The mGlu5 receptor antagonist MTEP attenuates opiate self-administration and cue-induced opiate-seeking behaviour in mice

Drug and Alcohol Dependence

Volumn 123, Issue 1-3, 2012, Pages 264-268

  Brown, Robyn M ^a   Stagnitti, Monique R ^a   Duncan, Jhodie R ^a   Lawrence, Andrew J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Drug seeking; Intra venous self administration; MGluR5; Morphine; Opiates; Reinstatement; Relapse

Indexed keywords

3 [(2 METHYL 4 THIAZOLYL)ETHYNYL]PYRIDINE; METABOTROPIC RECEPTOR 5;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG RESPONSE; DRUG SEEKING BEHAVIOR; DRUG SELECTIVITY; DRUG SELF ADMINISTRATION; DRUG TARGETING; MALE; MOUSE; NONHUMAN; OPIATE ADDICTION; PRIORITY JOURNAL; PROTEIN FUNCTION; REWARD;

ANALGESICS, OPIOID; ANALYSIS OF VARIANCE; ANIMALS; CONDITIONING, OPERANT; CUES; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, INTRAVENOUS; MALE; MICE; MORPHINE; MOTOR ACTIVITY; NARCOTICS; OPIOID-RELATED DISORDERS; PIPERIDINES; RECEPTORS, METABOTROPIC GLUTAMATE; REINFORCEMENT (PSYCHOLOGY); SELF ADMINISTRATION; SUBSTANCE ABUSE, INTRAVENOUS; THIAZOLES;

MUS;

EID: 84861224182     PISSN: 03768716     EISSN: 18790046     Source Type: Journal    
DOI: 10.1016/j.drugalcdep.2011.11.002     Document Type: Article

References (36)

1. Anderson J.J., Rao S.P., Rowe B., Giracello D.R., Holtz G., Chapman D.F., Tehrani L., Bradbury M.J., Cosford N.D., Varney M.A. [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization. J. Pharmacol. Exp. Ther. 2002, 303:1044-1051.
2. Aoki T., Narita M., Shibasaki M., Suzuki T. Metabotropic glutamate receptor 5 localized in the limbic forebrain is critical for the development of morphine-induced rewarding effect in mice. Eur. J. Neurosci. 2004, 20:1633-1638.
3. Backstrom P., Hyytia P. Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology 2006, 31:778-786.
4. Backstrom P., Bachteler D., Koch S., Hyytia P., Spanagel R. mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology 2004, 29:921-928.
5. Bespalov A.Y., Dravolina O.A., Sukhanov I., Zakharova E., Blokhina E., Zvartau E., Danysz W., van Heeke G., Markou A. Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats. Neuropharmacology 2005, 49(Suppl. 1):167-178.
6. Bird M.K., Kirchhoff J., Djouma E., Lawrence A.J. Metabotropic glutamate 5 receptors regulate sensitivity to ethanol in mice. Int. J. Neuropsychopharmacol. 2008, 11:765-774.
7. Bird M.K., Reid C.A., Chen F., Tan H.O., Petrou S., Lawrence A.J. Cocaine-mediated synaptic potentiation is absent in VTA neurons from mGlu5-deficient mice. Int. J. Neuropsychopharmacol. 2010, 13:133-141.
8. Bossert J.M., Busch R.F., Gray S.M. The novel mGluR2/3 agonist LY379268 attenuates cue-induced reinstatement of heroin seeking. Neuroreport 2005, 16:1013-1016.
9. Bossert J.M., Gray S.M., Lu L., Shaham Y. Activation of group II metabotropic glutamate receptors in the nucleus accumbens shell attenuates context-induced relapse to heroin seeking. Neuropsychopharmacology 2006, 31:2197-2209.
10. 2A receptor in opiate reinforcement vs opiate-seeking behavior. Neuropsychopharmacology 2009, 34:844-856.
11. Chiamulera C., Epping-Jordan M.P., Zocchi A., Marcon C., Cottiny C., Tacconi S., Corsi M., Orzi F., Conquet F. Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nat. Neurosci. 2001, 4:873-874.
12. Cosford N.D., Roppe J., Tehrani L., Schweiger E.J., Seiders T.J., Chaudary A., Rao S., Varney M.A. [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor. Bioorg. Med. Chem. Lett. 2003, 13:351-354.
13. Cowen M.S., Djouma E., Lawrence A.J. The metabotropic glutamate 5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine reduces ethanol self-administration in multiple strains of alcohol-preferring rats and regulates olfactory glutamatergic systems. J. Pharmacol. Exp. Ther. 2005, 315:590-600.
14. Cowen M.S., Krstew E., Lawrence A.J. Assessing appetitive and consummatory phases of ethanol self-administration in C57BL/6J mice under operant conditions: regulation by mGlu5 receptor antagonism. Psychopharmacology (Berl.) 2007, 190:21-29.
15. D'Ascenzo M., Podda M.V., Fellin T., Azzena G.B., Haydon P., Grassi C. Activation of mGluR5 induces spike afterdepolarization and enhanced excitability in medium spiny neurons of the nucleus accumbens by modulating persistent Na+ currents. J. Physiol. 2009, 587:3233-3250.
16. Darke S., Degenhardt L., Mattick R. Mortality Amongst Illicit Drug Users: Epidemiology, Causes and Intervention 2007, Cambridge University Press, Cambridge.
17. Duncan J.R., Lawrence A.J. The role of metabotropic glutamate receptors in addiction: evidence from preclinical models. Pharmacol. Biochem. Behav. 2011, PMID:21443897 [Epub ahead of print].
18. Gass J.T., Osborne M.P., Watson N.L., Brown J.L., Olive M.F. mGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in rats. Neuropsychopharmacology 2009, 34:820-833.
19. Hodge C.W., Miles M.F., Sharko A.C., Stevenson R.A., Hillmann J.R., Lepoutre V., Besheer J., Schroeder J.P. The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice. Psychopharmacology (Berl.) 2006, 183:429-438.
20. Kalivas P.W., Lalumiere R.T., Knackstedt L., Shen H. Glutamate transmission in addiction. Neuropharmacology 2009, 56(Suppl. 1):169-173.
21. Kenny P.J., Boutrel B., Gasparini F., Koob G.F., Markou A. Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats. Psychopharmacology (Berl.) 2005, 179:247-254.
22. Kenny P.J., Paterson N.E., Boutrel B., Semenova S., Harrison A.A., Gasparini F., Koob G.F., Skoubis P.D., Markou A. Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats. Ann. N. Y. Acad. Sci. 2003, 1003:415-418.
23. LaLumiere R.T., Kalivas P.W. Glutamate release in the nucleus accumbens core is necessary for heroin seeking. J. Neurosci. 2008, 28:3170-3177.
24. Lea P.M., Faden A.I. Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. CNS Drug Rev. 2006, 12:149-166.
25. Lee B., Platt D.M., Rowlett J.K., Adewale A.S., Spealman R.D. Attenuation of behavioral effects of cocaine by the metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine. J. Pharmacol. Exp. Ther. 2005, 312:1232-1240.
26. McGeehan A.J., Janak P.H., Olive M.F. Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, d-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice. Psychopharmacology (Berl.) 2004, 174:266-273.
27. Novak M., Halbout B., O'Connor E.C., Rodriguez J., Su T., Chai M., Crombag H.S., Bilbao A., Spanagel R., Stephens D.N., Schutz G., Engblom D. Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons. J. Neurosci. 2010, 30:11973-11982.
28. O'Connor E.C., Crombag H.S., Mead A.N., Stephens D.N. The mGluR5 antagonist MTEP dissociates the acquisition of predictive and incentive motivational properties of reward-paired stimuli in mice. Neuropsychopharmacology 2010, 35:1807-1817.
29. Olive M.F. Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction. Eur. J. Pharmacol. 2010, 639:47-58.
30. Paterson N.E., Markou A. The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats. Psychopharmacology (Berl.) 2005, 179:255-261.
31. Paterson N.E., Semenova S., Gasparini F., Markou A. The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice. Psychopharmacology (Berl.) 2003, 167:257-264.
32. Popik P., Wrobel M. Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist. Neuropharmacology 2002, 43:1210-1217.
33. Romano C., Sesma M.A., McDonald C.T., O'Malley K., Van den Pol A.N., Olney J.W. Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain. J. Comp. Neurol. 1995, 355:455-469.
34. Shigemoto R., Nomura S., Ohishi H., Sugihara H., Nakanishi S., Mizuno N. Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neurosci. Lett. 1993, 163:53-57.
35. van der Kam E.L., de Vry J., Tzschentke T.M. Effect of 2-methyl-6-(phenylethynyl) pyridine on intravenous self-administration of ketamine and heroin in the rat. Behav. Pharmacol. 2007, 18:717-724.
36. van der Kam E.L., De Vry J., Tzschentke T.M. The mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) supports intravenous self-administration and induces conditioned place preference in the rat. Eur. J. Pharmacol. 2009, 607:114-120.