-
1
-
-
38949186761
-
Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats
-
Adams, C. L., Cowen, M. S., Short, J. L., and Lawrence, A. J. (2008). Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats. Int. J. Neuropsychopharmacol. 11, 229-241.
-
(2008)
Int. J. Neuropsychopharmacol.
, vol.11
, pp. 229-241
-
-
Adams, C.L.1
Cowen, M.S.2
Short, J.L.3
Lawrence, A.J.4
-
2
-
-
76449090047
-
Cue-conditioned alcohol seeking in rats following abstinence: involvement of mGlu5 receptors
-
Adams, C. L., Short, J. L., and Lawrence, A. J. (2010). Cue-conditioned alcohol seeking in rats following abstinence: involvement of mGlu5 receptors. Br. J. Pharmacol. 159, 534-542.
-
(2010)
Br. J. Pharmacol.
, vol.159
, pp. 534-542
-
-
Adams, C.L.1
Short, J.L.2
Lawrence, A.J.3
-
3
-
-
0042467972
-
Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons
-
Agnati, L. F., Ferre, S., Lluis, C., Franco, R., and Fuxe, K. (2003). Molecular mechanisms and therapeutical implications of intramembrane receptor/receptor interactions among heptahelical receptors with examples from the striatopallidal GABA neurons. Pharmacol. Rev. 55, 509-550.
-
(2003)
Pharmacol. Rev.
, vol.55
, pp. 509-550
-
-
Agnati, L.F.1
Ferre, S.2
Lluis, C.3
Franco, R.4
Fuxe, K.5
-
4
-
-
73549120626
-
Theoretical considerations on the topological organization of receptor mosaics
-
Agnati, L. F., Fuxe, K., Woods, A. S., Genedani, S., and Guidolin, D. (2009). Theoretical considerations on the topological organization of receptor mosaics. Curr. Protein Pept. Sci. 10, 559-569.
-
(2009)
Curr. Protein Pept. Sci.
, vol.10
, pp. 559-569
-
-
Agnati, L.F.1
Fuxe, K.2
Woods, A.S.3
Genedani, S.4
Guidolin, D.5
-
5
-
-
0020458065
-
New vistas on synaptic plasticity: the receptor mosaic hypothesis of the engram
-
Agnati, L. F., Fuxe, K., Zoli, M., Rondanini, C., and Ogren, S. O. (1982). New vistas on synaptic plasticity: the receptor mosaic hypothesis of the engram. Med. Biol. 60, 183-190.
-
(1982)
Med. Biol.
, vol.60
, pp. 183-190
-
-
Agnati, L.F.1
Fuxe, K.2
Zoli, M.3
Rondanini, C.4
Ogren, S.O.5
-
6
-
-
77957076205
-
An integrated view on the role of receptor mosaics at perisynaptic level: focus on adenosine A(2A),dopamine D(2),cannabinoid CB(1), and metabotropic glutamate mGlu(5) receptors
-
Agnati, L. F., Guidolin, D., Albertin, G., Trivello, E., Ciruela, F., Genedani, S., Tarakanov, A., and Fuxe, K. (2010a). An integrated view on the role of receptor mosaics at perisynaptic level: focus on adenosine A(2A),dopamine D(2),cannabinoid CB(1), and metabotropic glutamate mGlu(5) receptors. J. Recept. Signal Transduct. Res. 30, 355-369.
-
(2010)
J. Recept. Signal Transduct. Res.
, vol.30
, pp. 355-369
-
-
Agnati, L.F.1
Guidolin, D.2
Albertin, G.3
Trivello, E.4
Ciruela, F.5
Genedani, S.6
Tarakanov, A.7
Fuxe, K.8
-
7
-
-
77957025793
-
On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromers
-
Agnati, L. F., Guidolin, D., Vilardaga, J. P., Ciruela, F., and Fuxe, K. (2010b). On the expanding terminology in the GPCR field: the meaning of receptor mosaics and receptor heteromers. J. Recept. Signal Transduct. Res. 30, 287-303.
-
(2010)
J. Recept. Signal Transduct. Res.
, vol.30
, pp. 287-303
-
-
Agnati, L.F.1
Guidolin, D.2
Vilardaga, J.P.3
Ciruela, F.4
Fuxe, K.5
-
8
-
-
78649299930
-
Heteromerization of G proteincoupled receptors: relevance to neurological disorders and neurotherapeutics
-
Albizu, L., Moreno, J. L., Gonzalez-Maeso, J., and Sealfon, S. C. (2010). Heteromerization of G proteincoupled receptors: relevance to neurological disorders and neurotherapeutics. CNS Neurol. Disord. Drug Targets 9, 636-650.
-
(2010)
CNS Neurol. Disord. Drug Targets
, vol.9
, pp. 636-650
-
-
Albizu, L.1
Moreno, J.L.2
Gonzalez-Maeso, J.3
Sealfon, S.C.4
-
9
-
-
4544339812
-
Ethanol operant self-administration in rats is regulated by adenosine A2 receptors
-
Arolfo, M. P.,Yao, L., Gordon, A. S., Diamond, I., and Janak, P. H. (2004). Ethanol operant self-administration in rats is regulated by adenosine A2 receptors. Alcohol. Clin. Exp. Res. 28, 1308-1316.
-
(2004)
Alcohol. Clin. Exp. Res.
, vol.28
, pp. 1308-1316
-
-
Arolfo, M.P.1
Yao, L.2
Gordon, A.S.3
Diamond, I.4
Janak, P.H.5
-
10
-
-
0035124349
-
Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges
-
Attucci, S., Carla,V., Mannaioni, G., and Moroni, F. (2001). Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges. Br. J. Pharmacol. 132, 799-806.
-
(2001)
Br. J. Pharmacol.
, vol.132
, pp. 799-806
-
-
Attucci, S.1
Carla, V.2
Mannaioni, G.3
Moroni, F.4
-
11
-
-
9644272348
-
mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior
-
Backstrom, P., Bachteler, D., Koch, S., Hyytia, P., and Spanagel, R. (2004). mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 29, 921-928.
-
(2004)
Neuropsychopharmacology
, vol.29
, pp. 921-928
-
-
Backstrom, P.1
Bachteler, D.2
Koch, S.3
Hyytia, P.4
Spanagel, R.5
-
12
-
-
33645025726
-
Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking
-
Backstrom, P., and Hyytia, P. (2006). Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology 31, 778-786.
-
(2006)
Neuropsychopharmacology
, vol.31
, pp. 778-786
-
-
Backstrom, P.1
Hyytia, P.2
-
13
-
-
23644451337
-
Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cueand schedule-induced reinstatement of nicotine self-administration behavior in rats
-
Bespalov, A. Y., Dravolina, O. A., Sukhanov, I., Zakharova, E., Blokhina, E., Zvartau, E., Danysz, W., Van Heeke, G., and Markou, A. (2005). Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cueand schedule-induced reinstatement of nicotine self-administration behavior in rats. Neuropharmacology 49(SUPPL. 1), 167-178.
-
(2005)
Neuropharmacology
, vol.49
, Issue.SUPPL 1
, pp. 167-178
-
-
Bespalov, A.Y.1
Dravolina, O.A.2
Sukhanov, I.3
Zakharova, E.4
Blokhina, E.5
Zvartau, E.6
Danysz, W.7
Van Heeke, G.8
Markou, A.9
-
14
-
-
50849097895
-
Metabotropic glutamate 5 receptors regulate sensitivity to ethanol in mice
-
Bird, M. K., Kirchhoff, J., Djouma, E., and Lawrence, A. J. (2008). Metabotropic glutamate 5 receptors regulate sensitivity to ethanol in mice. Int. J. Neuropsychopharmacol. 11, 765-774.
-
(2008)
Int. J. Neuropsychopharmacol.
, vol.11
, pp. 765-774
-
-
Bird, M.K.1
Kirchhoff, J.2
Djouma, E.3
Lawrence, A.J.4
-
15
-
-
70449654395
-
Group I metabotropic glutamate receptors: involvement in drugseeking and drug-induced plasticity
-
Bird, M. K., and Lawrence, A. J. (2009a). Group I metabotropic glutamate receptors: involvement in drugseeking and drug-induced plasticity. Curr. Mol. Pharmacol. 2, 83-94.
-
(2009)
Curr. Mol. Pharmacol.
, vol.2
, pp. 83-94
-
-
Bird, M.K.1
Lawrence, A.J.2
-
16
-
-
70449675086
-
The promiscuous mGlu5 receptor-a range of partners for therapeutic possibilities?
-
Bird, M. K., and Lawrence,A. J. (2009b). The promiscuous mGlu5 receptor-a range of partners for therapeutic possibilities? Trends Pharmacol. Sci. 30, 617-623.
-
(2009)
Trends Pharmacol. Sci.
, vol.30
, pp. 617-623
-
-
Bird, M.K.1
Lawrence, A.J.2
-
17
-
-
77949656831
-
Cocaine-mediated synaptic potentiation is absent in VTA neurons from mGlu5-deficient mice
-
Bird, M. K., Reid, C. A., Chen, F., Tan, H. O., Petrou, S., and Lawrence, A. J. (2010). Cocaine-mediated synaptic potentiation is absent in VTA neurons from mGlu5-deficient mice. Int. J. Neuropsychopharmacol. 13, 133-141.
-
(2010)
Int. J. Neuropsychopharmacol.
, vol.13
, pp. 133-141
-
-
Bird, M.K.1
Reid, C.A.2
Chen, F.3
Tan, H.O.4
Petrou, S.5
Lawrence, A.J.6
-
18
-
-
23044434010
-
The dopamine D2 receptor: new surprises from an old friend
-
Bonci, A., and Hopf, F. W. (2005). The dopamine D2 receptor: new surprises from an old friend. Neuron 47, 335-338.
-
(2005)
Neuron
, vol.47
, pp. 335-338
-
-
Bonci, A.1
Hopf, F.W.2
-
19
-
-
84864360309
-
mGlu5 and adenosine A2A receptor interactions regulate the conditioned effects of cocaine
-
doi:10.1017/S146114571100126X. [Epub ahead of print]
-
Brown, R. M., Duncan, J. R., Stagnitti, M. R., Ledent, C., and Lawrence, A. J. (2011a). mGlu5 and adenosine A2A receptor interactions regulate the conditioned effects of cocaine. Int. J. Neuropsychopharmacol. 1-7. doi:10.1017/S146114571100126X. [Epub ahead of print].
-
(2011)
Int. J. Neuropsychopharmacol.
, pp. 1-7
-
-
Brown, R.M.1
Duncan, J.R.2
Stagnitti, M.R.3
Ledent, C.4
Lawrence, A.J.5
-
20
-
-
84861224182
-
The mGlu5 receptor antagonist MTEP attenuates opiate self-administration and cue-induced opiate-seeking behaviour in mice
-
doi:10.1016/j.drugalcdep.2011.11.002. [Epub ahead of print]
-
Brown, R. M., Stagnitti, M. R., Duncan, J. R., and Lawrence, A. J. (2011b). The mGlu5 receptor antagonist MTEP attenuates opiate self-administration and cue-induced opiate-seeking behaviour in mice. Drug Alcohol Depend. doi:10.1016/j.drugalcdep.2011.11.002. [Epub ahead of print].
-
(2011)
Drug Alcohol Depend
-
-
Brown, R.M.1
Stagnitti, M.R.2
Duncan, J.R.3
Lawrence, A.J.4
-
21
-
-
54949150308
-
Adenosine A2A receptors and their role in drug addiction
-
Brown, R. M., and Short, J. L. (2008). Adenosine A2A receptors and their role in drug addiction. J. Pharm. Pharmacol. 60, 1409-1430.
-
(2008)
J. Pharm. Pharmacol.
, vol.60
, pp. 1409-1430
-
-
Brown, R.M.1
Short, J.L.2
-
22
-
-
59949105615
-
A differential role for the adenosine A2A receptor in opiate reinforcement vs opiate-seeking behavior
-
Brown, R. M., Short, J. L., Cowen, M. S., Ledent, C., and Lawrence, A. J. (2009). A differential role for the adenosine A2A receptor in opiate reinforcement vs opiate-seeking behavior. Neuropsychopharmacology 34, 844-856.
-
(2009)
Neuropsychopharmacology
, vol.34
, pp. 844-856
-
-
Brown, R.M.1
Short, J.L.2
Cowen, M.S.3
Ledent, C.4
Lawrence, A.J.5
-
23
-
-
65549160499
-
Metabotropic glutamate type 5, dopamine D2 and adenosine A2A receptors form higher-order oligomers in living cells
-
Cabello, N., Gandia, J., Bertarelli, D. C., Watanabe, M., Lluis, C., Franco, R., Ferre, S., Lujan, R., and Ciruela, F. (2009). Metabotropic glutamate type 5, dopamine D2 and adenosine A2A receptors form higher-order oligomers in living cells. J. Neurochem. 109, 1497-1507.
-
(2009)
J. Neurochem.
, vol.109
, pp. 1497-1507
-
-
Cabello, N.1
Gandia, J.2
Bertarelli, D.C.3
Watanabe, M.4
Lluis, C.5
Franco, R.6
Ferre, S.7
Lujan, R.8
Ciruela, F.9
-
24
-
-
0344875553
-
Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer
-
Canals, M., Marcellino, D., Fanelli, F., Ciruela, F., De Benedetti, P., Goldberg, S. R., Neve, K., Fuxe, K.,Agnati, L. F., Woods, A. S., Ferre, S., Lluis, C., Bouvier, M., and Franco, R. (2003). Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. J. Biol. Chem. 278, 46741-46749.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 46741-46749
-
-
Canals, M.1
Marcellino, D.2
Fanelli, F.3
Ciruela, F.4
De Benedetti, P.5
Goldberg, S.R.6
Neve, K.7
Fuxe, K.8
Agnati, L.F.9
Woods, A.S.10
Ferre, S.11
Lluis, C.12
Bouvier, M.13
Franco, R.14
-
25
-
-
0034867765
-
Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice
-
Chiamulera, C., Epping-Jordan, M. P., Zocchi, A., Marcon, C., Cottiny, C., Tacconi, S., Corsi, M., Orzi, F., and Conquet, F. (2001). Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nat. Neurosci. 4, 873-874.
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 873-874
-
-
Chiamulera, C.1
Epping-Jordan, M.P.2
Zocchi, A.3
Marcon, C.4
Cottiny, C.5
Tacconi, S.6
Corsi, M.7
Orzi, F.8
Conquet, F.9
-
26
-
-
33644551294
-
Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers
-
Ciruela, F., Casado, V., Rodrigues, R. J., Lujan, R., Burgueno, J., Canals, M., Borycz, J., Rebola, N., Goldberg, S. R., Mallol, J., Cortes, A., Canela, E. I., Lopez-Gimenez, J. F., Milligan, G., Lluis, C., Cunha, R. A., Ferre, S., and Franco, R. (2006). Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. J. Neurosci. 26, 2080-2087.
-
(2006)
J. Neurosci.
, vol.26
, pp. 2080-2087
-
-
Ciruela, F.1
Casado, V.2
Rodrigues, R.J.3
Lujan, R.4
Burgueno, J.5
Canals, M.6
Borycz, J.7
Rebola, N.8
Goldberg, S.R.9
Mallol, J.10
Cortes, A.11
Canela, E.I.12
Lopez-Gimenez, J.F.13
Milligan, G.14
Lluis, C.15
Cunha, R.A.16
Ferre, S.17
Franco, R.18
-
27
-
-
79951835556
-
mGluR5 positive allosteric modulation enhances extinction learning following cocaine selfadministration
-
Cleva, R. M., Hicks, M. P., Gass, J. T., Wischerath, K. C., Plasters, E. T., Widholm, J. J., and Olive, M. F. (2011). mGluR5 positive allosteric modulation enhances extinction learning following cocaine selfadministration. Behav. Neurosci. 125, 10-19.
-
(2011)
Behav. Neurosci.
, vol.125
, pp. 10-19
-
-
Cleva, R.M.1
Hicks, M.P.2
Gass, J.T.3
Wischerath, K.C.4
Plasters, E.T.5
Widholm, J.J.6
Olive, M.F.7
-
28
-
-
79953077013
-
Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders
-
Cleva, R. M., and Olive, M. F. (2011). Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders. Molecules 16, 2097-2106.
-
(2011)
Molecules
, vol.16
, pp. 2097-2106
-
-
Cleva, R.M.1
Olive, M.F.2
-
29
-
-
3242765264
-
Simultaneous blockade of adenosine A2A and metabotropic glutamate mGlu5 receptors increase their efficacy in reversing Parkinsonian deficits in rats
-
Coccurello, R., Breysse, N., and Amalric, M. (2004). Simultaneous blockade of adenosine A2A and metabotropic glutamate mGlu5 receptors increase their efficacy in reversing Parkinsonian deficits in rats. Neuropsychopharmacology 29, 1451-1461.
-
(2004)
Neuropsychopharmacology
, vol.29
, pp. 1451-1461
-
-
Coccurello, R.1
Breysse, N.2
Amalric, M.3
-
30
-
-
84866034395
-
Counting the Cost: Estimates of the Social Costs of Drug Abuse in Australia in 1998-9. Canberra
-
Collins, D. J., and Lapsley, H. M. (2002). Counting the Cost: Estimates of the Social Costs of Drug Abuse in Australia in 1998-9. Canberra: Commonwealth Department of Health and Aged Care.
-
(2002)
Commonwealth Department of Health and Aged Care
-
-
Collins, D.J.1
Lapsley, H.M.2
-
31
-
-
27144492737
-
The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcoholpreferring rats and regulates olfactory glutamatergic systems
-
Cowen, M. S., Djouma, E., and Lawrence, A. J. (2005). The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcoholpreferring rats and regulates olfactory glutamatergic systems. J. Pharmacol. Exp. Ther. 315, 590-600.
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.315
, pp. 590-600
-
-
Cowen, M.S.1
Djouma, E.2
Lawrence, A.J.3
-
32
-
-
33845368429
-
Assessing appetitive and consummatory phases of ethanol self-administration in C57BL/6J mice under operant conditions: regulation by mGlu5 receptor antagonism
-
(Berl)
-
Cowen, M. S., Krstew, E., and Lawrence, A. J. (2007). Assessing appetitive and consummatory phases of ethanol self-administration in C57BL/6J mice under operant conditions: regulation by mGlu5 receptor antagonism. Psychopharmacology (Berl.) 190, 21-29.
-
(2007)
Psychopharmacology
, vol.190
, pp. 21-29
-
-
Cowen, M.S.1
Krstew, E.2
Lawrence, A.J.3
-
33
-
-
0035940687
-
Inactivation of adenosine A2A receptor impairs long term potentiation in the accumbens nucleus without altering basal synaptic transmission
-
D'Alcantara, P., Ledent, C., Swillens, S., and Schiffmann, S. N. (2001). Inactivation of adenosine A2A receptor impairs long term potentiation in the accumbens nucleus without altering basal synaptic transmission. Neuroscience 107, 455-464.
-
(2001)
Neuroscience
, vol.107
, pp. 455-464
-
-
D'Alcantara, P.1
Ledent, C.2
Swillens, S.3
Schiffmann, S.N.4
-
34
-
-
44649101927
-
G proteincoupled receptor dimers: functional consequences, disease states and drug targets
-
Dalrymple, M. B., Pfleger, K. D., and Eidne, K. A. (2008). G proteincoupled receptor dimers: functional consequences, disease states and drug targets. Pharmacol. Ther. 118, 359-371.
-
(2008)
Pharmacol. Ther.
, vol.118
, pp. 359-371
-
-
Dalrymple, M.B.1
Pfleger, K.D.2
Eidne, K.A.3
-
35
-
-
84907131987
-
Relapse prevention: an emerging technology for promoting long-term drug abstinence
-
Dejong, W. (1994). Relapse prevention: an emerging technology for promoting long-term drug abstinence. Int. J. Addict. 29, 681-705.
-
(1994)
Int. J. Addict.
, vol.29
, pp. 681-705
-
-
Dejong, W.1
-
36
-
-
33646812582
-
Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis
-
Dhami, G. K., and Ferguson, S. S. (2006). Regulation of metabotropic glutamate receptor signaling, desensitization and endocytosis. Pharmacol. Ther. 111, 260-271.
-
(2006)
Pharmacol. Ther.
, vol.111
, pp. 260-271
-
-
Dhami, G.K.1
Ferguson, S.S.2
-
37
-
-
0037123728
-
Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats
-
Diaz-Cabiale, Z., Vivo, M., Del Arco, A., O'Connor, W. T., Harte, M. K., Muller, C. E., Martinez, E., Popoli, P., Fuxe, K., and Ferre, S. (2002). Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A(2A) and dopamine D(2) receptors. Neurosci. Lett. 324, 154-158.
-
(2002)
Interactions with adenosine A(2A) and dopamine D(2) receptors. Neurosci. Lett.
, vol.324
, pp. 154-158
-
-
Diaz-Cabiale, Z.1
Vivo, M.2
Del Arco, A.3
O'Connor, W.T.4
Harte, M.K.5
Muller, C.E.6
Martinez, E.7
Popoli, P.8
Fuxe, K.9
Ferre, S.10
-
38
-
-
0023413016
-
The distribution of adenosine A1 receptors and 5′nucleotidase in the brain of some commonly used experimental animals
-
Fastbom, J., Pazos, A., and Palacios, J. M. (1987). The distribution of adenosine A1 receptors and 5′nucleotidase in the brain of some commonly used experimental animals. Neuroscience 22, 813-826.
-
(1987)
Neuroscience
, vol.22
, pp. 813-826
-
-
Fastbom, J.1
Pazos, A.2
Palacios, J.M.3
-
39
-
-
34548384722
-
Neurotransmitter receptor heteromers and their integrative role in "local modules": the striatal spine module
-
Ferre, S., Agnati, L. F., Ciruela, F., Lluis, C., Woods, A. S., Fuxe, K., and Franco, R. (2007a). Neurotransmitter receptor heteromers and their integrative role in "local modules": the striatal spine module. Brain Res. Rev. 55, 55-67.
-
(2007)
Brain Res. Rev
, vol.55
, pp. 55-67
-
-
Ferre, S.1
Agnati, L.F.2
Ciruela, F.3
Lluis, C.4
Woods, A.S.5
Fuxe, K.6
Franco, R.7
-
40
-
-
34548530597
-
Functional relevance of neurotransmitter receptor heteromers in the central nervous system
-
Ferre, S., Ciruela, F., Woods, A. S., Lluis, C., and Franco, R. (2007b). Functional relevance of neurotransmitter receptor heteromers in the central nervous system. Trends Neurosci. 30, 440-446.
-
(2007)
Trends Neurosci
, vol.30
, pp. 440-446
-
-
Ferre, S.1
Ciruela, F.2
Woods, A.S.3
Lluis, C.4
Franco, R.5
-
41
-
-
36148933708
-
Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry implications for drug addiction, sleep and pain
-
Ferre, S., Diamond, I., Goldberg, S. R., Yao, L., Hourani, S. M., Huang, Z. L., Urade, Y., and Kitchen, I. (2007c). Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry implications for drug addiction, sleep and pain. Prog. Neurobiol. 83, 332-347.
-
(2007)
Prog. Neurobiol
, vol.83
, pp. 332-347
-
-
Ferre, S.1
Diamond, I.2
Goldberg, S.R.3
Yao, L.4
Hourani, S.M.5
Huang, Z.L.6
Urade, Y.7
Kitchen, I.8
-
42
-
-
60249098735
-
Building a new conceptual framework for receptor heteromers
-
Ferre, S., Baler, R., Bouvier, M., Caron, M. G., Devi, L. A., Durroux, T., Fuxe, K., George, S. R., Javitch, J. A., Lohse, M. J., Mackie, K., Milligan, G., Pfleger, K. D., Pin, J. P., Volkow, N. D.,Waldhoer, M.,Woods, A. S., and Franco, R. (2009). Building a new conceptual framework for receptor heteromers. Nat. Chem. Biol. 5, 131-134.
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 131-134
-
-
Ferre, S.1
Baler, R.2
Bouvier, M.3
Caron, M.G.4
Devi, L.A.5
Durroux, T.6
Fuxe, K.7
George, S.R.8
Javitch, J.A.9
Lohse, M.J.10
Mackie, K.11
Milligan, G.12
Pfleger, K.D.13
Pin, J.P.14
Volkow, N.D.15
Waldhoer, M.16
Woods, A.S.17
Franco, R.18
-
43
-
-
2942552330
-
Adenosine A2A-dopamine D2 receptor-receptor heteromers Targets for neuro-psychiatric disorders
-
Ferre, S., Ciruela, F., Canals, M., Marcellino, D., Burgueno, J., Casado, V., Hillion, J., Torvinen, M., Fanelli, F., Benedetti Pd, P., Goldberg, S. R., Bouvier, M., Fuxe, K., Agnati, L. F., Lluis, C., Franco, R., and Woods, A. (2004). Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders. Parkinsonism Relat. Disord. 10, 265-271.
-
(2004)
Parkinsonism Relat. Disord
, vol.10
, pp. 265-271
-
-
Ferre, S.1
Ciruela, F.2
Canals, M.3
Marcellino, D.4
Burgueno, J.5
Casado, V.6
Hillion, J.7
Torvinen, M.8
Fanelli, F.9
Benedetti Pd, P.10
Goldberg, S.R.11
Bouvier, M.12
Fuxe, K.13
Agnati, L.F.14
Lluis, C.15
Franco, R.16
Woods, A.17
-
44
-
-
0037015027
-
Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function
-
Ferre, S., Karcz-Kubicha, M., Hope, B. T., Popoli, P., Burgueno, J., Gutierrez, M. A., Casado, V., Fuxe, K., Goldberg, S. R., Lluis, C., Franco, R., and Ciruela, F. (2002). Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function. Proc. Natl. Acad. Sci. U.S.A. 99, 11940-11945.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 11940-11945
-
-
Ferre, S.1
Karcz-Kubicha, M.2
Hope, B.T.3
Popoli, P.4
Burgueno, J.5
Gutierrez, M.A.6
Casado, V.7
Fuxe, K.8
Goldberg, S.R.9
Lluis, C.10
Franco, R.11
Ciruela, F.12
-
45
-
-
0027948322
-
Antagonistic interaction between adenosine A2A receptors and dopamine D2 receptors in the ventral striopallidal system
-
Ferre, S., O'Connor, W. T., Snaprud, P., Ungerstedt, U., and Fuxe, K. (1994). Antagonistic interaction between adenosine A2A receptors and dopamine D2 receptors in the ventral striopallidal system. Implications for the treatment of schizophrenia. Neuroscience 63, 765-773.
-
(1994)
Implications for the treatment of schizophrenia. Neuroscience
, vol.63
, pp. 765-773
-
-
Ferre, S.1
O'Connor, W.T.2
Snaprud, P.3
Ungerstedt, U.4
Fuxe, K.5
-
46
-
-
0032587703
-
Adenosine A2A and group I metabotropic glutamate receptors synergistically modulate the binding characteristics of dopamine D2 receptors in the rat striatum
-
Ferre, S., Popoli, P., Rimondini, R., Reggio, R., Kehr, J., and Fuxe, K. (1999). Adenosine A2A and group I metabotropic glutamate receptors synergistically modulate the binding characteristics of dopamine D2 receptors in the rat striatum. Neuropharmacology 38, 129-140.
-
(1999)
Neuropharmacology
, vol.38
, pp. 129-140
-
-
Ferre, S.1
Popoli, P.2
Rimondini, R.3
Reggio, R.4
Kehr, J.5
Fuxe, K.6
-
47
-
-
0026763441
-
Molecular cloning of the rat A2 adenosine receptor: selective coexpression with D2 dopamine receptors in rat striatum. Mol
-
Fink, J. S., Weaver, D. R., Rivkees, S. A., Peterfreund, R. A., Pollack, A. E., Adler, E. M., and Reppert, S. M. (1992). Molecular cloning of the rat A2 adenosine receptor: selective coexpression with D2 dopamine receptors in rat striatum. Mol. Brain Res. 14, 186-195.
-
(1992)
Brain Res
, vol.14
, pp. 186-195
-
-
Fink, J.S.1
Weaver, D.R.2
Rivkees, S.A.3
Peterfreund, R.A.4
Pollack, A.E.5
Adler, E.M.6
Reppert, S.M.7
-
48
-
-
67349104137
-
Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice
-
Fontinha, B. M., Delgado-Garcis, J. M., Madronal, N., Ribeiro, J. A., Sebastiao, A. M., and Gruart, A. (2009). Adenosine A2A receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice. Neuropsychopharmacology 34, 1865-1874.
-
(2009)
Neuropsychopharmacology
, vol.34
, pp. 1865-1874
-
-
Fontinha, B.M.1
Delgado-Garcis, J.M.2
Madronal, N.3
Ribeiro, J.A.4
Sebastiao, A.M.5
Gruart, A.6
-
49
-
-
0028183014
-
VI. Nomenclature and classification of purinoceptors
-
Fredholm, B. B., Abbracchio, M. P., Burnstock, G., Daly, J. W., Harden, T. K., Jacobson, K. A., Leff, P., and Williams, M. (1994). VI. Nomenclature and classification of purinoceptors. Pharmacol. Rev. 46, 143-156.
-
(1994)
Pharmacol. Rev
, vol.46
, pp. 143-156
-
-
Fredholm, B.B.1
Abbracchio, M.P.2
Burnstock, G.3
Daly, J.W.4
Harden, T.K.5
Jacobson, K.A.6
Leff, P.7
Williams, M.8
-
50
-
-
0035209620
-
International Union of Pharmacology XXV Nomenclature and classification of adenosine receptors
-
Fredholm, B. B., Ap, I. J., Jacobson, K. A., Klotz, K. N., and Linden, J. (2001a). International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol. Rev. 53, 527-552.
-
(2001)
Pharmacol. Rev
, vol.53
, pp. 527-552
-
-
Fredholm, B.B.1
Ap, I.J.2
Jacobson, K.A.3
Klotz, K.N.4
Linden, J.5
-
51
-
-
0035865444
-
Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells
-
Fredholm, B. B., Irenius, E., Kull, B., and Schulte, G. (2001b). Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells. Biochem. Pharmacol. 61, 443-448.
-
(2001)
Biochem. Pharmacol.
, vol.61
, pp. 443-448
-
-
Fredholm, B.B.1
Irenius, E.2
Kull, B.3
Schulte, G.4
-
52
-
-
0344306449
-
Adenosine-dopamine interactions: development of a concept and some comments on therapeutic possibilities
-
Fredholm, B. B., and Svenningsson, P. (2003). Adenosine-dopamine interactions: development of a concept and some comments on therapeutic possibilities. Neurology 61, S5-S9.
-
(2003)
Neurology
, vol.61
-
-
Fredholm, B.B.1
Svenningsson, P.2
-
53
-
-
10744224952
-
Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson's disease
-
Fuxe, K., Agnati, L. F., Jacobsen, K., Hillion, J., Canals, M., Torvinen, M., Tinner-Staines, B., Staines, W., Rosin, D., Terasmaa, A., Popoli, P., Leo, G., Vergoni, V., Lluis, C., Ciruela, F., Franco, R., and Ferre, S. (2003). Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson's disease. Neurology 61, S19-S23.
-
(2003)
Neurology
, vol.61
-
-
Fuxe, K.1
Agnati, L.F.2
Jacobsen, K.3
Hillion, J.4
Canals, M.5
Torvinen, M.6
Tinner-Staines, B.7
Staines, W.8
Rosin, D.9
Terasmaa, A.10
Popoli, P.11
Leo, G.12
Vergoni, V.13
Lluis, C.14
Ciruela, F.15
Franco, R.16
Ferre, S.17
-
54
-
-
33845911715
-
Intramembrane receptorreceptor interactions: a novel principle in molecular medicine
-
Fuxe, K., Canals, M., Torvinen, M., Marcellino, D., Terasmaa, A., Genedani, S., Leo, G., Guidolin, D., Diaz-Cabiale, Z., Rivera, A., Lundstrom, L., Langel, U., Narvaez, J., Tanganelli, S., Lluis, C., Ferre, S., Woods, A., Franco, R., and Agnati, L. F. (2007). Intramembrane receptorreceptor interactions: a novel principle in molecular medicine. J. Neural Transm. 114, 49-75.
-
(2007)
J. Neural Transm.
, vol.114
, pp. 49-75
-
-
Fuxe, K.1
Canals, M.2
Torvinen, M.3
Marcellino, D.4
Terasmaa, A.5
Genedani, S.6
Leo, G.7
Guidolin, D.8
Diaz-Cabiale, Z.9
Rivera, A.10
Lundstrom, L.11
Langel, U.12
Narvaez, J.13
Tanganelli, S.14
Lluis, C.15
Ferre, S.16
Woods, A.17
Franco, R.18
Agnati, L.F.19
-
55
-
-
79952114964
-
The changing world of G proteincoupled receptors
-
Fuxe, K., and Kenakin, T. (2010). The changing world of G proteincoupled receptors. J. Recept. Signal Transduct. Res. 30, 271.
-
(2010)
J. Recept. Signal Transduct. Res.
, vol.30
, pp. 271
-
-
Fuxe, K.1
Kenakin, T.2
-
56
-
-
77952184031
-
Adenosine-dopamine interactions in the pathophysiology and treatment of CNS disorders
-
Fuxe, K., Marcellino, D., Borroto-Escuela, D. O., Guescini, M., Fernandez-Duenas, V., Tanganelli, S., Rivera, A., Ciruela, F., and Agnati, L. F. (2010). Adenosine-dopamine interactions in the pathophysiology and treatment of CNS disorders. CNS Neurosci. Ther. 16, e18-e42.
-
(2010)
CNS Neurosci. Ther.
, vol.16
-
-
Fuxe, K.1
Marcellino, D.2
Borroto-Escuela, D.O.3
Guescini, M.4
Fernandez-Duenas, V.5
Tanganelli, S.6
Rivera, A.7
Ciruela, F.8
Agnati, L.F.9
-
57
-
-
46249098051
-
Receptorreceptor interactions within receptor mosaics. Impact on neuropsychopharmacology
-
Fuxe, K., Marcellino, D., Rivera, A., Diaz-Cabiale, Z., Filip, M., Gago, B., Roberts, D. C., Langel, U., Genedani, S., Ferraro, L., De La Calle, A., Narvaez, J., Tanganelli, S., Woods, A., and Agnati, L. F. (2008). Receptorreceptor interactions within receptor mosaics. Impact on neuropsychopharmacology. Brain Res. Rev. 58, 415-452.
-
(2008)
Brain Res.Rev
, vol.58
, pp. 415-452
-
-
Fuxe, K.1
Marcellino, D.2
Rivera, A.3
Diaz-Cabiale, Z.4
Filip, M.5
Gago, B.6
Roberts, D.C.7
Langel, U.8
Genedani, S.9
Ferraro, L.10
De La Calle, A.11
Narvaez, J.12
Tanganelli, S.13
Woods, A.14
Agnati, L.F.15
-
58
-
-
62749122197
-
Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory
-
Gass, J. T., and Olive, M. F. (2009). Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory. Biol. Psychiatry 65, 717-720.
-
(2009)
Biol. Psychiatry
, vol.65
, pp. 717-720
-
-
Gass, J.T.1
Olive, M.F.2
-
59
-
-
59949088634
-
mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats
-
Gass, J. T., Osborne, M. P., Watson, N. L., Brown, J. L., and Olive, M. F. (2009). mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats. Neuropsychopharmacology 34, 820-833.
-
(2009)
Neuropsychopharmacology
, vol.34
, pp. 820-833
-
-
Gass, J.T.1
Osborne, M.P.2
Watson, N.L.3
Brown, J.L.4
Olive, M.F.5
-
60
-
-
0026531301
-
The neostriatal mosaic: multiple levels of compartmental organization
-
Gerfen, C. R. (1992). The neostriatal mosaic: multiple levels of compartmental organization. Trends Neurosci. 15, 133-139.
-
(1992)
Trends Neurosci
, vol.15
, pp. 133-139
-
-
Gerfen, C.R.1
-
61
-
-
33751032604
-
Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain
-
Gimenez-Llort, L., Schiffmann, S. N., Shmidt, T., Canela, L., Camon, L., Wassholm, M., Canals, M., Terasmaa, A., Fernandez-Teruel, A., Tobena, A., Popova, E., Ferre, S., Agnati, L., Ciruela, F., Martinez, E., Scheel-Kruger, J., Lluis, C., Franco, R., Fuxe, K., and Bader, M. (2007). Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain. Neurobiol. Learn. Mem. 87, 42-56.
-
(2007)
Neurobiol. Learn. Mem.
, vol.87
, pp. 42-56
-
-
Gimenez-Llort, L.1
Schiffmann, S.N.2
Shmidt, T.3
Canela, L.4
Camon, L.5
Wassholm, M.6
Canals, M.7
Terasmaa, A.8
Fernandez-Teruel, A.9
Tobena, A.10
Popova, E.11
Ferre, S.12
Agnati, L.13
Ciruela, F.14
Martinez, E.15
Scheel-Kruger, J.16
Lluis, C.17
Franco, R.18
Fuxe, K.19
Bader, M.20
more..
-
62
-
-
0024506990
-
Lapse,relapse and survival among opiate addicts after treatment A prospective follow-up study
-
Gossop, M., Green, L., Phillips, G., and Bradley,B. (1989). Lapse,relapse and survival among opiate addicts after treatment. A prospective follow-up study. Br. J. Psychiatry 154, 348-353.
-
(1989)
Br. J. Psychiatry
, vol.154
, pp. 348-353
-
-
Gossop, M.1
Green, L.2
Phillips, G.3
Bradley, B.4
-
63
-
-
0035848459
-
Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum
-
Hettinger, B. D., Lee, A., Linden, J., and Rosin, D. L. (2001). Ultrastructural localization of adenosine A2A receptors suggests multiple cellular sites for modulation of GABAergic neurons in rat striatum. J. Comp. Neurol. 431, 331-346.
-
(2001)
J. Comp. Neurol.
, vol.431
, pp. 331-346
-
-
Hettinger, B.D.1
Lee, A.2
Linden, J.3
Rosin, D.L.4
-
64
-
-
72049083719
-
New horizons for therapeutics in drug and alcohol abuse
-
Jupp,B.,and Lawrence,A. J. (2009). New horizons for therapeutics in drug and alcohol abuse. Pharmacol. Ther. 125, 138-168.
-
(2009)
Pharmacol. Ther.
, vol.125
, pp. 138-168
-
-
Jupp, B.1
Lawrence, A.J.2
-
65
-
-
27744450594
-
Interactions between metabotropic glutamate 5 and adenosine A(2A) receptors in normal and parkinsonian mice
-
Kachroo, A., Orlando, L. R., Grandy, D. K., Chen, J. F., Young, A. B., and Schwarzschild, M. A. (2005). Interactions between metabotropic glutamate 5 and adenosine A(2A) receptors in normal and parkinsonian mice. J. Neurosci. 25, 10414-10419.
-
(2005)
J. Neurosci.
, vol.25
, pp. 10414-10419
-
-
Kachroo, A.1
Orlando, L.R.2
Grandy, D.K.3
Chen, J.F.4
Young, A.B.5
Schwarzschild, M.A.6
-
66
-
-
67651083577
-
The glutamate homeostasis hypothesis of addiction
-
Kalivas, P. W. (2009). The glutamate homeostasis hypothesis of addiction. Nat. Rev. Neurosci. 10,561-572.
-
(2009)
Nat. Rev. Neurosci.
, vol.10
, pp. 561-572
-
-
Kalivas, P.W.1
-
67
-
-
0038502133
-
Brain circuitry and the reinstatement of cocaine-seeking behavior
-
Kalivas, P. W., and McFarland, K. (2003). Brain circuitry and the reinstatement of cocaine-seeking behavior. Psychopharmacology (Berl.) 168, 44-56.
-
(2003)
Psychopharmacology (Berl)
, vol.168
, pp. 44-56
-
-
Kalivas, P.W.1
McFarland, K.2
-
68
-
-
14644405541
-
Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission
-
Kalivas, P. W., Volkow, N., and Seamans, J. (2005). Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission. Neuron 45, 647-650.
-
(2005)
Neuron
, vol.45
, pp. 647-650
-
-
Kalivas, P.W.1
Volkow, N.2
Seamans, J.3
-
69
-
-
0034721678
-
Signalprocessing machines at the postsynaptic density
-
Kennedy, M. B. (2000). Signalprocessing machines at the postsynaptic density. Science 290, 750-754.
-
(2000)
Science
, vol.290
, pp. 750-754
-
-
Kennedy, M.B.1
-
70
-
-
0345830608
-
Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats
-
Kenny, P. J., Paterson, N. E., Boutrel, B., Semenova, S., Harrison, A. A., Gasparini, F., Koob, G. F., Skoubis, P. D., and Markou, A. (2003). Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats. Ann. N. Y. Acad. Sci. 1003, 415-418.
-
(2003)
Ann. N. Y. Acad. Sci.
, vol.1003
, pp. 415-418
-
-
Kenny, P.J.1
Paterson, N.E.2
Boutrel, B.3
Semenova, S.4
Harrison, A.A.5
Gasparini, F.6
Koob, G.F.7
Skoubis, P.D.8
Markou, A.9
-
71
-
-
68849117968
-
A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease
-
Keywood, C., Wakefield, M., and Tack, J. (2009). A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease. Gut 58, 1192-1199.
-
(2009)
Gut
, vol.58
, pp. 1192-1199
-
-
Keywood, C.1
Wakefield, M.2
Tack, J.3
-
72
-
-
56349143278
-
Striatal plasticity and basal ganglia circuit function
-
Kreitzer, A. C., and Malenka, R. C. (2008). Striatal plasticity and basal ganglia circuit function. Neuron 60, 543-554.
-
(2008)
Neuron
, vol.60
, pp. 543-554
-
-
Kreitzer, A.C.1
Malenka, R.C.2
-
73
-
-
0029002052
-
D1 and D2 dopamine receptor gene expression in the rat striatum: sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum
-
Le Moine, C., and Bloch, B. (1995). D1 and D2 dopamine receptor gene expression in the rat striatum: sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum. J. Comp. Neurol. 355, 418-426.
-
(1995)
J. Comp. Neurol.
, vol.355
, pp. 418-426
-
-
Le Moine, C.1
Bloch, B.2
-
74
-
-
80054784232
-
CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor
-
Lindemann, L., Jaeschke, G., Michalon, A., Vieira, E., Honer, M., Spooren, W., Porter, R., Hartung, T., Kolczewski, S., Buttelmann, B., Flament, C., Diener, C., Fischer, C., Gatti, S., Prinssen, E. P., Parrott, N., Hoffmann, G., and Wettstein, J. G. (2011). CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor. J. Pharmacol. Exp. Ther. 339, 474-486.
-
(2011)
J. Pharmacol. Exp. Ther.
, vol.339
, pp. 474-486
-
-
Lindemann, L.1
Jaeschke, G.2
Michalon, A.3
Vieira, E.4
Honer, M.5
Spooren, W.6
Porter, R.7
Hartung, T.8
Kolczewski, S.9
Buttelmann, B.10
Flament, C.11
Diener, C.12
Fischer, C.13
Gatti, S.14
Prinssen, E.P.15
Parrott, N.16
Hoffmann, G.17
Wettstein, J.G.18
-
75
-
-
8644252687
-
Discovery of positive allosteric modulators for the metabotropic glutamatereceptorsubtype5fromaseries of N-(1 3-diphenyl-1Hpyrazol-5yl)benzamides that potentiate receptor function in vivo
-
Lindsley, C. W., Wisnoski, D. D., Leister, W. H., O'brien J, A., Lemaire, W., Williams, D. L. Jr., Burno, M., Sur, C., Kinney, G. G., Pettibone, D. J., Tiller, P. R., Smith, S., Duggan, M. E., Hartman, G. D., Conn, P. J., and Huff, J. R. (2004). Discovery of positive allosteric modulators for the metabotropic glutamatereceptorsubtype5fromaseries of N-(1,3-diphenyl-1Hpyrazol-5yl)benzamides that potentiate receptor function in vivo. J. Med. Chem. 47, 5825-5828.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 5825-5828
-
-
Lindsley, C.W.1
Wisnoski, D.D.2
Leister, W.H.3
O'brien, J.4
Lemaire, A.5
Williams Jr., W.6
Burno, D.L.7
Sur, M.8
Kinney, C.9
Pettibone, G.G.10
Tiller, D.J.11
Smith, P.R.12
Duggan, S.13
Hartman, M.E.14
Conn, G.D.15
Huff Jr., P.J.16
-
76
-
-
57349174038
-
ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2 4]-oxadiazol-5-yl]-piper idin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities
-
Liu, F., Grauer, S., Kelley, C., Navarra, R., Graf, R., Zhang, G., Atkinson, P. J., Popiolek, M., Wantuch, C., Khawaja, X., Smith, D., Olsen, M., Kouranova, E., Lai, M., Pruthi, F., Pulicicchio, C., Day, M., Gilbert, A., Pausch, M. H., Brandon, N. J., Beyer, C. E., Comery, T. A., Logue, S., Rosenzweig-Lipson, S., and Marquis, K. L. (2008). ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piper idin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. J. Pharmacol. Exp. Ther. 327, 827-839.
-
(2008)
J. Pharmacol. Exp. Ther.
, vol.327
, pp. 827-839
-
-
Liu, F.1
Grauer, S.2
Kelley, C.3
Navarra, R.4
Graf, R.5
Zhang, G.6
Atkinson, P.J.7
Popiolek, M.8
Wantuch, C.9
Khawaja, X.10
Smith, D.11
Olsen, M.12
Kouranova, E.13
Lai, M.14
Pruthi, F.15
Pulicicchio, C.16
Day, M.17
Gilbert, A.18
Pausch, M.H.19
Brandon, N.J.20
Beyer, C.E.21
Comery, T.A.22
Logue, S.23
Rosenzweig-Lipson, S.24
Marquis, K.L.25
more..
-
77
-
-
0030954048
-
Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP
-
Lu, Y. M., Jia, Z., Janus, C., Henderson, J. T., Gerlai, R.,Wojtowicz, J. M., and Roder, J. C. (1997). Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J. Neurosci. 17, 5196-5205.
-
(1997)
J. Neurosci.
, vol.17
, pp. 5196-5205
-
-
Lu, Y.M.1
Jia, Z.2
Janus, C.3
Henderson, J.T.4
Gerlai, R.5
Wojtowicz, J.M.6
Roder, J.C.7
-
78
-
-
6844250767
-
Dopamine receptors: from structure to function
-
Missale, C., Nash, S. R., Robinson, S. W., Jaber, M., and Caron, M. G. (1998). Dopamine receptors: from structure to function. Physiol. Rev. 78, 189-225.
-
(1998)
Physiol. Rev.
, vol.78
, pp. 189-225
-
-
Missale, C.1
Nash, S.R.2
Robinson, S.W.3
Jaber, M.4
Caron, M.G.5
-
79
-
-
78649907124
-
Uncovering GPCR heteromer-biased ligands
-
Mustafa, S., Ayoub, M. A., and Pfleger, K. D. G. (2010). Uncovering GPCR heteromer-biased ligands. Drug Discov. Today Technol. 7, e77-e85.
-
(2010)
Drug Discov. Today Technol
, vol.7
-
-
Mustafa, S.1
Ayoub, M.A.2
Pfleger, K.D.G.3
-
80
-
-
0033165926
-
Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD95/GKAP complex and cortactin
-
Naisbitt, S., Kim, E., Tu, J. C., Xiao, B., Sala, C., Valtschanoff, J., Weinberg, R. J., Worley, P. F., and Sheng, M. (1999). Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD95/GKAP complex and cortactin. Neuron 23, 569-582.
-
(1999)
Neuron
, vol.23
, pp. 569-582
-
-
Naisbitt, S.1
Kim, E.2
Tu, J.C.3
Xiao, B.4
Sala, C.5
Valtschanoff, J.6
Weinberg, R.J.7
Worley, P.F.8
Sheng, M.9
-
81
-
-
0037417810
-
Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling
-
Nishi, A., Liu, F., Matsuyama, S., Hamada, M., Higashi, H., Nairn, A. C., and Greengard, P. (2003). Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling. Proc. Natl. Acad. Sci. U.S.A. 100, 1322-1327.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 1322-1327
-
-
Nishi, A.1
Liu, F.2
Matsuyama, S.3
Hamada, M.4
Higashi, H.5
Nairn, A.C.6
Greengard, P.7
-
82
-
-
77956569789
-
Incentive learning underlying cocaineseeking requires mGluR5 receptors located on dopamine D1 receptorexpressing neurons
-
Novak, M., Halbout, B., O'Connor, E. C., Rodriguez Parkitna, J., Su, T., Chai, M., Crombag, H. S., Bilbao, A., Spanagel,R.,Stephens,D. N.,Schutz, G., and Engblom, D. (2010). Incentive learning underlying cocaineseeking requires mGluR5 receptors located on dopamine D1 receptorexpressing neurons. J. Neurosci. 30, 11973-11982.
-
(2010)
J. Neurosci.
, vol.30
, pp. 11973-11982
-
-
Novak, M.1
Halbout, B.2
O'Connor, E.C.3
Rodriguez Parkitna, J.4
Su, T.5
Chai, M.6
Crombag, H.S.7
Bilbao, A.8
Spanagel, R.9
Stephens, D.N.10
Schutz, G.11
Engblom, D.12
-
83
-
-
77953621158
-
The mGluR5 antagonist MTEP dissociates the acquisition of predictive and incentive motivational properties of reward-paired stimuli in mice
-
O'Connor, E. C., Crombag, H. S., Mead, A. N., and Stephens, D. N. (2010). The mGluR5 antagonist MTEP dissociates the acquisition of predictive and incentive motivational properties of reward-paired stimuli in mice. Neuropsychopharmacology 35, 1807-1817.
-
(2010)
Neuropsychopharmacology
, vol.35
, pp. 1807-1817
-
-
O'Connor, E.C.1
Crombag, H.S.2
Mead, A.N.3
Stephens, D.N.4
-
84
-
-
70349782435
-
Metabotropic glutamate receptor ligands as potential therapeutics for addiction
-
Olive, M. F. (2009). Metabotropic glutamate receptor ligands as potential therapeutics for addiction. Curr. Drug Abuse Rev. 2, 83-98.
-
(2009)
Curr. Drug Abuse Rev.
, vol.2
, pp. 83-98
-
-
Olive, M.F.1
-
85
-
-
0034856088
-
The selective mGlu5 receptor agonist CHPG inhibits quinpirole-induced turning in 6-hydroxydopaminelesioned rats and modulates the binding characteristics of dopamine D2 receptors in the rat striatum: interactions with adenosine A2A receptors
-
Popoli, P., Pezzola, A., Torvinen, M., Reggio, R., Pintor, A., Scarchilli, L., Fuxe, K., and Ferre, S. (2001). The selective mGlu5 receptor agonist CHPG inhibits quinpirole-induced turning in 6-hydroxydopaminelesioned rats and modulates the binding characteristics of dopamine D2 receptors in the rat striatum: interactions with adenosine A2A receptors. Neuropsychopharmacology 25, 505-513.
-
(2001)
Neuropsychopharmacology
, vol.25
, pp. 505-513
-
-
Popoli, P.1
Pezzola, A.2
Torvinen, M.3
Reggio, R.4
Pintor, A.5
Scarchilli, L.6
Fuxe, K.7
Ferre, S.8
-
86
-
-
73949159248
-
Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway
-
Quiroz, C., Lujan, R., Uchigashima, M., Simoes, A. P., Lerner, T. N., Borycz, J., Kachroo, A., Canas, P. M., Orru, M., Schwarzschild, M. A., Rosin, D. L., Kreitzer, A. C., Cunha, R. A., Watanabe, M., and Ferre, S. (2009). Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway. ScientificWorldJournal 9, 1321-1344.
-
(2009)
Scientific World Journal
, vol.9
, pp. 1321-1344
-
-
Quiroz, C.1
Lujan, R.2
Uchigashima, M.3
Simoes, A.P.4
Lerner, T.N.5
Borycz, J.6
Kachroo, A.7
Canas, P.M.8
Orru, M.9
Schwarzschild, M.A.10
Rosin, D.L.11
Kreitzer, A.C.12
Cunha, R.A.13
Watanabe, M.14
Ferre, S.15
-
87
-
-
79951516164
-
Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5
-
Reichel, C. M., Schwendt, M., Mcginty, J. F., Olive, M. F., and See, R. E. (2011). Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5. Neuropsychopharmacology 36, 782-792.
-
(2011)
Neuropsychopharmacology
, vol.36
, pp. 782-792
-
-
Reichel, C.M.1
Schwendt, M.2
Mcginty, J.F.3
Olive, M.F.4
See, R.E.5
-
88
-
-
54949117137
-
Drug addiction and the memory systems of the brain
-
Robbins, T. W., Ersche, K. D., and Everitt, B. J. (2008). Drug addiction and the memory systems of the brain. Ann. N. Y. Acad. Sci. 1141, 1-21.
-
(2008)
Ann. N. Y. Acad. Sci.
, vol.1141
, pp. 1-21
-
-
Robbins, T.W.1
Ersche, K.D.2
Everitt, B.J.3
-
89
-
-
13244264871
-
Co-localization and functional interaction between adenosine A2A and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum
-
Rodrigues, R. J., Alfaro, T. M., Rebola, N., Oliveira, C. R., and Cunha, R. A. (2005). Co-localization and functional interaction between adenosine A2A and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum. J. Neurochem. 92, 433-441.
-
(2005)
J. Neurochem.
, vol.92
, pp. 433-441
-
-
Rodrigues, R.J.1
Alfaro, T.M.2
Rebola, N.3
Oliveira, C.R.4
Cunha, R.A.5
-
90
-
-
0029002053
-
Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain
-
Romano, C., Sesma, M. A., Mcdonald, C. T., O'malley, K., Van Den Pol, A. N., and Olney, J. W. (1995). Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain. J. Comp. Neurol. 355, 455-469.
-
(1995)
J. Comp. Neurol.
, vol.355
, pp. 455-469
-
-
Romano, C.1
Sesma, M.A.2
Mcdonald, C.T.3
O'malley, K.4
Van Den Pol, A.N.5
Olney, J.W.6
-
91
-
-
0345168910
-
Anatomy of adenosine A2A receptors in brain: morphological substrates for integration of striatal function
-
Rosin, D. L., Hettinger, B. D., Lee, A., and Linden, J. (2003). Anatomy of adenosine A2A receptors in brain: morphological substrates for integration of striatal function. Neurology 61, S12-S18.
-
(2003)
Neurology
, vol.61
-
-
Rosin, D.L.1
Hettinger, B.D.2
Lee, A.3
Linden, J.4
-
92
-
-
36148983766
-
Adenosine A2A receptors and basal ganglia physiology
-
Schiffmann, S. N., Fisone, G., Moresco, R.,Cunha,R. A.,and Ferre,S. (2007). Adenosine A2A receptors and basal ganglia physiology. Prog. Neurobiol. 83, 277-292.
-
(2007)
Prog. Neurobiol
, vol.83
, pp. 277-292
-
-
Schiffmann, S.N.1
Fisone, G.2
Moresco, R.3
Cunha, R.A.4
Ferre, S.5
-
93
-
-
0026638085
-
Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area
-
Sesack, S. R., and Pickel, V. M. (1992). Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area. J. Comp. Neurol. 320, 145-160.
-
(1992)
J. Comp. Neurol.
, vol.320
, pp. 145-160
-
-
Sesack, S.R.1
Pickel, V.M.2
-
94
-
-
0027378595
-
Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain
-
Shigemoto, R., Nomura, S., Ohishi, H., Sugihara, H., Nakanishi, S., and Mizuno, N. (1993). Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neurosci. Lett. 163, 53-57.
-
(1993)
Neurosci. Lett.
, vol.163
, pp. 53-57
-
-
Shigemoto, R.1
Nomura, S.2
Ohishi, H.3
Sugihara, H.4
Nakanishi, S.5
Mizuno, N.6
-
95
-
-
30444460573
-
The role of metabotropic glutamate receptor 5 in learning and memory processes
-
Simonyi, A., Schachtman, T. R., and Christoffersen, G. R. (2005). The role of metabotropic glutamate receptor 5 in learning and memory processes. Drug News Perspect. 18, 353-361.
-
(2005)
Drug News Perspect
, vol.18
, pp. 353-361
-
-
Simonyi, A.1
Schachtman, T.R.2
Christoffersen, G.R.3
-
96
-
-
0025371482
-
The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones
-
Smith, A. D., and Bolam, J. P. (1990). The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones. Trends Neurosci. 13, 259-265.
-
(1990)
Trends Neurosci
, vol.13
, pp. 259-265
-
-
Smith, A.D.1
Bolam, J.P.2
-
97
-
-
0033909559
-
GABA(B) and group I metabotropic glutamate receptors in the striatopallidal complex in primates
-
Smith, Y., Charara, A., Hanson, J. E., Paquet, M., and Levey, A. I. (2000). GABA(B) and group I metabotropic glutamate receptors in the striatopallidal complex in primates. J. Anat. 196(Pt 4), 555-576.
-
(2000)
J. Anat.
, vol.196
, Issue.PT 4
, pp. 555-576
-
-
Smith, Y.1
Charara, A.2
Hanson, J.E.3
Paquet, M.4
Levey, A.I.5
-
98
-
-
0035652609
-
Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses
-
Sung, K. W., Choi, S., and Lovinger, D. M. (2001). Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses. J. Neurophysiol. 86, 2405-2412.
-
(2001)
J. Neurophysiol.
, vol.86
, pp. 2405-2412
-
-
Sung, K.W.1
Choi, S.2
Lovinger, D.M.3
-
99
-
-
0030836031
-
Cellular expression of adenosine A2A receptor messenger RNA in the rat central nervous system with special reference to dopamine innervated areas
-
Svenningsson, P., Le Moine, C., Kull, B., Sunahara, R., Bloch, B., and Fredholm, B. B. (1997). Cellular expression of adenosine A2A receptor messenger RNA in the rat central nervous system with special reference to dopamine innervated areas. Neuroscience 80, 1171-1185.
-
(1997)
Neuroscience
, vol.80
, pp. 1171-1185
-
-
Svenningsson, P.1
Le Moine, C.2
Kull, B.3
Sunahara, R.4
Bloch, B.5
Fredholm, B.B.6
-
100
-
-
0032509812
-
Localization of mGluR1alike immunoreactivity and mGluR5like immunoreactivity in identified populations of striatal neurons
-
Tallaksen-Greene, S. J., Kaatz, K. W., Romano, C., and Albin, R. L. (1998). Localization of mGluR1alike immunoreactivity and mGluR5like immunoreactivity in identified populations of striatal neurons. Brain Res. 780, 210-217.
-
(1998)
Brain Res
, vol.780
, pp. 210-217
-
-
Tallaksen-Greene, S.J.1
Kaatz, K.W.2
Romano, C.3
Albin, R.L.4
-
101
-
-
0035069188
-
Potential anxiolyticand antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist
-
Tatarczynska, E., Klodzinska, A., Chojnacka-Wojcik, E., Palucha, A., Gasparini, F., Kuhn, R., and Pilc, A. (2001). Potential anxiolyticand antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. Br. J. Pharmacol. 132, 1423-1430.
-
(2001)
Br. J. Pharmacol.
, vol.132
, pp. 1423-1430
-
-
Tatarczynska, E.1
Klodzinska, A.2
Chojnacka-Wojcik, E.3
Palucha, A.4
Gasparini, F.5
Kuhn, R.6
Pilc, A.7
-
102
-
-
28244486818
-
Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N-methyl-Daspartate effects
-
Tebano, M. T., Martire, A., Rebola, N., Pepponi, R., Domenici, M. R., Gro, M. C., Schwarzschild, M. A., Chen, J. F., Cunha, R. A., and Popoli, P. (2005). Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N-methyl-Daspartate effects. J. Neurochem. 95, 1188-1200.
-
(2005)
J. Neurochem
, vol.95
, pp. 1188-1200
-
-
Tebano, M.T.1
Martire, A.2
Rebola, N.3
Pepponi, R.4
Domenici, M.R.5
Gro, M.C.6
Schwarzschild, M.A.7
Chen, J.F.8
Cunha, R.A.9
Popoli, P.10
-
103
-
-
0028927526
-
Differential expression of mGluR5 metabotropic glutamate receptor mRNA by rat striatal neurons
-
Testa, C. M., Standaert, D. G., Landwehrmeyer, G. B., Penney, J. B. Jr., and Young, A. B. (1995). Differential expression of mGluR5 metabotropic glutamate receptor mRNA by rat striatal neurons. J. Comp. Neurol. 354, 241-252.
-
(1995)
J. Comp. Neurol.
, vol.354
, pp. 241-252
-
-
Testa, C.M.1
Standaert, D.G.2
Landwehrmeyer, G.B.3
Penney Jr., J.B.4
Young, A.B.5
-
104
-
-
12944279339
-
Biochemical identification of the dopamine D2 receptor domains interacting with the adenosine A2A receptor
-
Torvinen, M., Kozell, L. B., Neve, K. A., Agnati, L. F., and Fuxe, K. (2004). Biochemical identification of the dopamine D2 receptor domains interacting with the adenosine A2A receptor. J. Mol. Neurosci. 24, 173-180.
-
(2004)
J. Mol. Neurosci.
, vol.24
, pp. 173-180
-
-
Torvinen, M.1
Kozell, L.B.2
Neve, K.A.3
Agnati, L.F.4
Fuxe, K.5
-
105
-
-
0024453365
-
Convergence of hippocampal and dopaminergic input onto identified neurons in the nucleus accumbens of the rat
-
Totterdell, S., and Smith, A. D. (1989). Convergence of hippocampal and dopaminergic input onto identified neurons in the nucleus accumbens of the rat. J. Chem. Neuroanat. 2, 285-298.
-
(1989)
J. Chem. Neuroanat.
, vol.2
, pp. 285-298
-
-
Totterdell, S.1
Smith, A.D.2
-
106
-
-
77949286973
-
Regulator of G protein-signaling proteins and addictive drugs
-
Traynor, J. (2010). Regulator of G protein-signaling proteins and addictive drugs. Ann. N. Y. Acad. Sci. 1187, 341-352.
-
(2010)
Ann. N. Y. Acad. Sci.
, vol.1187
, pp. 341-352
-
-
Traynor, J.1
-
107
-
-
38349054282
-
Conformational cross-talk between alpha2Aadrenergic and mu-opioid receptors controls cell signaling
-
Vilardaga, J. P., Nikolaev, V. O., Lorenz, K., Ferrandon, S., Zhuang, Z., and Lohse, M. J. (2008). Conformational cross-talk between alpha2Aadrenergic and mu-opioid receptors controls cell signaling. Nat. Chem. Biol. 4, 126-131.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 126-131
-
-
Vilardaga, J.P.1
Nikolaev, V.O.2
Lorenz, K.3
Ferrandon, S.4
Zhuang, Z.5
Lohse, M.J.6
-
108
-
-
33646751913
-
Adenosine A2A blockade prevents synergy between m-opiate and cannabinoid CB1 receptors and eliminates heroinseeking behavior in addicted rats
-
Yao, L., Mcfarland, K., Fan, P., Jiang, Z., Ueda, T., and Diamond, I. (2006). Adenosine A2A blockade prevents synergy between m-opiate and cannabinoid CB1 receptors and eliminates heroinseeking behavior in addicted rats. Proc. Natl. Acad. Sci. U.S.A. 103, 7877-7882.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A
, vol.103
, pp. 7877-7882
-
-
Yao, L.1
Mcfarland, K.2
Fan, P.3
Jiang, Z.4
Ueda, T.5
Diamond, I.6
-
109
-
-
77954407168
-
Efficacy, tolerability and pharmacokinetics of a modified release formulation of ADX10059, a negative allosteric modulator of metabotropic glutamate receptor 5 an esophageal pHimpedance study in healthy subjects
-
Zerbib, F., Keywood, C., and Strabach, G. (2010). Efficacy, tolerability and pharmacokinetics of a modified release formulation of ADX10059, a negative allosteric modulator of metabotropic glutamate receptor 5: an esophageal pHimpedance study in healthy subjects. Neurogastroenterol. Motil. 22, 859-865, e231.
-
(2010)
Neurogastroenterol. Motil.e231
, vol.22
, pp. 859-865
-
-
Zerbib, F.1
Keywood, C.2
Strabach, G.3
|