Fibroblast growth factor 2 applied to the optic nerve after axotomy up-regulates BDNF and TrkB in ganglion cells by activating the ERK and PKA signaling pathways

Journal of Neurochemistry

Volumn 96, Issue 1, 2006, Pages 82-96

  Soto, Ileana ^a   Rosenthal, Joshua J C ^a   Blagburn, Jonathan M ^a   Blanco, Rosa E ^a,b  

^a UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

^b UNIVERSITY OF PUERTO RICO   (Puerto Rico)

Author keywords

Axotomy; Frog; Growth factor; Mitogen activated protein kinase; Neurotrophin; Retinal ganglion cells

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 8 CHLOROADENOSINE 3',5' PHOSPHATE; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; COMPLEMENTARY DNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; FROG; GENETIC TRANSCRIPTION; MOLECULAR INTERACTION; NERVE FIBER TRANSECTION; NONHUMAN; OPTIC NERVE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RETINA GANGLION CELL; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; EXON; GENETICS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANIMALIA; ANURA; RANA PIPIENS;

ANIMALS; AXOTOMY; BLOTTING, WESTERN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA, COMPLEMENTARY; ENZYME ACTIVATION; EXONS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLAST GROWTH FACTOR 2; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MITOGEN-ACTIVATED PROTEIN KINASES; OPTIC NERVE; RANA PIPIENS; RECEPTOR, TRKB; RETINAL GANGLION CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 33644847478     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2005.03510.x     Document Type: Article

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