Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation

Journal of Immunology

Volumn 166, Issue 2, 2001, Pages 936-944

  Beeton, C ^a   Barbaria, J ^a   Giraud, P ^a   Devaux, J ^a   Benoliel, A M ^a   Gola, M ^a   Sabatier, J M ^a   Bernard, D ^a   Crest, M ^a   Beraud E ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; INTERLEUKIN 2; KALIOTOXIN; MYELIN BASIC PROTEIN; POTASSIUM CHANNEL; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CHANNEL GATING; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; IMMUNOPATHOGENESIS; LYMPHOCYTE PROLIFERATION; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; RAT; T LYMPHOCYTE ACTIVATION;

EID: 0035863820     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.2.936     Document Type: Article

References (63)

1. Ion channel genes and human neurological disease: Recent progress, prospects, and challenges
2. + channel Kv1 subtypes in synaptic membranes from bovine brain
3. + channels in terminal and juxtaparanodal regions of neurons
4. Potassium channel distribution, clustering, and function in remyelinating rat axons
5. Effects of 4-aminopyridine on normal and demyelinated mammalian nerve fibres
6. 4-Aminopyridine leads to restoration of conduction in demyelinated rat sciatic nerve
7. Effects of 4-aminopyridine on demyelinated axons, synapses and muscle tension
8. Effects of 4-aminopyridine on transmission in excitatory and inhibitory synapses in the spinal cord
9. The current status of studies of aminopyridines in patients with multiple sclerosis
10. 4-Aminopyridine in the treatment of patients with multiple sclerosis
11. Distribution in rat brain of binding sites of kaliotoxin, a blocker of Kv1.1 and Kv1.3 a subunits
12. Voltage-gated potassium channel genes
13. Potassium and calcium channels in lymphocytes
14. Ion channels in the immune system as targets for immunosuppression
15. Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes
16. Voltagegated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation
17. ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide
18. + channels in human T lymphocytes
19. Novel nonpeptide agents potently block the c-type inactivated conformation of Kv1.3 and suppress T cell activation
20. UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation
21. Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels
22. + channel-blocking alkoxypsoralens inhibit the immune response of encephalitogenic T line cells and lymphocytes from Lewis rats challenged for experimental autoimmune encephalomyelitis
23. Blockade of the voltagegated potassium channel Kv1.3 inhibits immune responses in vivo
24. Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: Process of selection of lines and characterization of the cells
25. T lymphocyte lines induce autoimmune encephalomyelitis, delayed hypersensitivity and bystander encephalitis or arthritis
26. T cell activation is regulated by voltage-dependent and calcium-activated potassium channels
27. Pathogenic and non-pathogenic T lymphocytes specific for the encephalitogenic epitope of myelin basic protein: Functional characteristics and vaccination properties
28. Anergy induction in encephalitogenic T cells by brain microvessel endothelial cells is inhibited by interleukin-1
29. CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: Analysis of early and late activation events
30. Serum-free in vitro bioassay for the detection of tumor necrosis factor
31. Large scale preparation of myelin basic protein from central nervous tissue of several mammalian species
32. Synthesis and characterization of kaliotoxin
33. Patch-clamp recording and RT-PCR on single cells
34. A potassium-channel toxin from the sea anemone Bunodosoma granulifera, an inhibitor for Kv1 channels
35. 2+ indicators with greatly improved fluorescence properties
36. Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain
37. + channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines
38. Evidence for an internal phenylalkylamine · action on the voltage-gated potassium channel Kv1.3
39. + channels in human T lymphocytes: A role in mitogenesis?
40. Evidence for voltage modulation of IL-2 production in mitogen-stimulated human peripheral blood lymphocytes
41. Recent studies on dendrotoxins and potassium ion channels
42. Changes in the expression of potassium channels during mouse T cell development
43. + currents of encephalitogenic memory T cells decrease with encephalitogenicity while interleukin-2 (IL-2) receptor expression remains stable during IL-2 dependent cell expansion
44. + conductance is a post-activational event in rat T lymphocytes responsible for the adoptive transfer of experimental allergic encephalomyelitis
45. Characterization of animal toxins binding to ionic channels from electrophysiological recordings
46. Pattern of potassium channel expression in proliferating B lymphocytes depends upon the mode of activation
47. 2+ signaling, and receptor gene expression in antigen-specific mouse T cell
48. 1 progression
49. Potassium channel blockers inhibit adoptive transfer of experimental allergic encephalomyelitis by myelin-basic-protein-stimulated rat T lymohocytes
50. T lymphocyte entry into the central nervous system
51. Cellular immune reactivity within the CNS
52. The signature sequence of voltage-gated potassium channels projects into the external vestibule
53. 1 integrins
54. The role of TNF-α and lymphotoxin in demyelinating disease
55. An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis
56. Control of established experimental allergic encephalomylitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins
57. Regulation of new DNA synthesis in mammalian cells by cyclosporine: Demonstration of a transforming growth factor β-dependent mechanism of inhibition of cell growth
58. Oral tolerance: Immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens
59. Assessment of animals models for MS and demyelinating disease in the design of rational therapy
60. The pathophysiology of myelin basic protein-induced acute experimental allergic encephalomyelitis in the Lewis rat
61. Electrophysiological investigations in adoptively transferred experimental autoimmune encephalomyelitis in the Lewis rat
62. Glutamate excitotoxicity in a model of multiple sclerosis
63. Voltage-gated potassium channels are required for human T lymphocyte activation