Fragrance material review on β-methylphenethyl alcohol

Food and Chemical Toxicology

Volumn 50, Issue SUPPL. 2, 2012, Pages

  Scognamiglio, J ^a   Jones, L ^b   Letizia, C S ^a   Api, A M ^a  

^a RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS   (United States)

^b Leah Jones Consulting   (United States)

Author keywords

Fragrance material methylphenethyl alcohol; Review

Indexed keywords

BETA METHYLPHENETHYL ALCOHOL; FRAGRANCE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; BIOSAFETY; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; EXPOSURE; EYE TOXICITY; GENOTOXICITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LD 50; METABOLISM; NONHUMAN; PATCH TEST; PHYSICAL CHEMISTRY; REVIEW; RISK ASSESSMENT; SKIN ALLERGY; SKIN IRRITATION; SKIN SENSITIZATION; SKIN TOXICITY; TOXICITY TESTING; TOXICOKINETICS;

ANIMALS; HUMANS; PERFUME; PHENYLETHYL ALCOHOL; RABBITS; RATS; SKIN; TOXICITY TESTS;

EID: 84865772514     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.10.023     Document Type: Review

References (23)

1. Arctander, S., 1969. Perfume and Flavor Chemicals (Aroma Chemicals), vol. I, No. 1707. S. Arctander, Montclair, New Jersey.
2. Belsito D., Bickers D., Bruze M., Calow P., Dagli M., Fryer A.D., Greim H., Hanifin J.H., Miyachi Y., Saurat J.H., Sipes I.G. A toxicologic and dermatologic assessment of aryl alkyl alcohols when used as fragrance ingredients. Food and Chemical Toxicology 2012, 50(Suppl.2):S52-S99.
3. Cadby P., Troy W., Vey M. Consumer exposure to fragrance ingredients: providing estimates for safety evaluation. Regul. Toxicol. Pharmacol. 2002, 36:246-252.
4. Chakraborty J., Smith J.N. Enzymic oxidation of some alkylbenzenes in insects and vertebrates. Biochem. J. 1967, 102:498-503.
5. Council of Europe, 2000. Partial Agreement in the Social and Public Health Field. Chemically-defined Flavouring Substances. Group 2.2 Aromatic Alcohols, No. 2257. Council of Europe Publishing, Strasbourg, p. 80.
6. FDA (Food and Drug Administration), xxxx. Code of Federal Regulations, 21 CFR 172.515. Title 21 - Food and Drugs, vol. 3, Chapter I - Food and Drug Administration, Department of Health and Human Services. Part 172 - Food Additives Permitted for Direct Addition to Food for Human Consumption. Subpart F - Flavoring Agents and Related Substances, 515 - Synthetic Flavoring Substances and Adjuvants.
7. FEMA (Flavor and Extract Manufacturers Association) Recent progress in the consideration of flavoring ingredients under the Food Additives Amendment 3. GRAS substances. Food Technol. 1965, 19(2):151-197.
8. Ford R., Domeyer B., Easterday O., Maier K., Middleton J. Criteria for development of a database for safety evaluation of fragrance ingredients. Regul. Toxicol. Pharmacol. 2000, 31:166-181.
9. Gaunt I.F., Wright M.G., Cottrell R. Short-term toxicity of 2-phenylpropan-1-ol (hydratropic alcohol) in rats. Food Chem. Toxicol. 1982, 20:519-525.
10. Gruneberg J., Langecker H. Breakdown of 2-phenylpropyl alcohol in the organism of rabbits, dogs and man. Arch. Exp. Pathol. Pharmak. 1957, 231(Suppl.):91-95.
11. IFRA (International Fragrance Association), 2004. Volume of Use Survey, December 2004.
12. IFRA (International Fragrance Association), 2008. Use Level Survey, December 2008.
13. JECFA (Joint Expert Committee on Food Additives), 2006. Safety evaluation of certain food additives. WHO Food Additives Series: 54. Prepared by the Sixty-third Meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). World Health Organization, Geneva.
14. Kligman A.M. The identification of contact allergens by human assay. III. The maximization test. A procedure for screening and rating contact sensitizers. J. Invest. Dermatol. 1966, 47:393-409.
15. Kligman A.M., Epstein W. Updating the maximization test for identifying contact allergens. Contact Dermatitis 1975, 1:231-239.
16. Opdyke D. Fragrance Raw Materials Monographs. Hydratropic alcohol. Food and Chemical Toxicology 1975, 13:547.
17. RIFM (Research Institute for Fragrance Materials, Inc.), 1964a. Repeated Insult Patch Test with beta-Methylphenethyl Alcohol. Unpublished Report from International Flavors and Fragrances, Inc., 08 June. Report No. 51922. RIFM, Woodcliff Lake, NJ, USA.
18. RIFM (Research Institute for Fragrance Materials, Inc.), 1964b. Rabbit Eye Irritation Study with beta-Methylphenethyl Alcohol. Unpublished Report from International Flavors and Fragrances, Inc., 10 March. Report No. 51924. RIFM, Woodcliff Lake, NJ, USA.
19. RIFM (Research Institute for Fragrance Materials, Inc.), 1974a. Acute Toxicity Studies in Rats and Rabbits. RIFM Report No. 2027, September 27. RIFM, Woodcliff Lake, NJ, USA.
20. RIFM (Research Institute for Fragrance Materials, Inc.), 1974b. Report on Human Maximization Studies. RIFM Report No. 1779, September 25. RIFM, Woodcliff Lake, NJ, USA.
21. RIFM (Research Institute for Fragrance Materials, Inc.), 1979. The Short-term (13 week) Toxicity of 2-Phenyl-1-propanol in Rats. Unpublished Report. Report No. 7487. RIFM, Woodcliff Lake, NJ, USA.
22. Robinson D., Smith J.N., Williams R.T. Studies in detoxification. The metabolism of alkylbenzenes. Isopropylbenzene (cumene) and derivatives of hydratropic acid. Biochem. J. 1954, 59(1):153-159.
23. Wild D., King M.T., Gocke E., Eckhardt K. Study of artificial flavouring substances for mutagenicity in the Salmonella/microsome, basc and micronucleus tests. Food Chem. Toxicol. 1983, 21(6):707-719.