An extract of withania somnifera attenuates endothelin-1-stimulated pigmentation in human epidermal equivalents through the interruption of PKC activity within melanocytes

Phytotherapy Research

Volumn 25, Issue 9, 2011, Pages 1398-1411

  Nakajima, Hiroaki ^a   Wakabayashi, Yuki ^a   Wakamatsu, Kazumasa ^b   Imokawa, Genji ^a  

^a TOKYO UNIVERSITY OF TECHNOLOGY   (Japan)

^b FUJITA HEALTH UNIVERSITY   (Japan)

Author keywords

endothelin 1; human epidermal equivalents; intracellular signaling; melanocytes; pigmentation; Withania somnifera

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ENDOTHELIN 1; EUMELANIN; MESSENGER RNA; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE C; RAF PROTEIN; WITHAFERIN A; WITHANIA SOMNIFERA EXTRACT; MELANIN; PLANT EXTRACT;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPIGMENTATION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; EPIDERMIS; GENE EXPRESSION; HUMAN; HUMAN CELL; HYPERPIGMENTATION; MELANOCYTE; MELANOMA CELL; OXIDATION REDUCTION STATE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN PIGMENTATION; WESTERN BLOTTING; WITHANIA SOMNIFERA; CHEMISTRY; DRUG EFFECTS; MELANOMA; METABOLISM; PHOSPHORYLATION; PIGMENTATION; TUMOR CELL LINE; WITHANIA;

WITHANIA SOMNIFERA;

CELL LINE, TUMOR; ENDOTHELIN-1; HUMANS; MELANINS; MELANOCYTES; MELANOMA; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; PHOSPHORYLATION; PIGMENTATION; PLANT EXTRACTS; PROTEIN KINASE C; SIGNAL TRANSDUCTION; WITHANIA;

EID: 80052279446     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3552     Document Type: Article

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