The full-length calcium-sensing receptor dampens the calcemic response to 1α,25(OH)2 vitamin D3 in vivo independently of parathyroid hormone

American Journal of Physiology - Renal Physiology

Volumn 297, Issue 3, 2009, Pages

  Egbuna, Ogo ^a,c   Quinn, Steven ^a   Kantham, Lakshmi ^a   Butters, Robert ^a   Pang, Jiang ^a   Pollak, Martin ^a   Goltzman, David ^b   Brown, Edward ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Kidney; Vitamin D

Indexed keywords

CALCITONIN; CALCITRIOL; CALCIUM ION; CALCIUM SENSING RECEPTOR; CREATININE; PAMIDRONIC ACID; PARATHYROID HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; BONE; CALCITONIN BLOOD LEVEL; CALCIUM ABSORPTION; CALCIUM BLOOD LEVEL; CALCIUM EXCRETION; CALCIUM TRANSPORT; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIET; DRUG EFFECT; DRUG MECHANISM; DUODENUM; GENE EXPRESSION; GENOTYPE; HORMONE DEFICIENCY; IN VIVO STUDY; KIDNEY; MOUSE; NONHUMAN; PARATHYROID HORMONE BLOOD LEVEL; PRIORITY JOURNAL; REGULATORY MECHANISM; SINGLE DRUG DOSE; URINARY EXCRETION; WILD TYPE;

EID: 69449085358     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00164.2009     Document Type: Article

References (28)

1. Dusso A, Brown A, Slatoposky E. Vitamin D. Am J Physiol Renal Physiol 289: F8-F28, 2005.
2. Ba J, Friedman PA. Calcium-sensing receptor regulation of renal mineral ion transport. Cell Calcium 35: 229-237, 2004. (Pubitemid 38292366)
3. Brown EM. Calcium sensing by endocrine cells. Endocr Pathol 15: 187-220, 2004.
4. Buchan AM, Squires PE, Ring M, Meloche RM. Mechanism of action of the calcium-sensing receptor in human antral gastrin cells. Gastroenterology 120: 1128-1139, 2001. (Pubitemid 32246667)
5. Chang W, Tu C, Chen TH, Bikle D, Shoback D. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal 1: ra1, 2008.
6. Chattopadhyay N, Brown EM. Role of calcium-sensing receptor in mineral ion metabolism and inherited disorders of calcium-sensing. Mol Genet Metab 89: 189-202, 2006. (Pubitemid 44442994)
7. Chertow GM, Pupim LB, Block GA, Correa-Rotter R, Drueke TB, Floege J, Goodman WG, London GM, Mahaffey KW, Moe SM, Wheeler DC, Albizem M, Olson K, Klassen P, Parfrey P. Evaluation of Cinacalcet Therapy to Lower Cardiovascular Events (EVOLVE): rationale and design overview. Clin J Am Soc Nephrol 2: 898-905, 2007.
8. 2+-sensing receptor promotes loss of cancellous bone. Endocrinology 148: 3156-3163, 2007.
9. Efrati E, Arsentiev-Rozenfeld J, Zelikovic I. The human paracellin-1 gene (hPCLN-1): renal epithelial cell-specific expression and regulation. Am J Physiol Renal Physiol 288: F272-F283, 2005. (Pubitemid 40105385)
10. Fudge NJ, Kovacs CS. Physiological studies in heterozygous calcium sensing receptor (CaSR) gene-ablated mice confirm that the CaSR regulates calcitonin release in vivo. BMC Physiol 4: 5, 2004.
11. 2+ in kidneys of 25-hydroxyvitamin D3-1 alpha-hydroxylase knockout mice. Kidney Int 65: 531-539, 2004.
12. Jara A, Lee E, Stauber D, Moatamed F, Felsenfeld AJ, Kleeman CR. Phosphate depletion in the rat: effect of bisphosphonates and the calcemic response to PTH. Kidney Int 55: 1434-1443, 1999. (Pubitemid 29157142)
13. Kantham L, Quinn S, Egbuna O, Pang J, Butters R, Pollak M, Brown EM. The calcium sensing receptor defends against hypercalcemia independent of its regulation of PTH. Abstracts of the 29th Annual Meeting of the American Society for Bone and Mineral Research, Honolulu, Hawaii. Washington, DC: Am Soc Bone Min Res, 2007.
14. Kos CH, Karaplis AC, Peng JB, Hediger MA, Goltzman D, Mohammad KS, Guise TA, Pollak MR. The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone. J Clin Invest 111: 1021-1028, 2003. (Pubitemid 36397478)
15. Kutuzova GD, Deluca HF. Gene expression profiles in rat intestine identify pathways for 1,25-dihydroxyvitamin D3 stimulated calcium absorption and clarify its immunomodulatory properties. Arch Biochem Biophys 432: 152-166, 2004.
16. Lee CT, Huynh VM, Lai LW, Lien YH. Cyclosporine A-induced hypercalciuria in calbindin-D28k knockout and wild-type mice. Kidney Int 62: 2055-2061, 2002.
17. Lemay J, Demers C, Hendy GN, Delvin EE, Gascon-Barre M. Expression of the 1,25-dihydroxyvitamin D3-24-hydroxylase gene in rat intestine: response to calcium, vitamin D3 and calcitriol administration in vivo. J Bone Miner Res 10: 1148-1157, 1995.
18. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-ΔΔCT) method. Methods 25: 402-408, 2001. (Pubitemid 34164012)
19. Maiti A, Hait NC, Beckman MJ. Extracellular calcium-sensing receptor activation induces vitamin D receptor levels in proximal kidney HK-2G cells by a mechanism that requires phosphorylation of p38alpha MAPK. J Biol Chem 283: 175-183, 2008.
20. Mentaverri R, Yano S, Chattopadhyay N, Petit L, Kifor O, Kamel S, Terwilliger EF, Brazier M, Brown EM. The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis. FASEB J 20: 2562-2564, 2006. (Pubitemid 44953781)
21. Muindi JR, Modzelewski RA, Peng Y, Trump DL, Johnson CS. Pharmacokinetics of 1alpha,25-dihydroxyvitamin D3 in normal mice after systemic exposure to effective and safe antitumor doses. Oncology 66: 62-66, 2004. (Pubitemid 38410681)
22. Naveh-Many T, Silver J. Regulation of calcitonin gene transcription by vitamin D metabolites in vivo in the rat. J Clin Invest 81: 270-273, 1988. (Pubitemid 18092263)
23. Oda Y, Tu CL, Chang W, Crumrine D, Komuves L, Mauro T, Elias PM, Bikle DD. The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation. J Biol Chem 275: 1183-1190, 2000. (Pubitemid 30051170)
24. Oda Y, Tu CL, Pillai S, Bikle DD. The calcium sensing receptor and its alternatively spliced form in keratinocyte differentiation. J Biol Chem 273: 23344-23352, 1998. (Pubitemid 28417522)
25. Peleg S, Abruzzese RV, Cooper CW, Gagel RF. Down-regulation of calcitonin gene transcription by vitamin D requires two widely separated enhancer sequences. Mol Endocrinol 7: 999-1008, 1993. (Pubitemid 23252339)
26. Schoeber JP, Hoenderop JG, Bindels RJ. Concerted action of associated proteins in the regulation of TRPV5 and TRPV6. Biochem Soc Trans 35: 115-119, 2007.
27. Tfelt-Hansen J, Brown EM. The calcium-sensing receptor in normal physiology and pathophysiology: a review. Crit Rev Clin Lab Sci 42: 35-70, 2005. (Pubitemid 41656709)
28. Tu Q, Pi M, Karsenty G, Simpson L, Liu S, Quarles LD. Rescue of the skeletal phenotype in CasR-deficient mice by transfer onto the Gcm2 null background. J Clin Invest 111: 1029-1037, 2003. (Pubitemid 36397479)