Fragrance material review on 2-methyl-5-phenylpentanol

Food and Chemical Toxicology

Volumn 50, Issue SUPPL. 2, 2012, Pages

  Scognamiglio, J ^a   Jones, L ^b   Letizia, C S ^a   Api, A M ^a  

^a RESEARCH INSTITUTE FOR FRAGRANCE MATERIALS   (United States)

^b Leah Jones Consulting   (United States)

Author keywords

Fragrance material 2 methyl 5 phenylpentanol; Review

Indexed keywords

2 METHYL 5 PHENYLPENTANOL; ALCOHOL DERIVATIVE; ALKANOL; ARYL ALKYL ALCOHOL; BENZENE; COSMETIC; FRAGRANCE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ATAXIA; BODY POSTURE; BREATHING DISORDER; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; COMA; CONCENTRATION RESPONSE; COSMETIC INDUSTRY; COVALENT BOND; DERMATOLOGY; EXPOSURE; EYE IRRITATION; GENOTOXICITY; GUINEA PIG; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LD 50; MAXIMUM DAILY EXPOSURE; MAXIMUM SKIN LEVEL; MOLECULAR WEIGHT; NONHUMAN; OUTCOME ASSESSMENT; PALLOR; PATCH TEST; PHYSICAL CHEMISTRY; PRODUCT SAFETY; PTOSIS; RABBIT; REFLEX; REVIEW; RISK ASSESSMENT; SKIN EXAMINATION; SKIN IRRITATION; SKIN SENSITIZATION; SKIN TOXICITY; SOLUBILITY; TISSUE LEVEL; TOXICITY TESTING; TOXICOLOGICAL PARAMETERS; VAPOR PRESSURE;

ANIMALS; GUINEA PIGS; HUMANS; PENTANOLS; PERFUME; RATS; SKIN; TOXICITY TESTS;

EID: 84865772707     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.10.004     Document Type: Review

References (16)

1. Belsito D., Bickers D., Bruze M., Calow P., Dagli M., Fryer A.D., Greim H., Hanifin J.H., Miyachi Y., Saurat J.H., Sipes I.G. A toxicologic and dermatologic assessment of aryl alkyl alcohols when used as fragrance ingredients. Food and Chemical Toxicology 2012, 50(Suppl.2):S52-S99.
2. Cadby P., Troy W., Vey M. Consumer exposure to fragrance ingredients: providing estimates for safety evaluation. Regulatory Toxicology and Pharmacology 2002, 36:246-252.
3. Ford R., Domeyer B., Easterday O., Maier K., Middleton J. Criteria for development of a database for safety evaluation of fragrance ingredients. Regulatory Toxicology and Pharmacology 2000, 31:166-181.
4. IFRA (International Fragrance Association), 2008. Use Level Survey, December 2008.
5. Magnusson B., Kligman A.M. The identification of contact allergens by animal assay. The guinea pig maximization test. Journal of Investigative Dermatology 1969, 52(3):268-276.
6. RIFM (Research Institute for Fragrance Materials, Inc.), 1988a. 2-Methyl-5-phenylpentanol (rosaphen): range-finding acute oral toxicity test in the rat. 17 June. Report No. 58694 (RIFM, Woodcliff Lake, NJ, USA).
7. RIFM (Research Institute for Fragrance Materials, Inc.), 1988b. 2-Methyl-5-phenylpentanol (rosaphen): Magnusson & Kligman maximisation study in guinea pig. 22 May. Report No. 58697 (RIFM, Woodcliff Lake, NJ, USA).
8. RIFM (Research Institute for Fragrance Materials, Inc.), 1988c. 2-Methyl-5-phenylpentanol (rosaphen): acute dermal irritation test in the rabbit. 18 May. Report No. 58695 (RIFM, Woodcliff Lake, NJ, USA).
9. RIFM (Research Institute for Fragrance Materials, Inc.), 1988d. 2-Methyl-5-phenylpentanol (rosaphen): acute eye irritation test in the rabbit. 27 May. Report No. 58696 (RIFM, Woodcliff Lake, NJ, USA).
10. RIFM (Research Institute for Fragrance Materials, Inc.), 1988e. Mutagenicity study of 2-methyl-5-phenylpentanol (rosaphen) in the Salmonella typhimurium/mammalian microsome reverse mutation assay (Ames-Test). 19 May. Report No. 58698 (RIFM, Woodcliff Lake, NJ, USA).
11. RIFM (Research Institute for Fragrance Materials, Inc.), 1988f. The micronucleus test in bone marrow cells of mammals with 2-methyl-5-phenylpentanol (rosaphen). 9 December. Report No. 58702 (RIFM, Woodcliff Lake, NJ, USA).
12. RIFM (Research Institute for Fragrance Materials, Inc.), 1989a. Acute dermal toxicity of 2-methyl-5-phenylpentanol (rosaphen) in rats. 20 June. Report No. 58700 (RIFM, Woodcliff Lake, NJ, USA).
13. RIFM (Research Institute for Fragrance Materials, Inc.), 1990a. Assessment of the skin irritant effect of 2-methyl-5-phenylpentanol (rosaphen) in rabbits. 6 April. Report No. 58707 (RIFM, Woodcliff Lake, NJ, USA).
14. RIFM (Research Institute for Fragrance Materials, Inc.), 1990b. Subacute toxicity study in rats with 2-methyl-5-phenylpentanol (rosaphen). 16 March. Report No. 58699 (RIFM, Woodcliff Lake, NJ, USA).
15. RIFM (Research Institute for Fragrance Materials, Inc.), 1977. Eye irritation of 3-methyl-5-phenylpentanol in rabbits. Unpublished report from IFF Incorporated, 21 February. Report number 34991 (RIFM, Woodcliff Lake, NJ, USA).
16. RIFM (Research Institute for Fragrance Materials, Inc.), 1997. Repeat insult patch test with 2-methyl-5-phenylpentanol (rosaphen). 10 June. Report No. 58708 (RIFM, Woodcliff Lake, NJ, USA).