Granzyme B-Induced Neurotoxicity Is Mediated via Activation of PAR-1 Receptor and Kv1.3 Channel

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Wang, Tongguang ^b   Lee, Myoung Hwa ^b   Choi, Elliot ^b   Pardo Villamizar, Carlos A ^a   Lee, Sung Bin ^c   Yang, In Hong ^c,d   Calabresi, Peter A ^a   Nath, Avindra ^a,b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c Johns Hopkins University   (United States)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CLOFAZIMINE; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GRANZYME B; NOTCH1 RECEPTOR; PERFORIN; POTASSIUM CHANNEL KV1.3; PROTEINASE ACTIVATED RECEPTOR 1; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; CELL INTERACTION; CELL SURFACE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME MECHANISM; ENZYME RELEASE; FEMALE; FETUS; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; MOUSE; MULTIPLE SCLEROSIS; NERVE CELL; NERVE CELL CULTURE; NERVE CELL MEMBRANE; NERVOUS SYSTEM INFLAMMATION; NEUROTOXICITY; NONHUMAN; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; RECEPTOR BLOCKING; T LYMPHOCYTE;

ANIMALS; CELL COUNT; CLOFAZIMINE; FEMALE; GENE EXPRESSION REGULATION; GRANZYMES; HUMANS; KV1.3 POTASSIUM CHANNEL; MULTIPLE SCLEROSIS; NEURITES; NEURONS; NEUROTOXINS; PROTEOLYSIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, NOTCH1; RECEPTOR, PAR-1;

RATTUS;

EID: 84865584006     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043950     Document Type: Article

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