST CELL; HOST PATHOGEN INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SKIN; ANIMAL; BACTERIAL COUNT; BAGG ALBINO MOUSE; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; HEART; JOINT; LYME DISEASE; MICROBIOLOGY; PATHOGENICITY; PHYSIOLOGY; VIRULENCE;

ADHESINS, BACTERIAL; ANIMALS; BACTERIAL OUTER MEMBRANE PROTEINS; BORRELIA BURGDORFERI; COLONY COUNT, MICROBIAL; GENE DELETION; GENETIC COMPLEMENTATION TEST; HEART; JOINTS; LYME DISEASE; MICE; MICE, INBRED BALB C; MUTAGENESIS, INSERTIONAL; SKIN; VIRULENCE; VIRULENCE FACTORS;

EID: 40749130867     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00897-07     Document Type: Article

References (39)

1. Barthold, S. W. 1991. Infectivity of Borrelia burgdorferi relative to route of inoculation and genotype in laboratory mice. J. Infect. Dis. 163:419-420.
2. 1. J. Immunol. 177:657-664.
3. Brown, E. L., B. P. Guo, P. O'Neal, and M. Höök. 1999. Adherence of Borrelia burgdorferi. Identification of critical lysine residues in DbpA required for decorin binding. J. Biol. Chem. 274:26272-26278.
4. Brown, E. L., R. M. Wooten, B. J. Johnson, R. V. Iozzo, A. Smith, M. C. Dolan, B. P. Guo, J. J. Weis, and M. Höök. 2001. Resistance to Lyme disease in decorin-deficient mice. J. Clin. Investig. 107:845-852.
5. Burgdorfer, W., S. F. Hayes, and J. L. Benach. 1988. Development of Borrelia burgdorferi in ixodid tick vectors. Ann. N. Y. Acad. Sci. 539:172-179.
6. Cabello, F. C., H. P. Godfrey, and S. A. Newman. 2007. Hidden in plain sight: Borrelia burgdorferi and the extracellular matrix. Trends Microbiol. 15:350-354.
7. 3-chain integrin ligand identified using a phage display library. Mol. Microbiol. 34:926-940.
8. Coburn, J., J. R. Fischer, and J. M. Leong. 2005. Solving a sticky problem: new genetic approaches to host cell adhesion by the Lyme disease spirochete. Mol. Microbiol. 57:1182-1195.
9. 3 recognition. Infect. Immun. 69:3455-3459.
10. Elias, A. F., J. L. Bono, J. J. Kupko III, P. E. Stewart, J. G. Krum, and P. A. Rosa. 2003. New antibiotic resistance cassettes suitable for genetic studies in Borrelia burgdorferi. J. Mol. Microbiol. Biotechnol. 6:29-40.
11. Fischer, J. R., K. T. LeBlanc, and J. M. Leong. 2006. Fibronectin binding protein BBK32 of the Lyme disease spirochete promotes bacterial attachment to glycosaminoglycans. Infect. Immun. 74:435-441.
12. Fischer, J. R., N. Parveen, L. Magoun, and J. M. Leong. 2003. Decorin-binding proteins A and B confer distinct mammalian cell type-specific attachment by Borrelia burgdorferi, the Lyme disease spirochete. Proc. Natl. Acad. Sci. USA 100:7307-7312.
13. Guo, B. P., E. L. Brown, D. W. Dorward, L. C. Rosenberg, and M. Höök. 1998. Decorin-binding adhesins from Borrelia burgdorferi. Mol. Microbiol. 30:711-723.
14. Hagman, K. E., P. Lahdenne, T. G. Popova, S. F. Porcella, D. R. Akins, J. D. Radolf, and M. V. Norgard. 1998. Decorin-binding protein of Borrelia burgdorferi is encoded within a two-gene operon and is protective in the murine model of Lyme borreliosis. Infect. Immun. 66:2674-2683.
15. Hagman, K. E., X. Yang, S. K. Wikel, G. B. Scheeler, M. J. Caimano, J. D. Radolf, and M. V. Norgard. 2000. Decorin-binding protein A (DbpA) of Borrelia burgdorferi is not protective when immunized mice are challenged via tick infestation and correlates with the lack of DbpA expression by B. burgdorferi in ticks. Infect. Immun. 68:4759-4764.
16. Jewett, M. W., K. Lawrence, A. C. Bester, K. Tilly, D. Grimm, P. Shaw, M. VanRaden, F. Gherardini, and P. A. Rosa. 2007. The critical role of the linear plasmid lp36 in the infectious cycle of Borrelia burgdorferi. Mol. Microbiol. 64:1358-1374.
17. Kawabata, H., S. J. Norris, and H. Watanabe. 2004. BBE02 disruption mutants of Borrelia burgdorferi B31 have a highly transformable, infectious phenotype. Infect. Immun. 72:7147-7154.
18. Labandeira-Rey, M., J. Seshu, and J. T. Skare. 2003. The absence of linear plasmid 25 or 28-1 of Borrelia burgdorferi dramatically alters the kinetics of experimental infection via distinct mechanisms. Infect. Immun. 71:4608-4613.
19. Labandeira-Rey, M., and J. T. Skare. 2001. Decreased infectivity in Borrelia burgdorferi strain B31 is associated with loss of linear plasmid 25 or 28-1. Infect. Immun. 69:446-455.
20. Lawrenz, M. B., H. Kawabata, J. E. Purser, and S. J. Norris. 2002. Decreased electroporation efficiency in Borrelia burgdorferi containing linear plasmids lp25 and lp56: impact on transformation of infectious B. burgdorferi. Infect. Immun. 70:4798-4804.
21. Li, X., X. Liu, D. S. Beck, F. S. Kantor, and E. Fikrig. 2006. Borrelia burgdorferi lacking BBK32, a fibronectin-binding protein, retains full pathogenicity. Infect. Immun. 74:3305-3313.
22. Liang, F. T., E. L. Brown, T. Wang, R. V. Iozzo, and E. Fikrig. 2004. Protective niche for Borrelia burgdorferi to evade humoral immunity. Am. J. Pathol. 165:977-985.
23. Parveen, N., K. A. Cornell, J. L. Bono, C. Chamberland, P. Rosa, and J. M. Leong. 2006. Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice. Infect. Immun. 74:3016-3020.
24. Parveen, N., and J. M. Leong. 2000. Identification of a candidate glycosaminoglycan-binding adhesin of the Lyme disease spirochete Borrelia burgdorferi. Mol. Microbiol. 35:1220-1234.
25. Parveen, N., D. Robbins, and J. M. Leong. 1999. Strain variation in glycosaminoglycan recognition influences cell-type-specific binding by Lyme disease spirochetes. Infect. Immun. 67:1743-1749.
26. Probert, W. S., and B. J. Johnson. 1998. Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31. Mol. Microbiol. 30:1003-1015.
27. Probert, W. S., J. H. Kim, M. Hook, and B. J. Johnson. 2001. Mapping the ligand-binding region of Borrelia burgdorferi fibronectin-binding protein BBK32. Infect. Immun. 69:4129-4133.
28. Purser, J. E., M. B. Lawrenz, M. J. Caimano, J. K. Howell, J. D. Radolf, and S. J. Norris. 2003. A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host. Mol. Microbiol. 48:753-764.
29. Purser, J. E., and S. J. Norris. 2000. Correlation between plasmid content and infectivity in Borrelia burgdorferi. Proc. Natl. Acad. Sci. USA 97:13865-13870.
30. Reed, L. J., and H. Muench. 1938. A simple method of estimating fifty per cent endpoint. Am. J. Hyg. 27:493-497.
31. Seiler, K. P., and J. J. Weis. 1996. Immunity to Lyme disease: protection, pathology and persistence. Curr. Opin. Immunol. 8:503-509.
32. Seshu, J., M. D. Esteve-Gassent, M. Labandeira-Rey, J. H. Kim, J. P. Trzeciakowski, M. Hook, and J. T. Skare. 2006. Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi. Mol. Microbiol. 59:1591-1601.
33. Shi, Y., Q. Xu, S. V. Seemanapalli, K. McShan, and F. T. Liang. 2006. The dbpBA locus of Borrelia burgdorferi is not essential for infection of mice. Infect. Immun. 74:6509-6512.
34. Steere, A. C. 2001. Lyme disease. N. Engl. J. Med. 345:115-125.
35. Terekhova, D., R. Iyer, G. P. Wormser, and I. Schwartz. 2006. Comparative genome hybridization reveals substantial variation among clinical isolates of Borrelia burgdorferi sensu stricto with different pathogenic properties. J. Bacteriol. 188:6124-6134.
36. Xu, Q., K. McShan, and F. T. Liang. 2007. Identification of an ospC operator critical for immune evasion of Borrelia burgdorferi. Mol. Microbiol. 64:220-231.
37. Xu, Q., S. V. Seemanapalli, L. Lomax, K. McShan, X. Li, E. Fikrig, and F. T. Liang. 2005. Association of linear plasmid 28-1 with an arthritic phenotype of Borrelia burgdorferi. Infect. Immun. 73:7208-7215.
38. Xu, Q., S. V. Seemanapalli, K. E. Reif, C. R. Brown, and F. T. Liang. 2007. Increasing the recruitment of neutrophils to the site of infection dramatically attenuates Borrelia burgdorferi infectivity. J. Immunol. 178:5109-5115.
39. Xu, Q., S. V. Seemanaplli, K. McShan, and F. T. Liang. 2007. Increasing the Interaction of Borrelia burgdorferi with decorin significantly reduces the 50 percent infectious dose and severely impairs dissemination. Infect. Immun. 75:4272-4281.