Withanolide sulfoxide from Aswagandha roots inhibits nuclear transcription factor-kappa-B, cyclooxygenase and tumor cell proliferation

Phytotherapy Research

Volumn 23, Issue 7, 2009, Pages 987-992

  Mulabagal, Vanisree ^a   Subbaraju, Gottumukkala V ^b   Rao, Chirravuri V ^b   Sivaramakrishna, Chillara ^b   DeWitt, David L ^c   Holmes, Daniel ^a   Sung, Bokyung ^d   Aggarwal, Bharat B ^d   Tsay, Hsin Sheng ^e   Nair, Muraleedharan G ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Laila Research Centre   (India)

^c Michigan State University   (United States)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^e CHAOYANG UNIVERSITY OF TECHNOLOGY   (Taiwan)

Author keywords

Ashwagandha; Cancer cell proliferation; Cyclooxygenase; Tumor necrosis factor; Withania somnifera; Withanolide

Indexed keywords

ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; ASHWAGANDHANOLIDE; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ROFECOXIB; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; WITHANIA SOMNIFERA EXTRACT; WITHANOLIDE SULFOXIDE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER THERAPY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; PLANT ROOT; TUMOR CELL; WITHANIA SOMNIFERA;

CELL LINE, TUMOR; CELL PROLIFERATION; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ERGOSTEROL; HUMANS; MOLECULAR STRUCTURE; NF-KAPPA B; PLANT EXTRACTS; PLANT ROOTS; SULFOXIDES; WITHANIA; WITHANOLIDES;

WITHANIA SOMNIFERA;

EID: 67650115799     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2736     Document Type: Article

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