Primary mouse hepatocytes for systems biology approaches: A standardized in vitro system for modelling of signal transduction pathways

IEE Proceedings: Systems Biology

Volumn 153, Issue 6, 2006, Pages 433-447

  Klingmuller U ^a   Bauer, A ^b   Bohl, S ^a   Nickel, P J ^a   Breitkopf, K ^c   Dooley, S ^c   Zellmer, S ^b   Kern, C ^d   Merfort, I ^d   Sparna, T ^d   Donauer, J ^e   Walz, G ^e   Geyer, M ^e   Kreutz, C ^d   Hermes, M ^b   Gotschel F ^d   Hecht, A ^d   Walter, D ^d   Egger, L ^d   Neubert, K ^d   Borner, C ^d   Brulport, M ^b   Schormann, W ^b   Sauer, C ^b   Baumann, F ^b   Preiss, R ^b   MacNelly, S ^d   Godoy, P ^c   Wiercinska, E ^c   Ciuclan, L ^c   Edelmann, J ^b   Zeilinger, K ^f   Heinrich, M ^b   Zanger, U M ^g   Gebhardt, R ^b   Maiwald, T ^d   Heinrich, R ^h   Timmer, J ^d   von Weizsacker F ^d   Hengstler, J G ^b   more..

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d UNIVERSITY OF FREIBURG   (Germany)

^e UNIVERSITY OF FREIBURG   (Germany)

^f University Medicine   (Germany)

^g DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^h HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CELL CULTURE; ENZYME KINETICS; MATHEMATICAL MODELS; METABOLISM;

HEPATOCYTES; PHOSPHORYLATION; SIGNALLING PATHWAY;

BIOLOGY;

BETA CATENIN; CYTOCHROME P450 3A; FAS LIGAND; GLUTAMATE AMMONIA LIGASE; GLUTATHIONE TRANSFERASE; GLYCOGEN SYNTHASE KINASE 3BETA; GLYCOPROTEIN GP 130; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; JANUS KINASE; JANUS KINASE 1; LACTIC ACID; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SCATTER FACTOR; SMAD PROTEIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; STAT PROTEIN; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UREA; WNT PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL ISOLATION; CELL SECRETION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DNA RESPONSIVE ELEMENT; ENZYME ACTIVITY; ENZYME INHIBITION; GENE CONSTRUCT; GENETIC TRANSCRIPTION; HOMEOSTASIS; IN VITRO STUDY; LIVER CELL; LIVER CELL CULTURE; LIVER METABOLISM; MATHEMATICAL MODEL; MOUSE; NONHUMAN; PROCESS MONITORING; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RELIABILITY; REPORTER GENE; REPRODUCIBILITY; SIGNAL TRANSDUCTION; STANDARDIZATION; STARVATION; STRESS; SYSTEMS BIOLOGY;

ANIMALS; COMPUTER SIMULATION; CYTOKINES; HEPATOCYTES; MICE; MODELS, ANIMAL; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; SIGNAL TRANSDUCTION; SYSTEMS BIOLOGY;

EID: 33750795440     PISSN: 17412471     EISSN: None     Source Type: Journal    
DOI: 10.1049/ip-syb:20050067     Document Type: Article

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