Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A

Journal of Clinical Investigation

Volumn 106, Issue 4, 2000, Pages 561-569

  Pal, Utpal ^a   De Silva, Aravinda M ^b   Montgomery, Ruth R ^a   Fish, Durland ^a   Anguita, Juan ^a   Anderson, John F ^c   Lobet, Yves ^d   Fikrig, Erol ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c The Connecticut Agricultural Experiment Station   (United States)

^d GLAXOSMITHKLINE BIOLOGICALS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

OUTER MEMBRANE PROTEIN;

ARTICLE; BACTERIUM ADHERENCE; BORRELIA BURGDORFERI; CARBOXY TERMINAL SEQUENCE; INTESTINE; IXODES SCAPULARIS; LYME DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION;

EID: 0033863073     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI9427     Document Type: Article

References (38)

1. Nadelman, R.B., and Wormser, G.P. 1998. Lyme borreliosis. Lancet. 352:557-565.
2. Barbour, A.G., and Fish, D. 1993. The biological and social phenomenon of Lyme disease. Science. 260:1610-1616.
3. Fikrig, E., Barthold, S.W., Kantor, F.S., and Flavell, R.A. 1990. Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Science. 250:553-556.
4. Schaible, U.E., et al. 1990. Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. Proc. Natl. Acad. Sci. USA. 87:3768-3772.
5. Sigal, L.H., et al. 1998. A vaccine consisting of recombinant Borrelia burgdorferi outer-surface protein A to prevent Lyme disease. N. Engl. J. Med. 339:216-222.
6. Steere, A.C., et al. 1998. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. N. Engl. J. Med. 339:209-215.
7. de Silva, A.M., Telford, S.R., Brunet, L.R., Barthold, S.W., and Fikrig, E. 1996. Borrelia burgdorferi OspA is an arthropod-specific transmission-blocking Lyme disease vaccine. J. Exp. Med. 183:271-275.
8. de Silva, A.M., Fish, D., Burkot, T.R., Zhang, Y., and Fikrig, E. 1997. OspA antibodies inhibit the acquisition of Borrelia burgdorferi by Ixodes ticks. Infect. Immun. 65:3146-3150.
9. Coleman, J.L., et al. 1997. Plasminogen is required for efficient dissemination of Borrelia burgdorferi in ticks and for enhancement of spirochetemia in mice. Cell. 89:1111-1119.
10. Schwan, T.G., Piesman, J., Golde, W.T., Dolan, M.C., and Rosa, P.A. 1995. Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc. Natl. Acad. Sci. USA 92:2909-2913.
11. Montgomery, R.R., Malawista, S.E., Feen, K.J., and Bockenstedt, L.K. 1996. Direct demonstration of antigenic substitution of Borrelia burgdorferi ex vivo: exploration of the paradox of the early immune response to outer surface proteins A and C in Lyme disease. J. Exp. Med. 183:261-269.
12. Gern, L., Schaible, U.E., and Simon, M.M. 1993. Mode of inoculation of the Lyme disease agent Borrelia burgdorferi influences infection and immune responses in inbred strains of mice. J. Infect. Dis. 167:971-975.
13. Schaible, U.E., et al. 1993. Distinct patterns of protective antibodies are generated against Borrelia burgdorferi in mice experimentally inoculated with high and low doses of antigen. Immunol. Lett. 36:219-226.
14. de Silva, A.M., et al. 1998. Immune evasion by tick-borne and host-adapted Borrelia burgdorferi. J. Infect. Dis. 177:395-400.
15. Fikrig, E., et al. 1999. Borrelia burgdorferi erpT expression in the arthropod vector and murine host. Mol. Microbiol. 31:281-290.
16. Kalish, R.A., Leong, J.M., and Steere, A.C. 1995. Early and lare antibody responses to full-length and truncated constructs of outer surface protein A of Borrelia burgdorferi in Lyme disease. Infect. Immun. 63:2228-2235.
17. Schutzer, S.E., et al. 1997. Simultaneous expression of Borrelia OspA and OspC and IgM response in cerebrospinal fluid in early neurologic Lyme disease. J. Clin. Invest. 100:763-767.
18. Schutzer, S.E., Coyle, P.K., Dunn, J.J., Luft, B.J., and Brunner, M. 1994. Early and specific antibody responses to OspA in Lyme disease. J. Clin. Invest. 94:454-457.
19. Akin, E., McHugh, G.L., Flavell, R.A., Fikrig, E., and Steere, A.C. 1999. The immunoglobulin (IgG) antibody response to OspA and OspB correlates with severe and prolonged Lyme arthritis and the IgG response to P35 correlates with mild and brief arthritis. Infect. Immun. 67:173-181.
20. Kalish, R., Leong, J.M., and Steere, A.C. 1993. Association of treatment-resistant chronic Lyme arthritis with antibody reactivity to OspA and OspB of Borrelia burgdorferi. Infect. Immun. 61:2774-2779.
21. Gross, D.M., et al. 1998. Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science. 281:703-706.
22. Barthold, S.W., Fikrig, E., Bockenstedt, L.K., and Persing, D.H. 1995. Circumvention of outer surface protein A immunity by host-adapted Borrelia burgdorferi. Infect. Immun. 63:2255-2261.
23. Barbour, A.G. 1984. Isolation and cultivation of Lyme disease spirochetes. Yale J. Biol. Med. 57:521-525.
24. Anderson, J.F., et al. 1996. Novel Borrelia burgdorferi isolates from Ixodes scapularis and Ixodesdentatus ticks feeding on humans. J. Clin. Microbiol. 34:524-529.
25. Bockenstedt, L.K., Fikrig, E., Barthold, S.W., Flavell, R.A., and Kantor, F.S. 1996. Identification of a Borrelia burgdorferi OspA T cell epitope that promotes anti-OspA IgG in mice. J. Immunol. 157:5496-5502.
26. Bockenstedt, L.K., et al. 1997. Borrelia burgdorferi strain-specific Osp C-mediated immunity in mice. Infect. Immun. 65:4661-4667.
27. Fikrig, E., et al. 1992. Borrelia burgdorferi strain 25015: characterization of outer surface protein A and vaccination against infection. J. Immunol. 148:2256-2260.
28. Sadziene, A., Thomas, D.D., Bundoc, V.G., Holt, S.C., and Barbour, A.G. 1991. A flagella-less mutant of Borrelia burgdorferi. Structural, molecular, and in vitro functional characterization. J. Clin. Invest. 88:82-92.
29. Burgdorfer, W., et al. 1982. Lyme disease: a tickborne spirochetosis? Science. 216:1317-1319.
30. Kurtti, T.J., Munderloh, U.G., Krueger, D.E., Johnson, R.C., and Schwan, T.G. 1993. Adhesion to and invasion of cultured tick (Acarina: Ixodidae) cells by Borrelia burgdorferi (Spirochaetales: Spirochaetaceae) and maintenance of infectivity. J. Med. Entomol. 30:586-596.
31. Thomas, D.D., and Comstock, L.E. 1989. Interaction of Lyme disease spirochetes with cultured eukaryotic cells. Infect. Immun. 57:1324-1326.
32. Garcia-Monco J.C., Fernandez-Villar, B., and Benach, J.L. 1989. Adherence of the Lyme disease spirochete to glial cells and cells of glial origin. J. Infect. Dis. 160:497-506.
33. Garcia-Monco, J.C., and Benach, J.L. 1995. Lyme neuroborreliosis. Ann. Neurol. 37:691-702.
34. Li, H., Dunn, J.J., Luft, B.J., and Lawson, C.L. 1997. Crystal structure of Lyme disease antigen outer surface protein A complexed with an Fab. Proc. Natl. Acad. Sci. USA. 94:3584-3589.
35. Comstock, L.E., Fikrig, E., Shoberg, R.J., Flavell, R.A., and Thomas, D.D. 1993. A monoclonal antibody to OspA inhibits association of Borrelia burgdorferi with human endothelial cells. Infect. Immun. 61:423-431.
36. Guo, B.P., Brown, E.L., Dorward, D.W., Rosenberg, L.C., and Hook, M. 1998. Decorin-binding adhesins from Borrelia burgdorferi. Mol. Microbiol. 30:711-723.
37. Guo, B., Norris, S.J., Rosenberg, L.C., and Hook, M. 1995. Adherence of Borrelia burgdorferi to the proteoglycan decorin. Infect. Immun. 63:3467-3472.
38. Probert, W.S., and Johnson, B.J. 1998. Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31. Mol. Microbiol. 30:1003-1015.