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Volumn 17, Issue 8, 2012, Pages 9258-9272

Chemical genetics: Budding yeast as a platform for drug discovery and mapping of genetic pathways

Author keywords

Budding yeast; Chemical genetics; Genetic interaction; Saccharomyces cerevisiae

Indexed keywords

DRUG DEVELOPMENT; DRUG EFFECT; GENE REGULATORY NETWORK; GENETICS; HUMAN; MICROBIAL VIABILITY; MOLECULAR GENETICS; MUTATION; PHENOTYPE; REVIEW; SACCHAROMYCES CEREVISIAE;

EID: 84865504403     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules17089258     Document Type: Review
Times cited : (14)

References (77)
  • 2
    • 1842549914 scopus 로고
    • The origin of five mutations in eye color in drosophila and their modes of inheritance
    • Morgan, T.H. The Origin of Five Mutations in Eye Color in Drosophila and Their Modes of Inheritance. Science 1911, 33, 534-537.
    • (1911) Science , vol.33 , pp. 534-537
    • Morgan, T.H.1
  • 3
    • 0001378215 scopus 로고
    • Sex limited inheritance in drosophila
    • Morgan, T.H. Sex Limited Inheritance in Drosophila. Science 1910, 32, 120-122.
    • (1910) Science , vol.32 , pp. 120-122
    • Morgan, T.H.1
  • 4
    • 37049247905 scopus 로고
    • Chromosomes and Associative Inheritance
    • Morgan, T.H. Chromosomes and Associative Inheritance. Science 1911, 34, 636-638.
    • (1911) Science , vol.34 , pp. 636-638
    • Morgan, T.H.1
  • 5
    • 34548573170 scopus 로고    scopus 로고
    • Why are there still over 1,000 uncharacterized yeast genes?
    • Pena-Castillo, L.; Hughes, T.R. Why are there still over 1,000 uncharacterized yeast genes? Genetics 2007, 176, 7-14.
    • (2007) Genetics , vol.176 , pp. 7-14
    • Pena-Castillo, L.1    Hughes, T.R.2
  • 6
    • 0001579865 scopus 로고
    • Canalization of development and genetic assimilation of acquired characters
    • Waddington, C.H. Canalization of development and genetic assimilation of acquired characters. Nature 1959, 183, 1654-1655.
    • (1959) Nature , vol.183 , pp. 1654-1655
    • Waddington, C.H.1
  • 7
    • 0035830860 scopus 로고    scopus 로고
    • Principles for the buffering of genetic variation
    • Hartman, J.L., IV; Garvik, B.; Hartwell, L. Principles for the buffering of genetic variation. Science 2001, 291, 1001-1004.
    • (2001) Science , vol.291 , pp. 1001-1004
    • Hartman IV, J.L.1    Garvik, B.2    Hartwell, L.3
  • 8
    • 0031442653 scopus 로고    scopus 로고
    • A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair
    • Tishkoff, D.X.; Filosi, N.; Gaida, G.M.; Kolodner, R.D. A novel mutation avoidance mechanism dependent on S. cerevisiae RAD27 is distinct from DNA mismatch repair. Cell 1997, 88, 253-263.
    • (1997) Cell , vol.88 , pp. 253-263
    • Tishkoff, D.X.1    Filosi, N.2    Gaida, G.M.3    Kolodner, R.D.4
  • 9
    • 0035449349 scopus 로고    scopus 로고
    • The yeast Xrs2 complex functions in S phase checkpoint regulation
    • D'Amours, D.; Jackson, S.P. The yeast Xrs2 complex functions in S phase checkpoint regulation. Genes Dev. 2001, 15, 2238-2249.
    • (2001) Genes Dev , vol.15 , pp. 2238-2249
    • D'Amours, D.1    Jackson, S.P.2
  • 10
    • 0032161269 scopus 로고    scopus 로고
    • A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools
    • Zhao, X.; Muller, E.G.; Rothstein, R. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol. Cell 1998, 2, 329-340.
    • (1998) Mol. Cell , vol.2 , pp. 329-340
    • Zhao, X.1    Muller, E.G.2    Rothstein, R.3
  • 11
    • 0035796505 scopus 로고    scopus 로고
    • The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage
    • Zhao, X.; Chabes, A.; Domkin, V.; Thelander, L.; Rothstein, R. The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage. EMBO J. 2001, 20, 3544-3553.
    • (2001) EMBO J , vol.20 , pp. 3544-3553
    • Zhao, X.1    Chabes, A.2    Domkin, V.3    Thelander, L.4    Rothstein, R.5
  • 12
    • 0028353634 scopus 로고
    • Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
    • Weinert, T.A.; Kiser, G.L.; Hartwell, L.H. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev. 1994, 8, 652-665.
    • (1994) Genes Dev , vol.8 , pp. 652-665
    • Weinert, T.A.1    Kiser, G.L.2    Hartwell, L.H.3
  • 13
    • 28944450579 scopus 로고    scopus 로고
    • Changing perspectives in yeast research nearly a decade after the genome sequence
    • Dolinski, K.; Botstein, D. Changing perspectives in yeast research nearly a decade after the genome sequence. Genome Res. 2005, 15, 1611-1619.
    • (2005) Genome Res , vol.15 , pp. 1611-1619
    • Dolinski, K.1    Botstein, D.2
  • 19
    • 0242298316 scopus 로고    scopus 로고
    • DNA helicase gene interaction network defined using synthetic lethality analyzed by microarray
    • Ooi, S.L.; Shoemaker, D.D.; Boeke, J.D. DNA helicase gene interaction network defined using synthetic lethality analyzed by microarray. Nat. Genet. 2003, 35, 277-286.
    • (2003) Nat. Genet. , vol.35 , pp. 277-286
    • Ooi, S.L.1    Shoemaker, D.D.2    Boeke, J.D.3
  • 24
    • 43049146539 scopus 로고    scopus 로고
    • Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae
    • Ben-Aroya, S.; Coombes, C.; Kwok, T.; O'Donnell, K.A.; Boeke, J.D.; Hieter, P. Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol. Cell 2008, 30, 248-258.
    • (2008) Mol. Cell , vol.30 , pp. 248-258
    • Ben-Aroya, S.1    Coombes, C.2    Kwok, T.3    O'Donnell, K.A.4    Boeke, J.D.5    Hieter, P.6
  • 25
    • 77952088459 scopus 로고    scopus 로고
    • An overview of Cdk1-controlled targets and processes
    • Enserink, J.M.; Kolodner, R.D. An overview of Cdk1-controlled targets and processes. Cell Div. 2010, 5, 11.
    • (2010) Cell Div , vol.5 , pp. 11
    • Enserink, J.M.1    Kolodner, R.D.2
  • 26
    • 84858236398 scopus 로고    scopus 로고
    • Working without kinase activity: Phosphotransfer-independent functions of extracellular signal-regulated kinases
    • Rodriguez, J.; Crespo, P. Working without kinase activity: Phosphotransfer-independent functions of extracellular signal-regulated kinases. Sci. Signal. 2011, 4, re3.
    • (2011) Sci. Signal. , vol.4
    • Rodriguez, J.1    Crespo, P.2
  • 27
    • 79957887714 scopus 로고    scopus 로고
    • A kinase-independent role for Aurora A in the assembly of mitotic spindle microtubules in Caenorhabditis elegans embryos
    • Toya, M.; Terasawa, M.; Nagata, K.; Iida, Y.; Sugimoto, A. A kinase-independent role for Aurora A in the assembly of mitotic spindle microtubules in Caenorhabditis elegans embryos. Nat. Cell Biol. 2011, 13, 708-714.
    • (2011) Nat. Cell Biol. , vol.13 , pp. 708-714
    • Toya, M.1    Terasawa, M.2    Nagata, K.3    Iida, Y.4    Sugimoto, A.5
  • 28
    • 78449287872 scopus 로고    scopus 로고
    • A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity
    • Au-Yeung, B.B.; Levin, S.E.; Zhang, C.; Hsu, L.Y.; Cheng, D.A.; Killeen, N.; Shokat, K.M.; Weiss, A. A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity. Nat. Immunol. 2010, 11, 1085-1092.
    • (2010) Nat. Immunol. , vol.11 , pp. 1085-1092
    • Au-Yeung, B.B.1    Levin, S.E.2    Zhang, C.3    Hsu, L.Y.4    Cheng, D.A.5    Killeen, N.6    Shokat, K.M.7    Weiss, A.8
  • 29
    • 77953601228 scopus 로고    scopus 로고
    • Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development
    • Zhao, X.; Peng, X.; Sun, S.; Park, A.Y.; Guan, J.L. Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development. J. Cell Biol. 2010, 189, 955-965.
    • (2010) J. Cell Biol. , vol.189 , pp. 955-965
    • Zhao, X.1    Peng, X.2    Sun, S.3    Park, A.Y.4    Guan, J.L.5
  • 30
    • 11344274449 scopus 로고    scopus 로고
    • A kinase-independent function of Cks1 and Cdk1 in regulation of transcription
    • Yu, V.P.; Baskerville, C.; Grunenfelder, B.; Reed, S.I. A kinase-independent function of Cks1 and Cdk1 in regulation of transcription. Mol. Cell 2005, 17, 145-151.
    • (2005) Mol. Cell , vol.17 , pp. 145-151
    • Yu, V.P.1    Baskerville, C.2    Grunenfelder, B.3    Reed, S.I.4
  • 34
    • 84856081012 scopus 로고    scopus 로고
    • What makes the engine hum: Rad6, a cell cycle supercharger
    • Enserink, J.M.; Kolodner, R.D. What makes the engine hum: Rad6, a cell cycle supercharger. Cell Cycle 2012, 11, 249-252.
    • (2012) Cell Cycle , vol.11 , pp. 249-252
    • Enserink, J.M.1    Kolodner, R.D.2
  • 36
    • 70349546862 scopus 로고    scopus 로고
    • Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution
    • Holt, L.J.; Tuch, B.B.; Villen, J.; Johnson, A.D.; Gygi, S.P.; Morgan, D.O. Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution. Science 2009, 325, 1682-1686.
    • (2009) Science , vol.325 , pp. 1682-1686
    • Holt, L.J.1    Tuch, B.B.2    Villen, J.3    Johnson, A.D.4    Gygi, S.P.5    Morgan, D.O.6
  • 37
    • 65649090278 scopus 로고    scopus 로고
    • Cdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae
    • Enserink, J.M.; Hombauer, H.; Huang, M.E.; Kolodner, R.D. Cdc28/Cdk1 positively and negatively affects genome stability in S. cerevisiae. J. Cell Biol. 2009, 185, 423-437.
    • (2009) J. Cell Biol. , vol.185 , pp. 423-437
    • Enserink, J.M.1    Hombauer, H.2    Huang, M.E.3    Kolodner, R.D.4
  • 38
    • 77957368466 scopus 로고    scopus 로고
    • Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity
    • Granata, M.; Lazzaro, F.; Novarina, D.; Panigada, D.; Puddu, F.; Abreu, C.M.; Kumar, R.; Grenon, M.; Lowndes, N.F.; Plevani, P.; et al. Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity. PLoS Genet. 2010, 6, e1001047.
    • (2010) PLoS Genet , vol.6
    • Granata, M.1    Lazzaro, F.2    Novarina, D.3    Panigada, D.4    Puddu, F.5    Abreu, C.M.6    Kumar, R.7    Grenon, M.8    Lowndes, N.F.9    Plevani, P.10
  • 39
    • 70449641057 scopus 로고    scopus 로고
    • Progression through the RNA polymerase II CTD cycle
    • Buratowski, S. Progression through the RNA polymerase II CTD cycle. Mol. Cell 2009, 36, 541-546.
    • (2009) Mol. Cell , vol.36 , pp. 541-546
    • Buratowski, S.1
  • 40
    • 0029066929 scopus 로고
    • KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity
    • Cismowski, M.J.; Laff, G.M.; Solomon, M.J.; Reed, S.I. KIN28 encodes a C-terminal domain kinase that controls mRNA transcription in Saccharomyces cerevisiae but lacks cyclin-dependent kinase-activating kinase (CAK) activity. Mol. Cell Biol. 1995, 15, 2983-2992.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 2983-2992
    • Cismowski, M.J.1    Laff, G.M.2    Solomon, M.J.3    Reed, S.I.4
  • 41
    • 0029008667 scopus 로고
    • The KIN28 gene is required both for RNA polymerase II mediated transcription and phosphorylation of the Rpb1p CTD
    • Valay, J.G.; Simon, M.; Dubois, M.F.; Bensaude, O.; Facca, C.; Faye, G. The KIN28 gene is required both for RNA polymerase II mediated transcription and phosphorylation of the Rpb1p CTD. J. Mol. Biol. 1995, 249, 535-544.
    • (1995) J. Mol. Biol. , vol.249 , pp. 535-544
    • Valay, J.G.1    Simon, M.2    Dubois, M.F.3    Bensaude, O.4    Facca, C.5    Faye, G.6
  • 42
    • 62549104640 scopus 로고    scopus 로고
    • Phosphorylation of the Pol II CTD by KIN28 enhances BUR1/BUR2 recruitment and Ser2 CTD phosphorylation near promoters
    • Qiu, H.; Hu, C.; Hinnebusch, A.G. Phosphorylation of the Pol II CTD by KIN28 enhances BUR1/BUR2 recruitment and Ser2 CTD phosphorylation near promoters. Mol. Cell 2009, 33, 752-762.
    • (2009) Mol. Cell , vol.33 , pp. 752-762
    • Qiu, H.1    Hu, C.2    Hinnebusch, A.G.3
  • 44
    • 70149118362 scopus 로고    scopus 로고
    • Phosphorylation of the RNA polymerase II C-terminal domain by TFIIH kinase is not essential for transcription of Saccharomyces cerevisiae genome
    • Hong, S.W.; Hong, S.M.; Yoo, J.W.; Lee, Y.C.; Kim, S.; Lis, J.T.; Lee, D.K. Phosphorylation of the RNA polymerase II C-terminal domain by TFIIH kinase is not essential for transcription of Saccharomyces cerevisiae genome. Proc. Natl. Acad. Sci. USA 2009, 106, 14276-14280.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 14276-14280
    • Hong, S.W.1    Hong, S.M.2    Yoo, J.W.3    Lee, Y.C.4    Kim, S.5    Lis, J.T.6    Lee, D.K.7
  • 46
    • 78649317232 scopus 로고    scopus 로고
    • Regulation of the initiation step of DNA replication by cyclin-dependent kinases
    • Tanaka, S.; Araki, H. Regulation of the initiation step of DNA replication by cyclin-dependent kinases. Chromosoma 2010, 119, 565-574.
    • (2010) Chromosoma , vol.119 , pp. 565-574
    • Tanaka, S.1    Araki, H.2
  • 47
    • 55449084143 scopus 로고    scopus 로고
    • Cdc7-Dbf4 regulates NDT80 transcription as well as reductional segregation during budding yeast meiosis
    • Lo, H.C.; Wan, L.; Rosebrock, A.; Futcher, B.; Hollingsworth, N.M. Cdc7-Dbf4 regulates NDT80 transcription as well as reductional segregation during budding yeast meiosis. Mol. Biol. Cell 2008, 19, 4956-4967.
    • (2008) Mol. Biol. Cell , vol.19 , pp. 4956-4967
    • Lo, H.C.1    Wan, L.2    Rosebrock, A.3    Futcher, B.4    Hollingsworth, N.M.5
  • 48
    • 80655144724 scopus 로고    scopus 로고
    • Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway
    • Shi, Y.; Stefan, C.J.; Rue, S.M.; Teis, D.; Emr, S.D. Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway. Mol. Biol. Cell 2011, 22, 4093-4107.
    • (2011) Mol. Biol. Cell , vol.22 , pp. 4093-4107
    • Shi, Y.1    Stefan, C.J.2    Rue, S.M.3    Teis, D.4    Emr, S.D.5
  • 49
    • 84857917830 scopus 로고    scopus 로고
    • Chemical-genomic profiling: Systematic analysis of the cellular targets of bioactive molecules
    • Andrusiak, K.; Piotrowski, J.S.; Boone, C. Chemical-genomic profiling: Systematic analysis of the cellular targets of bioactive molecules. Bioorg. Med. Chem. 2012, 20, 1952-1960.
    • (2012) Bioorg. Med. Chem. , vol.20 , pp. 1952-1960
    • Andrusiak, K.1    Piotrowski, J.S.2    Boone, C.3
  • 50
    • 0035165578 scopus 로고    scopus 로고
    • Rapamycin in transplantation: A review of the evidence
    • Saunders, R.N.; Metcalfe, M.S.; Nicholson, M.L. Rapamycin in transplantation: A review of the evidence. Kidney Int. 2001, 59, 3-16.
    • (2001) Kidney Int , vol.59 , pp. 3-16
    • Saunders, R.N.1    Metcalfe, M.S.2    Nicholson, M.L.3
  • 51
    • 0016724057 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
    • Vezina, C.; Kudelski, A.; Sehgal, S.N. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. 1975, 28, 721-726.
    • (1975) J. Antibiot. , vol.28 , pp. 721-726
    • Vezina, C.1    Kudelski, A.2    Sehgal, S.N.3
  • 52
    • 0016713286 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization
    • Sehgal, S.N.; Baker, H.; Vezina, C. Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization. J. Antibiot. 1975, 28, 727-732.
    • (1975) J. Antibiot. , vol.28 , pp. 727-732
    • Sehgal, S.N.1    Baker, H.2    Vezina, C.3
  • 53
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • Heitman, J.; Movva, N.R.; Hall, M.N. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 1991, 253, 905-909.
    • (1991) Science , vol.253 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 54
    • 0027311858 scopus 로고
    • Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression
    • Kunz, J.; Henriquez, R.; Schneider, U.; Deuter-Reinhard, M.; Movva, N.R.; Hall, M.N. Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression. Cell 1993, 73, 585-596.
    • (1993) Cell , vol.73 , pp. 585-596
    • Kunz, J.1    Henriquez, R.2    Schneider, U.3    Deuter-Reinhard, M.4    Movva, N.R.5    Hall, M.N.6
  • 55
    • 79953207023 scopus 로고    scopus 로고
    • A brief history of TOR
    • Loewith, R. A brief history of TOR. Biochem. Soc. Trans. 2011, 39, 437-442.
    • (2011) Biochem. Soc. Trans. , vol.39 , pp. 437-442
    • Loewith, R.1
  • 56
    • 48449096999 scopus 로고    scopus 로고
    • Yeast Barcoders: A chemogenomic application of a universal donor-strain collection carrying bar-code identifiers
    • Yan, Z.; Costanzo, M.; Heisler, L.E.; Paw, J.; Kaper, F.; Andrews, B.J.; Boone, C.; Giaever, G.; Nislow, C. Yeast Barcoders: A chemogenomic application of a universal donor-strain collection carrying bar-code identifiers. Nat. Methods 2008, 5, 719-725.
    • (2008) Nat. Methods , vol.5 , pp. 719-725
    • Yan, Z.1    Costanzo, M.2    Heisler, L.E.3    Paw, J.4    Kaper, F.5    Andrews, B.J.6    Boone, C.7    Giaever, G.8    Nislow, C.9
  • 59
    • 0037168646 scopus 로고    scopus 로고
    • A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage
    • Chang, M.; Bellaoui, M.; Boone, C.; Brown, G.W. A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc. Natl. Acad. Sci. USA 2002, 99, 16934-16939.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 16934-16939
    • Chang, M.1    Bellaoui, M.2    Boone, C.3    Brown, G.W.4
  • 66
    • 84865480260 scopus 로고    scopus 로고
    • Yeast toxicogenomics: Genome-wide responses to chemical stresses with impact in environmental health, pharmacology, and biotechnology
    • Dos Santos, S.C.; Teixeira, M.C.; Cabrito, T.R.; Sa-Correia, I. Yeast toxicogenomics: Genome-wide responses to chemical stresses with impact in environmental health, pharmacology, and biotechnology. Front. Genet. 2012, 3, 63.
    • (2012) Front. Genet. , vol.3 , pp. 63
    • Dos Santos, S.C.1    Teixeira, M.C.2    Cabrito, T.R.3    Sa-Correia, I.4
  • 67
    • 84865522287 scopus 로고    scopus 로고
    • Evolutionary and biochemical aspects of chemical stress resistance in saccharomyces cerevisiae
    • Venancio, T.M.; Bellieny-Rabelo, D.; Aravind, L. Evolutionary and Biochemical Aspects of Chemical Stress Resistance in Saccharomyces cerevisiae. Front. Genet. 2012, 3, 47.
    • (2012) Front. Genet. , vol.3 , pp. 47
    • Venancio, T.M.1    Bellieny-Rabelo, D.2    Aravind, L.3
  • 68
    • 77954607480 scopus 로고    scopus 로고
    • Robustness and evolvability in natural chemical resistance: Identification of novel systems properties, biochemical mechanisms and regulatory interactions
    • Venancio, T.M.; Balaji, S.; Geetha, S.; Aravind, L. Robustness and evolvability in natural chemical resistance: Identification of novel systems properties, biochemical mechanisms and regulatory interactions. Mol. Biosyst. 2010, 6, 1475-1491.
    • (2010) Mol. Biosyst. , vol.6 , pp. 1475-1491
    • Venancio, T.M.1    Balaji, S.2    Geetha, S.3    Aravind, L.4
  • 69
    • 72949119090 scopus 로고    scopus 로고
    • High-confidence mapping of chemical compounds and protein complexes reveals novel aspects of chemical stress response in yeast
    • Venancio, T.M.; Balaji, S.; Aravind, L. High-confidence mapping of chemical compounds and protein complexes reveals novel aspects of chemical stress response in yeast. Mol. Biosyst. 2010, 6, 175-181.
    • (2010) Mol. Biosyst. , vol.6 , pp. 175-181
    • Venancio, T.M.1    Balaji, S.2    Aravind, L.3
  • 72
    • 42949084786 scopus 로고    scopus 로고
    • Chemical-genetic approaches for exploring the mode of action of natural products
    • Lopez, A.; Parsons, A.B.; Nislow, C.; Giaever, G.; Boone, C. Chemical-genetic approaches for exploring the mode of action of natural products. Fortschr. Arzneimittelforsch. 2008, 66, 237, 239-271.
    • (2008) Fortschr. Arzneimittelforsch. , vol.66 , Issue.237 , pp. 239-271
    • Lopez, A.1    Parsons, A.B.2    Nislow, C.3    Giaever, G.4    Boone, C.5
  • 73
    • 77954212737 scopus 로고    scopus 로고
    • A survey of yeast genomic assays for drug and target discovery
    • Smith, A.M.; Ammar, R.; Nislow, C.; Giaever, G. A survey of yeast genomic assays for drug and target discovery. Pharmacol. Ther. 2010, 127, 156-164.
    • (2010) Pharmacol. Ther. , vol.127 , pp. 156-164
    • Smith, A.M.1    Ammar, R.2    Nislow, C.3    Giaever, G.4
  • 74
    • 34848926209 scopus 로고    scopus 로고
    • Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches
    • McClellan, A.J.; Xia, Y.; Deutschbauer, A.M.; Davis, R.W.; Gerstein, M.; Frydman, J. Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches. Cell 2007, 131, 121-135.
    • (2007) Cell , vol.131 , pp. 121-135
    • McClellan, A.J.1    Xia, Y.2    Deutschbauer, A.M.3    Davis, R.W.4    Gerstein, M.5    Frydman, J.6
  • 75
    • 84860851412 scopus 로고    scopus 로고
    • Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks
    • Lee, M.J.; Ye, A.S.; Gardino, A.K.; Heijink, A.M.; Sorger, P.K.; Macbeath, G.; Yaffe, M.B. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell 2012, 149, 780-794.
    • (2012) Cell , vol.149 , pp. 780-794
    • Lee, M.J.1    Ye, A.S.2    Gardino, A.K.3    Heijink, A.M.4    Sorger, P.K.5    MacBeath, G.6    Yaffe, M.B.7
  • 76
    • 28844441230 scopus 로고    scopus 로고
    • A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis
    • Janes, K.A.; Albeck, J.G.; Gaudet, S.; Sorger, P.K.; Lauffenburger, D.A.; Yaffe, M.B. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science 2005, 310, 1646-1653.
    • (2005) Science , vol.310 , pp. 1646-1653
    • Janes, K.A.1    Albeck, J.G.2    Gaudet, S.3    Sorger, P.K.4    Lauffenburger, D.A.5    Yaffe, M.B.6
  • 77
    • 53749085729 scopus 로고    scopus 로고
    • Cytokine-induced signaling networks prioritize dynamic range over signal strength
    • Janes, K.A.; Reinhardt, H.C.; Yaffe, M.B. Cytokine-induced signaling networks prioritize dynamic range over signal strength. Cell 2008, 135, 343-354.
    • (2008) Cell , vol.135 , pp. 343-354
    • Janes, K.A.1    Reinhardt, H.C.2    Yaffe, M.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.