An integrative model links multiple inputs and signaling pathways to the onset of DNA synthesis in hepatocytes

FEBS Journal

Volumn 279, Issue 18, 2012, Pages 3290-3313

  Huard, Jérémy ^a   Mueller, Stephanie ^b   Gilles, Ernst D ^a   Klingmüller, Ursula ^b   Klamt, Steffen ^a  

^a MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS   (Germany)

^b GERMAN CANCER RESEARCH CENTER   (Germany)

Author keywords

DNA synthesis; hepatocytes; integration; logical modeling; signaling pathways

Indexed keywords

DNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; CELL CYCLE PHASE; CELL CYCLE REGULATION; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; DNA REPLICATION; DNA SYNTHESIS; ENZYME ACTIVATION; EXPERIMENTAL DESIGN; G1 PHASE CELL CYCLE CHECKPOINT; GENE MUTATION; INTERMETHOD COMPARISON; LIVER CELL; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; NONHUMAN; POSITIVE FEEDBACK; PREDICTION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; VALIDATION PROCESS;

ANIMALS; CELL CYCLE; CELL PROLIFERATION; DNA REPLICATION; EPIDERMAL GROWTH FACTOR; HEPATOCYTE GROWTH FACTOR; HEPATOCYTES; INSULIN; INTERLEUKIN-6; LIVER REGENERATION; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; PHOSPHATIDYLINOSITOL 3-KINASES; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84865971299     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2012.08572.x     Document Type: Conference Paper

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