A toxicological and dermatological assessment of aryl alkyl alcohols when used as fragrance ingredients

Food and Chemical Toxicology

Volumn 50, Issue SUPPL. 2, 2012, Pages

  Belsito, D ^a   Bickers, D ^a   Bruze, M ^b   Calow, P ^c   Dagli, M L ^d   Fryer, A D ^e   Greim, H ^f   Miyachi, Y ^g   Saurat, J H ^h   Sipes, I G ⁱ   Api, A M ^j  

^a NewYork Presbyterian Hospital   (United States)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c Science and Public Policy   (United States)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

^e OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^f TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^g KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^h UNIVERSITY OF GENEVA   (Switzerland)

ⁱ UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^j RIFM   (United States)

more..

Author keywords

Aryl alkyl alcohols; Fragrance ingredients; Safety review

Indexed keywords

1 6 PRIMARY ARYL ALKYL ALCOHOL; 1 PHENYLETHANOL; 2 (3 METHYLPHENYL)ETHANOL; 2 (4 METHYLPHENOXY)ETHANOL; 2 (4 TERT BUTYL PHENYL)ETHANOL; 2 4 TOLYLETHANOL; 2 BENZYLHEPTANOL; 2 METHOXYBENZYL ALCOHOL; 2 METHYL 4 PHENYLPENTANOL; 2 METHYL 5 PHENYLPENTANOL; 2 PHENOXYETHANOL; 2 PHENYLPENTANOL; 2 TOLYLETHANOL; 2,2 DIMETHYL 3 PHENYLPROPANOL; 3 (4 ISOPROPYL)PHENYL 2 METHYL 1 PROPANOL; 3 METHYL 5 PHENYLPENTANOL; 4 ISOPROPYLBENZYL ALCOHOL; 4 METHOXYBENZYL ALCOHOL; 4 METHYL 1 PHENYL 2 PENTANOL; 4 TOLYL ALCOHOL; ALCOHOL DERIVATIVE; ARYL ALKYL ALCOHOL DERIVATIVE; BENZYL ALCOHOL; BETA METHOXY BENZENEETHANOL; BETA METHYLPHENETHYL ALCOHOL; BETA, BETA 3 TRIMETHYL BENZENEPROPANOL; FRAGRANCE; PHENETHYL ALCOHOL; PHENYLPROPANOL; UNCLASSIFIED DRUG;

ALCOHOL METABOLISM; CARCINOGENESIS; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; COSMETIC INDUSTRY; DRUG BLOOD LEVEL; ENVIRONMENTAL EXPOSURE; GENOTOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOTOPE LABELING; LD 50; MICRONUCLEUS; MUTAGENICITY; NONHUMAN; OXIDATION; PHOTOSENSITIZATION; PHOTOTOXICITY; REVIEW; TISSUE LEVEL; TOXICOKINETICS;

ALCOHOLS; ANIMALS; GUINEA PIGS; HUMANS; PERFUME; RATS; SKIN; TOXICITY TESTS;

BACTERIA (MICROORGANISMS); MAMMALIA; MUS; RATTUS;

EID: 84865740513     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.10.042     Document Type: Review

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144. RIFM (Research Institute for Fragrance Materials, Inc.), 1963d. Eye irritation study with α,α-4-trimethylphenethyl alcohol (Methyl-p Dimethyl Benzyl Carbinol) in rabbits. Unpublished report from International Flavors and Fragrances, 22 November. Report Number 53556, RIFM, Woodcliff Lake, NJ, USA.
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146. RIFM (Research Institute for Fragrance Materials, Inc.), 1964b. Repeated insult patch test of phenethyl alcohol in human subjects. Unpublished report from International Flavors and Fragrances, 16 October. Report Number 10539, RIFM, Woodcliff Lake, NJ, USA.
147. RIFM (Research Institute for Fragrance Materials, Inc.), 1964c. Repeated insult patch test of p-tolyl alcohol in humans subjects. Unpublished report from International Flavors and Fragrances, 31 March. Report Number 15233, RIFM, Woodcliff Lake, NJ, USA.
148. RIFM (Research Institute for Fragrance Materials, Inc.), 1964d. Repeated insult patch test with alpha,alpha-dimethylphenethyl alcohol. Unpublished report from International Flavors and Fragrances, 28 April. Report Number 50696, RIFM, Woodcliff Lake, NJ, USA.
149. RIFM (Research Institute for Fragrance Materials, Inc.), 1964e. Repeated insult patch test with 1-phenyl-3-methyl-3-pentanol (phenyl ethyl methyl ethyl carbinol) in humans. Unpublished report from International Flavors and Fragrances, 02 April. Report Number 54742, RIFM, Woodcliff Lake, NJ, USA.
150. RIFM (Research Institute for Fragrance Materials, Inc.), 1964f. Repeated insult patch test with α,α-4-trimethylphenethyl alcohol(Methyl-p Dimethyl Benzyl Carbinol). Unpublished report from International Flavors and Fragrances, 31 March. Report Number 53555, RIFM, Woodcliff Lake, NJ, USA.
151. RIFM (Research Institute for Fragrance Materials, Inc.), 1964g. Eye irritation study with 2-methoxybenzyl alcohol in rabbits. Unpublished report from International Flavors and Fragrances, 26 October. Report Number 53113, RIFM, Woodcliff Lake, NJ, USA.
152. RIFM (Research Institute for Fragrance Materials, Inc.), 1964h. Rabbit eye irritation study with beta-methylphenethyl alcohol. Unpublished report from International Flavors and Fragrances, 10 March. Report Number 51924, RIFM, Woodcliff Lake, NJ, USA.
153. RIFM (Research Institute for Fragrance Materials, Inc.), 1964i. Eye irritation of p-tolyl alcohol in rabbits. Unpublished report from International Flavors and Fragrances, 16 March. Report Number 15232, RIFM, Woodcliff Lake, NJ, USA.
154. RIFM (Research Institute for Fragrance Materials, Inc.), 1964j. Eye irritation study with 3-methyl-1-phenylbutan-2-ol in rabbits. Unpublished report from International Flavors and Fragrances, 21 September. Report Number 53076, RIFM, Woodcliff Lake, NJ, USA.
155. RIFM (Research Institute for Fragrance Materials, Inc.), 1964k. Eye irritation study with 1-phenyl-3-methyl-3-pentanol (phenyl ethyl methyl ethyl carbinol) in rabbits. Unpublished report from International Flavors and Fragrances, 02, March. Report Number 54745, RIFM, Woodcliff Lake, NJ, USA.
156. RIFM (Research Institute for Fragrance Materials, Inc.), 1964l. Eye irritation study with α,α-4-trimethylphenethyl alcohol (Methyl-p Dimethyl Benzyl Carbinol) in rabbits. Unpublished report from International Flavors and Fragrances, 10 March. Report Number 53557, RIFM, Woodcliff Lake, NJ, USA.
157. RIFM (Research Institute for Fragrance Materials, Inc.), 1965a. Repeated insult patch test with 2-methoxybenzyl alcohol. Unpublished report from International Flavors and Fragrances, 01 March. Report Number 53112, RIFM, Woodcliff Lake, NJ, USA.
158. RIFM (Research Institute for Fragrance Materials, Inc.), 1965b. Eye irritation study of phenethyl alcohol in rabbits' eyes. Unpublished report from International Flavors and Fragrances, 10 March. Report Number 10543, RIFM, Woodcliff Lake, NJ, USA.
159. RIFM (Research Institute for Fragrance Materials, Inc.), 1966a. Repeated insult patch test with p-alpha,alpha-trimethylbenzyl alcohol. Unpublished report from International Flavors and Fragrances, 24 June. Report Number 50597, RIFM, Woodcliff Lake, NJ, USA.
160. RIFM (Research Institute for Fragrance Materials, Inc.), 1966b. Eye irritation test with p-alpha,alpha-trimethylbenzyl alcohol in rabbits. Unpublished report from International Flavors and Fragrances, 03 May. Report Number 50596, RIFM, Woodcliff Lake, NJ, USA.
161. RIFM (Research Institute for Fragrance Materials, Inc.), 1970. The contact sensitizing potential of fragrance materials in humans. RIFM Report Number 1760, October 07, RIFM, Woodcliff Lake, NJ, USA.
162. RIFM (Research Institute for Fragrance Materials, Inc.), 1971a. Appraisal of sensitizing powers by maximization testing in humans. RIFM Report Number 1805, May 24, RIFM, Woodcliff Lake, NJ, USA.
163. RIFM (Research Institute for Fragrance Materials, Inc.), 1971b. Repeated insult patch test with 2-(4-methylphenoxy)ethanol in humans. Unpublished report from International Flavors and Fragrances, 02 December. Report Number 55017, RIFM, Woodcliff Lake, NJ, USA.
164. RIFM (Research Institute for Fragrance Materials, Inc.), 1971c. Eye irritation study with 2-(4-methylphenoxy)ethanol in rabbits. Unpublished report from International Flavors and Fragrances, 28 June. Report Number 55019, RIFM, Woodcliff Lake, NJ, USA.
165. RIFM (Research Institute for Fragrance Materials, Inc.), 1972. Repeated insult patch test with 2-(4-methylphenoxy)ethanol in humans. Unpublished report from International Flavors and Fragrances, 17 January. Report Number 55018, RIFM, Woodcliff Lake, NJ, USA.
166. RIFM (Research Institute for Fragrance Materials, Inc.), 1973a. Acute toxicity studies on rats and rabbits. RIFM Report Number 2021, February 01, RIFM, Woodcliff Lake, NJ, USA.
167. RIFM (Research Institute for Fragrance Materials, Inc.), 1973b. Acute oral and dermal toxicity studies. RIFM Report Number 2032, January 30, RIFM, Woodcliff Lake, NJ, USA.
168. RIFM (Research Institute for Fragrance Materials, Inc.), 1973c. Report on human maximization studies. RIFM Report Number 1803, March 23, RIFM, Woodcliff Lake, NJ, USA.
169. RIFM (Research Institute for Fragrance Materials, Inc.), 1973d. Report on human maximization studies. RIFM Report Number 1802, May 25, RIFM, Woodcliff Lake, NJ, USA.
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171. RIFM (Research Institute for Fragrance Materials, Inc.), 1974a. Acute toxicity studies in rats and rabbits. RIFM Report Number 2027, September 27, RIFM, Woodcliff Lake, NJ, USA.
172. RIFM (Research Institute for Fragrance Materials, Inc.), 1974b. Acute toxicity studies on phenethyl alcohol. Unpublished report from BASF, 02 July. Report Number 4451, RIFM, Woodcliff Lake, NJ, USA.
173. RIFM (Research Institute for Fragrance Materials, Inc.), 1975a. Acute toxicity studies on rats, rabbits and guinea pigs. RIFM Report Number 2020, February 10, RIFM, Woodcliff Lake, NJ, USA.
174. RIFM (Research Institute for Fragrance Materials, Inc.), 1975b. Repeated insult patch test of 3-methyl-5-phenylpentanol in human subjects. Unpublished report from IFF Incorporated, Report Number 34989, RIFM, Woodcliff Lake, NJ, USA.
175. RIFM (Research Institute for Fragrance Materials, Inc.), 1975c. Repeated insult patch test of 3-methyl-5-phenylpentanol in human subjects. Unpublished report from IFF Incorporated, 17 June Report Number 34990, RIFM, Woodcliff Lake, NJ, USA.
176. RIFM (Research Institute for Fragrance Materials, Inc.), 1975d. Report on human maximization studies. RIFM Report Number 1798, March 05, RIFM, Woodcliff Lake, NJ, USA.
177. RIFM (Research Institute for Fragrance Materials, Inc.), 1975e. Acute toxicity study of 3-methyl-5-phenylpentanol in rabbits. Unpublished report from IFF Incorporated, Report Number 34994, RIFM, Woodcliff Lake, NJ, USA.
178. RIFM (Research Institute for Fragrance Materials, Inc.), 1975f. Acute toxicity study of 3-methyl-5-phenylpentanol in rabbits. Unpublished report from IFF Incorporated, 27 February Report Number 34995, RIFM, Woodcliff Lake, NJ, USA.
179. RIFM (Research Institute for Fragrance Materials, Inc.), 1975g. Eye irritation test of 3-methyl-5-phenylpentanol in rabbits. Unpublished report from IFF Incorporated, 02 April. Report Number 34992, RIFM, Woodcliff Lake, NJ, USA.
180. RIFM (Research Institute for Fragrance Materials, Inc.), 1975h. Eye irritation study of 3-methyl-5-phenylpentanol in rabbits. Unpublished report from IFF Incorporated, 12 March. Report Number 34993, RIFM, Woodcliff Lake, NJ, USA.
181. RIFM (Research Institute for Fragrance Materials, Inc.), 1977a. Acute toxicity study in rats, rabbits and guinea pigs. RIFM Report Number 1695, April 08, RIFM, Woodcliff Lake, NJ, USA.
182. RIFM (Research Institute for Fragrance Materials, Inc.), 1977b. Skin irritation study of 2-phenoxyethanol in rabbits. Unpublished report from International Flavors and Fragrances, 14 October. Report Number 7692, RIFM, Woodcliff Lake, NJ, USA.
183. RIFM (Research Institute for Fragrance Materials, Inc.), 1977c. Report on human maximization studies. RIFM Report Number 1702, February 07, RIFM, Woodcliff Lake, NJ, USA.
184. RIFM (Research Institute for Fragrance Materials, Inc.), 1977d. Eye irritation of 3-methyl-5-phenylpentanol in rabbits. Unpublished report from IFF Incorporated, 21 February. Report Number 34991, RIFM, Woodcliff Lake, NJ, USA.
185. RIFM (Research Institute for Fragrance Materials, Inc.), 1977e. Eye irritation study of 2-phenoxyethanol in rabbits. Unpublished report from International Flavors and Fragrances, 24 October. Report Number 7691, RIFM, Woodcliff Lake, NJ, USA.
186. RIFM (Research Institute for Fragrance Materials, Inc.), 1978a. Acute toxicity studies in rats, mice, rabbits, and guinea pigs. RIFM Report Number 1699, October 03, RIFM, Woodcliff Lake, NJ, USA.
187. RIFM (Research Institute for Fragrance Materials, Inc.), 1978b. Repeated insult patch test of 2-phenoxyethanol in human subjects. Unpublished report from International Flavors and Fragrances, 30 May. Report Number 7690, RIFM, Woodcliff Lake, NJ, USA.
188. RIFM (Research Institute for Fragrance Materials, Inc.), 1978c. Report on human maximization studies. RIFM Report Number 1698, July 21, RIFM, Woodcliff Lake, NJ, USA.
189. RIFM (Research Institute for Fragrance Materials, Inc.), 1978d. Skin irritation and capacity for allergenic sensitization of alpha,alpha-dimethylphenethyl alcohol (dimethyl benzyl carbinol) in guinea pigs. Unpublished report from Givaudan, 22 August. Report Number 57070, RIFM, Woodcliff Lake, NJ, USA.
190. RIFM (Research Institute for Fragrance Materials, Inc.), 1979a. Acute dermal toxicity study of benzeneethanol, beta-methoxy in rabbits. Unpublished report from Firmenich Incorporated, 05 September. Report Number 41462, RIFM, Woodcliff Lake, NJ, USA.
191. RIFM (Research Institute for Fragrance Materials, Inc.), 1979b. Acute oral toxicity study of benzeneethanol, b-methoxy- in rats. Unpublished report from Firmenich Incorporated, 05 September. Report Number 41461, RIFM, Woodcliff Lake, NJ, USA.
192. RIFM (Research Institute for Fragrance Materials, Inc.), 1979c. The short-term (13 week) toxicity of 2-phenyl-1-propanol in rats. Unpublished report from Gaunt, I.F., Wright, M.G., Cottrell, R. Report Number 7487, RIFM, Woodcliff Lake, NJ, USA.
193. RIFM (Research Institute for Fragrance Materials, Inc.), 1979d. Report on human maximization studies. RIFM Report Number 1697, May 25, RIFM, Woodcliff Lake, NJ, USA.
194. RIFM (Research Institute for Fragrance Materials, Inc.), 1979e. Repeated insult patch test/photosensitization study of benzeneethanol, beta-methoxy- in human subjects. Unpublished report from Firmenich Incorporated, 10 September. Report Number 41465, RIFM, Woodcliff Lake, NJ, USA.
195. RIFM (Research Institute for Fragrance Materials, Inc.), 1979f. Primary skin irritation study of benzeneethanol, beta-methoxy- in rabbits. Unpublished report from Firmenich Incorporated, 05 September. Report Number 41463, RIFM, Woodcliff Lake, NJ, USA.
196. RIFM (Research Institute for Fragrance Materials, Inc.), 1979g. Primary eye irritation study of benzeneethanol, beta-methoxy- in rabbits. Unpublished report from Firmenich Incorporated, 05 September. Report Number 41464, RIFM, Woodcliff Lake, NJ, USA.
197. RIFM (Research Institute for Fragrance Materials, Inc.), 1979h. Primary ocular irritation study of phenethyl alcohol in rabbits. Unpublished report from International Flavors and Fragrances, 04 September. Report Number 10542, RIFM, Woodcliff Lake, NJ, USA.
198. RIFM (Research Institute for Fragrance Materials, Inc.), 1980a. Acute dermal toxicity of 3-methyl-5-phenylpentanol in rats. Unpublished report from IFF Incorporated, Report Number 34999, RIFM, Woodcliff Lake, NJ, USA.
199. RIFM (Research Institute for Fragrance Materials, Inc.), 1980b. Acute oral median lethal dose (LD50) toxicity of 3-methyl-5-phenylpentanol in rats. Unpublished report from IFF Incorporated, Report Number 34997, RIFM, Woodcliff Lake, NJ, USA.
200. RIFM (Research Institute for Fragrance Materials, Inc.), 1980c. Acute oral median lethal dose (LD50 toxicity of 3-methyl-5-phenylpentanol in rats. Unpublished report from IFF Incorporated, Report Number 34998, RIFM, Woodcliff Lake, NJ, USA.
201. RIFM (Research Institute for Fragrance Materials, Inc.), 1980d. The acute toxicity of inhaled phenyl ethyl alcohol in the albino rat. RIFM Report Number 5692, The acute toxicity of inhaled phenyl ethyl alcohol in the albino rat, RIFM, Woodcliff Lake, NJ, USA.
202. RIFM (Research Institute for Fragrance Materials, Inc.), 1980e. 3-Methyl-5-phenylpentanol: Test for contact sensitization potential in the guinea pig (maximisation test). Unpublished report from Naarden International, Report Number 43266, RIFM, Woodcliff Lake, NJ, USA.
203. RIFM (Research Institute for Fragrance Materials, Inc.), 1981a. 2,2-Dimethyl-3-phenylpropanol: Acute dermal toxicity in rats. Unpublished report from Dragoco Gerberding and Co. GmbH, Report Number 37808, RIFM, Woodcliff Lake, NJ, USA.
204. RIFM (Research Institute for Fragrance Materials, Inc.), 1981b. 2,2-Dimethyl-3-phenylpropanol: Acute oral toxicity in rats. Unpublished report from Dragoco Gerberding and Co. GmbH, Report Number 37809, RIFM, Woodcliff Lake, NJ, USA.
205. RIFM (Research Institute for Fragrance Materials, Inc.), 1981c. The short-term (90-day) toxicity of 4-methyl-1-phenyl-2-pentanol in rats. Private communication to FEMA. Unpublished report from D.M. Conning, G.P. Ford, W.H. Butler, 01 October. Report Number 29935, RIFM, Woodcliff Lake, NJ, USA.
206. RIFM (Research Institute for Fragrance Materials, Inc.), 1981d. Draize animal mucous membrane irritation test of 2,2-dimethyl-3-phenylpropanol 20% in peanut oil in rabbits. Unpublished report from Dragoco Gerberding and Co. GmbH, Report Number 37805, RIFM, Woodcliff Lake, NJ, USA.
207. RIFM (Research Institute for Fragrance Materials, Inc.), 1981e. Epicutaneous patch test of 2,2-dimethyl-3-phenylpropanol on humans. Unpublished report from Dragoco Gerberding and Co. GmbH, Report Number 37802, RIFM, Woodcliff Lake, NJ, USA.
208. RIFM (Research Institute for Fragrance Materials, Inc.), 1981f. 2,2-Dimethyl-3-phenylpropanol 20% in peanut-oil: Delayed contact hypersensitivity modified by Buehler. Unpublished report from Dragoco Gerberding adn Co. GmbH, Report Number 37806, RIFM, Woodcliff Lake, NJ, USA.
209. RIFM (Research Institute for Fragrance Materials, Inc.), 1981g. 2,2-Dimethyl-3-phenylpropanol 20% in peanut oil: Experimental investigation on photosensitizing effect in guinea-pigs. Unpublished report from Dragoco Gerberding and Co. GmbH, Report Number 37807, RIFM, Woodcliff Lake, NJ, USA.
210. RIFM (Research Institute for Fragrance Materials, Inc.), 1982a. Acute toxicity studies. RIFM Report Number 1689, February 22, RIFM, Woodcliff Lake, NJ, USA.
211. RIFM (Research Institute for Fragrance Materials, Inc.), 1982b. Acute oral toxicity study of phenethyl alcohol in rats (14 days). Unpublished report from International Flavors and Fragrances, 27 December. Report Number 10541, RIFM, Woodcliff Lake, NJ, USA.
212. RIFM (Research Institute for Fragrance Materials, Inc.), 1982c. Report on human maximization studies. RIFM Report Number 1643, January 13, RIFM, Woodcliff Lake, NJ, USA.
213. RIFM (Research Institute for Fragrance Materials, Inc.), 1982d. 2,2-Dimethyl-3-phenylpropanol 10% in peanut oil and peanut oil (control substance): Experimental investigation on phototoxic effect in guinea pigs. Unpublished report from Dragoco Gerberding and Co. GmbH, Report Number 37804, RIFM, Woodcliff Lake, NJ, USA.
214. RIFM (Research Institute for Fragrance Materials, Inc.), 1982e. A phototoxicity study of 2,2-dimethyl-3-phenylpropanol in the guinea pig. Unpublished report from Dragoco Gerberding & Co. GmbH, Report Number 38154, RIFM, Woodcliff Lake, NJ, USA.
215. RIFM (Research Institute for Fragrance Materials, Inc.), 1983a. Acute dermal toxicity test of phenethyl alcohol in rabbits. Unpublished report from International Flavors and Fragrances, 03 January. Report Number 10540, RIFM, Woodcliff Lake, NJ, USA.
216. RIFM (Research Institute for Fragrance Materials, Inc.), 1983b. Submission to EPA. Unpublished report from Union Carbide Corporation, Report Number 7155, RIFM, Woodcliff Lake, NJ, USA.
217. RIFM (Research Institute for Fragrance Materials, Inc.), 1983c. Submission to EPA. Unpublished report from Dow Chemical Company, Report Number 7158, RIFM, Woodcliff Lake, NJ, USA.
218. RIFM (Research Institute for Fragrance Materials, Inc.), 1983d. Evaluation to determine potential hazards of phenethyl alcohol by dermal contact. Unpublished report from International Flavors and Fragrances, 13 February. Report Number 10545, RIFM, Woodcliff Lake, NJ, USA.
219. RIFM (Research Institute for Fragrance Materials, Inc.), 1983e. Evaluation of phenethyl alcohol by dermal contact. Unpublished report from International Flavors and Fragrances, 06 January. Report Number 10547, RIFM, Woodcliff Lake, NJ, USA.
220. RIFM (Research Institute for Fragrance Materials, Inc.), 1983f. Guinea pig skin irritation test with phenethyl alcohol. Unpublished report from Quest International, 05 July. Report Number 46688, RIFM, Woodcliff Lake, NJ, USA.
221. RIFM (Research Institute for Fragrance Materials, Inc.), 1984a. Submission to EPA. Unpublished report from Eastman Kodak Company, Report Number 7157, RIFM, Woodcliff Lake, NJ, USA.
222. RIFM (Research Institute for Fragrance Materials, Inc.), 1984b. Primary irritation test in rabbits. RIFM Report Number 1795, June 01, RIFM, Woodcliff Lake, NJ, USA.
223. RIFM (Research Institute for Fragrance Materials, Inc.), 1985a. Acute toxicological study with benzenepropanol beta,beta-3-trimethyl- after oral application to the rat. Unpublished report from Symrise GmbH & Co. KG, 01 May. Report Number 49518, RIFM, Woodcliff Lake, NJ, USA.
224. RIFM (Research Institute for Fragrance Materials, Inc.), 1985b. Submission to EPA. Unpublished report from Dow Chemical Company, Report Number 7153, RIFM, Woodcliff Lake, NJ, USA.
225. RIFM (Research Institute for Fragrance Materials, Inc.), 1985c. Effect of dietary administration of micro-encapsulated phenylethyl alcohol on pregnancy of the rat. Unpublished report from A.M. Bottomley, H.E. Ratcliffe, D.M. John, A. Anderson and I.S. Dawe Report Number 2960, RIFM, Woodcliff Lake, NJ, USA.
226. RIFM (Research Institute for Fragrance Materials, Inc.), 1985d. alpha,alpha-Dimethylphenethyl alcohol (Dimethyl benzyl carbinol): repeated insult patch test. Unpublished report from Givaudan, 06 March. Report Number 57071, RIFM, Woodcliff Lake, NJ, USA.
227. RIFM (Research Institute for Fragrance Materials, Inc.), 1985e. Primary irritation test in rabbits. RIFM Report Number 3099, June 01, RIFM, Woodcliff Lake, NJ, USA.
228. RIFM (Research Institute for Fragrance Materials, Inc.), 1985f. Irritant effects of benzenepropanol beta,beta-3-trimethyl- on rabbit skin. Unpublished report from Symrise GmbH & Co. KG, 01 May. Report Number 49520, RIFM, Woodcliff Lake, NJ, USA.
229. RIFM (Research Institute for Fragrance Materials, Inc.), 1985g. Delayed contact hypersensitivity of benzenepropanol beta,beta-3-trimethyl- in guinea-pigs modified by B. Magnusson and A.M. Kligman. Unpublished report from Symrise GmbH & Co. KG, 08 October. Report Number 49522, RIFM, Woodcliff Lake, NJ, USA.
230. RIFM (Research Institute for Fragrance Materials, Inc.), 1985h. beta,beta-3-Trimethyl benzenepropanol (muguetol B): experimental investigation on phototoxic effect in guinea pigs. Unpublished report from Symrise GmbH & Co. KG, 04 January. Report Number 58665, RIFM, Woodcliff Lake, NJ, USA.
231. RIFM (Research Institute for Fragrance Materials, Inc.), 1985i. beta,beta-3-Trimethyl benzenepropanol (muguetol B): experimental investigation on photo-sensitizing effect in guinea-pigs. Unpublished report from Symrise GmbH & Co. KG, 04 January. Report Number 58683, RIFM, Woodcliff Lake, NJ, USA.
232. RIFM (Research Institute for Fragrance Materials, Inc.), 1986a. Dermal absorption and disposition of (14)C-2-phenylethanol in rats. RIFM Report Number 14274, Dermal absorption and disposition of (14)C-2-phenylethanol in rats, RIFM, Woodcliff Lake, NJ, USA.
233. RIFM (Research Institute for Fragrance Materials, Inc.), 1986b. Submission to EPA. Unpublished report from Dow Chemical Company, Report Number 9744, RIFM, Woodcliff Lake, NJ, USA.
234. RIFM (Research Institute for Fragrance Materials, Inc.), 1986c. Submission to EPA. Unpublished report from Dow Chemical Company, Report Number 7152, RIFM, Woodcliff Lake, NJ, USA.
235. RIFM (Research Institute for Fragrance Materials, Inc.), 1986d. Effect of phenylethyl alcohol (PEA) on pregnancy of the rat. RIFM Report Number 14279, April 03, RIFM, Woodcliff Lake, NJ, USA.
236. RIFM (Research Institute for Fragrance Materials, Inc.), 1986e. Screening of priority chemicals for reproductive hazards. Unpublished report. Report Number 5943, September 5, RIFM, Woodcliff Lake, NJ, USA.
237. RIFM (Research Institute for Fragrance Materials, Inc.), 1987a. The dermal absorption of (14)C-2-phenylethanol in man following a single topical application. RIFM Report Number 14275, June 25, RIFM, Woodcliff Lake, NJ, USA.
238. RIFM (Research Institute for Fragrance Materials, Inc.), 1987b. Benzenepropanol beta,beta-3-trimethyl-: Acute percutaneous toxicity in rabbits. Unpublished report from Symrise GmbH & Co. KG, 05 May. Report Number 49519, RIFM, Woodcliff Lake, NJ, USA.
239. RIFM (Research Institute for Fragrance Materials, Inc.), 1987c. Sub-acute (28-Day) oral toxicity study with beta,beta-3-trimethyl benzenepropanol (majantol) in rats. Unpublished report from Symrise GmbH & Co. KG, 04 January. Report Number 58687, RIFM, Woodcliff Lake, NJ, USA.
240. RIFM (Research Institute for Fragrance Materials, Inc.), 1987d. Microbial metabolic activation test to assess the potential mutagenic effect of 2-methyl-4-phenylpentanol. Unpublished report from IFF Incorporated, 27 November. Report Number 47036, RIFM, Woodcliff Lake, NJ, USA.
241. RIFM (Research Institute for Fragrance Materials, Inc.), 1987e. Mutagenicity evaluation of benzenepropanol beta,beta-3-trimethyl- in the Ames Salmonella/Microsome Plate Assay. Unpublished report from Symrise GmbH & Co. KG, 26 March. Report Number 49524, RIFM, Woodcliff Lake, NJ, USA.
242. RIFM (Research Institute for Fragrance Materials, Inc.), 1987f. Repeated insult patch test with 2-methyl-4-phenylpentanol. Unpublished report from IFF Incorporated, 30 April. Report Number 47033, RIFM, Woodcliff Lake, NJ, USA.
243. RIFM (Research Institute for Fragrance Materials, Inc.), 1987g. Evaluation of the skin irritating and sensitizing propensities of 2-methyl-4-phenylpentanol in humans. Unpublished report from IFF Incorporated, 12 March. Report Number 47032, RIFM, Woodcliff Lake, NJ, USA.
244. RIFM (Research Institute for Fragrance Materials, Inc.), 1987h. Irritant effects on rabbit skin with 2-methyl-4-phenylpentanol. Unpublished report from IFF Incorporation, 03 September. Report Number 47028, RIFM, Woodcliff Lake, NJ, USA.
245. RIFM (Research Institute for Fragrance Materials, Inc.), 1987i. Eye irritation test of benzenepropanol beta,beta-3-trimethyl- in rabbits. Unpublished report from Symrise GmbH & Co. KG, 01 May. Report Number 49521, RIFM, Woodcliff Lake, NJ, USA.
246. RIFM (Research Institute for Fragrance Materials, Inc.), 1987j. Submission to EPA. Unpublished report from Emery Chemicals, Report Number 18899, RIFM, Woodcliff Lake, NJ, USA.
247. RIFM (Research Institute for Fragrance Materials, Inc.), 1987k. In vivo micronucleus test in mice of beta,beta-3-trimethyl benzenepropanol (majantol). Unpublished report from Symrise GmbH & Co. KG, 26 March. Report Number 58688, RIFM, Woodcliff Lake, NJ, USA.
248. RIFM (Research Institute for Fragrance Materials, Inc.), 1988a. The percutaneous absorption and disposition of (14)C-2-phenylethanol in rabbits. RIFM report number 14276, May 19, RIFM, Woodcliff Lake, NJ, USA.
249. RIFM (Research Institute for Fragrance Materials, Inc.), 1988b. Plasma concentrations and pharmacokinetics of phenylacetic acid and phenylethanol in rats following single dermal applications of phenylethanol. RIFM Report Number 14277, February 24, RIFM, Woodcliff Lake, NJ, USA.
250. RIFM (Research Institute for Fragrance Materials, Inc.), 1988c. Acute dermal toxicity of 2-methyl-4-phenylpentanol in albino rabbits. Unpublished report from IFF Incorporated, 24 March. Report Number 47027, RIFM, Woodcliff Lake, NJ, USA.
251. RIFM (Research Institute for Fragrance Materials, Inc.), 1988d. Acute oral toxicity study of 2-methyl-4-phenylpentanol in albino rats. Unpublished report from IFF Incorporated, 24 March. Report Number 47026, RIFM, Woodcliff Lake, NJ, USA.
252. RIFM (Research Institute for Fragrance Materials, Inc.), 1988e. Mouse micronucleus test on 2-methyl-4-phenylpentanol. Unpublished report from IFF Incorporated, 04 February. Report Number 47035, RIFM, Woodcliff Lake, NJ, USA.
253. RIFM (Research Institute for Fragrance Materials, Inc.), 1988f. Twenty-eight day oral toxicity study in rats with 2-methyl-4-phenylpentanol. Unpublished report from IFF Incorporated, 10 March. Report Number 47034, RIFM, Woodcliff Lake, NJ, USA.
254. RIFM (Research Institute for Fragrance Materials, Inc.), 1988g. Mutagenicity study of 2-methyl-5-phenylpentanol (rosaphen) in the Salmonella typhimurium/mammalian microsome reverse mutation assay (Ames-Test). 01 August. Report Number 58698, RIFM, Woodcliff Lake, NJ, USA.
255. RIFM (Research Institute for Fragrance Materials, Inc.), 1988h. The Micronucleus Test in bone marrow cells of mammals with 2-methyl-5-phenylpentanol (rosaphen). 01 August. Report number 58702 (RIFM, Woodcliff Lake, NJ, USA).
256. RIFM (Research Institute for Fragrance Materials, Inc.), 1988i. Dosage-range developmental toxicity (embryo/fetal toxicity and teratogenicity) study of 2-phenylethylalcohol (PEA) administered dermally to presumed pregnant mice. RIFM Report Number 14280, August 03, RIFM, Woodcliff Lake, NJ, USA.
257. RIFM (Research Institute for Fragrance Materials, Inc.), 1988i. Delayed contact hypersensitivity with 2-methyl-4-phenylpentanol in guinea pigs. Unpublished report from IFF Incorporated, 14 April. Report Number 47030, RIFM, Woodcliff Lake, NJ, USA.
258. RIFM (Research Institute for Fragrance Materials, Inc.), 1988k. 2-Methyl-5-phenylpentanol (rosaphen): Acute dermal irritation test in the rabbit. 01 August. Report Number 58695, RIFM, Woodcliff Lake, NJ, USA.
259. RIFM (Research Institute for Fragrance Materials, Inc.), 1988l. 2-Methyl-5-phenylpentanol (rosaphen): Magnusson & Kligman Maximisation study in guinea pig. 01 August. Report Number 58697, RIFM, Woodcliff Lake, NJ, USA.
260. RIFM (Research Institute for Fragrance Materials, Inc.), 1988m. Irritation study of phenylethyl alcohol in rabbits. RIFM Report Number 34332, RIFM, Woodcliff Lake, NJ, USA.
261. RIFM (Research Institute for Fragrance Materials, Inc.), 1988n. Acute dermal irritation study in rabbits. RIFM Report Number 9403, November 01, RIFM, Woodcliff Lake, NJ, USA.
262. RIFM (Research Institute for Fragrance Materials, Inc.), 1988o. Acute eye irritation/corrosion test with 2-methyl-4-phenylpentanol in rabbits. Unpublished report from IFF Incorporated, 13 July. Report Number 47029, RIFM, Woodcliff Lake, NJ, USA.
263. RIFM (Research Institute for Fragrance Materials, Inc.), 1988p. 2-Methyl-5-phenylpentanol (rosaphen): Acute eye irritation test in the rabbit. 01 August. Report Number 58696, RIFM, Woodcliff Lake, NJ, USA.
264. RIFM (Research Institute for Fragrance Materials, Inc.), 1988q. Phenethyl alcohol 1%: Acute eye irritation test in the rabbit. Unpublished report from Haarmann & Reimer GmbH, 25 March. Report Number 35560, RIFM, Woodcliff Lake, NJ, USA.
265. RIFM (Research Institute for Fragrance Materials, Inc.), 1989a. Acute dermal toxicity of 2-methyl-5-phenylpentanol (rosaphen) in rats. Unpublished report from Symrise, 01 August. Report Number 58700, RIFM, Woodcliff Lake, NJ, USA.
266. RIFM (Research Institute for Fragrance Materials, Inc.), 1989b. Acute dermal irritation of rabbits. RIFM Report Number 10226, September 01, RIFM, Woodcliff Lake, NJ, USA.
267. RIFM (Research Institute for Fragrance Materials, Inc.), 1989c. Repeated insult patch test in human subjects. RIFM Report Number 9433, June 07, RIFM, Woodcliff Lake, NJ, USA.
268. RIFM (Research Institute for Fragrance Materials, Inc.), 1990a. Plasma and urine concentrations and pharmacokinetics of phenylacetic acid and phenylethanol in the rat following single doses of phenylethanol administered via different routes. RIFM Report Number 14278, RIFM, Woodcliff Lake, NJ, USA.
269. RIFM (Research Institute for Fragrance Materials, Inc.), 1990b. Subacute toxicity study in rats with 2-methyl-5-phenylpentanol (rosaphen). Unpublished report from Symrise, 01 August. Report Number 58699, RIFM, Woodcliff Lake, NJ, USA.
270. RIFM (Research Institute for Fragrance Materials, Inc.), 1990fc. Repeated insult patch test in humans with o-tolylethanol. Unpublished report from International Flavors and Fragrances, 27 July. Report number 48836 (RIFM, Woodcliff Lake, NJ, USA).
271. RIFM (Research Institute for Fragrance Materials, Inc.), 1990d. Assessment of the skin irritant effect of 2-methyl-5-phenylpentanol (rosaphen) in rabbits. Unpublished report from Symrise, 01 August. Report Number 58707, RIFM, Woodcliff Lake, NJ, USA.
272. RIFM (Research Institute for Fragrance Materials, Inc.), 1992a. Submission to EPA. Unpublished report from Proctor and Gamble Company, Report Number 20505, RIFM, Woodcliff Lake, NJ, USA.
273. RIFM (Research Institute for Fragrance Materials, Inc.), 1992b. Submission to EPA. Unpublished report from Dow Chemical Company, Report Number 18661, RIFM, Woodcliff Lake, NJ, USA.
274. RIFM (Research Institute for Fragrance Materials, Inc.), 1997. Repeat insult patch test with 2-methyl-5-phenylpentanol (rosaphen). Unpublished report from Symrise, 01 August. Report Number 58708, RIFM, Woodcliff Lake, NJ, USA.
275. RIFM (Research Institute for Fragrance Materials, Inc.), 2000a. Acute oral toxicity study of 2-(4-methylphenoxy)ethanol in rats. Unpublished report from Firmenich Incorporated, 06 October. Report Number 41306, RIFM, Woodcliff Lake, NJ, USA.
276. RIFM (Research Institute for Fragrance Materials, Inc.), 2000b. alpha-Propylphenethyl alcohol: Acute oral toxicity study. Unpublished report from Firmenich Incorporated, Report Number 38883, RIFM, Woodcliff Lake, NJ, USA.
277. RIFM (Research Institute for Fragrance Materials, Inc.), 2000c. p-alpha,alpha-Trimethylbenzyl alcohol: Acute oral toxicity study in rats. Unpublished report from Firmenich Incorporated, 03 August. Report Number 42115, RIFM, Woodcliff Lake, NJ, USA.
278. RIFM (Research Institute for Fragrance Materials, Inc.), 2001. Benzyl alcohol: A 5 day inhalation toxicity study in the rat. Unpublished report from A. Dotti, H. Huber, C. Kroling, B. Madorin, 23 April. Report Number 54635, RIFM, Woodcliff Lake, NJ, USA.
279. RIFM (Research Institute for Fragrance Materials, Inc.), 2002a. Repeated insult patch test (RIPT) with benzyl alcohol. RIFM Report Number 44247, March 03, RIFM, Woodcliff Lake, NJ, USA.
280. RIFM (Research Institute for Fragrance Materials, Inc.), 2002b. Murine local lymph node assay with 2-(4-methylphenoxy)ethanol. Unpublished report from Firmenich Incorporated, 22 January. Report Number 41989, RIFM, Woodcliff Lake, NJ, USA.
281. RIFM (Research Institute for Fragrance Materials, Inc.), 2002c. Benzenepropanol beta,beta-3-trimethyl-: Local Lymph Node Assay. Unpublished report from Symrise GmbH & Co. KG, 09 December. Report Number 49523, RIFM, Woodcliff Lake, NJ, USA.
282. RIFM (Research Institute for Fragrance Materials, Inc.), 2002d. beta,beta-3-Trimethyl benzenepropanol (majantol): Local Lymph Node Assay. Unpublished report from Symrise GmbH & Co. KG, 04 January. Report Number 58693, RIFM, Woodcliff Lake, NJ, USA.
283. RIFM (Research Institute for Fragrance Materials, Inc.), 2003a. Repeated insult patch test (RIPT) with benzyl alcohol. RIFM Report Number 44246, November 03, RIFM, Woodcliff Lake, NJ, USA.
284. RIFM (Research Institute for Fragrance Materials, Inc.), 2003b. Murine local lymph node assay of alpha-isobutylphenethyl alcohol. Unpublished report from Firmenich Incorporated, 20 February. Report Number 42657, RIFM, Woodcliff Lake, NJ, USA.
285. RIFM (Research Institute for Fragrance Materials, Inc.), 2004a. Modified primary dermal irritation test (MPDI) with benzyl alcohol. RIFM Report Number 44236, March 03, RIFM, Woodcliff Lake, NJ, USA.
286. RIFM (Research Institute for Fragrance Materials, Inc.), 2004b. Repeated insult patch test with benzyl alcohol (modified Draize procedure). RIFM Report Number 45131, April 30, RIFM, Woodcliff Lake, NJ, USA.
287. RIFM (Research Institute for Fragrance Materials, Inc.), 2004c. Repeated insult patch test with benzyl alcohol. RIFM Report Number 47046, July 07, RIFM, Woodcliff Lake, NJ, USA.
288. RIFM (Research Institute for Fragrance Materials, Inc.), 2004d. 2-Methyl-4-phenylpentanol: Local Lymph Node Assay. Unpublished report from International Flavors and Fragrances, 22 November. Report Number 47827, RIFM, Woodcliff Lake, NJ, USA.
289. RIFM (Research Institute for Fragrance Materials, Inc.), 2004e. Phenethyl alcohol: Local Lymph Node Assay. RIFM Report Number 44369, February 16, RIFM, Woodcliff Lake, NJ, USA.
290. RIFM (Research Institute for Fragrance Materials, Inc.), 2005a. Repeated insult patch test with benzyl alcohol. RIFM Report Number 47873, March 16, RIFM, Woodcliff Lake, NJ, USA.
291. RIFM (Research Institute for Fragrance Materials, Inc.), 2005b. Forty-eight hours patch test with benzenepropanol beta,beta-3-trimethyl. Unpublished report from Symrise GmbH & Co. KG, 10 June. Report Number 49525, RIFM, Woodcliff Lake, NJ, USA.
292. RIFM (Research Institute for Fragrance Materials, Inc.), 2005c. Repeated insult patch test with benzenepropanol beta,beta-3-trimethyl. Unpublished report from Symrise GmbH & Co. KG, 12 September. Report Number 49526, RIFM, Woodcliff Lake, NJ, USA.
293. RIFM (Research Institute for Fragrance Materials, Inc.), 2005d. Anisyl alcohol diluted with vehicle 1:3 EtOH:DEP: Local Lymph Node Assay. RIFM Report Number 48750, Anisyl alcohol diluted with vehicle 1:3 EtOH:DEP: Local Lymph Node Assay, RIFM, Woodcliff Lake, NJ, USA.
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