OspB Antibody Prevents Borrelia burgdorferi Colonization of Ixodes scapularis

Infection and Immunity

Volumn 72, Issue 3, 2004, Pages 1755-1759

  Fikrig, Erol ^a   Pal, Utpal ^a   Chen, Manchuan ^a   Anderson, John F ^b   Flavell, Richard A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Section of Immunobiology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; BACTERIAL PROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; MEMBRANE PROTEIN; OSPB ANTIBODY; OUTER SURFACE PROTEIN A; PROTEIN OSPB; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL TRANSMISSION; BACTERIUM ADHERENCE; BORRELIA BURGDORFERI; COMPLEX FORMATION; CONTROLLED STUDY; GENETIC TRANSCRIPTION; HOST PATHOGEN INTERACTION; IXODES SCAPULARIS; MOUSE; NONHUMAN; OPERON; PRIORITY JOURNAL; PROTEIN BINDING; SCID MOUSE; SPIROCHETE; TICK;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; ARACHNID VECTORS; BACTERIAL ADHESION; BACTERIAL OUTER MEMBRANE PROTEINS; BORRELIA BURGDORFERI; DIGESTIVE SYSTEM; IMMUNOGLOBULIN FAB FRAGMENTS; IXODES; LYME DISEASE; TRYPSIN;

EID: 1342302473     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.3.1755-1759.2004     Document Type: Article

References (23)

1. Barthold, S. W., M. S. deSouza, J. L. Janotka, A. L. Smith, and D. H. Persing. 1993. Chronic Lyme borreliosis in the laboratory mouse. Am. J. Pathol. 143:959-971.
2. Brunet, L. R., A. Spielman, E. Fikrig, and S. R. Telford, 3rd. 1997. Heterogeneity of Lyme disease spirochaetes within individual vector ticks. Res. Microbiol. 148:437-445.
3. de Silva, A. M., and E. Fikrig. 1997. Arthropod- and host-specific gene expression by Borrelia burgdorferi. J. Clin. Investig. 99:377-379.
4. de Silva, A. M., S. R. Telford, L. R. Brunet, S. W. Barthold, and E. Fikrig. 1996. Borrelia burgdorferi OspA is arthropod-specific transmission-blocking Lyme disease vaccine. J. Exp. Med. 183:271-275.
5. Escudero, R., M. L. Halluska, P. B. Backenson, J. L. Coleman, and J. L. Benach. 1997. Characterization of the physiological requirements for the bactericidal effects of a monoclonal antibody to OspB of Borrelia burgdorferi by confocal microscopy. Infect. Immun. 65:1908-1915.
6. Fikrig, E., S. W. Barthold, W. Sun, W. Feng, S. R. Telford, and R. A. Flavell. 1997. Borrelia burgdorferi P35 and P37 proteins, expressed in vivo, elicit protective immunity. Immunity 6:531-539.
7. Fikrig, E., H. Tao, F. S. Kantor, S. W. Barthold, and R. A. Flavell. 1993. Evasion of protective immunity by Borrelia burgdorferi by truncation of OspB. Proc. Natl. Acad. Sci. USA 90:4092-4097.
8. Fingerle, V., H. Laux, U. G. Munderloh, U. Schulte-Spechtel, and B. Wilske. 2000. Differential expression of outer surface proteins A and C by individual Borrelia burgdorferi in different genospecies. Med. Microbiol. Immunol. (Berlin) 189:59-66.
9. Fraser, C. M., S. Casjens, W. M. Huang, G. G. Sutton, R. Clayton, R. Lathigra, O. White, K. A. Ketchum, R. Dodson, E. K. Hickey, M. Gwinn, B. Dougherty, J. F. Tomb, R. D. Fleischmann, D. Richardson, J. Peterson, A. R. Kerlavage, J. Quackenbush, S. Salzberg, M. Hanson, R. van Vugt, N. Palmer, M. D. Adams, J. Gocayne, J. C. Venter, et al. 1997. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 390:580-586.
10. Gilmore, R. D., Jr., M. L. Mbow, and B. Stevenson. 2001. Analysis of Borrelia burgdorferi gene expression during life cycle phases of the tick vector Ixodes scapularis. Microb. Infect. 3:799-808.
11. Guo, B. P., E. L. Brown, D. W. Dorward, L. C. Rosenberg, and M. Hook. 1998. Decorin-binding adhesins from Borrelia burgdorferi. Mol. Microbiol. 30:711-723.
12. Howe, T. R., F. W. LaQuier, and A. G. Barbour. 1986. Organization of genes encoding two outer membrane proteins of the Lyme disease agent Borrelia burgdorferi within a single transcriptional unit. Infect. Immun. 54:207-212.
13. Katona, L. I., S. Ayalew, J. L. Coleman, and J. L. Benach. 2000. A bactericidal monoclonal antibody elicits a change in its antigen, OspB of Borrelia burgdorferi, that can be detected by limited proteolysis. J. Immunol. 164:1425-1431.
14. Ma, J., P. A. Bulger, D. R. Davis, B. Perilli-Palmer, D. A. Bedore, C. R. Kensil, E. M. Young, C. H. Hung, J. R. Seals, C. S. Pavia, et al. 1994. Impact of the saponin adjuvant QS-21 and aluminum hydroxide on the immunogenicity of recombinant OspA and OspB of Borrelia burgdorferi. Vaccine 12:925-932.
15. Ma, J., C. Gingrich-Baker, P. M. Franchi, P. Bulger, and R. T. Coughlin. 1995. Molecular analysis of neutralizing epitopes on outer surface proteins A and B of Borrelia burgdorferi. Infect. Immun. 63:2221-2227.
16. Nadelman, R. B., and G. P. Wormser. 1998. Lyme borreliosis. Lancet 352:557-565.
17. Oliver, J. H., Jr., K. L. Clark, F. W. Chandler, Jr., L. Tao, A. M. James, C. W. Banks, L. O. Huey, A. R. Banks, D. C. Williams, and L. A. Durden. 2000. Isolation, cultivation, and characterization of Borrelia burgdorferi from rodents and ticks in the Charleston area of South Carolina. J. Clin. Microbiol. 38:120-124.
18. Pal, U., A. M. de Silva, R. R. Montgomery, D. Fish, J. Anguita, J. F. Anderson, Y. Lobet, and E. Fikrig. 2000. Attachment of Borrelia burgdorferi within Ixodes scapularis mediated by outer surface protein A. J. Clin. Investig. 106:561-569.
19. Pal, U., R. R. Montgomery, D. Lusitani, P. Voet, V. Weynants, S. E. Malawista, Y. Lobet, and E. Fikrig. 2001. Inhibition of Borrelia burgdorferitick interactions in vivo by outer surface protein A antibody. J. Immunol. 166:7398-7403.
20. Schwan, T. G., and J. Piesman. 2000. Temporal changes in outer surface proteins A and C of the Lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice. J. Clin. Microbiol. 38:382-388.
21. Schwan, T. G., J. Piesman, W. T. Golde, M. C. Dolan, and P. A. Rosa. 1995. Induction of an outer surface protein on Borrelia burgdorferi during tick feeding. Proc. Natl. Acad. Sci. USA 92:2909-2913.
22. Steere, A. C. 2001. Lyme disease. N. Engl. J. Med. 345:115-125.
23. Stepanova-Tresova, G., J. Kopecky, and M. Kuthejlova. 2000. Identification of Borrelia burgdorferi sensu stricto, Borrelia garinii and Borrelia afzelii in Ixodes ricinus ticks from southern Bohemia using monoclonal antibodies. Zentbl. Bakteriol. 289:797-806.