Differential binding of host complement inhibitor factor H by Borrelia burgdorferi Erp surface proteins: A possible mechanism underlying the expansive host range of Lyme disease spirochetes

Infection and Immunity

Volumn 70, Issue 2, 2002, Pages 491-497

  Stevenson, Brian ^a   El Hage, Nazira ^a   Hines, Melissa A ^a   Miller, Jennifer C ^a   Babb, Kelly ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT FACTOR H; COMPLEMENT INHIBITOR; MEMBRANE PROTEIN; PROTEIN ERP; UNCLASSIFIED DRUG;

ARTICLE; BACTERICIDAL ACTIVITY; BINDING AFFINITY; BORRELIA BURGDORFERI; HOST; HUMAN; IMMUNITY; LYME DISEASE; NONHUMAN; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; SPIROCHETE;

ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; BORRELIA BURGDORFERI; CATS; CATTLE; COMPLEMENT FACTOR H; DOGS; HUMANS; LIPOPROTEINS; LYME DISEASE; MICE; PROTEIN BINDING; RABBITS; RATS; RATS, INBRED F344; TICKS;

EID: 0036156137     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.2.491-497.2002     Document Type: Article

References (78)

1. Molecular and evolutionary analysis of Borrelia burgdorferi 297 circular plasmid-encoded lipoproteins with OspE- and OspF-like leader peptides
2. A protein with characteristics of factor H is present on rodent platelets and functions as the immune adherence receptor
3. Complement evasion by Borrelia burgdorferi: Serum-resistant strains promote C3b inactivation
4. Antigenically variable Borrelia burgdorferi isolated from cottontail rabbits and Ixodes dentatus in rural and urban areas
5. Experimental Lyme disease in dogs produces arthritis and persistent infection
6. Distinct regulatory pathways control the synthesis of Borrelia burgdorferi infection-associated OspC and Erp surface proteins
7. Isolation and cultivation of Lyme disease spirochetes
8. Lyme borreliosis in selected strains and ages of laboratory mice
9. An animal model for Lyme arthritis
10. Differences of two Borrelia burgdorferi strains in complement activation and serum resistance
11. Reservoir competence of four chaparral-dwelling rodents for Borrelia burgdorferi in California
12. Lyme disease-a tick-borne spirochetosis?
13. A bacterial genome in flux: The twelve linear and nine circular extrachromosomal DNAs of an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi
14. Homology throughout the multiple 32-kilobase circular plasmids present in Lyme disease spirochetes
15. Recommendations for test performance and interpretation from the second national conference on serologic diagnosis of Lyme disease
16. PspC, a pneumococcal surface protein, binds human factor H
17. Long-term study of cell-mediated responses to Borrelia burgdorferi in the laboratory mouse
18. Outer surface protein A (OspA) from the Lyme disease spirochete, Borrelia burgdorferi: High level expression and purification of a soluble recombinant form of OspA
19. Why do bacterial plasmids carry some genes and not others?
20. Transduction by φBB-1, a bacteriophage of Borrelia burgdorferi
21. Molecular evidence for a new bacteriophage of Borrelia burgdorferi
22. Surface exposure and protease insensitivity of Borrelia burgdorferi Erp (OspEF-related) lipoproteins
23. Stability of erp loci during Borrelia burgdorferi infection: Recombination is not required for chronic infection of immunocompetent mice
24. Rabbit model of Lyme borreliosis: Erythema migrans, infection-derived immunity, and identification of Borrelia burgdorferi proteins associated with virulence and protective immunity
25. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi
26. FHL-1/reconectin and factor H: Two human complement regulators which are encoded by the same gene are differently expressed and regulated
27. Analysis of Borrelia burgdorferi gene expression during life cycle phases of the tick vector Ixodes scapularis
28. Regulation of OspE-related, OspF-related, and Elp lipoproteins of Borrelia burgdorferi strain 297 by mammalian host-specific signals
29. The complement regulatory factor H binds to the surface protein OspE of Borrelia burgdorferi
30. Isolation of rabbit C3, factor B, and factor H and comparison of their properties with those of the human analog
31. Species specificity of recognition by the alternative pathway of complement
32. The wild hidden face of Lyme borreliosis in Europe
33. Complement evasion by bacteria and parasites
34. Ixodes (Ixodes) scapularis (Acari: Ixodidae): Redescription of all active stages, distribution, hosts, geographical variation, and medical and veterinary importance
35. Role of immunoglobulin G in killing of Borrelia burgdorferi by the classical complement pathway
36. Experimental Lyme disease in rabbits: Spirochetes found in erythema migrans and blood
37. Comparison of two laboratory methods for the determination of serum resistance in Borrelia burgdorferi isolates
38. Borreliacidal activity of early Lyme disease sera against complement-resistant Borrelia afzelii FEM1 wild-type and an OspC-lacking FEM1 variant
39. Immune evasion of Borrelia burgdorferi by acquisition of human complement regulators FHL-1/reconectin and factor H
40. Mechanism of complement resistance of pathogenic Borrelia burgdorferi isolates
41. Murine protein H is comprised of 20 repeating units, 61 amino acids in length
42. A comparative study of mammalian and reptilian alternative pathway of complement-mediated killing of the Lyme disease spirochete (Borrelia burgdorferi)
43. Serum complement sensitivity as a key factor in Lyme disease ecology
44. Outer surface proteins E and F of Borrelia burgdorferi, the agent of Lyme disease
45. Borreliacidal factor in the blood of the western fence lizard
46. Reservoir competence of the southeastern five-lined skink (Eumeces inexpectatus) and the green anole (Anolis carolinensis) for Borrelia burgdorferi
47. Human complement regulators: A major target for pathogenic microorganisms
48. Spirochete-associated arthritis (Lyme disease) in a dog
49. Transovarial transmission of Borrelia burgdorferi in Ixodes dammini (Acari: Ixodidae)
50. Tick parasitism and antibodies to Borrelia burgdorferi in cats
51. Genetic analysis of Borrelia garinii OspA serotype 4 strains associated with neuroborreliosis: Evidence for extensive genetic homogeneity
52. Competence of dogs as reservoirs for Lyme disease spirochetes (Borrelia burgdorferi)
53. Bacteriophages in the evolution of pathogen-host interactions
54. A second allele of eppA in Borrelia burgdorferi strain B31 is located on the previously undetected circular plasmid cp9-2
55. Borrelia burgdorferi B31 Erp proteins that are dominant immunoblot antigens of animals infected with isolate B31 are recognized by only a subset of human Lyme disease patient sera
56. Resistance to both complement activation and phagocytosis in type 3 pneumococci is mediated by the binding of complement regulatory factor H
57. A Lyme borreliosis cycle in seabirds and Ixodes uriae ticks
58. Host recognition and target differentiation by factor H, a regulator of the alternative pathway of complement
59. Lyme borreliosis in cattle and horses: A review of the literature
60. Complement resistance in Borrelia burgdorferi strain 297: Outer membrane proteins prevent MAC formation at lysis susceptible sites
61. Expression and immunological analysis of the plasmid-borne mlp genes of Borrelia burgdorferi strain B31
62. Efficiency of transovarial transmission of the Lyme disease spirochete, Borrelia burgdorferi in the western black-legged tick, Ixodes pacificus (Acari: Ixodidae)
63. Borrelia
64. Induction of an outer surface protein on Borrelia burgdorferi during tick feeding
65. Norway rats as reservoir hosts for Lyme disease spirochetes on Monhegan Island
66. Borrelia burgdorferi Erp proteins are immunogenic in mammals infected by tick bite, and their synthesis is inducible in cultured bacteria
67. Evidence of past recombination events among the genes encoding the Erp antigens of Borrelia burgdorferi
68. Characterization of cp18, a naturally truncated member of the cp32 family of Borrelia burgdorferi plasmids
69. Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi
70. A family of genes located on four separate 32-kilobase circular plasmids in Borrelia burgdorferi B31
71. Repetition, conservation, and variation: The multiple cp32 plasmids of Borrelia species
72. Mutation and recombination in the upstream homology box-flanked ospE-related genes of the Lyme disease spirochetes result in the development of new antigenic variants during infection
73. Enzootic transmission of the agent of Lyme disease in rabbits
74. Complement-mediated serum sensitivity among spirochetes that cause Lyme disease
75. Identification, characterization, and expression of three new members of the Borrelia burgdorferi Mlp (2.9) lipoprotein gene family
76. The factor H protein family