The FEMA GRAS assessment of benzyl derivatives used as flavor ingredients

Food and Chemical Toxicology

Volumn 43, Issue 8, 2005, Pages 1207-1240

  Adams, T B ^a   Cohen, S M ^b   Doull, J ^c   Feron, V J ^d   Goodman, J I ^e   Marnett, L J ^f   Munro, I C ^g   Portoghese, P S ^h   Smith, R L ⁱ   Waddell, W J ^j   Wagner, B M ^k,l  

^a Flavor and Extract Manufacturers Association   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^d TNO   (Netherlands)

^e MICHIGAN STATE UNIVERSITY   (United States)

^f VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g CanTox Inc   (Canada)

^h UNIVERSITY OF MINNESOTA   (United States)

ⁱ IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^j University of Louisville School of Medicine   (United States)

^k NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^l Bernard M Wagner Associates   (United States)

more..

Author keywords

Benzyl derivatives; FEMA GRAS; Flavoring ingredients

Indexed keywords

2,4 DIMETHYLBENZALDEHYDE; BENZALDEHYDE; BENZALDEHYDE DERIVATIVE; BENZOIC ACID; BENZOIC ACID DERIVATIVE; BENZYL ACETATE; BENZYL ALCOHOL DERIVATIVE; BENZYL BENZOATE; BENZYL BUTYRATE; BENZYL DERIVATIVE; ESTER DERIVATIVE; FLAVORING AGENT; GLYCERYL TRIBENZOATE; PROPYLENE GLYCOL DIBENZOATE; UNCLASSIFIED DRUG;

ABSORPTION; ACUTE TOXICITY; CARCINOGENICITY; CHEMICAL STRUCTURE; CHRONIC TOXICITY; CONCENTRATION (PARAMETERS); DATA ANALYSIS; DETOXIFICATION; EVALUATION; EXCRETION; EXPERIMENTAL TEST; EXPOSURE; FLAVOR; FOOD ANALYSIS; FOOD COMPOSITION; FOOD INTAKE; FOOD POISONING; FOOD SAFETY; GENOTOXICITY; HEALTH CARE ORGANIZATION; HUMAN; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; INFORMATION; METABOLISM; MORTALITY; MUTAGENESIS; NONHUMAN; REPRODUCTION; REVIEW; RISK ASSESSMENT; SCIENCE; STRUCTURE ANALYSIS; TERATOLOGY; TOXICITY;

ANIMALS; BENZALDEHYDES; BENZOIC ACID; BENZYL ALCOHOL; FLAVORING AGENTS; FOOD INDUSTRY; HUMANS; TOXICITY TESTS; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

ANIMALIA;

EID: 20444383559     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2004.11.014     Document Type: Review

References (162)

1. 1 mice Toxicology 37 1985 159 170
2. K.M. Abdo, M.L. Wenk, G.J. Harry, J. Mahler, T.J. Goehl, and R.D. Irwin Glycine modulates the toxicity of benzyl acetate in F344 rats Toxicologic Pathology 26 1998 395 402
3. H.U. Aeschbacher, U. Wolleb, J. Loliger, J.C. Spadone, and R. Liardon Contribution of coffee aroma constituents to the mutagenicity of coffee Food and Chemical Toxicology 27 1989 227 232
4. L.P. Amsel, and G. Levy Drug biotransformation interactions in man II: a pharmacokinetic study of the simultaneous conjugation of benzoic and salicylic acids with glycine Journal of Pharmaceutical Sciences 58 1969 321
5. M.W. Anders Biotransformation and bioactivation of xenobiotics by the kidney D.H. Hutson J. Caldwell G.D. Paulson Intermediary Xenobiotic Metabolism in Animals 1989 Taylor and Francis New York 81 97
6. D. Anderson, and J.A. Styles The bacterial mutation test British Journal of Cancer 37 1978 924 930
7. B.E. Anderson, E. Zeiger, M.D. Shelby, M.A. Resnick, D.K. Gulati, J.L. Ivett, and K.S. Loveday Chromosome aberration and sister chromatid exchange test results with 42 chemicals Environmental and Molecular Mutagenesis 16 Supp. 18 1990 55 137
8. J.C. Ball, S. Foxall-Van Aken, and T.E. Jensen Mutagenicity studies of p-substituted benzyl derivatives in the Ames Salmonella plate-incorporation assay Mutation Research 138 1984 145 151
9. Bernard, B.K., 1983. Response of the fragrance and flavor industries to the NTP draft report on benzyl acetate. The Flavor and Extract Manufacturers Association, Washington, DC, USA.
10. P.G. Brantom, I.F. Gaunt, P. Grasso, A.B.G. Lansdown, and S.D. Gangolli Short-term toxicity of tolualdehyde in rats Food and Cosmetics Toxicology 10 1972 637 647
11. H.G. Bray, W.V. Thorpe, and K. White Kinetic studies of the metabolism of foreign organic compounds. The formation of benzoic acid from benzamide, toluene, benzyl alcohol and benzaldehyde and its conjugation with glycine and glucuronic acid in the rabbit The Biochemical Journal 48 1951 88 96
12. J.W. Bridges, M.R. French, R.L. Smith, and R.T. Williams The fate of benzoic acid in various species The Biochemical Journal 118 1970 47 51
13. Carson, S., 1972a. 90-Day studies with glyceryl tribenzoate in rats. Unpublished Report to the Flavor and Extracts Manufacturers Association, Washington, DC, USA.
14. Carson, S., 1972b. 90-Day studies with propylene glycol dibenzoate in rats. Unpublished Report to the Flavor and Extracts Manufacturers Association, Washington, DC, USA.
15. W.J. Caspary, R. Langenbach, B.W. Penman, C. Crespi, B.C. Myhr, and A.D. Mitchell The mutagenic activity of selected compounds at the TK locus: rodent vs. human cells Mutation Research 196 1988 61 81
16. 14C] benzyl acetate in the rat Food and Chemical Toxicology 24 1986 1257 1265
17. M.A.J. Chidgey, J.F. Kennedy, and J. Caldwell Studies on benzyl acetate. II. Use of specific metabolic inhibitors to define the pathway leading to the formation of benzylmercaptic acid in the rat Food and Chemical Toxicology 24 1986 1267 1272
18. Ciba-Geigy, 1991. Acute oral toxicity study in rats with TK12186. Submission to the US Environmental Protection Agency. EPA/Office of Toxic Substances Document No. 8EHQ-1191-1557; OTS 0534655.
19. J.J. Clapp, and L. Young Formation of mercaptic acids in rats after the administration of aralkyl esters The Biochemical Journal 118 1970 765 771
20. D.B. Clayson, F. Iverson, E.A. Nera, and E. Lok The significance of induced forestomach tumors Annual Reviews of Pharmacology and Toxicology 30 1990 441 463
21. Costello, B.A., Moore, G.R., 1984. Acute oral toxicity LD50 study of 4-ethylbenzaldehyde in rats. Unpublished Report to the Flavor and Extracts Manufacturers Association, Washington, DC, USA.
22. J.A. Cotruvo, V.F. Simmon, and R.J. Spanggord Investigation of mutagenic effects of products of ozonation reactions in water Annals of the New York Academy of Sciences 298 1977 124 140
23. C. Davison Salicylate metabolism in man Journal of Pharmacology and Experimental Therapeutics 179 1971 249 268
24. DeGroot, A.P., Spanjers, M.Th., van der Heijden, C.A., 1974. Acute and sub-acute oral toxicity studies in rats with five flavor compounds. Unpublished Report to the Flavor and Extracts Manufacturers Association, Washington, DC, USA.
25. S.L. Diack, and H.B. Lewis Studies in the synthesis of hippuric acid in the animal organism Journal of Biological Chemistry 77 1928 89 95
26. D.M. Dillon, D.B. McGregor, R.D. Combes, and E. Zeiger Detection of mutagenicity in Salmonella of some aldehydes and peroxides Environmental and Molecular Mutagenesis 19 1992 15
27. J.H. Draize, E. Alvarez, M.F. Whitesell, G. Woodard, E.C. Hagan, and A.A. Nelson Toxicological investigations of compounds proposed for use as insect repellents Journal of Pharmacology and Experimental Therapeutics 93 1948 26 39
28. Food and Drug Administration (FDA), 1975. Mutagenic Evaluation of Compound FDA 73-70, Benzoic acid, Certified A.C.S. Food and Drug Administration (FDA), Litton Bionetics, Inc. Washington, DC.
29. Food and Drug Administration (FDA), 1993. Priority-based assessment of food additives (PAFA) database. Center for Food Safety and Applied Nutrition. p. 58.
30. I. Florin, L. Rutberg, M. Curvall, and C.R. Enzell Screening of tobacco smoke constituents for mutagenicity using the Ames test Toxicology 18 1980 219 232
31. E.R. Fluck, L.A. Poirier, and H.W. Ruelius Evaluation of a DNA polymerase-deficient mutant of E. coli for the rapid detection of carcinogens Chemico-Biological Interactions 15 1976 219 231
32. P. Foureman, J.M. Mason, R. Valencia, and S. Zimmering Chemial mutagenesis testing in Drosophila: X. Results of 70 coded chemicals tested for the National Toxicology Program Environmental and Molecular Mutagenesis 23 1994 208 227
33. S.M. Galloway, M.J. Armstrong, C. Reuben, S. Colman, B. Brown, C. Cannon, A.D. Bloom, F. Nakamura, M. Ahmed, S. Duk, J. Rimpo, B.H. Margolin, M.A. Resnick, B. Anderson, and E. Zeiger Chromosome aberrations and sister chromatid exchange in Chinese hamster ovary cells: evaluations of 108 chemicals Environmental and Molecular Mutagenesis 10 Suppl. 10 1987 1 35
34. B. Gillam The reaction of aralkyl sulphate esters with glutathione catalysed by rat liver preparations Biochemistry Journal 121 1971 667
35. R. Glosnicka, and H. Dziadziuszko Mutagenic action of styrene and its metabolites. II. Genotoxic activity of styrene, styrene oxide, styrene glycol and benzoic acid tested with the SOS chromotest Bulletin of the Institute of Maritime and Tropical Medicine in Gdynia 37 1986 3 4
36. B.E. Graham, and M.H. Kuizenga Toxicity studies on benzyl benzoate and related benzyl compounds The Journal of Pharmacology and Experimental Therapeutics 84 1945 358 362
37. H.C. Grice Safety evaluation of butylated hydroxyanisole from the perspective of effects on forestomach and oesophageal squamous epithelium Food and Chemical Toxicology 26 1988 717 723
38. E.C. Hagan, W.H. Hansen, O.G. Fitzhugh, P.M. Jenner, W.I. Jones, J.M. Taylor, E.L. Long, A.A. Nelson, and J.B. Brouwer Food flavourings and compounds of related structure. II. Subacute and chronic toxicity Food and Cosmetics Toxicology 5 1967 141 157
39. B.D. Hardin, R.L. Schuler, J.R. Burg, G.M. Booth, K.P. Hazelden, K.M. MacKenzie, V.J. Piccirillo, and K.N. Smith Evaluation of 60 chemicals in a preliminary developmental toxicity test Teratogenesis, Carcinogenesis, and Mutagenesis 7 1987 29 48
40. 1) mice Journal of the National Cancer Institute 75 1985 975 984
41. S. Haworth, T. Lawlor, K. Mortelmans, W. Speck, and E. Zeiger Salmonella mutagenicity test results for 250 chemicals Environmental Mutagenesis 5 Suppl. 1 1983 3 142
42. M. Hayashi, M. Kishi, T. Sofuni, and M. Ishidate Jr. Micronucleus tests in mice on 39 food additives and eight miscellaneous chemicals Food and Chemical Toxicology 26 1988 487 500
43. J.D. Heck, T.A. Vollmuth, M.A. Cifone, D.R. Jagannath, B. Myhr, and R.D. Curren An evaluation of food flavoring ingredients in a genetic toxicity screening battery Toxicology 9 1989 257 (Abstract# 1031)
44. E. Heymann Carboxylesterases and amidases W.B. Jakoby J.R. Bend J. Caldwell Enzymatic Basis of Detoxication second ed. 1980 Academic Press New York 291 323
45. Hoffmann-LaRoche, 1967. Acute toxicity, eye and skin irritation tests of fragrance materials. Unpublished Report to the Research Institute for Fragrance Materials, Woodcliff Lake, NJ, USA.
46. T. Ishida, M. Toyota, and Y. Asakawa Terpenoid biotransformation in mammals. V. Metabolism of (+)-citronellal, (±)-7-hydroxycitronellal, citral, (-)-perillaldehyde, (-)-myrtenal, cuminaldehyde, thujone, and (±)-carvone in rabbits Xenobiotica 19 1989 843 855
47. M. Ishidate Jr., T. Sofuni, D. Yoshikawa, M. Hayashi, T. Nohmi, M. Sawada, and A. Marsouka Primary mutagenicity screening of food additives currently used in Japan Food and Chemical Toxicology 22 1984 623 636
48. S. Ishiguro, A. Miyamoto, T. Obi, and A. Nishio Teratological studies on benzyl acetate in pregnant rats Bulletin of the Faculty of Agriculture, Kagoshima University 43 1993 25 31
49. T. Jansson, M. Curvall, A. Hedin, and C.R. Enzell In vitro studies of the biological effects of cigarette smoke condensate: III. Induction of SCE by some phenolic and related constituents derived from cigarette smoke: a study of structure-activity relationships Mutation Research 206 1988 17 24
50. P.M. Jenner, E.C. Hagan, J.M. Taylor, E.L. Cook, and O.G. Fitzhugh Food flavorings and compounds of related structure I. Acute oral toxicity Food and Cosmetics Toxicology 2 1964 327 343
51. Joint FAO/WHO Expert Committee on Food Additives (JECFA), 1980. Evaluation of certain food additives. The twenty-third report of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). World Health Organization Technical Report Series No. 648. World Health Organization, Geneva. 〈interrefhttp://whqlibdoc.who.int/trs/WHO_TRS_648.pdfurlhttp://whqlibdoc. who.int/trs/WHO_TRS_648.pdf〉.
52. Joint FAO/WHO Expert Committee on Food Additives (JECFA), 1997. Evaluation of certain food additives and contaminants. The forty-sixth report of the Joint FAO/WHO Expert Committee on Food Additives (JECFA). World Health Organization Technical Report Series No. 868. World Health Organization, Geneva. 〈 http://whqlibdoc.who.int/trs/WHO_TRS_868.pdf 〉.
53. A. Kasamaki, H. Takahashi, N. Tsumura, J. Niwa, T. Fujita, and S. Urasawa Genotoxicity of flavoring agents Mutation Research 105 1982 387 392
54. W.M. Kluwe, C.A. Montgomery, H.D. Giles, and J.D. Prejean Encephalopathy in rats and nephropathy in rats and mice after subchronic oral exposure to benzaldehyde Food and Chemical Toxicology 21 1983 245 250
55. A.A. Kravets-Bekker, and O.P. Ivanova Sanitary-toxicological characteristics of methyl benzoate and potassium benzoate Farmacevtski Vestnik 2 1970 125 129
56. K. Kubota, and T. Ishizaki Dose-dependent pharmacokinetics of benzoic acid following oral administration of sodium benzoate to humans European Journal of Clinical Pharmacology 41 1991 363 368
57. K. Kubota, Y. Horai, K. Kushida, and T. Ishizaki Determination of benzoic acid in human plasma and urine by high-performance liquid chromatography Journal of Chromatography 425 1988 75 76
58. K. Kuroda, S. Tanaka, Y.S. Yoo, and T. Ishibashi Rec-assay of food additives Nihon Koshu Eisei Zasshi. Japanese Society of Public Health 31 1984 277 281
59. K. Kuroda, Y.S. Yoo, and T. Ishibashi Antimutagenic activity of food additives Mutation Research 130 1984 369
60. S. Laham, and M. Potvin Biological conversion of benzaldehyde to benzylmercaptic acid in the Sprague-Dawley rat Drug and Chemical Toxicology 10 1987 209 225
61. S. Laham, M. Potvin, and M. Robinet Metabolism of benzaldehyde in New Zealand white rabbits Chemosphere 17 1988 517 524
62. M. LeBel, L. Ferron, M. Masson, J. Pichette, and C. Carrier Benzyl alcohol metabolism and elimination in neonates Developmental Pharmacology and Therapeutics 11 1988 347 356
63. Leegwater, DC., van Straten, S., 1974. In vitro study on the hydrolysis of twenty-six organic esters by pancreatin. Unpublished CIVO/TNO Report No. 4319, Flavor and Extract Manufacturers Association, Washington, DC, USA.
64. Levenstein, I., 1973. Acute toxicity study in rats and rabbits. Unpublished Report, Research Institute for Fragrance Materials, Woodcliff Lake, NJ, USA.
65. Levenstein, I., 1974. Acute toxicity study in rats and rabbits. Unpublished Report, Research Institute for Fragrance Materials, Woodcliff Lake, NJ, USA.
66. Lewis, C.A., Palanker, A.L., 1979. Acute toxicity studies in rats and rabbits. Unpublished Report, Research Institute for Fragrance Materials, Woodcliff Lake, NJ, USA.
67. D.S. Longnecker, B.D. Roebuck, T.J. Curphey, E. Lhoste, C.I. Coon, and D. MacMillan Effects of corn oil and benzyl acetate on number and size of azaserine-induced foci in the pancreas of LEW and F344 rats Environmental Health Perspectives 68 1986 197 201
68. D.S. Longnecker, B.D. Roebuck, T.J. Curphey, and D.L. MacMillan Evaluation of promotion of pancreatic carcinogenesis in rats by benzyl acetate Food and Chemical Toxicology 28 1990 665 668
69. Lucas, C.D., Putnam, J.M., Hallagan, J.B., 1999. 1995 Poundage and Technical Effects Update Survey. Flavor and Extract Manufacturers Association (FEMA) of the United States, Washington DC, USA.
70. Maarse, H., Visscher, C.A., Willemsens, L.C., Boelens, M.H., 1999. Volatile Components in Food-Qualitative and Quantitative Data. Centraal Instituut Voor Voedingsonderzioek TNO. Zeist, The Netherlands.
71. L.J. Marnett, H.K. Hurd, M.C. Hollstein, D.E. Levin, H. Esterbauer, and B.N. Ames Naturally-occurring carbonyl compounds are mutagens in Salmonella tester strain TA104 Mutation Research 148 1985 25 34
72. A. Matsouka, K. Yamakage, H. Kusakabe, S. Wakuri, M. Asakura, T. Noguchi, T. Sugiyama, H. Shimada, S. Nakayama, Y. Kasahara, Y. Takahashi, K.F. Miura, M. Hatanaka, M. Ishidate Jr., T. Morita, K. Watanabe, M. Hara, K. Odawara, N. Tanaka, M. Hayashi, and T. Sofuni Re-evaluation of chromosomal aberration induction on nine mouse lymphoma assay 'unique positive' NTP carcinogens Mutation Research 369 1996 243 252
73. S. Matsui, R. Yamamoto, and H. Yamada The Bacillus subtilis/microsome rec-assay for the detection of DNA damaging substances which may occur in chlorinated and ozonated waters Water Science Technology: A Journal of the International Association on Water Pollution Research 21 1989 857 887
74. J. McCann, E. Choi, E. Yamasaki, and B.N. Ames Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals Proceedings of the National Academy of Sciences of the United States of America 79 1975 5135 5139
75. S.E. McCloskey, J.J. Gershanik, J.J.L. Lertora, L. White, and W.J. George Toxicity of benzyl alcohol in adult and neonatal mice Journal of Pharmaceutical Sciences 75 1986 702 705
76. - mouse lymphoma cell forward mutation assay: III. 72 coded chemicals Environmental and Molecular Mutagenesis 12 1988 85 154 Erratum, 12(3), 345
77. D.B. McGregor, A.G. Brown, S. Howgate, D. McBride, C. Riach, and W.J. Caspary Responses of the L5178Y mouse lymphoma cell forward mutation assay. V: 27 coded chemicals Environmental and Molecular Mutagenesis 17 1991 196 219
78. T.F. McMahon, J.J. Diliberto, and L.S. Birnbaum Age related changes in disposition of benzyl acetate (BA): a model compound for glycine conjugation (Abstracts of the 28th Annual Meeting of the Society of Toxicology) Toxicology 9 1989 88
79. P. Milvy, and A.J. Garro Mutagenic activity of styrene oxide (1,2 epoxyethyl benzene), a presumed styrene metabolite Mutation Research 40 1976 15 18
80. J. Mirsalis, K. Tyson, J. Beck, E. Loh, K. Steinmetz, C. Contreras, L. Austera, S. Martin, and J. Spalding Induction of unscheduled DNA synthesis (UDS) in hepatocytes following in vitro and in vivo treatment Environmental Mutagenesis 5 1983 482 Abstract #Ef-5
81. J.C. Mirsalis, C.K. Tyson, K.L. Steinmetz, E.K. Loh, C.M. Hamilton, J.P. Bakke, and J.W. Spalding Measurement of unscheduled DNA synthesis and s-phase synthesis in rodent hepatocytes following in vivo treatment: testing of 24 compounds Environmental and Molecular Mutagenesis 14 1989 155 164
82. Moreno, O.M., 1972. Acute toxicity studies in mice, rats and rabbits. Unpublished Report to the Research Institute for Fragrance Materials, Woodcliff Lake, NJ, USA.
83. Moreno, O.M., 1973. Acute toxicity studies on rats and rabbits. Unpublished Report, Research Institute for Fragrance Materials, Woodcliff Lake, NJ, USA.
84. Moreno, O.M., 1974. Acute toxicity studies. Unpublished Report, Research Institute for Fragrance Materials, Woodcliff Lake, NJ, USA.
85. Moreno, O.M., 1976. Acute toxicity studies in rats, mice, rabbits and guinea pigs. Unpublished Report to the Research Institute for Fragrance Materials, Woodcliff Lake, NJ, USA.
86. Moreno, O.M., 1977. Acute toxicity studies in rats, rabbits and guinea pigs. Unpublished Report, Research Institute for Fragrance Materials, Woodcliff Lake, NJ, USA.
87. Moreno, O.M., 1979. Acute toxicity studies in rats, rabbits and guinea pigs. Unpublished Report, Research Institute for Fragrance Materials, Woodcliff Lake, NJ, USA.
88. Moreno, O.M., 1980. Acute toxicity studies. Unpublished Report, Research Institute for Fragrance Materials, Woodcliff Lake, NJ, USA.
89. Morgareidge, K., 1962. In vitro digestion of four acetals. Unpublished Report, Flavor and Extracts Manufacturers Association, Washington, DC, USA.
90. Morgareidge, K., 1972. Teratologic evaluation of FDA 71-37 (sodium benzoate). Food and Drug Research Labs, Inc. Report to the US Food and Drug Administration PB-221 777.
91. Morita, S., Yamada, A., Ohgaki, S., Noda, T., Taniguchi, S., 1980. Safety evaluation of chemicals for use in household products. I. Teratological studies on benzyl benzoate and 2-(morpholinothio)benzothiazole in rats. Annual Report of the Osaka City Institute of Public Health and Environmental Sciences 43, pp. 90-97.
92. R.E. Morrissey, B.A. Schwetz, J.C. Lamb IV, M.D. Ross, J.L. Teague, and R.W. Morris Evaluation of rodent sperm, vaginal cytology, and reproductive organ weight data from National Toxicology Program 13-week studies Fundamental and Applied Toxicology 11 1988 343 358
93. K. Mortelmans, S. Haworth, T. Lawlor, W. Speck, B. Tainer, and E. Zeiger Salmonella mutagenicity tests: II. Results from the testing of 270 chemicals Environmental Mutagenesis 8 1986 1 119
94. B. Myhr, D. McGregor, L. Bowers, C. Riach, A.G. Brown, I. Edwards, D. McBride, R. Martin, and W.J. Caspary L5178Y mouse lymphoma cell mutation assay results with 41 compounds Environmental and Molecular Mutagenesis 16 1990 138 167
95. S. Nakamura, Y. Oda, T. Shimada, I. Oki, and K. Sugimoto SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: Examination with 151 chemicals Mutation Research 192 1987 239 246
96. National Academy of Sciences (NAS) 1970. 1970 poundage and technical effects update of substances added to food. Committee on Food Additives Survey Data, Food and Nutrition Board, Institute of Medicine, Washington, DC.
97. National Academy of Sciences (NAS), 1982. 1982 poundage and technical effects update of substances added to food. Committee on Food Additives Survey Data, Food and Nutrition Board, Institute of Medicine, Washington, DC.
98. National Academy of Sciences (NAS), 1987. 1987 poundage and technical effects update of substances added to food. Committee on Food Additives Survey Data, Food and Nutrition Board, Institute of Medicine, Washington, DC.
99. 1 mice (gavage studies). NTP-TR-250; PB-86-2506. The National Toxicology Program, Research Triangle, NC.
100. 1 mice (gavage studies). NTP-TR-331; NIH Publication No. 89-2587. The National Toxicology Program, Research Triangle, NC.
101. 1 mice (gavage studies). NTP-TR-343; NIH Publication No. 89-2599. The National Toxicology Program, Research Triangle, NC.
102. 1 mice (gavage studies). NTP-TR-378; NIH Publication No. 90-2833. The National Toxicology Program, Research Triangle, NC.
103. 1 mice (gavage studies). NTP-TR-382: NIH Publication No. 90-2837. The National Toxicology Program, Research Triangle, NC.
104. National Toxicology Program (NTP), 1992. Toxicology and carcinogenesis studies of coumarin in F344/N rats and B6C3F1 mice (gavage studies). NTP-TR-422: NIH Publication No. 92-31.3153. The National Toxicology Program, Research Triangle, NC.
105. 1 mice (feed studies). NTP-TR-431; NIH Publication No. 92-3162. The National Toxicology Program, Research Triangle, NC.
106. National Toxicology Program (NTP), 1993b. Toxicology and carcinogenesis studies of 3,4-dihydrocoumarin in F344/N rats and B6C3F1 mice (gavage studies). NTP-TR-423: NIH Publication No. 93-3154. The National Toxicology Program, Research Triangle, NC.
107. National Toxicology Program (NTP), 1994a. Comparative Toxicology studies of corn oil, safflower oil and tricarpylin in male F344/N rats as vehicles for gavage. NTP-TR-426: NIH Publication No. 94-3157. The National Toxicology Program, Research Triangle, NC.
108. National Toxicology Program (NTP). 1994b, Effect of dietary restriction on toxicology and carcinogenesis studies in F344/N rats and B6C3F1 mice. NTP-TR-460: NIH Publication No. 97-3376. The National Toxicology Program, Research Triangle, NC.
109. N.M. Nielson, and H. Bundgaard Prodrugs as drugs delivery systems. 68. Chemical and plasma-catalyzed hydrolysis of various esters of benzoic acid: A reference system for designing prodrug esters carboxylic acid agents International Journal of Pharmceutics 39 1987 75 85
110. T. Nohmi, R. Miyata, K. Yoshikawa, and M. Ishidate Jr. Mutagenicity tests on organic chemical contaminants in city water and related compounds. I. Bacterial mutagenicity tests Eisei Shikenjo Hokoku Bulletin of the National Institute of Hygiene Science 103 1985 60 64
111. M. Nonaka DNA repair tests on food additives Environmental and Molecular Mutagenesis 14 Suppl. 15 1989 143 Abstract #414
112. Nutley, B.P., 1990. Investigations into the metabolism of cinnamic acid, cinnamyl alcohol and cinnamaldehyde in relation to their safety evaluation. A thesis submitted for the degree of Doctor of Philosophy in the University of London Department of Pharmacology.
113. Y. Oda, Y. Hamano, K. Inoue, H. Yamamoto, T. Nihara, and N. Kunita Mutagenicity of food flavors in bacteria Osaka-Furitsu Koshu Eisei Kenkyu Hokoku. Shokuhin Eisei Hen 91 1979 325
114. T. Ohta, K. Watanabe, M. Moriya, Y. Shirasu, and T. Kada Anti-mutagenic effects of coumarin and umbelliferone on mutagenesis induced by 4-nitroquinoline 1-oxide or UV irradiation in E. coli Mutation Research 117 1983 135 138
115. T. Ohta, M. Watanabe, R. Tsukamoto, T. Shirasu, and T. Kada Antimutagenic effects of 5-fluorourcil and 5-fluorodeoxyuridine on UV induced mutagenesis in Escherichia coli Mutation Research 173 1 1986 19 24
116. T. Ohta, M. Watanabe, K. Watanabe, Y. Shirasu, and T. Kada Inhibitory effects of flavourings on mutagenesis induced by chemicals in bacteria Food and Chemical Toxicology 24 1 1986 51 54
117. H. Onodera, T. Ogiu, C. Matsuoka, K. Furuta, M. Takeuchi, Y. Oono, T. Kubota, M. Miyahara, A. Maekawa, and S. Odashima Studies on the effect of sodium benzoate on the fetuses and offspring of Wistar rats Bulletin of the National Institute of Hygiene and Science 96 1978 47 55
118. Oser, B.L., 1957. Toxicological screening of components of food flavors Class V. aromatic esters. Food Research Laboratories, Inc. Unpublished Report to the Flavor and Extracts Manufacturers Association, Washington, DC, USA.
119. B.L. Oser, S. Carson, and M. Oser Toxicological tests on flavouring matters Food and Cosmetics Toxicology 3 1965 563 569
120. Owen, G., Meyer, F.J., 1971. Acute oral and dermal toxicity studies. Unpublished Report to the Research Institute for Fragrance Materials, Woodcliff Lake, NJ, USA.
121. Proctor and Gamble, 1992. Submission to the Environmental Protection Agency. Unpublished Report.
122. W.H. Rapson, M.A. Nazar, and V.V. Butsky Mutagenicity produced by aqueous chlorination of organic compounds Bulletin of Environmental Contamination and Toxicology 24 1980 590 596
123. P. Rockwell, and I. Raw A mutagenic screening of various herbs, spices and food additives Nutrition and Cancer 1 1979 10 15
124. E.G. Rogan, E.L. Cavalieri, B.A. Walker, R. Balasubramanian, P.G. Wislocki, R.W. Roth, and R.K. Saugier Mutagenicity of benzylic acetate, sulfates, and bromides of polycyclic aromatic hydrocarbons Chemico-Biological Interactions 58 1986 253 275
125. C.J. Rudd, A.D. Mitchell, and J. Spalding L5178Y mouse lymphoma cell mutagenesis assay of coded chemicals incorporating analyses of the colony size distributions Environmental Mutagenesis 5 1983 419 Abstract # Cd-19
126. I. Sado Synergistic toxicity of official permissible preservative food additives Nippon Eiseigaku Zasshi 28 1973 463 476
127. Y. Sasaki, and R. Endo Mutagenicity of aldehydes in Salmonella Mutation Research 54 1978 251 252
128. Y.F. Sasaki, H. Imanishi, T. Ohta, and Y. Shirasu Modifying effects of components of plant essence on the induction of sister chromatid exchanges in cultured Chinese hamster ovary cells Mutation Research 226 1989 103 110
129. E.W. Schafer Jr., and W.A. Bowles Jr. Acute oral toxicity and repellency of 933 chemicals to house and deer mice Archives of Environmental Contamination and Toxicology 14 1985 111 129
130. Schunk, H.H., Shibamoto, T., Tan, H.K., Wei, C-I., 1986. Biological and chemical studies on photochemical products obtained from euronol, benzyl acetate and benzyl benzoate. In: Lawrence, B.M., Mookherjee, B.D., Willis, B.J. (Eds.), Flavors and Fragrances: A World Perspective. Proceedings of the 10th International Congress of Essential Oils, Fragrance and Flavors, Washington, DC, USA, 16-029 November, 1986, pp. 1045-1068.
131. J. Sekizawa, and T. Shibamoto Genotoxicity of safrole-related chemicals in microbial test systems Mutation Research 101 1982 127 140
132. Shelanski, M., Moldovan, M., 1971. Acute toxicity in rats. Unpublished Report, Research Institute for Fragrance Materials, Woodcliff Lake, NJ, USA.
133. M.D. Shelby, G.L. Erexson, G.J. Hook, and R.R. Tice Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals Environmental and Molecular Mutagenesis 21 1993 160 179
134. Shell Oil Company, 1982. Study of the comparative toxicity of benzoic acid and p-t-butylbenzoic acid. Submission to the US Environmental Protection Agency. EPA/Office of Toxic Substances Document No. 8EHQ-0682-04405; 88-8200380; OTS0505458.
135. A.J. Shtenberg, and A.D. Ignat'ev Toxicological evaluation of some combinations of food preservatives Food and Cosmetics Toxicology 8 1970 369 380
136. R.L. Smith, and R.A. Ford Recent progress in the consideration of flavoring ingredients under the Food Additives Amendment. 16. GRAS substances Food Technology 47 6 1993 104 117
137. H.F. Smyth Jr., C.P. Carpenter, and C.S. Weil Range finding toxicity data: list IV Archives of Industrial Hygiene and Occupational Medicine 4 1951 119 122
138. H.F. Smyth Jr., C.P. Carpenter, C.S. Weil, and U.C. Pozzani Range finding toxicity data: list V Archives of Industrial Hygiene and Occupational Medicine 4 1954 119 122
139. Y. Sodemoto, and M. Enomoto Report of carcinogenesis bioassay of sodium benzoate in rats: absence of carcinogenicity of sodium benzoate in rats Journal of Environmental Pathology and Toxicology 4 1980 87 95
140. M.D. Sofuni, M. Hayashi, A. Matsouka, M. Sawada, M. Hatanaka, and M. Ishidate Jr. Mutagenicity tests on organic chemical contaminants in city water and related compounds. II. Chromosome aberration tests in cultured mammalian cells Eisei Shikenjo Hokoku Bulletin of the National Institute of Hygiene Science 103 1985 64 75
141. A. Sporn, I. Dinu, and V. Stanciu Cercetari cu privire la toxicitatea aldehidei benzoice Igiena 16 1967 23 24
142. K.L. Steinmetz, and J.C. Mirsalis Measurement of DNA repair in primary cultures of rat pancreatic cells following in vivo treatment Environmental Mutagenesis 6 1984 446
143. J. Stofberg, and F. Grundschober Consumption ratio and food predominance of flavoring materials Perfumer and Flavorist 12 1987 27
144. J. Stofberg, and J.C. Kirschman The consumption ratio of flavoring materials: a mechanism for setting priorities for safety evaluation Food and Chemical Toxicology 23 1985 857 860
145. R.D. Storer, T.M. McKelvey, A.R. Kraynak, M.C. Elia, J.E. Barnum, L.S. Harmon, W.W. Nichols, and J.G. DeLuca Revalidation of the in vitro alkaline elution/rat hepatocyte assay for DNA damage: improved criteria for assessment of cytotoxicity and genotoxicity and results for 81 compounds Mutation Research 368 1996 59 101
146. W. Szybalski Special microbial systems. II. Observations on chemical mutagenesis in microorganisms Annals of the New York Academy of Sciences 1958 475 489
147. J.M. Taylor, P.M. Jenner, and W.I. Jones A comparison of the toxicity of some allyl, propenyl, and propyl compounds in the rat Toxicology and Applied Pharmacology 6 1964 378 387
148. Temellini, A., 1993. Conjugation of benzoic acid with glycine in human liver and kidney: a study on the interindividual variability. Fifth North American ISSX Meeting, Tucson, AZ, October 17-21, 1993, p. 4.
149. B. Toth Lack of tumorigenicity of sodium benzoate in mice Fundamental and Applied Toxicology 4 1984 494 496
150. S. Vamvakas, W. Dekant, and M.W. Anders Mutagenicity of benzyl S-haloalkyl and S-haloalkenyl sulfides in the Ames test Biochemical Pharmacology 38 1989 935 939
151. R. Van Doorn, Ch.-M. Leijdekkers, R.P. Bos, R.M.E. Brouns, and P.Th. Henderson Alcohol and sulphate intermediates in the metabolism of toluene and xylenes to mercapturic acids Journal of Applied Toxicology 1 1981 236 242
152. R. Waters, R. Mirzayans, J. Meredith, G. Mallalah, N. Danford, and J.M. Parry Correlations in mammalian cells between types of DNA damage, rates of DNA repair and the biological consequence Progress in Mutation Research (DNA Repair, Chromosome Alterations Chromatin Structure) 4 1982 247 259
153. P.W. Wester, and R. Kroes Forestomach carcinogens: pathology and relevance to man Toxicologic Pathology 16 1988 165 171
154. Weir, R.J., Wong, L.C.K., 1971. Acute oral and dermal toxicity studies in rabbits. Unpublished Report, Research Institute for Fragrance Materials, Woodcliff Lake, NJ, USA.
155. R.T. Williams Detoxication Mechanisms second ed. 1959 Chapman & Hall, Ltd. London
156. R.C. Woodruff, J.M. Mason, R. Valencia, and S. Zimmering Chemical mutagenesis testing in Drosophila. V. Results of 53 coded compounds tested for the National Toxicology Program Environmental Mutagenesis 7 1985 677 702
157. Y.S. Yoo Mutagenic and antimutagenic activities of flavoring agents used in foodstuffs Osaka-Shiritsu Daigaku Igaki Zasshi 4 1986 267 288
158. York, R.G., Barnwell, P., Bailes, W., 1986. Final Report. Screening of
159. K. Yoshikawa Anomalous nonidentity between Salmonella genotoxicants and rodent carcinogens: Nongenotoxic carcinogens and genotoxic noncarcinogens Environmental Health Perspectives 104 1996 40 46
160. J.H. Yuan, T.J. Goehl, K. Abdo, J. Clark, O. Espinosa, C. Bugge, and D. Garcia Effects of gavage versus dosed feed administration on the toxicokinetics of benzyl acetate in rats and mice Food and Chemical Toxicology 33 1995 151 158
161. E. Zeiger, B. Anderson, S. Haworth, T. Lawlor, and K. Mortelmans Salmonella mutagenicity tests: IV. Results from the testing of 300 chemicals Environmental and Molecular Mutagenesis 11 Suppl. 12 1988 1 158
162. E. Zeiger, B. Anderson, S. Haworth, T. Lawlor, and K. Mortelmans Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals Environmental and Molecular Mutagenesis 19 Suppl. 21 1992 2 141