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Volumn 7, Issue 9, 2012, Pages 1156-1168

Embryonic and induced pluripotent stem cell differentiation as a tool in neurobiology

Author keywords

Embryonic stem cells; Induced pluripotent stem cells; Neuronal differentiation; Pluripotency

Indexed keywords

CELL LINES; DEVELOPMENTAL STAGE; EMBRYONIC STEM CELLS; EPIBLAST CELLS; EPIGENETIC ANALYSIS; GERM CELLS; HIGH-THROUGHPUT; HUMAN NEURONS; IN-VIVO; NEUROLOGICAL DISEASE; NEUROLOGICAL DISORDERS; NEURONAL DEVELOPMENT; NEURONAL DIFFERENTIATION; NEURONAL DYSFUNCTION; PLURIPOTENCY; PLURIPOTENT; PLURIPOTENT STEM CELLS; PRE-IMPLANTATION EMBRYOS; PRIMARY CULTURE; THERAPEUTIC INTERVENTION; VERSATILE TOOLS;

EID: 84866049231     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201200040     Document Type: Review
Times cited : (9)

References (132)
  • 1
    • 0019826665 scopus 로고
    • Establishment in culture of pluripotential cells from mouse embryos.
    • Evans, M. J., Kaufman, M. H., Establishment in culture of pluripotential cells from mouse embryos. Nature 1981, 292, 154-156.
    • (1981) Nature , vol.292 , pp. 154-156
    • Evans, M.J.1    Kaufman, M.H.2
  • 2
    • 0001007610 scopus 로고
    • Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.
    • Martin, G. R., Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl. Acad. Sci. USA 1981, 78, 7634-7638.
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 7634-7638
    • Martin, G.R.1
  • 3
    • 0030951337 scopus 로고    scopus 로고
    • The origin and efficient derivation of embryonic stem cells in the mouse.
    • Brook, F. A., Gardner, R. L., The origin and efficient derivation of embryonic stem cells in the mouse. Proc. Natl. Acad. Sci. USA 1997, 94, 5709-5712.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 5709-5712
    • Brook, F.A.1    Gardner, R.L.2
  • 4
    • 0027321548 scopus 로고
    • Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.
    • Nagy, A., Rossant, J., Nagy, R., Abramow-Newerly, W., Roder, J. C., Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc. Natl. Acad. Sci. USA 1993, 90, 8424-8428.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8424-8428
    • Nagy, A.1    Rossant, J.2    Nagy, R.3    Abramow-Newerly, W.4    Roder, J.C.5
  • 5
    • 0031695616 scopus 로고    scopus 로고
    • The role of leukemia inhibitory factor and interleukin-6 in human reproduction.
    • Smith, S. K., Charnock-Jones, D. S., Sharkey, A. M., The role of leukemia inhibitory factor and interleukin-6 in human reproduction. Hum. Reprod. 1998, 13, 237-246.
    • (1998) Hum. Reprod. , vol.13 , pp. 237-246
    • Smith, S.K.1    Charnock-Jones, D.S.2    Sharkey, A.M.3
  • 6
    • 0032127977 scopus 로고    scopus 로고
    • Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3.
    • Niwa, H., Burdon, T., Chambers, I., Smith, A., Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes. Dev. 1998, 12, 2048-2060.
    • (1998) Genes. Dev. , vol.12 , pp. 2048-2060
    • Niwa, H.1    Burdon, T.2    Chambers, I.3    Smith, A.4
  • 7
    • 0027233526 scopus 로고
    • Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation.
    • Escary, J. L., Perreau, J., Dumenil, D., Ezine, S., Brulet, P., Leukaemia inhibitory factor is necessary for maintenance of haematopoietic stem cells and thymocyte stimulation. Nature 1993, 363, 361-364.
    • (1993) Nature , vol.363 , pp. 361-364
    • Escary, J.L.1    Perreau, J.2    Dumenil, D.3    Ezine, S.4    Brulet, P.5
  • 8
    • 0026768292 scopus 로고
    • Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor.
    • Stewart, C. L., Kaspar, P., Brunet, L. J., Bhatt, H. et al., Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature 1992, 359, 76-79.
    • (1992) Nature , vol.359 , pp. 76-79
    • Stewart, C.L.1    Kaspar, P.2    Brunet, L.J.3    Bhatt, H.4
  • 9
    • 0029620955 scopus 로고
    • Essential function of LIF receptor in motor neurons.
    • Li, M., Sendtner, M., Smith, A., Essential function of LIF receptor in motor neurons. Nature 1995, 378, 724-727.
    • (1995) Nature , vol.378 , pp. 724-727
    • Li, M.1    Sendtner, M.2    Smith, A.3
  • 10
    • 0029061551 scopus 로고
    • Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death.
    • Ware, C. B., Horowitz, M. C., Renshaw, B. R., Hunt, J. S. et al., Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Development 1995, 121, 1283-1299.
    • (1995) Development , vol.121 , pp. 1283-1299
    • Ware, C.B.1    Horowitz, M.C.2    Renshaw, B.R.3    Hunt, J.S.4
  • 11
    • 34548587064 scopus 로고    scopus 로고
    • FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment.
    • Kunath, T., Saba-El-Leil, M. K., Almousailleakh, M., Wray, J. et al., FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development 2007, 134, 2895-2902.
    • (2007) Development , vol.134 , pp. 2895-2902
    • Kunath, T.1    Saba-El-Leil, M.K.2    Almousailleakh, M.3    Wray, J.4
  • 12
    • 44349170450 scopus 로고    scopus 로고
    • The ground state of embryonic stem cell self-renewal.
    • Ying, Q. L., Wray, J., Nichols, J., Batlle-Morera, L. et al., The ground state of embryonic stem cell self-renewal. Nature 2008, 453, 519-523.
    • (2008) Nature , vol.453 , pp. 519-523
    • Ying, Q.L.1    Wray, J.2    Nichols, J.3    Batlle-Morera, L.4
  • 13
    • 54949105021 scopus 로고    scopus 로고
    • Promotion of reprogramming to ground state pluripotency by signal inhibition.
    • Silva, J., Barrandon, O., Nichols, J., Kawaguchi, J. et al., Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol. 2008, 6, e253.
    • (2008) PLoS Biol. , vol.6
    • Silva, J.1    Barrandon, O.2    Nichols, J.3    Kawaguchi, J.4
  • 14
    • 67650432118 scopus 로고    scopus 로고
    • Validated germline-competent embryonic stem cell lines from nonobese diabetic mice.
    • Nichols, J., Jones, K., Phillips, J. M., Newland, S. A. et al., Validated germline-competent embryonic stem cell lines from nonobese diabetic mice. Nat. Med. 2009, 15, 814-818.
    • (2009) Nat. Med. , vol.15 , pp. 814-818
    • Nichols, J.1    Jones, K.2    Phillips, J.M.3    Newland, S.A.4
  • 15
    • 57649181379 scopus 로고    scopus 로고
    • Capture of authentic embryonic stem cells from rat blastocysts.
    • Buehr, M., Meek, S., Blair, K., Yang, J. et al., Capture of authentic embryonic stem cells from rat blastocysts. Cell 2008, 135, 1287-1298.
    • (2008) Cell , vol.135 , pp. 1287-1298
    • Buehr, M.1    Meek, S.2    Blair, K.3    Yang, J.4
  • 16
    • 57649245579 scopus 로고    scopus 로고
    • Germline competent embryonic stem cells derived from rat blastocysts.
    • Li, P., Tong, C., Mehrian-Shai, R., Jia, L. et al., Germline competent embryonic stem cells derived from rat blastocysts. Cell 2008, 135, 1299-1310.
    • (2008) Cell , vol.135 , pp. 1299-1310
    • Li, P.1    Tong, C.2    Mehrian-Shai, R.3    Jia, L.4
  • 17
    • 19544371373 scopus 로고    scopus 로고
    • Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century.
    • Capecchi, M. R., Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century. Nat. Rev. Genet. 2005, 6, 507-512.
    • (2005) Nat. Rev. Genet. , vol.6 , pp. 507-512
    • Capecchi, M.R.1
  • 18
    • 79955600698 scopus 로고    scopus 로고
    • The liberation of embryonic stem cells.
    • Blair, K., Wray, J., Smith, A., The liberation of embryonic stem cells. PLoS Genet. 2011, 7, e1002019.
    • (2011) PLoS Genet. , vol.7
    • Blair, K.1    Wray, J.2    Smith, A.3
  • 19
    • 77956524118 scopus 로고    scopus 로고
    • Production of p53 gene knockout rats by homologous recombination in embryonic stem cells.
    • Tong, C., Li, P., Wu, N. L., Yan, Y., Ying, Q. L., Production of p53 gene knockout rats by homologous recombination in embryonic stem cells. Nature 2010, 467, 211-213.
    • (2010) Nature , vol.467 , pp. 211-213
    • Tong, C.1    Li, P.2    Wu, N.L.3    Yan, Y.4    Ying, Q.L.5
  • 20
    • 78649974857 scopus 로고    scopus 로고
    • Efficient gene targeting by homologous recombination in rat embryonic stem cells.
    • Meek, S., Buehr, M., Sutherland, L., Thomson, A. et al., Efficient gene targeting by homologous recombination in rat embryonic stem cells. PLoS One 2010, 5, e14225.
    • (2010) PLoS One , vol.5
    • Meek, S.1    Buehr, M.2    Sutherland, L.3    Thomson, A.4
  • 22
    • 0029776359 scopus 로고    scopus 로고
    • Pluripotent cell lines derived from common marmoset (Callithrix jacchus) blastocysts.
    • Thomson, J. A., Kalishman, J., Golos, T. G., Durning, M. et al., Pluripotent cell lines derived from common marmoset (Callithrix jacchus) blastocysts. Biol. Reprod. 1996, 55, 254-259.
    • (1996) Biol. Reprod. , vol.55 , pp. 254-259
    • Thomson, J.A.1    Kalishman, J.2    Golos, T.G.3    Durning, M.4
  • 23
    • 0032491416 scopus 로고    scopus 로고
    • Embryonic stem cell lines derived from human blastocysts.
    • Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., Waknitz, M. A. et al., Embryonic stem cell lines derived from human blastocysts. Science 1998, 282, 1145-1147.
    • (1998) Science , vol.282 , pp. 1145-1147
    • Thomson, J.A.1    Itskovitz-Eldor, J.2    Shapiro, S.S.3    Waknitz, M.A.4
  • 24
    • 0027473965 scopus 로고
    • Cultured cell lines from human teratomas: windows into tumour growth and differentiation and early human development.
    • Roach, S., Cooper, S., Bennett, W., Pera, M. F., Cultured cell lines from human teratomas: windows into tumour growth and differentiation and early human development. Eur. Urol. 1993, 23, 82-88.
    • (1993) Eur. Urol. , vol.23 , pp. 82-88
    • Roach, S.1    Cooper, S.2    Bennett, W.3    Pera, M.F.4
  • 25
    • 0032412865 scopus 로고    scopus 로고
    • Non-disclosure preimplantation genetic diagnosis for Huntington's disease: practical and ethical dilemmas.
    • Braude, P. R., De Wert, G. M., Evers-Kiebooms, G., Pettigrew, R. A., Geraedts, J. P., Non-disclosure preimplantation genetic diagnosis for Huntington's disease: practical and ethical dilemmas. Prenatal Diag. 1998, 18, 1422-1426.
    • (1998) Prenatal Diag. , vol.18 , pp. 1422-1426
    • Braude, P.R.1    De Wert, G.M.2    Evers-Kiebooms, G.3    Pettigrew, R.A.4    Geraedts, J.P.5
  • 26
    • 34447527158 scopus 로고    scopus 로고
    • Derivation of pluripotent epiblast stem cells from mammalian embryos.
    • Brons, I. G., Smithers, L. E., Trotter, M. W., Rugg-Gunn, P. et al., Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 2007, 448, 191-195.
    • (2007) Nature , vol.448 , pp. 191-195
    • Brons, I.G.1    Smithers, L.E.2    Trotter, M.W.3    Rugg-Gunn, P.4
  • 27
    • 34447528757 scopus 로고    scopus 로고
    • New cell lines from mouse epiblast share defining features with human embryonic stem cells.
    • Tesar, P. J., Chenoweth, J. G., Brook, F. A., Davies, T. J. et al., New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 2007, 448, 196-199.
    • (2007) Nature , vol.448 , pp. 196-199
    • Tesar, P.J.1    Chenoweth, J.G.2    Brook, F.A.3    Davies, T.J.4
  • 28
    • 70450280575 scopus 로고    scopus 로고
    • Expression and activation of the reprogramming transcription factors.
    • Guo, J., Li, Z. C., Feng, Y. H., Expression and activation of the reprogramming transcription factors. Biochem. Biophys. Res. Commun. 2009, 390, 1081-1086.
    • (2009) Biochem. Biophys. Res. Commun. , vol.390 , pp. 1081-1086
    • Guo, J.1    Li, Z.C.2    Feng, Y.H.3
  • 29
    • 0035799309 scopus 로고    scopus 로고
    • Establishment of human embryonic stem cell-transfected clones carrying a marker for undifferentiated cells.
    • Eiges, R., Schuldiner, M., Drukker, M., Yanuka, O. et al., Establishment of human embryonic stem cell-transfected clones carrying a marker for undifferentiated cells. Curr. Biol. 2001, 11, 514-518.
    • (2001) Curr. Biol. , vol.11 , pp. 514-518
    • Eiges, R.1    Schuldiner, M.2    Drukker, M.3    Yanuka, O.4
  • 30
    • 0037303676 scopus 로고    scopus 로고
    • Stable genetic modification of human embryonic stem cells by lentiviral vectors.
    • Gropp, M., Itsykson, P., Singer, O., Ben-Hur, T. et al., Stable genetic modification of human embryonic stem cells by lentiviral vectors. Mol. Ther. 2003, 7, 281-287.
    • (2003) Mol. Ther. , vol.7 , pp. 281-287
    • Gropp, M.1    Itsykson, P.2    Singer, O.3    Ben-Hur, T.4
  • 31
    • 0037240651 scopus 로고    scopus 로고
    • High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors.
    • Ma, Y., Ramezani, A., Lewis, R., Hawley, R. G., Thomson, J. A., High-level sustained transgene expression in human embryonic stem cells using lentiviral vectors. Stem Cells 2003, 21, 111-117.
    • (2003) Stem Cells , vol.21 , pp. 111-117
    • Ma, Y.1    Ramezani, A.2    Lewis, R.3    Hawley, R.G.4    Thomson, J.A.5
  • 32
    • 0037336820 scopus 로고    scopus 로고
    • Homologous recombination in human embryonic stem cells.
    • Zwaka, T. P., Thomson, J. A., Homologous recombination in human embryonic stem cells. Nat. Biotechnol. 2003, 21, 319-321.
    • (2003) Nat. Biotechnol. , vol.21 , pp. 319-321
    • Zwaka, T.P.1    Thomson, J.A.2
  • 33
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
    • Takahashi, K., Yamanaka, S., Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126, 663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 34
    • 50849142559 scopus 로고    scopus 로고
    • A high-efficiency system for the generation and study of human induced pluripotent stem cells.
    • Maherali, N., Ahfeldt, T., Rigamonti, A., Utikal, J. et al., A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell 2008, 3, 340-345.
    • (2008) Cell Stem Cell , vol.3 , pp. 340-345
    • Maherali, N.1    Ahfeldt, T.2    Rigamonti, A.3    Utikal, J.4
  • 35
    • 55849117368 scopus 로고    scopus 로고
    • Generation of mouse induced pluripotent stem cells without viral vectors.
    • Okita, K., Nakagawa, M., Hyenjong, H., Ichisaka, T., Yamanaka, S., Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008, 322, 949-953.
    • (2008) Science , vol.322 , pp. 949-953
    • Okita, K.1    Nakagawa, M.2    Hyenjong, H.3    Ichisaka, T.4    Yamanaka, S.5
  • 36
    • 49449096588 scopus 로고    scopus 로고
    • A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types.
    • Wernig, M., Lengner, C. J., Hanna, J., Lodato, M. A. et al., A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat. Biotechnol. 2008, 26, 916-924.
    • (2008) Nat. Biotechnol. , vol.26 , pp. 916-924
    • Wernig, M.1    Lengner, C.J.2    Hanna, J.3    Lodato, M.A.4
  • 37
    • 46449094276 scopus 로고    scopus 로고
    • Dissecting direct reprogramming through integrative genomic analysis.
    • Mikkelsen, T. S., Hanna, J., Zhang, X., Ku, M. et al., Dissecting direct reprogramming through integrative genomic analysis. Nature 2008, 454, 49-55.
    • (2008) Nature , vol.454 , pp. 49-55
    • Mikkelsen, T.S.1    Hanna, J.2    Zhang, X.3    Ku, M.4
  • 38
    • 77952699848 scopus 로고    scopus 로고
    • Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs.
    • Hanna, J., Cheng, A. W., Saha, K., Kim, J. et al., Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc. Natl. Acad. Sci. USA 2010, 107, 9222-9227.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 9222-9227
    • Hanna, J.1    Cheng, A.W.2    Saha, K.3    Kim, J.4
  • 39
    • 70349162894 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cells from neural stem cells.
    • Kim, J. B., Zaehres, H., Arauzo-Bravo, M. J., Scholer, H. R., Generation of induced pluripotent stem cells from neural stem cells. Nat. Protoc. 2009, 4, 1464-1470.
    • (2009) Nat. Protoc. , vol.4 , pp. 1464-1470
    • Kim, J.B.1    Zaehres, H.2    Arauzo-Bravo, M.J.3    Scholer, H.R.4
  • 40
    • 36749043230 scopus 로고    scopus 로고
    • Induced pluripotent stem cell lines derived from human somatic cells.
    • Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J. et al., Induced pluripotent stem cell lines derived from human somatic cells. Science 2007, 318, 1917-1920.
    • (2007) Science , vol.318 , pp. 1917-1920
    • Yu, J.1    Vodyanik, M.A.2    Smuga-Otto, K.3    Antosiewicz-Bourget, J.4
  • 41
    • 45449094570 scopus 로고    scopus 로고
    • Reprogramming of pancreatic beta cells into induced pluripotent stem cells.
    • Stadtfeld, M., Brennand, K., Hochedlinger, K., Reprogramming of pancreatic beta cells into induced pluripotent stem cells. Curr. Biol. 2008, 18, 890-894.
    • (2008) Curr. Biol. , vol.18 , pp. 890-894
    • Stadtfeld, M.1    Brennand, K.2    Hochedlinger, K.3
  • 42
    • 41949134533 scopus 로고    scopus 로고
    • Generation of pluripotent stem cells from adult mouse liver and stomach cells.
    • Aoi, T., Yae, K., Nakagawa, M., Ichisaka, T. et al., Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science 2008, 321, 699-702.
    • (2008) Science , vol.321 , pp. 699-702
    • Aoi, T.1    Yae, K.2    Nakagawa, M.3    Ichisaka, T.4
  • 43
    • 41949098160 scopus 로고    scopus 로고
    • Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency.
    • Hanna, J., Markoulaki, S., Schorderet, P., Carey, B. W. et al., Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell 2008, 133, 250-264.
    • (2008) Cell , vol.133 , pp. 250-264
    • Hanna, J.1    Markoulaki, S.2    Schorderet, P.3    Carey, B.W.4
  • 44
    • 55049122748 scopus 로고    scopus 로고
    • Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression.
    • Eminli, S., Utikal, J., Arnold, K., Jaenisch, R., Hochedlinger, K., Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression. Stem Cells 2008, 26, 2467-2474.
    • (2008) Stem Cells , vol.26 , pp. 2467-2474
    • Eminli, S.1    Utikal, J.2    Arnold, K.3    Jaenisch, R.4    Hochedlinger, K.5
  • 45
    • 44349103591 scopus 로고    scopus 로고
    • A combined chemical and genetic approach for the generation of induced pluripotent stem cells.
    • Shi, Y., Do, J. T., Desponts, C., Hahm, H. S. et al., A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell 2008, 2, 525-528.
    • (2008) Cell Stem Cell , vol.2 , pp. 525-528
    • Shi, Y.1    Do, J.T.2    Desponts, C.3    Hahm, H.S.4
  • 46
    • 77955457666 scopus 로고    scopus 로고
    • Direct reprogramming of rat neural precursor cells and fibroblasts into pluripotent stem cells.
    • Chang, M. Y., Kim, D., Kim, C. H., Kang, H. C. et al., Direct reprogramming of rat neural precursor cells and fibroblasts into pluripotent stem cells. PLoS One 2010, 5, e9838.
    • (2010) PLoS One , vol.5
    • Chang, M.Y.1    Kim, D.2    Kim, C.H.3    Kang, H.C.4
  • 47
    • 41349090105 scopus 로고    scopus 로고
    • Generation of human induced pluripotent stem cells from dermal fibroblasts.
    • Lowry, W. E., Richter, L., Yachechko, R., Pyle, A. D. et al., Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc. Natl. Acad. Sci. USA 2008, 105, 2883-2888.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 2883-2888
    • Lowry, W.E.1    Richter, L.2    Yachechko, R.3    Pyle, A.D.4
  • 48
    • 50249098740 scopus 로고    scopus 로고
    • Generation of human-induced pluripotent stem cells.
    • Park, I. H., Lerou, P. H., Zhao, R., Huo, H., Daley, G. Q., Generation of human-induced pluripotent stem cells. Nat. Protoc. 2008, 3, 1180-1186.
    • (2008) Nat. Protoc. , vol.3 , pp. 1180-1186
    • Park, I.H.1    Lerou, P.H.2    Zhao, R.3    Huo, H.4    Daley, G.Q.5
  • 49
    • 55749089875 scopus 로고    scopus 로고
    • Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes.
    • Aasen, T., Raya, A., Barrero, M. J., Garreta, E. et al., Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat. Biotechnol. 2008, 26, 1276-1284.
    • (2008) Nat. Biotechnol. , vol.26 , pp. 1276-1284
    • Aasen, T.1    Raya, A.2    Barrero, M.J.3    Garreta, E.4
  • 50
    • 70349438821 scopus 로고    scopus 로고
    • Two factor reprogramming of human neural stem cells into pluripotency.
    • Hester, M. E., Song, S., Miranda, C. J., Eagle, A. et al., Two factor reprogramming of human neural stem cells into pluripotency. PLoS One 2009, 4, e7044.
    • (2009) PLoS One , vol.4
    • Hester, M.E.1    Song, S.2    Miranda, C.J.3    Eagle, A.4
  • 51
    • 84861765926 scopus 로고    scopus 로고
    • Methods for iPS cell generation for basic research and clinical applications.
    • Mochiduki, Y., Okita, K., Methods for iPS cell generation for basic research and clinical applications. Biotechnol. J. 2012, 7, 789-797.
    • (2012) Biotechnol. J. , vol.7 , pp. 789-797
    • Mochiduki, Y.1    Okita, K.2
  • 52
    • 84861789192 scopus 로고    scopus 로고
    • Programmable genetic switches to control transcriptional machinery of pluripotency.
    • Pandian, G. N., Sugiyama, H., Programmable genetic switches to control transcriptional machinery of pluripotency. Biotechnol. J. 2012, 7, 798-809.
    • (2012) Biotechnol. J. , vol.7 , pp. 798-809
    • Pandian, G.N.1    Sugiyama, H.2
  • 53
    • 0028790603 scopus 로고
    • Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction.
    • Hawley, S. H., Wunnenberg-Stapleton, K., Hashimoto, C., Laurent, M. N. et al., Disruption of BMP signals in embryonic Xenopus ectoderm leads to direct neural induction. Genes. Dev. 1995, 9, 2923-2935.
    • (1995) Genes. Dev. , vol.9 , pp. 2923-2935
    • Hawley, S.H.1    Wunnenberg-Stapleton, K.2    Hashimoto, C.3    Laurent, M.N.4
  • 54
    • 0030937808 scopus 로고    scopus 로고
    • Vertebrate embryonic cells will become nerve cells unless told otherwise.
    • Hemmati-Brivanlou, A., Melton, D., Vertebrate embryonic cells will become nerve cells unless told otherwise. Cell 1997, 88, 13-17.
    • (1997) Cell , vol.88 , pp. 13-17
    • Hemmati-Brivanlou, A.1    Melton, D.2
  • 55
    • 0033602043 scopus 로고    scopus 로고
    • Embryonic stem cell development in a chemically defined medium.
    • Wiles, M. V., Johansson, B. M., Embryonic stem cell development in a chemically defined medium. Exp. Cell. Res. 1999, 247, 241-248.
    • (1999) Exp. Cell. Res. , vol.247 , pp. 241-248
    • Wiles, M.V.1    Johansson, B.M.2
  • 56
    • 0029059425 scopus 로고
    • Induction of epidermis and inhibition of neural fate by Bmp-4.
    • Wilson, P. A., Hemmati-Brivanlou, A., Induction of epidermis and inhibition of neural fate by Bmp-4. Nature 1995, 376, 331-333.
    • (1995) Nature , vol.376 , pp. 331-333
    • Wilson, P.A.1    Hemmati-Brivanlou, A.2
  • 57
    • 0028907753 scopus 로고
    • Embryonic stem cells express neuronal properties in vitro.
    • Bain, G., Kitchens, D., Yao, M., Huettner, J. E., Gottlieb, D. I., Embryonic stem cells express neuronal properties in vitro. Dev. Biol. 1995, 168, 342-357.
    • (1995) Dev. Biol. , vol.168 , pp. 342-357
    • Bain, G.1    Kitchens, D.2    Yao, M.3    Huettner, J.E.4    Gottlieb, D.I.5
  • 58
    • 0028787590 scopus 로고
    • Differentiation of pluripotent embryonic stem cells into the neuronal lineage in vitro gives rise to mature inhibitory and excitatory neurons.
    • Strubing, C., Ahnert-Hilger, G., Shan, J., Wiedenmann, B. et al., Differentiation of pluripotent embryonic stem cells into the neuronal lineage in vitro gives rise to mature inhibitory and excitatory neurons. Mech. Dev. 1995, 53, 275-287.
    • (1995) Mech. Dev. , vol.53 , pp. 275-287
    • Strubing, C.1    Ahnert-Hilger, G.2    Shan, J.3    Wiedenmann, B.4
  • 59
    • 0029147524 scopus 로고
    • In vitro differentiation of embryonic stem cells into glial cells and functional neurons.
    • Fraichard, A., Chassande, O., Bilbaut, G., Dehay, C. et al., In vitro differentiation of embryonic stem cells into glial cells and functional neurons. J. Cell. Sci. 1995, 108, 3181-3188.
    • (1995) J. Cell. Sci. , vol.108 , pp. 3181-3188
    • Fraichard, A.1    Chassande, O.2    Bilbaut, G.3    Dehay, C.4
  • 60
    • 0034705056 scopus 로고    scopus 로고
    • Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation.
    • Liu, S., Qu, Y., Stewart, T. J., Howard, M. J. et al., Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc. Natl. Acad. Sci. USA 2000, 97, 6126-6131.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 6126-6131
    • Liu, S.1    Qu, Y.2    Stewart, T.J.3    Howard, M.J.4
  • 61
    • 0034633526 scopus 로고    scopus 로고
    • Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells.
    • Schuldiner, M., Yanuka, O., Itskovitz-Eldor, J., Melton, D. A., Benvenisty, N., Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc. Natl. Acad. Sci. USA 2000, 97, 11307-11312.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11307-11312
    • Schuldiner, M.1    Yanuka, O.2    Itskovitz-Eldor, J.3    Melton, D.A.4    Benvenisty, N.5
  • 62
    • 0035929503 scopus 로고    scopus 로고
    • Induced neuronal differentiation of human embryonic stem cells.
    • Schuldiner, M., Eiges, R., Eden, A., Yanuka, O. et al., Induced neuronal differentiation of human embryonic stem cells. Brain Res. 2001, 913, 201-205.
    • (2001) Brain Res. , vol.913 , pp. 201-205
    • Schuldiner, M.1    Eiges, R.2    Eden, A.3    Yanuka, O.4
  • 63
    • 0030248408 scopus 로고    scopus 로고
    • Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro.
    • Okabe, S., Forsberg-Nilsson, K., Spiro, A. C., Segal, M., McKay, R. D., Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro. Mech. Dev. 1996, 59, 89-102.
    • (1996) Mech. Dev. , vol.59 , pp. 89-102
    • Okabe, S.1    Forsberg-Nilsson, K.2    Spiro, A.C.3    Segal, M.4    McKay, R.D.5
  • 64
    • 84862753723 scopus 로고    scopus 로고
    • Activated charcoal composite biomaterial promotes human embryonic stem cell differentiation toward neuronal lineage.
    • Chen, E. Y., Wang, Y. C., Mintz, A., Richards, A. et al., Activated charcoal composite biomaterial promotes human embryonic stem cell differentiation toward neuronal lineage. J. Biomed. Mater. Res. A 2012, 100, 2006-2017.
    • (2012) J. Biomed. Mater. Res. A , vol.100 , pp. 2006-2017
    • Chen, E.Y.1    Wang, Y.C.2    Mintz, A.3    Richards, A.4
  • 65
    • 84856225535 scopus 로고    scopus 로고
    • The effects of electrospun TSF nanofiber diameter and alignment on neuronal differentiation of human embryonic stem cells.
    • Wang, J., Ye, R., Wei, Y., Wang, H. et al., The effects of electrospun TSF nanofiber diameter and alignment on neuronal differentiation of human embryonic stem cells. J. Biomed. Mater. Res. A 2012, 100, 632-645.
    • (2012) J. Biomed. Mater. Res. A , vol.100 , pp. 632-645
    • Wang, J.1    Ye, R.2    Wei, Y.3    Wang, H.4
  • 66
    • 0034044317 scopus 로고    scopus 로고
    • Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells.
    • Lee, S. H., Lumelsky, N., Studer, L., Auerbach, J. M., McKay, R. D., Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat. Biotechnol. 2000, 18, 675-679.
    • (2000) Nat. Biotechnol. , vol.18 , pp. 675-679
    • Lee, S.H.1    Lumelsky, N.2    Studer, L.3    Auerbach, J.M.4    McKay, R.D.5
  • 67
    • 0032577445 scopus 로고    scopus 로고
    • FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate.
    • Ye, W., Shimamura, K., Rubenstein, J. L., Hynes, M. A., Rosenthal, A., FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 1998, 93, 755-766.
    • (1998) Cell , vol.93 , pp. 755-766
    • Ye, W.1    Shimamura, K.2    Rubenstein, J.L.3    Hynes, M.A.4    Rosenthal, A.5
  • 68
    • 0033638174 scopus 로고    scopus 로고
    • Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity.
    • Kawasaki, H., Mizuseki, K., Nishikawa, S., Kaneko, S. et al., Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron 2000, 28, 31-40.
    • (2000) Neuron , vol.28 , pp. 31-40
    • Kawasaki, H.1    Mizuseki, K.2    Nishikawa, S.3    Kaneko, S.4
  • 69
    • 0345832441 scopus 로고    scopus 로고
    • Directed neuronal differentiation of human embryonic stem cells.
    • Schulz, T. C., Palmarini, G. M., Noggle, S. A., Weiler, D. A. et al., Directed neuronal differentiation of human embryonic stem cells. BMC Neurosci. 2003, 4, 27.
    • (2003) BMC Neurosci. , vol.4 , pp. 27
    • Schulz, T.C.1    Palmarini, G.M.2    Noggle, S.A.3    Weiler, D.A.4
  • 70
    • 10444246723 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells to dopaminergic neurons in serum-free suspension culture.
    • Schulz, T. C., Noggle, S. A., Palmarini, G. M., Weiler, D. A. et al., Differentiation of human embryonic stem cells to dopaminergic neurons in serum-free suspension culture. Stem Cells 2004, 22, 1218-1238.
    • (2004) Stem Cells , vol.22 , pp. 1218-1238
    • Schulz, T.C.1    Noggle, S.A.2    Palmarini, G.M.3    Weiler, D.A.4
  • 71
    • 4344592974 scopus 로고    scopus 로고
    • Derivation of midbrain dopamine neurons from human embryonic stem cells.
    • Perrier, A. L., Tabar, V., Barberi, T., Rubio, M. E. et al., Derivation of midbrain dopamine neurons from human embryonic stem cells. Proc. Natl. Acad. Sci. USA 2004, 101, 12543-12548.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 12543-12548
    • Perrier, A.L.1    Tabar, V.2    Barberi, T.3    Rubio, M.E.4
  • 72
    • 84355166561 scopus 로고    scopus 로고
    • Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease.
    • Kriks, S., Shim, J. W., Piao, J. H., Ganat, Y. M. et al., Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease. Nature 2011, 480, 547-551.
    • (2011) Nature , vol.480 , pp. 547-551
    • Kriks, S.1    Shim, J.W.2    Piao, J.H.3    Ganat, Y.M.4
  • 73
    • 84864353544 scopus 로고    scopus 로고
    • Xi, J., Liu, Y., Liu, H., Chen, H. et al., Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem Cells 2012, DOI: 10.1002/stem.1152.
    • Xi, J., Liu, Y., Liu, H., Chen, H. et al., Specification of midbrain dopamine neurons from primate pluripotent stem cells. Stem Cells 2012, DOI: 10.1002/stem.1152.
  • 74
    • 0037047320 scopus 로고    scopus 로고
    • Directed differentiation of embryonic stem cells into motor neurons.
    • Wichterle, H., Lieberam, I., Porter, J. A., Jessell, T. M., Directed differentiation of embryonic stem cells into motor neurons. Cell 2002, 110, 385-397.
    • (2002) Cell , vol.110 , pp. 385-397
    • Wichterle, H.1    Lieberam, I.2    Porter, J.A.3    Jessell, T.M.4
  • 75
    • 77956205121 scopus 로고    scopus 로고
    • Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation.
    • Peljto, M., Dasen, J. S., Mazzoni, E. O., Jessell, T. M., Wichterle, H., Functional diversity of ESC-derived motor neuron subtypes revealed through intraspinal transplantation. Cell Stem Cell 2010, 7, 355-366.
    • (2010) Cell Stem Cell , vol.7 , pp. 355-366
    • Peljto, M.1    Dasen, J.S.2    Mazzoni, E.O.3    Jessell, T.M.4    Wichterle, H.5
  • 76
    • 0032425468 scopus 로고    scopus 로고
    • LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons.
    • Sharma, K., Sheng, H. Z., Lettieri, K., Li, H. et al., LIM homeodomain factors Lhx3 and Lhx4 assign subtype identities for motor neurons. Cell 1998, 95, 817-828.
    • (1998) Cell , vol.95 , pp. 817-828
    • Sharma, K.1    Sheng, H.Z.2    Lettieri, K.3    Li, H.4
  • 77
    • 47749149893 scopus 로고    scopus 로고
    • Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1.
    • Dasen, J. S., De Camilli, A., Wang, B., Tucker, P. W., Jessell, T. M., Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1. Cell 2008, 134, 304-316.
    • (2008) Cell , vol.134 , pp. 304-316
    • Dasen, J.S.1    De Camilli, A.2    Wang, B.3    Tucker, P.W.4    Jessell, T.M.5
  • 78
    • 33645219877 scopus 로고    scopus 로고
    • Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons.
    • Soundararajan, P., Miles, G. B., Rubin, L. L., Brownstone, R. M., Rafuse, V. F., Motoneurons derived from embryonic stem cells express transcription factors and develop phenotypes characteristic of medial motor column neurons. J. Neurosci. 2006, 26, 3256-3268.
    • (2006) J. Neurosci. , vol.26 , pp. 3256-3268
    • Soundararajan, P.1    Miles, G.B.2    Rubin, L.L.3    Brownstone, R.M.4    Rafuse, V.F.5
  • 79
    • 79952070300 scopus 로고    scopus 로고
    • Programming embryonic stem cells to neuronal subtypes.
    • Peljto, M., Wichterle, H., Programming embryonic stem cells to neuronal subtypes. Curr. Opin. Neurobiol. 2011, 21, 43-51.
    • (2011) Curr. Opin. Neurobiol. , vol.21 , pp. 43-51
    • Peljto, M.1    Wichterle, H.2
  • 80
    • 34547858511 scopus 로고    scopus 로고
    • Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons.
    • Lee, H., Shamy, G. A., Elkabetz, Y., Schofield, C. M. et al., Directed differentiation and transplantation of human embryonic stem cell-derived motoneurons. Stem Cells 2007, 25, 1931-1939.
    • (2007) Stem Cells , vol.25 , pp. 1931-1939
    • Lee, H.1    Shamy, G.A.2    Elkabetz, Y.3    Schofield, C.M.4
  • 81
    • 13844271605 scopus 로고    scopus 로고
    • Specification of motoneurons from human embryonic stem cells.
    • Li, X. J., Du, Z. W., Zarnowska, E. D., Pankratz, M. et al., Specification of motoneurons from human embryonic stem cells. Nat. Biotechnol. 2005, 23, 215-221.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 215-221
    • Li, X.J.1    Du, Z.W.2    Zarnowska, E.D.3    Pankratz, M.4
  • 82
    • 65649115029 scopus 로고    scopus 로고
    • Directed differentiation of human-induced pluripotent stem cells generates active motor neurons.
    • Karumbayaram, S., Novitch, B. G., Patterson, M., Umbach, J. A. et al., Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells 2009, 27, 806-811.
    • (2009) Stem Cells , vol.27 , pp. 806-811
    • Karumbayaram, S.1    Novitch, B.G.2    Patterson, M.3    Umbach, J.A.4
  • 83
    • 0036205830 scopus 로고    scopus 로고
    • Glial cells generate neurons: the role of the transcription factor Pax6.
    • Heins, N., Malatesta, P., Cecconi, F., Nakafuku, M. et al., Glial cells generate neurons: the role of the transcription factor Pax6. Nat. Neurosci. 2002, 5, 308-315.
    • (2002) Nat. Neurosci. , vol.5 , pp. 308-315
    • Heins, N.1    Malatesta, P.2    Cecconi, F.3    Nakafuku, M.4
  • 84
    • 79960149431 scopus 로고    scopus 로고
    • The role of Pax6 in forebrain development.
    • Georgala, P. A., Carr, C. B., Price, D. J., The role of Pax6 in forebrain development. Dev. Neurobiol. 2011, 71, 690-709.
    • (2011) Dev. Neurobiol. , vol.71 , pp. 690-709
    • Georgala, P.A.1    Carr, C.B.2    Price, D.J.3
  • 85
    • 0037313844 scopus 로고    scopus 로고
    • Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture.
    • Ying, Q. L., Stavridis, M., Griffiths, D., Li, M., Smith, A., Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat. Biotechnol. 2003, 21, 183-186.
    • (2003) Nat. Biotechnol. , vol.21 , pp. 183-186
    • Ying, Q.L.1    Stavridis, M.2    Griffiths, D.3    Li, M.4    Smith, A.5
  • 86
    • 24944484633 scopus 로고    scopus 로고
    • Niche-independent symmetrical self-renewal of a mammalian tissue stem cell.
    • Conti, L., Pollard, S. M., Gorba, T., Reitano, E. et al., Niche-independent symmetrical self-renewal of a mammalian tissue stem cell. PLoS Biol. 2005, 3, e283.
    • (2005) PLoS Biol. , vol.3
    • Conti, L.1    Pollard, S.M.2    Gorba, T.3    Reitano, E.4
  • 87
    • 0026526516 scopus 로고
    • A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes.
    • Reynolds, B. A., Tetzlaff, W., Weiss, S., A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes. J. Neurosci. 1992, 12, 4565-4574.
    • (1992) J. Neurosci. , vol.12 , pp. 4565-4574
    • Reynolds, B.A.1    Tetzlaff, W.2    Weiss, S.3
  • 88
    • 14544296563 scopus 로고    scopus 로고
    • Directed differentiation of telencephalic precursors from embryonic stem cells.
    • Watanabe, K., Kamiya, D., Nishiyama, A., Katayama, T. et al., Directed differentiation of telencephalic precursors from embryonic stem cells. Nat. Neurosci. 2005, 8, 288-296.
    • (2005) Nat. Neurosci. , vol.8 , pp. 288-296
    • Watanabe, K.1    Kamiya, D.2    Nishiyama, A.3    Katayama, T.4
  • 89
    • 34250192881 scopus 로고    scopus 로고
    • Generation of a defined and uniform population of CNS progenitors and neurons from mouse embryonic stem cells.
    • Bibel, M., Richter, J., Lacroix, E., Barde, Y. A., Generation of a defined and uniform population of CNS progenitors and neurons from mouse embryonic stem cells. Nat. Protoc. 2007, 2, 1034-1043.
    • (2007) Nat. Protoc. , vol.2 , pp. 1034-1043
    • Bibel, M.1    Richter, J.2    Lacroix, E.3    Barde, Y.A.4
  • 90
    • 4344601961 scopus 로고    scopus 로고
    • Differentiation of mouse embryonic stem cells into a defined neuronal lineage.
    • Bibel, M., Richter, J., Schrenk, K., Tucker, K. L. et al., Differentiation of mouse embryonic stem cells into a defined neuronal lineage. Nat. Neurosci. 2004, 7, 1003-1009.
    • (2004) Nat. Neurosci. , vol.7 , pp. 1003-1009
    • Bibel, M.1    Richter, J.2    Schrenk, K.3    Tucker, K.L.4
  • 91
    • 84862158944 scopus 로고    scopus 로고
    • Ectopic expression of neurogenin 2 alone is sufficient to induce differentiation of embryonic stem cells into mature neurons.
    • Thoma, E. C., Wischmeyer, E., Offen, N., Maurus, K. et al., Ectopic expression of neurogenin 2 alone is sufficient to induce differentiation of embryonic stem cells into mature neurons. PLoS One 2012, 7, e38651.
    • (2012) PLoS One , vol.7
    • Thoma, E.C.1    Wischmeyer, E.2    Offen, N.3    Maurus, K.4
  • 92
    • 62149125434 scopus 로고    scopus 로고
    • Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling.
    • Chambers, S. M., Fasano, C. A., Papapetrou, E. P., Tomishima, M. et al., Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat. Biotechnol. 2009, 27, 275-280.
    • (2009) Nat. Biotechnol. , vol.27 , pp. 275-280
    • Chambers, S.M.1    Fasano, C.A.2    Papapetrou, E.P.3    Tomishima, M.4
  • 93
    • 84862778046 scopus 로고    scopus 로고
    • Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses.
    • S471.
    • Shi, Y., Kirwan, P., Smith, J., Robinson, H. P., Livesey, F. J., Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses. Nat. Neurosci. 2012, 15, 477-486, S471.
    • (2012) Nat. Neurosci. , vol.15 , pp. 477-486
    • Shi, Y.1    Kirwan, P.2    Smith, J.3    Robinson, H.P.4    Livesey, F.J.5
  • 94
    • 77956300096 scopus 로고    scopus 로고
    • Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not.
    • Nikoletopoulou, V., Lickert, H., Frade, J. M., Rencurel, C. et al., Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nature 2010, 467, 59-63.
    • (2010) Nature , vol.467 , pp. 59-63
    • Nikoletopoulou, V.1    Lickert, H.2    Frade, J.M.3    Rencurel, C.4
  • 95
    • 51649129596 scopus 로고    scopus 로고
    • Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.
    • Mohn, F., Weber, M., Rebhan, M., Roloff, T. C. et al., Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors. Mol. Cell 2008, 30, 755-766.
    • (2008) Mol. Cell , vol.30 , pp. 755-766
    • Mohn, F.1    Weber, M.2    Rebhan, M.3    Roloff, T.C.4
  • 96
    • 84859987415 scopus 로고    scopus 로고
    • Target genes of Topoisomerase IIbeta regulate neuronal survival and are defined by their chromatin state.
    • Tiwari, V. K., Burger, L., Nikoletopoulou, V., Deogracias, R. et al., Target genes of Topoisomerase IIbeta regulate neuronal survival and are defined by their chromatin state. Proc. Natl. Acad. Sci. USA 2012, 109, E934-943.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109
    • Tiwari, V.K.1    Burger, L.2    Nikoletopoulou, V.3    Deogracias, R.4
  • 97
    • 34248169728 scopus 로고    scopus 로고
    • The polycomb group protein Suz12 is required for embryonic stem cell differentiation.
    • Pasini, D., Bracken, A. P., Hansen, J. B., Capillo, M., Helin, K., The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol. Cell. Biol. 2007, 27, 3769-3779.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 3769-3779
    • Pasini, D.1    Bracken, A.P.2    Hansen, J.B.3    Capillo, M.4    Helin, K.5
  • 98
    • 79952069900 scopus 로고    scopus 로고
    • The genetics of neurodevelopmental disease.
    • Mitchell, K. J., The genetics of neurodevelopmental disease. Curr. Opin. Neurobiol. 2011, 21, 197-203.
    • (2011) Curr. Opin. Neurobiol. , vol.21 , pp. 197-203
    • Mitchell, K.J.1
  • 99
    • 77952884942 scopus 로고    scopus 로고
    • Functional improvement of focal cerebral ischemia injury by subdural transplantation of induced pluripotent stem cells with fibrin glue.
    • Chen, S. J., Chang, C. M., Tsai, S. K., Chang, Y. L. et al., Functional improvement of focal cerebral ischemia injury by subdural transplantation of induced pluripotent stem cells with fibrin glue. Stem Cells Dev. 2010, 19, 1757-1767.
    • (2010) Stem Cells Dev. , vol.19 , pp. 1757-1767
    • Chen, S.J.1    Chang, C.M.2    Tsai, S.K.3    Chang, Y.L.4
  • 100
    • 79955602167 scopus 로고    scopus 로고
    • Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation.
    • Cheung, A. Y., Horvath, L. M., Grafodatskaya, D., Pasceri, P. et al., Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation. Hum. Mol. Genet. 2011, 20, 2103-2115.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 2103-2115
    • Cheung, A.Y.1    Horvath, L.M.2    Grafodatskaya, D.3    Pasceri, P.4
  • 101
    • 0035093830 scopus 로고    scopus 로고
    • Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice.
    • Chen, R. Z., Akbarian, S., Tudor, M., Jaenisch, R., Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat. Genet. 2001, 27, 327-331.
    • (2001) Nat. Genet. , vol.27 , pp. 327-331
    • Chen, R.Z.1    Akbarian, S.2    Tudor, M.3    Jaenisch, R.4
  • 102
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells.
    • Marchetto, M. C., Carromeu, C., Acab, A., Yu, D. et al., A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 2010, 143, 527-539.
    • (2010) Cell , vol.143 , pp. 527-539
    • Marchetto, M.C.1    Carromeu, C.2    Acab, A.3    Yu, D.4
  • 103
    • 60549115413 scopus 로고    scopus 로고
    • Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice.
    • Tropea, D., Giacometti, E., Wilson, N. R., Beard, C. et al., Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice. Proc. Natl. Acad. Sci. USA 2009, 106, 2029-2034.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 2029-2034
    • Tropea, D.1    Giacometti, E.2    Wilson, N.R.3    Beard, C.4
  • 104
    • 78549247463 scopus 로고    scopus 로고
    • L1 retrotransposition in neurons is modulated by MeCP2.
    • Muotri, A. R., Marchetto, M. C., Coufal, N. G., Oefner, R. et al., L1 retrotransposition in neurons is modulated by MeCP2. Nature 2010, 468, 443-446.
    • (2010) Nature , vol.468 , pp. 443-446
    • Muotri, A.R.1    Marchetto, M.C.2    Coufal, N.G.3    Oefner, R.4
  • 105
    • 0032905253 scopus 로고    scopus 로고
    • Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells.
    • Coffee, B., Zhang, F., Warren, S. T., Reines, D., Acetylated histones are associated with FMR1 in normal but not fragile X-syndrome cells. Nat. Genet. 1999, 22, 98-101.
    • (1999) Nat. Genet. , vol.22 , pp. 98-101
    • Coffee, B.1    Zhang, F.2    Warren, S.T.3    Reines, D.4
  • 106
    • 0026339303 scopus 로고
    • Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome.
    • Oberle, I., Rousseau, F., Heitz, D., Kretz, C. et al., Instability of a 550-base pair DNA segment and abnormal methylation in fragile X syndrome. Science 1991, 252, 1097-1102.
    • (1991) Science , vol.252 , pp. 1097-1102
    • Oberle, I.1    Rousseau, F.2    Heitz, D.3    Kretz, C.4
  • 107
    • 35848937244 scopus 로고    scopus 로고
    • Developmental study of fragile X syndrome using human embryonic stem cells derived from preimplantation genetically diagnosed embryos.
    • Eiges, R., Urbach, A., Malcov, M., Frumkin, T. et al., Developmental study of fragile X syndrome using human embryonic stem cells derived from preimplantation genetically diagnosed embryos. Cell Stem Cell 2007, 1, 568-577.
    • (2007) Cell Stem Cell , vol.1 , pp. 568-577
    • Eiges, R.1    Urbach, A.2    Malcov, M.3    Frumkin, T.4
  • 108
    • 77956214743 scopus 로고    scopus 로고
    • Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells.
    • Urbach, A., Bar-Nur, O., Daley, G. Q., Benvenisty, N., Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell Stem Cell 2010, 6, 407-411.
    • (2010) Cell Stem Cell , vol.6 , pp. 407-411
    • Urbach, A.1    Bar-Nur, O.2    Daley, G.Q.3    Benvenisty, N.4
  • 109
    • 59749105767 scopus 로고    scopus 로고
    • Childhood IQ and adult mental disorders: a test of the cognitive reserve hypothesis.
    • Koenen, K. C., Moffitt, T. E., Roberts, A. L., Martin, L. T. et al., Childhood IQ and adult mental disorders: a test of the cognitive reserve hypothesis. Am. J. Psychiatry 2009, 166, 50-57.
    • (2009) Am. J. Psychiatry , vol.166 , pp. 50-57
    • Koenen, K.C.1    Moffitt, T.E.2    Roberts, A.L.3    Martin, L.T.4
  • 110
    • 79953048441 scopus 로고    scopus 로고
    • Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation.
    • Chiang, C. H., Su, Y., Wen, Z., Yoritomo, N. et al., Integration-free induced pluripotent stem cells derived from schizophrenia patients with a DISC1 mutation. Mol. Psychiatry 2011, 16, 358-360.
    • (2011) Mol. Psychiatry , vol.16 , pp. 358-360
    • Chiang, C.H.1    Su, Y.2    Wen, Z.3    Yoritomo, N.4
  • 111
    • 79955884485 scopus 로고    scopus 로고
    • Modelling schizophrenia using human induced pluripotent stem cells.
    • Brennand, K. J., Simone, A., Jou, J., Gelboin-Burkhart, C. et al., Modelling schizophrenia using human induced pluripotent stem cells. Nature 2011, 473, 221-225.
    • (2011) Nature , vol.473 , pp. 221-225
    • Brennand, K.J.1    Simone, A.2    Jou, J.3    Gelboin-Burkhart, C.4
  • 112
    • 58249110796 scopus 로고    scopus 로고
    • Induced pluripotent stem cells from a spinal muscular atrophy patient.
    • Ebert, A. D., Yu, J., Rose, F. F. Jr., Mattis, V. B. et al., Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 2009, 457, 277-280.
    • (2009) Nature , vol.457 , pp. 277-280
    • Ebert, A.D.1    Yu, J.2    Rose Jr., F.F.3    Mattis, V.B.4
  • 113
    • 79956212343 scopus 로고    scopus 로고
    • Constructing and deconstructing stem cell models of neurological disease.
    • Han, S. S., Williams, L. A., Eggan, K. C., Constructing and deconstructing stem cell models of neurological disease. Neuron 2011, 70, 626-644.
    • (2011) Neuron , vol.70 , pp. 626-644
    • Han, S.S.1    Williams, L.A.2    Eggan, K.C.3
  • 114
    • 84863360741 scopus 로고    scopus 로고
    • Induced pluripotent stem cells in the study of neurological diseases.
    • Saporta, M. A., Grskovic, M., Dimos, J. T., Induced pluripotent stem cells in the study of neurological diseases. Stem Cell Res. Ther. 2011, 2, 37.
    • (2011) Stem Cell Res. Ther. , vol.2 , pp. 37
    • Saporta, M.A.1    Grskovic, M.2    Dimos, J.T.3
  • 115
    • 77957670482 scopus 로고    scopus 로고
    • Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats.
    • Hargus, G., Cooper, O., Deleidi, M., Levy, A. et al., Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proc. Natl. Acad. Sci. USA 2010, 107, 15921-15926.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 15921-15926
    • Hargus, G.1    Cooper, O.2    Deleidi, M.3    Levy, A.4
  • 116
    • 61349100729 scopus 로고    scopus 로고
    • Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors.
    • Soldner, F., Hockemeyer, D., Beard, C., Gao, Q. et al., Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 2009, 136, 964-977.
    • (2009) Cell , vol.136 , pp. 964-977
    • Soldner, F.1    Hockemeyer, D.2    Beard, C.3    Gao, Q.4
  • 117
    • 79952172335 scopus 로고    scopus 로고
    • LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress.
    • Nguyen, H. N., Byers, B., Cord, B., Shcheglovitov, A. et al., LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress. Cell Stem Cell 2011, 8, 267-280.
    • (2011) Cell Stem Cell , vol.8 , pp. 267-280
    • Nguyen, H.N.1    Byers, B.2    Cord, B.3    Shcheglovitov, A.4
  • 118
    • 84865615516 scopus 로고    scopus 로고
    • Redefining Parkinson's disease research using induced pluripotent stem cells.
    • Pu, J., Jiang, H., Zhang, B., Feng, J., Redefining Parkinson's disease research using induced pluripotent stem cells. Curr. Neurol. Neurosci. Rep. 2012, 12, 392-398.
    • (2012) Curr. Neurol. Neurosci. Rep. , vol.12 , pp. 392-398
    • Pu, J.1    Jiang, H.2    Zhang, B.3    Feng, J.4
  • 119
    • 79955786943 scopus 로고    scopus 로고
    • Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells.
    • Seibler, P., Graziotto, J., Jeong, H., Simunovic, F. et al., Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells. J. Neurosci. 2011, 31, 5970-5976.
    • (2011) J. Neurosci. , vol.31 , pp. 5970-5976
    • Seibler, P.1    Graziotto, J.2    Jeong, H.3    Simunovic, F.4
  • 120
    • 50549089957 scopus 로고    scopus 로고
    • Disease-specific induced pluripotent stem cells.
    • Park, I. H., Arora, N., Huo, H., Maherali, N. et al., Disease-specific induced pluripotent stem cells. Cell 2008, 134, 877-886.
    • (2008) Cell , vol.134 , pp. 877-886
    • Park, I.H.1    Arora, N.2    Huo, H.3    Maherali, N.4
  • 121
    • 80053604531 scopus 로고    scopus 로고
    • Anti-Abeta drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease.
    • Yahata, N., Asai, M., Kitaoka, S., Takahashi, K. et al., Anti-Abeta drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease. PLoS One 2011, 6, e25788.
    • (2011) PLoS One , vol.6
    • Yahata, N.1    Asai, M.2    Kitaoka, S.3    Takahashi, K.4
  • 122
    • 0027401203 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis.
    • Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A. et al., Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993, 362, 59-62.
    • (1993) Nature , vol.362 , pp. 59-62
    • Rosen, D.R.1    Siddique, T.2    Patterson, D.3    Figlewicz, D.A.4
  • 123
    • 6344257200 scopus 로고    scopus 로고
    • A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis.
    • Nishimura, A. L., Mitne-Neto, M., Silva, H. C., Richieri-Costa, A. et al., A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. Am. J. Hum. Genet. 2004, 75, 822-831.
    • (2004) Am. J. Hum. Genet. , vol.75 , pp. 822-831
    • Nishimura, A.L.1    Mitne-Neto, M.2    Silva, H.C.3    Richieri-Costa, A.4
  • 124
    • 50149098605 scopus 로고    scopus 로고
    • Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons.
    • Dimos, J. T., Rodolfa, K. T., Niakan, K. K., Weisenthal, L. M. et al., Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science 2008, 321, 1218-1221.
    • (2008) Science , vol.321 , pp. 1218-1221
    • Dimos, J.T.1    Rodolfa, K.T.2    Niakan, K.K.3    Weisenthal, L.M.4
  • 125
    • 80052225992 scopus 로고    scopus 로고
    • Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients.
    • Mitne-Neto, M., Machado-Costa, M., Marchetto, M. C., Bengtson, M. H. et al., Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients. Hum. Mol. Genet. 2011, 20, 3642-3652.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 3642-3652
    • Mitne-Neto, M.1    Machado-Costa, M.2    Marchetto, M.C.3    Bengtson, M.H.4
  • 126
    • 77951975098 scopus 로고    scopus 로고
    • Vesicle associated membrane protein B (VAPB) is decreased in ALS spinal cord.
    • Anagnostou, G., Akbar, M. T., Paul, P., Angelinetta, C. et al., Vesicle associated membrane protein B (VAPB) is decreased in ALS spinal cord. Neurobiol. Aging 2010, 31, 969-985.
    • (2010) Neurobiol. Aging , vol.31 , pp. 969-985
    • Anagnostou, G.1    Akbar, M.T.2    Paul, P.3    Angelinetta, C.4
  • 127
    • 0141642203 scopus 로고    scopus 로고
    • Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice.
    • Clement, A. M., Nguyen, M. D., Roberts, E. A., Garcia, M. L. et al., Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science 2003, 302, 113-117.
    • (2003) Science , vol.302 , pp. 113-117
    • Clement, A.M.1    Nguyen, M.D.2    Roberts, E.A.3    Garcia, M.L.4
  • 128
    • 56549096129 scopus 로고    scopus 로고
    • Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation.
    • Di Giorgio, F. P., Boulting, G. L., Bobrowicz, S., Eggan, K. C., Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. Cell Stem Cell 2008, 3, 637-648.
    • (2008) Cell Stem Cell , vol.3 , pp. 637-648
    • Di Giorgio, F.P.1    Boulting, G.L.2    Bobrowicz, S.3    Eggan, K.C.4
  • 129
    • 34247475338 scopus 로고    scopus 로고
    • Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons.
    • Nagai, M., Re, D. B., Nagata, T., Chalazonitis, A. et al., Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat. Neurosci. 2007, 10, 615-622.
    • (2007) Nat. Neurosci. , vol.10 , pp. 615-622
    • Nagai, M.1    Re, D.B.2    Nagata, T.3    Chalazonitis, A.4
  • 130
    • 56549115885 scopus 로고    scopus 로고
    • Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells.
    • Marchetto, M. C., Muotri, A. R., Mu, Y., Smith, A. M. et al., Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell 2008, 3, 649-657.
    • (2008) Cell Stem Cell , vol.3 , pp. 649-657
    • Marchetto, M.C.1    Muotri, A.R.2    Mu, Y.3    Smith, A.M.4
  • 131
    • 1842426937 scopus 로고    scopus 로고
    • Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin.
    • Pera, M. F., Andrade, J., Houssami, S., Reubinoff, B. et al., Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin. J. Cell Sci. 2004, 117, 1269-1280.
    • (2004) J. Cell Sci. , vol.117 , pp. 1269-1280
    • Pera, M.F.1    Andrade, J.2    Houssami, S.3    Reubinoff, B.4
  • 132
    • 20344368813 scopus 로고    scopus 로고
    • Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells.
    • Yan, Y., Yang, D., Zarnowska, E. D., Du, Z. et al., Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells. Stem Cells 2005, 23, 781-790.
    • (2005) Stem Cells , vol.23 , pp. 781-790
    • Yan, Y.1    Yang, D.2    Zarnowska, E.D.3    Du, Z.4


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